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Items: 40

1.

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity.

Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF, Lan K.

Drug Metab Dispos. 2019 Jun;47(6):574-581. doi: 10.1124/dmd.119.086637. Epub 2019 Mar 27.

PMID:
30918015
2.

Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency.

Polic V, Sevrioukova IF, Auclair K.

Arch Biochem Biophys. 2018 Sep 1;653:90-96. doi: 10.1016/j.abb.2018.06.014. Epub 2018 Jun 26.

PMID:
29958895
3.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1314. doi: 10.1016/j.chembiol.2017.09.012. No abstract available.

4.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6. doi: 10.1016/j.chembiol.2017.08.009. Epub 2017 Sep 14. Erratum in: Cell Chem Biol. 2017 Oct 19;24(10):1314.

5.

High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.

Sevrioukova IF.

Biochemistry. 2017 Jun 20;56(24):3058-3067. doi: 10.1021/acs.biochem.7b00334. Epub 2017 Jun 7.

6.

Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.

Sevrioukova IF, Poulos TL.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):486-491. doi: 10.1073/pnas.1616198114. Epub 2016 Dec 28.

7.

Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders.

Sevrioukova IF.

J Mol Biol. 2016 Sep 11;428(18):3650-65. doi: 10.1016/j.jmb.2016.05.004. Epub 2016 May 10.

PMID:
27178839
8.

Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD(+)/H Binding to Mitochondrial Apoptosis-Inducing Factor.

Sorrentino L, Calogero AM, Pandini V, Vanoni MA, Sevrioukova IF, Aliverti A.

Biochemistry. 2015 Dec 1;54(47):6996-7009. doi: 10.1021/acs.biochem.5b00898. Epub 2015 Nov 16.

PMID:
26535916
9.

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model.

Kaur P, Chamberlin AR, Poulos TL, Sevrioukova IF.

J Med Chem. 2016 May 12;59(9):4210-20. doi: 10.1021/acs.jmedchem.5b01146. Epub 2015 Sep 24.

10.

Anion-Dependent Stimulation of CYP3A4 Monooxygenase.

Sevrioukova IF, Poulos TL.

Biochemistry. 2015 Jul 7;54(26):4083-96. doi: 10.1021/acs.biochem.5b00510. Epub 2015 Jun 23.

PMID:
26066995
11.

Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions.

Sevrioukova IF, Poulos TL.

Adv Exp Med Biol. 2015;851:83-105. doi: 10.1007/978-3-319-16009-2_3. Review.

12.

Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism.

Sevrioukova IF, Poulos TL.

Curr Top Med Chem. 2014;14(11):1348-55. Review.

13.

Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues.

Sevrioukova IF, Poulos TL.

Biochemistry. 2013 Jul 2;52(26):4474-81. doi: 10.1021/bi4005396. Epub 2013 Jun 20.

PMID:
23746300
14.

Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.

Sevrioukova IF, Poulos TL.

J Med Chem. 2013 May 9;56(9):3733-41. doi: 10.1021/jm400288z. Epub 2013 Apr 26.

15.

Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.

Rinaldi C, Grunseich C, Sevrioukova IF, Schindler A, Horkayne-Szakaly I, Lamperti C, Landouré G, Kennerson ML, Burnett BG, Bönnemann C, Biesecker LG, Ghezzi D, Zeviani M, Fischbeck KH.

Am J Hum Genet. 2012 Dec 7;91(6):1095-102. doi: 10.1016/j.ajhg.2012.10.008.

16.

Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems.

Sevrioukova IF, Poulos TL.

Dalton Trans. 2013 Mar 7;42(9):3116-26. doi: 10.1039/c2dt31833d. Epub 2012 Sep 27. Review.

17.

Interaction of human cytochrome P4503A4 with ritonavir analogs.

Sevrioukova IF, Poulos TL.

Arch Biochem Biophys. 2012 Apr 15;520(2):108-16. doi: 10.1016/j.abb.2012.02.018. Epub 2012 Mar 5.

18.

Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand.

Sevrioukova IF, Poulos TL.

J Biol Chem. 2012 Jan 27;287(5):3510-7. doi: 10.1074/jbc.M111.317081. Epub 2011 Dec 7.

19.

Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: a mechanistic study.

Misevičienė L, Anusevičius Z, Sarlauskas J, Sevrioukova IF, Cėnas N.

Arch Biochem Biophys. 2011 Aug 15;512(2):183-9. doi: 10.1016/j.abb.2011.05.015. Epub 2011 Jun 2.

20.

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir.

Sevrioukova IF, Poulos TL.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18422-7. doi: 10.1073/pnas.1010693107. Epub 2010 Oct 11.

21.

Apoptosis-inducing factor: structure, function, and redox regulation.

Sevrioukova IF.

Antioxid Redox Signal. 2011 Jun 15;14(12):2545-79. doi: 10.1089/ars.2010.3445. Epub 2011 Mar 10. Review.

22.

Structural biology of redox partner interactions in P450cam monooxygenase: a fresh look at an old system.

Sevrioukova IF, Poulos TL.

Arch Biochem Biophys. 2011 Mar 1;507(1):66-74. doi: 10.1016/j.abb.2010.08.022. Epub 2010 Sep 15. Review.

23.

Arginines 65 and 310 in putidaredoxin reductase are critical for interaction with putidaredoxin.

Sevrioukova IF, Poulos TL.

Biochemistry. 2010 Jun 29;49(25):5160-6. doi: 10.1021/bi100626f.

PMID:
20524621
24.

Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex.

Sevrioukova IF, Poulos TL, Churbanova IY.

J Biol Chem. 2010 Apr 30;285(18):13616-20. doi: 10.1074/jbc.M110.104968. Epub 2010 Feb 23.

25.

Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex.

Churbanova IY, Poulos TL, Sevrioukova IF.

Biochemistry. 2010 Jan 12;49(1):58-67. doi: 10.1021/bi901872s.

PMID:
19954240
26.

Redox-linked conformational dynamics in apoptosis-inducing factor.

Sevrioukova IF.

J Mol Biol. 2009 Jul 31;390(5):924-38. doi: 10.1016/j.jmb.2009.05.013. Epub 2009 May 15.

27.

Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor.

Churbanova IY, Sevrioukova IF.

J Biol Chem. 2008 Feb 29;283(9):5622-31. doi: 10.1074/jbc.M709147200. Epub 2007 Dec 31.

28.

Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation.

Corbett MC, Latimer MJ, Poulos TL, Sevrioukova IF, Hodgson KO, Hedman B.

Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):951-60. Epub 2007 Aug 17.

PMID:
17704563
29.
31.

The putidaredoxin reductase-putidaredoxin electron transfer complex: theoretical and experimental studies.

Kuznetsov VY, Blair E, Farmer PJ, Poulos TL, Pifferitti A, Sevrioukova IF.

J Biol Chem. 2005 Apr 22;280(16):16135-42. Epub 2005 Feb 15.

32.
33.

Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida.

Sevrioukova IF, Garcia C, Li H, Bhaskar B, Poulos TL.

J Mol Biol. 2003 Oct 17;333(2):377-92.

PMID:
14529624
34.

Putidaredoxin reductase, a new function for an old protein.

Sevrioukova IF, Poulos TL.

J Biol Chem. 2002 Jul 12;277(28):25831-9. Epub 2002 May 13.

35.

Laser flash induced electron transfer in P450cam monooxygenase: putidaredoxin reductase-putidaredoxin interaction.

Sevrioukova IF, Hazzard JT, Tollin G, Poulos TL.

Biochemistry. 2001 Sep 4;40(35):10592-600.

PMID:
11524002
36.

The FMN-binding domain of cytochrome P450BM-3: resolution, reconstitution, and flavin analogue substitution.

Haines DC, Sevrioukova IF, Peterson JA.

Biochemistry. 2000 Aug 8;39(31):9419-29.

PMID:
10924137
37.
38.

Structure of a cytochrome P450-redox partner electron-transfer complex.

Sevrioukova IF, Li H, Zhang H, Peterson JA, Poulos TL.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1863-8.

39.

Reaction of carbon monoxide and molecular oxygen with P450terp (CYP108) and P450BM-3 (CYP102).

Sevrioukova IF, Peterson JA.

Arch Biochem Biophys. 1995 Mar 10;317(2):397-404.

PMID:
7893155
40.

NADPH-P-450 reductase: structural and functional comparisons of the eukaryotic and prokaryotic isoforms.

Sevrioukova IF, Peterson JA.

Biochimie. 1995;77(7-8):562-72. Review.

PMID:
8589067

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