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Phase Separation in Biology and Disease.

Forman-Kay JD, Kriwacki RW, Seydoux G.

J Mol Biol. 2018 Nov 2;430(23):4603-4606. doi: 10.1016/j.jmb.2018.09.006. Epub 2018 Sep 11. No abstract available.


Single-molecule study reveals the frenetic lives of proteins in gradients.

Folkmann AW, Seydoux G.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9336-9338. doi: 10.1073/pnas.1812248115. Epub 2018 Sep 4. No abstract available.


The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates.

Seydoux G.

J Mol Biol. 2018 Nov 2;430(23):4702-4710. doi: 10.1016/j.jmb.2018.08.007. Epub 2018 Aug 8. Review.


Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks.

Paix A, Folkmann A, Goldman DH, Kulaga H, Grzelak MJ, Rasoloson D, Paidemarry S, Green R, Reed RR, Seydoux G.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10745-E10754. doi: 10.1073/pnas.1711979114. Epub 2017 Nov 28.


Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

Lee CS, Lu T, Seydoux G.

Elife. 2017 Nov 7;6. pii: e30201. doi: 10.7554/eLife.30201.


Not just Salk.

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V.

Science. 2017 Sep 15;357(6356):1105-1106. doi: 10.1126/science.aao6221. No abstract available.


MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes.

Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH.

Genetics. 2017 Oct;207(2):447-463. doi: 10.1534/genetics.117.300179. Epub 2017 Aug 21.


Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans.

Paix A, Folkmann A, Seydoux G.

Methods. 2017 May 15;121-122:86-93. doi: 10.1016/j.ymeth.2017.03.023. Epub 2017 Apr 7.


Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3.

Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G.

Elife. 2016 Dec 3;5. pii: e21337. doi: 10.7554/eLife.21337.


Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Housden BE, Muhar M, Gemberling M, Gersbach CA, Stainier DY, Seydoux G, Mohr SE, Zuber J, Perrimon N.

Nat Rev Genet. 2017 Jan;18(1):24-40. doi: 10.1038/nrg.2016.118. Epub 2016 Oct 31. Review.


Cas9-assisted recombineering in C. elegans: genome editing using in vivo assembly of linear DNAs.

Paix A, Schmidt H, Seydoux G.

Nucleic Acids Res. 2016 Sep 6;44(15):e128. doi: 10.1093/nar/gkw502. Epub 2016 Jun 1.


High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes.

Paix A, Folkmann A, Rasoloson D, Seydoux G.

Genetics. 2015 Sep;201(1):47-54. doi: 10.1534/genetics.115.179382. Epub 2015 Jul 17.


Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.

Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G.

Elife. 2014 Dec 23;3:e04591. doi: 10.7554/eLife.04591.


Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.

Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E.

Science. 2014 Oct 24;346(6208):1257998. doi: 10.1126/science.1257998. Epub 2014 Oct 23.


Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans.

Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G.

Genetics. 2014 Dec;198(4):1347-56. doi: 10.1534/genetics.114.170423. Epub 2014 Sep 23.


P granules.

Wang JT, Seydoux G.

Curr Biol. 2014 Jul 21;24(14):R637-R638. doi: 10.1016/j.cub.2014.06.018. No abstract available.


Identification of suppressors of mbk-2/DYRK by whole-genome sequencing.

Wang Y, Wang JT, Rasoloson D, Stitzel ML, O' Connell KF, Smith HE, Seydoux G.

G3 (Bethesda). 2014 Feb 19;4(2):231-41. doi: 10.1534/g3.113.009126.


The PAR network: redundancy and robustness in a symmetry-breaking system.

Motegi F, Seydoux G.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130010. doi: 10.1098/rstb.2013.0010. Print 2013. Review.


'Goldilocks' suppressor screen identifies web of polarity regulators.

Seydoux G.

Nat Cell Biol. 2013 Jan;15(1):9-10. doi: 10.1038/ncb2666.


Germ cell specification.

Wang JT, Seydoux G.

Adv Exp Med Biol. 2013;757:17-39. doi: 10.1007/978-1-4614-4015-4_2. Review.


Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes.

Motegi F, Zonies S, Hao Y, Cuenca AA, Griffin E, Seydoux G.

Nat Cell Biol. 2011 Oct 9;13(11):1361-7. doi: 10.1038/ncb2354.


Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle.

Griffin EE, Odde DJ, Seydoux G.

Cell. 2011 Sep 16;146(6):955-68. doi: 10.1016/j.cell.2011.08.012.


RNA granules in germ cells.

Voronina E, Seydoux G, Sassone-Corsi P, Nagamori I.

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a002774. doi: 10.1101/cshperspect.a002774. Review.


Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans.

Gallo CM, Wang JT, Motegi F, Seydoux G.

Science. 2010 Dec 17;330(6011):1685-9. doi: 10.1126/science.1193697. Epub 2010 Dec 2.


The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells.

Merritt C, Seydoux G.

Development. 2010 Jun;137(11):1787-98. doi: 10.1242/dev.050799. Epub 2010 Apr 28.


Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.

Zonies S, Motegi F, Hao Y, Seydoux G.

Development. 2010 May;137(10):1669-77. doi: 10.1242/dev.045823. Epub 2010 Apr 14.


The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.

Voronina E, Seydoux G.

Development. 2010 May;137(9):1441-50. doi: 10.1242/dev.047654. Epub 2010 Mar 24.


Transgenic solutions for the germline.

Merritt C, Seydoux G.

WormBook. 2010 Feb 8:1-21. doi: 10.1895/wormbook.1.148.1. Review. No abstract available.


Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.

Cheng KC, Klancer R, Singson A, Seydoux G.

Cell. 2009 Oct 30;139(3):560-72. doi: 10.1016/j.cell.2009.08.047.


Less is more: specification of the germline by transcriptional repression.

Nakamura A, Seydoux G.

Development. 2008 Dec;135(23):3817-27. doi: 10.1242/dev.022434. Review.


3' UTRs are the primary regulators of gene expression in the C. elegans germline.

Merritt C, Rasoloson D, Ko D, Seydoux G.

Curr Biol. 2008 Oct 14;18(19):1476-82. doi: 10.1016/j.cub.2008.08.013. Epub 2008 Sep 25.


Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos.

Gallo CM, Munro E, Rasoloson D, Merritt C, Seydoux G.

Dev Biol. 2008 Nov 1;323(1):76-87. doi: 10.1016/j.ydbio.2008.07.008. Epub 2008 Jul 16.


Conserved regulation of MAP kinase expression by PUF RNA-binding proteins.

Lee MH, Hook B, Pan G, Kershner AM, Merritt C, Seydoux G, Thomson JA, Wickens M, Kimble J.

PLoS Genet. 2007 Dec 28;3(12):e233. doi: 10.1371/journal.pgen.0030233.


Revisiting the role of microtubules in C. elegans polarity.

Motegi F, Seydoux G.

J Cell Biol. 2007 Nov 5;179(3):367-9.


Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition.

Stitzel ML, Cheng KC, Seydoux G.

Curr Biol. 2007 Sep 18;17(18):1545-54.


Regulation of the oocyte-to-zygote transition.

Stitzel ML, Seydoux G.

Science. 2007 Apr 20;316(5823):407-8. Review.


Pathway to totipotency: lessons from germ cells.

Seydoux G, Braun RE.

Cell. 2006 Dec 1;127(5):891-904. Review.


Toti "potent" repressors.

Gallo CM, Seydoux G.

Bioessays. 2006 Sep;28(9):865-7.


The 2006 Genetics Society of America Medal. Victor Ambros.

Seydoux G.

Genetics. 2006 Feb;172(2):721-2. No abstract available.


Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline.

D'Agostino I, Merritt C, Chen PL, Seydoux G, Subramaniam K.

Dev Biol. 2006 Apr 1;292(1):244-52. Epub 2006 Feb 24.


Stabilization of cell polarity by the C. elegans RING protein PAR-2.

Hao Y, Boyd L, Seydoux G.

Dev Cell. 2006 Feb;10(2):199-208.


The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation.

Stitzel ML, Pellettieri J, Seydoux G.

Curr Biol. 2006 Jan 10;16(1):56-62. Epub 2005 Dec 15.


A clean start: degradation of maternal proteins at the oocyte-to-embryo transition.

DeRenzo C, Seydoux G.

Trends Cell Biol. 2004 Aug;14(8):420-6. Review.


Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans.

Pellettieri J, Reinke V, Kim SK, Seydoux G.

Dev Cell. 2003 Sep;5(3):451-62.


Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.

DeRenzo C, Reese KJ, Seydoux G.

Nature. 2003 Aug 7;424(6949):685-9. Epub 2003 Jul 23.


Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.

Cuenca AA, Schetter A, Aceto D, Kemphues K, Seydoux G.

Development. 2003 Apr;130(7):1255-65.


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