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Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial.

Sullivan FM, Farmer E, Mair FS, Treweek S, Kendrick D, Jackson C, Robertson C, Briggs A, McCowan C, Bedford L, Young B, Vedhara K, Gallant S, Littleford R, Robertson J, Sewell H, Dorward A, Sarvesvaran J, Schembri S.

BMC Cancer. 2017 Mar 11;17(1):187. doi: 10.1186/s12885-017-3175-y.


1,2-Dichloroethane Exposure Alters the Population Structure, Metabolism, and Kinetics of a Trichloroethene-Dechlorinating Dehalococcoides mccartyi Consortium.

Mayer-Blackwell K, Fincker M, Molenda O, Callahan B, Sewell H, Holmes S, Edwards EA, Spormann AM.

Environ Sci Technol. 2016 Nov 15;50(22):12187-12196. Epub 2016 Nov 3.


Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer.

Massion PP, Healey GF, Peek LJ, Fredericks L, Sewell HF, Murray A, Robertson JF.

J Thorac Oncol. 2017 Mar;12(3):578-584. doi: 10.1016/j.jtho.2016.08.143. Epub 2016 Sep 8.


Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

Aldajani WA, Salazar F, Sewell HF, Knox A, Ghaemmaghami AM.

Oncotarget. 2016 Sep 6;7(36):57606-57617. doi: 10.18632/oncotarget.11586.


Human Blood Autoantibodies in the Detection of Colorectal Cancer.

Negm OH, Hamed MR, Schoen RE, Whelan RL, Steele RJ, Scholefield J, Dilnot EM, Shantha Kumara HM, Robertson JF, Sewell HF.

PLoS One. 2016 Jul 6;11(7):e0156971. doi: 10.1371/journal.pone.0156971. eCollection 2016.


Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.

Sewell H, Tanaka T, El Omari K, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH.

Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643.


An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Sharquie IK, Al-Ghouleh A, Fitton P, Clark MR, Armour KL, Sewell HF, Shakib F, Ghaemmaghami AM.

BMC Immunol. 2013 Dec 13;14:54. doi: 10.1186/1471-2172-14-54.


Breach of race equality duties.

Sewell H.

Nurs Stand. 2013 Oct 30-Nov 5;28(9):65. doi: 10.7748/ns2013. No abstract available.


Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis.

Monaghan TM, Robins A, Knox A, Sewell HF, Mahida YR.

PLoS One. 2013 Sep 10;8(9):e74452. doi: 10.1371/journal.pone.0074452. eCollection 2013.


The role of lectins in allergic sensitization and allergic disease.

Salazar F, Sewell HF, Shakib F, Ghaemmaghami AM.

J Allergy Clin Immunol. 2013 Jul;132(1):27-36. doi: 10.1016/j.jaci.2013.02.001. Epub 2013 Mar 25. Review.


Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(®)-Lung Test.

Macdonald IK, Murray A, Healey GF, Parsy-Kowalska CB, Allen J, McElveen J, Robertson C, Sewell HF, Chapman CJ, Robertson JF.

PLoS One. 2012;7(12):e51002. doi: 10.1371/journal.pone.0051002. Epub 2012 Dec 13.


Development and validation of a high throughput system for discovery of antigens for autoantibody detection.

Macdonald IK, Allen J, Murray A, Parsy-Kowalska CB, Healey GF, Chapman CJ, Sewell HF, Robertson JF.

PLoS One. 2012;7(7):e40759. doi: 10.1371/journal.pone.0040759. Epub 2012 Jul 18.


The effect of an intercalated BSc on subsequent academic performance.

Mahesan N, Crichton S, Sewell H, Howell S.

BMC Med Educ. 2011 Oct 3;11:76. doi: 10.1186/1472-6920-11-76.


EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer.

Lam S, Boyle P, Healey GF, Maddison P, Peek L, Murray A, Chapman CJ, Allen J, Wood WC, Sewell HF, Robertson JF.

Cancer Prev Res (Phila). 2011 Jul;4(7):1126-34. doi: 10.1158/1940-6207.CAPR-10-0328.


Differential binding and internalization of Clostridium difficile toxin A by human peripheral blood monocytes, neutrophils and lymphocytes.

Modi N, Gulati N, Solomon K, Monaghan T, Robins A, Sewell HF, Mahida YR.

Scand J Immunol. 2011 Sep;74(3):264-271. doi: 10.1111/j.1365-3083.2011.02578.x.


Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity.

Emara M, Royer PJ, Abbas Z, Sewell HF, Mohamed GG, Singh S, Peel S, Fox J, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Biol Chem. 2011 Apr 15;286(15):13033-40. doi: 10.1074/jbc.M111.220657. Epub 2011 Feb 18.


Smaller budgets will have bigger impacts for social care.

Sewell H.

Ment Health Today. 2010 Dec-2011 Jan:20. No abstract available.


Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain.

Tanaka T, Sewell H, Waters S, Phillips SE, Rabbitts TH.

J Biol Chem. 2011 Feb 4;286(5):3707-16. doi: 10.1074/jbc.M110.188193. Epub 2010 Oct 27.


The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.

Royer PJ, Emara M, Yang C, Al-Ghouleh A, Tighe P, Jones N, Sewell HF, Shakib F, Martinez-Pomares L, Ghaemmaghami AM.

J Immunol. 2010 Aug 1;185(3):1522-31. doi: 10.4049/jimmunol.1000774. Epub 2010 Jul 7.


Technical validation of an autoantibody test for lung cancer.

Murray A, Chapman CJ, Healey G, Peek LJ, Parsons G, Baldwin D, Barnes A, Sewell HF, Fritsche HA, Robertson JF.

Ann Oncol. 2010 Aug;21(8):1687-93. doi: 10.1093/annonc/mdp606. Epub 2010 Feb 2.


Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1.

Horlock C, Shakib F, Jones NS, Sewell HF, Ghaemmaghami AM.

Int Arch Allergy Immunol. 2009;150(3):237-51. doi: 10.1159/000222676. Epub 2009 Jun 4.


Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.

Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T.

Cancer Res. 2009 Jun 1;69(11):4784-90. doi: 10.1158/0008-5472.CAN-08-4774.


Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.

Hasan AA, Ghaemmaghami AM, Fairclough L, Robins A, Sewell HF, Shakib F.

Immunobiology. 2009;214(1):2-16. doi: 10.1016/j.imbio.2008.04.006. Epub 2008 Jun 20.


The molecular basis of allergenicity.

Shakib F, Ghaemmaghami AM, Sewell HF.

Trends Immunol. 2008 Dec;29(12):633-42. doi: 10.1016/ Epub 2008 Oct 24. Review.


An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcepsilonRI with FcgammaRIIb.

Wigginton SJ, Furtado PB, Armour KL, Clark MR, Robins A, Emara M, Ghaemmaghami AM, Sewell HF, Shakib F.

Clin Exp Allergy. 2008 Feb;38(2):313-9. Epub 2007 Dec 7.


The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets.

Richens J, Fairclough L, Ghaemmaghami AM, Mahdavi J, Shakib F, Sewell HF.

Immunobiology. 2007;212(1):29-38. Epub 2006 Sep 18.


The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses.

Furmonaviciene R, Ghaemmaghami AM, Boyd SE, Jones NS, Bailey K, Willis AC, Sewell HF, Mitchell DA, Shakib F.

Clin Exp Allergy. 2007 Feb;37(2):231-42.


An attempt to define allergen-specific molecular surface features: a bioinformatic approach.

Furmonaviciene R, Sutton BJ, Glaser F, Laughton CA, Jones N, Sewell HF, Shakib F.

Bioinformatics. 2005 Dec 1;21(23):4201-4. Epub 2005 Oct 4.


Habitat-specific diversity of Borrelia burgdorferi sensu lato in Europe, exemplified by data from Latvia.

Etti S, Hails R, Schäfer SM, De Michelis S, Sewell HS, Bormane A, Donaghy M, Kurtenbach K.

Appl Environ Microbiol. 2003 May;69(5):3008-10.


Association of Borrelia afzelii with rodents in Europe.

Hanincová K, Schäfer SM, Etti S, Sewell HS, Taragelová V, Ziak D, Labuda M, Kurtenbach K.

Parasitology. 2003 Jan;126(Pt 1):11-20.


Differential survival of Lyme borreliosis spirochetes in ticks that feed on birds.

Kurtenbach K, Schäfer SM, Sewell HS, Peacey M, Hoodless A, Nuttall PA, Randolph SE.

Infect Immun. 2002 Oct;70(10):5893-5.


The key roles of selection and migration in the ecology of Lyme borreliosis.

Kurtenbach K, De Michelis S, Sewell HS, Etti S, Schäfer SM, Holmes E, Hails R, Collares-Pereira M, Santos-Reis M, Hanincová K, Labuda M, Bormane A, Donaghy M.

Int J Med Microbiol. 2002 Jun;291 Suppl 33:152-4.


Host association of Borrelia burgdorferi sensu lato--the key role of host complement.

Kurtenbach K, De Michelis S, Etti S, Schäfer SM, Sewell HS, Brade V, Kraiczy P.

Trends Microbiol. 2002 Feb;10(2):74-9. Review.


Distinct combinations of Borrelia burgdorferi sensu lato genospecies found in individual questing ticks from Europe.

Kurtenbach K, De Michelis S, Sewell HS, Etti S, Schäfer SM, Hails R, Collares-Pereira M, Santos-Reis M, Haninçová K, Labuda M, Bormane A, Donaghy M.

Appl Environ Microbiol. 2001 Oct;67(10):4926-9.


Comparative molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources.

Furmonaviciene R, Sewell HF, Shakib F.

Clin Exp Allergy. 2000 Sep;30(9):1307-13.


Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

McElveen JE, Furtado PB, Smith SJ, Clark MR, Spendlove I, Sewell HF, Shakib F.

Mol Pathol. 2000 Apr;53(2):77-82.


Identification of peptide motifs recognized by a human IgG autoanti-IgE antibody using a phage display library.

Shakib F, Hooi DS, Smith SJ, Furmonaviciene R, Sewell HF.

Clin Exp Allergy. 2000 Jul;30(7):1041-6.


Genetic diversity of Borrelia burgdorferi sensu lato in ticks from mainland Portugal.

De Michelis S, Sewell HS, Collares-Pereira M, Santos-Reis M, Schouls LM, Benes V, Holmes EC, Kurtenbach K.

J Clin Microbiol. 2000 Jun;38(6):2128-33.


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