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Items: 1 to 50 of 61

1.

Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies.

Meel MH, Sewing ACP, Waranecki P, Metselaar DS, Wedekind LE, Koster J, van Vuurden DG, Kaspers GJL, Hulleman E.

Exp Cell Res. 2017 Nov 15;360(2):397-403. doi: 10.1016/j.yexcr.2017.09.032. Epub 2017 Sep 22.

PMID:
28947132
2.

Multiregional Tumor Drug-Uptake Imaging by PET and Microvascular Morphology in End-Stage Diffuse Intrinsic Pontine Glioma.

Veldhuijzen van Zanten SEM, Sewing ACP, van Lingen A, Hoekstra OS, Wesseling P, Meel MH, van Vuurden DG, Kaspers GJL, Hulleman E, Bugiani M.

J Nucl Med. 2018 Apr;59(4):612-615. doi: 10.2967/jnumed.117.197897. Epub 2017 Aug 17.

3.

Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma.

Sewing ACP, Lagerweij T, van Vuurden DG, Meel MH, Veringa SJE, Carcaboso AM, Gaillard PJ, Peter Vandertop W, Wesseling P, Noske D, Kaspers GJL, Hulleman E.

J Neurosurg Pediatr. 2017 May;19(5):518-530. doi: 10.3171/2016.9.PEDS16152. Epub 2017 Feb 17.

PMID:
28291423
4.

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models.

Jansen MH, Lagerweij T, Sewing AC, Vugts DJ, van Vuurden DG, Molthoff CF, Caretti V, Veringa SJ, Petersen N, Carcaboso AM, Noske DP, Vandertop WP, Wesseling P, van Dongen GA, Kaspers GJ, Hulleman E.

Mol Cancer Ther. 2016 Sep;15(9):2166-74. doi: 10.1158/1535-7163.MCT-15-0558. Epub 2016 Jun 20.

5.

The effect of different collagen modifications for titanium and titanium nitrite surfaces on functions of gingival fibroblasts.

Ritz U, Nusselt T, Sewing A, Ziebart T, Kaufmann K, Baranowski A, Rommens PM, Hofmann A.

Clin Oral Investig. 2017 Jan;21(1):255-265. doi: 10.1007/s00784-016-1784-5. Epub 2016 Mar 12.

PMID:
26969500
6.

Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study.

Sewing AC, Caretti V, Lagerweij T, Schellen P, Jansen MH, van Vuurden DG, Idema S, Molthoff CF, Vandertop WP, Kaspers GJ, Noske DP, Hulleman E.

J Neurosci Methods. 2014 Dec 30;238:88-94. doi: 10.1016/j.jneumeth.2014.09.020. Epub 2014 Sep 27.

PMID:
25263805
7.

Human pontine glioma cells can induce murine tumors.

Caretti V, Sewing AC, Lagerweij T, Schellen P, Bugiani M, Jansen MH, van Vuurden DG, Navis AC, Horsman I, Vandertop WP, Noske DP, Wesseling P, Kaspers GJ, Nazarian J, Vogel H, Hulleman E, Monje M, Wurdinger T.

Acta Neuropathol. 2014;127(6):897-909. doi: 10.1007/s00401-014-1272-4. Epub 2014 Apr 29.

8.

Cyclic-RGD is as effective as rhBMP-2 in anterior interbody fusion of the sheep cervical spine.

Scholz M, Schleicher P, Sewing A, Gelinsky M, Kandziora F.

Spine (Phila Pa 1976). 2013 Jan 15;38(2):E59-65. doi: 10.1097/BRS.0b013e31827ad2ff.

PMID:
23124266
9.

Comparison of recruitment manoeuvres in ventilated sheep with acute respiratory distress syndrome.

Engel M, Nowacki RM, Reiss LK, Uhlig S, Willems CH, Kloosterboer N, van Iwaarden JF, Sewing AC, Seehase M, Lambermont VA, Collins JJ, Zimmermann LJ, Vos GD, Kramer BW.

Lung. 2013 Feb;191(1):77-86. doi: 10.1007/s00408-012-9428-2. Epub 2012 Nov 2.

PMID:
23117276
10.

Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α.

Sewing AC, Kantores C, Ivanovska J, Lee AH, Masood A, Jain A, McNamara PJ, Tanswell AK, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L75-87. doi: 10.1152/ajplung.00072.2012. Epub 2012 May 11.

11.

Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits.

Alt V, Bitschnau A, Böhner F, Heerich KE, Magesin E, Sewing A, Pavlidis T, Szalay G, Heiss C, Thormann U, Hartmann S, Pabst W, Wenisch S, Schnettler R.

Acta Biomater. 2011 Mar;7(3):1274-80. doi: 10.1016/j.actbio.2010.11.012. Epub 2010 Dec 1.

PMID:
21081183
12.

Cages augmented with mineralized collagen and platelet-rich plasma as an osteoconductive/inductive combination for interbody fusion.

Scholz M, Schleicher P, Eindorf T, Friedersdorff F, Gelinsky M, König U, Sewing A, Haas NP, Kandziora F.

Spine (Phila Pa 1976). 2010 Apr 1;35(7):740-6. doi: 10.1097/BRS.0b013e3181bdc6cc.

PMID:
20228704
13.

Compound management beyond efficiency.

Burr I, Winchester T, Keighley W, Sewing A.

J Biomol Screen. 2009 Jun;14(5):485-91. doi: 10.1177/1087057109333978. Epub 2009 Jun 5.

PMID:
19502566
14.

New working paradigms in research laboratories.

Keighley W, Sewing A.

Drug Discov Today. 2009 Jul;14(13-14):625-9. doi: 10.1016/j.drudis.2009.05.004. Epub 2009 May 27.

PMID:
19477291
15.

Cyclo-DfKRG peptide modulates in vitro and in vivo behavior of human osteoprogenitor cells on titanium alloys.

Pallu S, Fricain JC, Bareille R, Bourget C, Dard M, Sewing A, Amédée J.

Acta Biomater. 2009 Nov;5(9):3581-92. doi: 10.1016/j.actbio.2009.05.018. Epub 2009 May 23.

PMID:
19467347
16.

Effect of modifications of dual acid-etched implant surfaces on periimplant bone formation. Part II: calcium phosphate coatings.

Schliephake H, Aref A, Scharnweber D, Rösler S, Sewing A.

Clin Oral Implants Res. 2009 Jan;20(1):38-44. doi: 10.1111/j.1600-0501.2008.01616.x.

PMID:
19126106
17.

Effect of modifications of dual acid-etched implant surfaces on peri-implant bone formation. Part I: organic coatings.

Schliephake H, Aref A, Scharnweber D, Bierbaum S, Sewing A.

Clin Oral Implants Res. 2009 Jan;20(1):31-7. doi: 10.1111/j.1600-0501.2008.01603.x.

PMID:
19126105
18.

Comparison of new bone formation, implant integration, and biocompatibility between RGD-hydroxyapatite and pure hydroxyapatite coating for cementless joint prostheses--an experimental study in rabbits.

Bitschnau A, Alt V, Böhner F, Heerich KE, Margesin E, Hartmann S, Sewing A, Meyer C, Wenisch S, Schnettler R.

J Biomed Mater Res B Appl Biomater. 2009 Jan;88(1):66-74. doi: 10.1002/jbm.b.31150.

PMID:
18615683
19.

Additive effect of RGD coating to functionalized titanium surfaces on human osteoprogenitor cell adhesion and spreading.

Le Guillou-Buffello D, Bareille R, Gindre M, Sewing A, Laugier P, Amédée J.

Tissue Eng Part A. 2008 Aug;14(8):1445-55. doi: 10.1089/ten.tea.2007.0292.

PMID:
18611146
20.

Helping science to succeed: improving processes in R&D.

Sewing A, Winchester T, Carnell P, Hampton D, Keighley W.

Drug Discov Today. 2008 Mar;13(5-6):227-33. doi: 10.1016/j.drudis.2007.11.011. Epub 2008 Mar 5. Review.

PMID:
18342798
21.

High-throughput lead finding and optimisation for GPCR targets.

Sewing A, Cawkill D.

Ernst Schering Found Symp Proc. 2006;(2):249-67. Review.

PMID:
17703586
22.

Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation.

Moger J, Gribbon P, Sewing A, Winlove CP.

Biochim Biophys Acta. 2007 Jun;1770(6):912-8. Epub 2007 Feb 12.

PMID:
17360121
23.

Biomimetic calcium phosphate composite coating of dental implants.

Schliephake H, Scharnweber D, Roesseler S, Dard M, Sewing A, Aref A.

Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):738-46.

PMID:
17066635
24.

Resonance frequency measurements of implant stability in the dog mandible: experimental comparison with histomorphometric data.

Schliephake H, Sewing A, Aref A.

Int J Oral Maxillofac Surg. 2006 Oct;35(10):941-6. Epub 2006 Oct 5.

PMID:
17027234
25.

The application of fluorescence lifetime readouts in high-throughput screening.

Moger J, Gribbon P, Sewing A, Winlove CP.

J Biomol Screen. 2006 Oct;11(7):765-72. Epub 2006 Aug 30.

PMID:
16943393
26.

Data visualization during the early stages of drug discovery.

Maniyar DM, Nabney IT, Williams BS, Sewing A.

J Chem Inf Model. 2006 Jul-Aug;46(4):1806-18.

PMID:
16859312
27.

Analysing the output from primary screening.

Nowlin D, Bingham P, Berridge A, Gribbon P, Laflin P, Sewing A.

Comb Chem High Throughput Screen. 2006 Jun;9(5):331-7.

PMID:
16787146
28.

A novel method for analyzing [Ca2+] flux kinetics in high-throughput screening.

Gribbon P, Chambers C, Palo K, Kupper J, Mueller J, Sewing A.

J Biomol Screen. 2006 Aug;11(5):511-8. Epub 2006 Jun 7.

PMID:
16760374
29.

The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model.

Alt V, Bitschnau A, Osterling J, Sewing A, Meyer C, Kraus R, Meissner SA, Wenisch S, Domann E, Schnettler R.

Biomaterials. 2006 Sep;27(26):4627-34. Epub 2006 May 19.

PMID:
16712926
30.

Experiences in implementing uHTS--cutting edge technology meets the real world.

Gribbon P, Schaertl S, Wickenden M, Williams G, Grimley R, Stuhmeier F, Preckel H, Eggeling C, Kraemer J, Everett J, Keighley WW, Sewing A.

Curr Drug Discov Technol. 2004 Jan;1(1):27-35. Review.

PMID:
16472217
31.

Improving the design and analysis of high-throughput screening technology comparison experiments using statistical modeling.

Woodward PW, Williams C, Sewing A, Benson N.

J Biomol Screen. 2006 Feb;11(1):5-12. Epub 2005 Oct 18.

PMID:
16234338
32.

Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation.

Schliephake H, Aref A, Scharnweber D, Bierbaum S, Roessler S, Sewing A.

Clin Oral Implants Res. 2005 Oct;16(5):563-9.

PMID:
16164462
33.

G-protein coupled receptor assays: to measure affinity or efficacy that is the question.

Williams C, Sewing A.

Comb Chem High Throughput Screen. 2005 Jun;8(4):285-92. Review.

PMID:
16101004
34.

The effect of cyclo-DfKRG peptide immobilization on titanium on the adhesion and differentiation of human osteoprogenitor cells.

Pallu S, Bourget C, Bareille R, Labrugère C, Dard M, Sewing A, Jonczyk A, Vernizeau M, Christine Durrieu M, Amédée-Vilamitjana J.

Biomaterials. 2005 Dec;26(34):6932-40.

PMID:
15950276
35.

Evaluating real-life high-throughput screening data.

Gribbon P, Lyons R, Laflin P, Bradley J, Chambers C, Williams BS, Keighley W, Sewing A.

J Biomol Screen. 2005 Mar;10(2):99-107.

PMID:
15799953
36.

Functionalization of dental implant surfaces using adhesion molecules.

Schliephake H, Scharnweber D, Dard M, Sewing A, Aref A, Roessler S.

J Biomed Mater Res B Appl Biomater. 2005 Apr;73(1):88-96.

PMID:
15786448
37.

High-throughput drug discovery: what can we expect from HTS?

Gribbon P, Sewing A.

Drug Discov Today. 2005 Jan 1;10(1):17-22. Review. No abstract available.

PMID:
15676295
38.

Development and automation of a 384-well cell fusion assay to identify inhibitors of CCR5/CD4-mediated HIV virus entry.

Bradley J, Gill J, Bertelli F, Letafat S, Corbau R, Hayter P, Harrison P, Tee A, Keighley W, Perros M, Ciaramella G, Sewing A, Williams C.

J Biomol Screen. 2004 Sep;9(6):516-24.

PMID:
15452338
39.

Biomimetic coatings functionalized with adhesion peptides for dental implants.

Roessler S, Born R, Scharnweber D, Worch H, Sewing A, Dard M.

J Mater Sci Mater Med. 2001 Oct-Dec;12(10-12):871-7.

PMID:
15348332
40.

Use of a mineralized collagen membrane to enhance repair of calvarial defects in rats.

Schliephake H, Tavassol F, Gelinsky M, Dard M, Sewing A, Pompe W.

Clin Oral Implants Res. 2004 Feb;15(1):112-8.

PMID:
14731184
41.

Fluorescence readouts in HTS: no gain without pain?

Gribbon P, Sewing A.

Drug Discov Today. 2003 Nov 15;8(22):1035-43. Review.

PMID:
14690634
42.

High-throughput screening for ion channel modulators.

Falconer M, Smith F, Surah-Narwal S, Congrave G, Liu Z, Hayter P, Ciaramella G, Keighley W, Haddock P, Waldron G, Sewing A.

J Biomol Screen. 2002 Oct;7(5):460-5.

PMID:
14599362
43.

Measuring intracellular calcium fluxes in high throughput mode.

Chambers C, Smith F, Williams C, Marcos S, Liu ZH, Hayter P, Ciaramella G, Keighley W, Gribbon P, Sewing A.

Comb Chem High Throughput Screen. 2003 Jun;6(4):355-62.

PMID:
12769679
44.

Electrochemically assisted deposition of thin calcium phosphate coatings at near-physiological pH and temperature.

Rössler S, Sewing A, Stölzel M, Born R, Scharnweber D, Dard M, Worch H.

J Biomed Mater Res A. 2003 Mar 15;64(4):655-63.

PMID:
12601777
45.

Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible.

Schliephake H, Scharnweber D, Dard M, Röbetaler S, Sewing A, Hüttmann C.

J Biomed Mater Res A. 2003 Feb 1;64(2):225-34.

PMID:
12522808
46.

Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest. An experimental pilot study in dogs.

Schliephake H, Scharnweber D, Dard M, Rössler S, Sewing A, Meyer J, Hoogestraat D.

Clin Oral Implants Res. 2002 Jun;13(3):312-9.

PMID:
12010163
48.

Tools for tissue engineering of mineralized oral structures.

Dard M, Sewing A, Meyer J, Verrier S, Roessler S, Scharnweber D.

Clin Oral Investig. 2000 Jun;4(2):126-9. Review.

PMID:
11218500
49.

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H.

EMBO J. 1999 Oct 1;18(19):5310-20.

50.

Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation.

Zwicker J, Brüsselbach S, Jooss KU, Sewing A, Behn M, Lucibello FC, Müller R.

Oncogene. 1999 Jan 7;18(1):19-25.

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