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Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer.

Massion PP, Healey GF, Peek LJ, Fredericks L, Sewell HF, Murray A, Robertson JF.

J Thorac Oncol. 2017 Mar;12(3):578-584. doi: 10.1016/j.jtho.2016.08.143. Epub 2016 Sep 8.


Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

Aldajani WA, Salazar F, Sewell HF, Knox A, Ghaemmaghami AM.

Oncotarget. 2016 Sep 6;7(36):57606-57617. doi: 10.18632/oncotarget.11586.


Human Blood Autoantibodies in the Detection of Colorectal Cancer.

Negm OH, Hamed MR, Schoen RE, Whelan RL, Steele RJ, Scholefield J, Dilnot EM, Shantha Kumara HM, Robertson JF, Sewell HF.

PLoS One. 2016 Jul 6;11(7):e0156971. doi: 10.1371/journal.pone.0156971. eCollection 2016.


An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Sharquie IK, Al-Ghouleh A, Fitton P, Clark MR, Armour KL, Sewell HF, Shakib F, Ghaemmaghami AM.

BMC Immunol. 2013 Dec 13;14:54. doi: 10.1186/1471-2172-14-54.


Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis.

Monaghan TM, Robins A, Knox A, Sewell HF, Mahida YR.

PLoS One. 2013 Sep 10;8(9):e74452. doi: 10.1371/journal.pone.0074452. eCollection 2013.


The role of lectins in allergic sensitization and allergic disease.

Salazar F, Sewell HF, Shakib F, Ghaemmaghami AM.

J Allergy Clin Immunol. 2013 Jul;132(1):27-36. doi: 10.1016/j.jaci.2013.02.001. Epub 2013 Mar 25. Review.


Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(®)-Lung Test.

Macdonald IK, Murray A, Healey GF, Parsy-Kowalska CB, Allen J, McElveen J, Robertson C, Sewell HF, Chapman CJ, Robertson JF.

PLoS One. 2012;7(12):e51002. doi: 10.1371/journal.pone.0051002. Epub 2012 Dec 13.


Development and validation of a high throughput system for discovery of antigens for autoantibody detection.

Macdonald IK, Allen J, Murray A, Parsy-Kowalska CB, Healey GF, Chapman CJ, Sewell HF, Robertson JF.

PLoS One. 2012;7(7):e40759. doi: 10.1371/journal.pone.0040759. Epub 2012 Jul 18.


EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer.

Lam S, Boyle P, Healey GF, Maddison P, Peek L, Murray A, Chapman CJ, Allen J, Wood WC, Sewell HF, Robertson JF.

Cancer Prev Res (Phila). 2011 Jul;4(7):1126-34. doi: 10.1158/1940-6207.CAPR-10-0328.


Differential binding and internalization of Clostridium difficile toxin A by human peripheral blood monocytes, neutrophils and lymphocytes.

Modi N, Gulati N, Solomon K, Monaghan T, Robins A, Sewell HF, Mahida YR.

Scand J Immunol. 2011 Sep;74(3):264-271. doi: 10.1111/j.1365-3083.2011.02578.x.


Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity.

Emara M, Royer PJ, Abbas Z, Sewell HF, Mohamed GG, Singh S, Peel S, Fox J, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Biol Chem. 2011 Apr 15;286(15):13033-40. doi: 10.1074/jbc.M111.220657. Epub 2011 Feb 18.


The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.

Royer PJ, Emara M, Yang C, Al-Ghouleh A, Tighe P, Jones N, Sewell HF, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Immunol. 2010 Aug 1;185(3):1522-31. doi: 10.4049/jimmunol.1000774. Epub 2010 Jul 7.


Technical validation of an autoantibody test for lung cancer.

Murray A, Chapman CJ, Healey G, Peek LJ, Parsons G, Baldwin D, Barnes A, Sewell HF, Fritsche HA, Robertson JF.

Ann Oncol. 2010 Aug;21(8):1687-93. doi: 10.1093/annonc/mdp606. Epub 2010 Feb 2.


Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1.

Horlock C, Shakib F, Jones NS, Sewell HF, Ghaemmaghami AM.

Int Arch Allergy Immunol. 2009;150(3):237-51. doi: 10.1159/000222676. Epub 2009 Jun 4.


Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.

Hasan AA, Ghaemmaghami AM, Fairclough L, Robins A, Sewell HF, Shakib F.

Immunobiology. 2009;214(1):2-16. doi: 10.1016/j.imbio.2008.04.006. Epub 2008 Jun 20.


The molecular basis of allergenicity.

Shakib F, Ghaemmaghami AM, Sewell HF.

Trends Immunol. 2008 Dec;29(12):633-42. doi: 10.1016/ Epub 2008 Oct 24. Review.


An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcepsilonRI with FcgammaRIIb.

Wigginton SJ, Furtado PB, Armour KL, Clark MR, Robins A, Emara M, Ghaemmaghami AM, Sewell HF, Shakib F.

Clin Exp Allergy. 2008 Feb;38(2):313-9. Epub 2007 Dec 7.


The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets.

Richens J, Fairclough L, Ghaemmaghami AM, Mahdavi J, Shakib F, Sewell HF.

Immunobiology. 2007;212(1):29-38. Epub 2006 Sep 18.


The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses.

Furmonaviciene R, Ghaemmaghami AM, Boyd SE, Jones NS, Bailey K, Willis AC, Sewell HF, Mitchell DA, Shakib F.

Clin Exp Allergy. 2007 Feb;37(2):231-42.


An attempt to define allergen-specific molecular surface features: a bioinformatic approach.

Furmonaviciene R, Sutton BJ, Glaser F, Laughton CA, Jones N, Sewell HF, Shakib F.

Bioinformatics. 2005 Dec 1;21(23):4201-4. Epub 2005 Oct 4.


Comparative molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources.

Furmonaviciene R, Sewell HF, Shakib F.

Clin Exp Allergy. 2000 Sep;30(9):1307-13.


Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

McElveen JE, Furtado PB, Smith SJ, Clark MR, Spendlove I, Sewell HF, Shakib F.

Mol Pathol. 2000 Apr;53(2):77-82.


Identification of peptide motifs recognized by a human IgG autoanti-IgE antibody using a phage display library.

Shakib F, Hooi DS, Smith SJ, Furmonaviciene R, Sewell HF.

Clin Exp Allergy. 2000 Jul;30(7):1041-6.


Epitope discovery using bacteriophage display: the minimum epitope of an anti-IRBP antibody.

Tighe PJ, Powell-Richards A, Sewell HF, Fischer D, Donoso L, Dua HS.

Exp Eye Res. 1999 Jun;68(6):679-84.


Investigation of the expression of IL-1beta converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages.

McAlindon ME, Galvin A, McKaig B, Gray T, Sewell HF, Mahida YR.

Clin Exp Immunol. 1999 May;116(2):251-7.


The interaction between the dust mite antigen Der p 1 and cell-signalling molecules in amplifying allergic disease.

Schulz O, Sewell HF, Shakib F.

Clin Exp Allergy. 1999 Apr;29(4):439-44. Review. No abstract available.


Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis.

Coutinho HB, da Mota HC, Coutinho VB, Robalinho TI, Furtado AF, Walker E, King G, Mahida YR, Sewell HF, Wakelin D.

J Clin Pathol. 1998 Jul;51(7):512-4.


Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis.

Mahida YR, Galvin A, Makh S, Hyde S, Sanfilippo L, Borriello SP, Sewell HF.

Infect Immun. 1998 Nov;66(11):5462-9.


Differential lamina propria cell migration via basement membrane pores of inflammatory bowel disease mucosa.

McAlindon ME, Gray T, Galvin A, Sewell HF, Podolsky DK, Mahida YR.

Gastroenterology. 1998 Oct;115(4):841-8.


Immunodepression induced by Trypanosoma cruzi and mouse hepatitis virus type 3 is associated with thymus apoptosis.

Verinaud L, Da Cruz-Höfling MA, Sakurada JK, Rangel HA, Vassallo J, Wakelin D, Sewell HF, Camargo IJ.

Clin Diagn Lab Immunol. 1998 Mar;5(2):186-91.


Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells.

Mahida YR, Galvin AM, Gray T, Makh S, McAlindon ME, Sewell HF, Podolsky DK.

Clin Exp Immunol. 1997 Aug;109(2):377-86.


Intra-abdominal sepsis: an immunocytochemical study of the small intestine mucosa.

Coutinho HB, Robalinho TI, Coutinho VB, Amorim AM, Furtado AF, Ferraz A, Ferraz E, Walker F, King G, Sewell HF, Wakelin D.

J Clin Pathol. 1997 Apr;50(4):294-8.


Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23.

Schulz O, Sutton BJ, Beavil RL, Shi J, Sewell HF, Gould HJ, Laing P, Shakib F.

Eur J Immunol. 1997 Mar;27(3):584-8.


Immunocytochemistry of mucosal changes in patients infected with the intestinal nematode Strongyloides stercoralis.

Coutinho HB, Robalinho TI, Coutinho VB, Almeida JR, Filho JT, King G, Jenkins D, Mahida Y, Sewell HF, Wakelin D.

J Clin Pathol. 1996 Sep;49(9):717-20.


Immunocytochemical demonstration that human duodenal Brunner's glands may participate in intestinal defence.

Coutinho HB, Robalinho TI, Coutinho VB, Amorin AM, Almeida JR, Filho JT, Walker E, King G, Sewell HF, Wakelin D.

J Anat. 1996 Aug;189 ( Pt 1):193-7.


Der p I, a major allergen of the house dust mite, proteolytically cleaves the low-affinity receptor for human IgE (CD23).

Schulz O, Laing P, Sewell HF, Shakib F.

Eur J Immunol. 1995 Nov;25(11):3191-4.


Arthropathy, leucopenia and recurrent infection associated with a TcR gamma delta population.

Hodges E, Quin C, Farrell AM, Christmas S, Sewell HF, Doherty M, Powell RJ, Smith JL.

Br J Rheumatol. 1995 Oct;34(10):978-83.


Immunocytochemical study of the ontogeny of the marsupial Didelphis albiventris immune system.

Coutinho HB, Sewell HF, Tighe P, King G, Nogueira JC, Robalinho TI, Coutinho VB, Cavalcanti VM.

J Anat. 1995 Aug;187 ( Pt 1):37-46.

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