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Advanced Heart Failure and End-Stage Heart Failure: Does a Difference Exist.

Severino P, Mather PJ, Pucci M, D'Amato A, Mariani MV, Infusino F, Birtolo LI, Maestrini V, Mancone M, Fedele F.

Diagnostics (Basel). 2019 Nov 1;9(4). pii: E170. doi: 10.3390/diagnostics9040170. Review.


Praziquantel-Solid Lipid Nanoparticles Produced by Supercritical Carbon Dioxide Extraction: Physicochemical Characterization, Release Profile, and Cytotoxicity.

Andrade LN, Oliveira DML, Chaud MV, Alves TFR, Nery M, da Silva CF, Gonsalves JKC, Nunes RS, Corrêa CB, Amaral RG, Sanchez-Lopez E, Souto EB, Severino P.

Molecules. 2019 Oct 28;24(21). pii: E3881. doi: 10.3390/molecules24213881.


Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review of Classical and New Compounds: Part-I.

Vieira R, Souto SB, Sánchez-López E, Machado AL, Severino P, Jose S, Santini A, Fortuna A, García ML, Silva AM, Souto EB.

Pharmaceuticals (Basel). 2019 Oct 10;12(4). pii: E152. doi: 10.3390/ph12040152. Review.


Electrocardiographic features, mapping and ablation of idiopathic outflow tract ventricular arrhythmias.

Lavalle C, Mariani MV, Piro A, Straito M, Severino P, Della Rocca DG, Forleo GB, Romero J, Di Biase L, Fedele F.

J Interv Card Electrophysiol. 2019 Oct 24. doi: 10.1007/s10840-019-00617-9. [Epub ahead of print] Review.


Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing.

Hissae Yassue-Cordeiro P, Zandonai CH, Pereira Genesi B, Santos Lopes P, Sanchez-Lopez E, Garcia ML, Camargo Fernandes-Machado NR, Severino P, B Souto E, Ferreira da Silva C.

Pharmaceutics. 2019 Oct 14;11(10). pii: E535. doi: 10.3390/pharmaceutics11100535.


Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules.

Barbosa TC, Nascimento LÉD, Bani C, Almeida T, Nery M, Santos RS, Menezes LRO, Zielińska A, Fernandes AR, Cardoso JC, Jäguer A, Jäguer E, Sanchez-Lopez E, Nalone L, Souto EB, Severino P.

Toxics. 2019 Sep 22;7(4). pii: E51. doi: 10.3390/toxics7040051.


Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Strategies for In Vivo Administration: Part-II.

Vieira R, Souto SB, Sánchez-López E, Machado AL, Severino P, Jose S, Santini A, Silva AM, Fortuna A, García ML, Souto EB.

J Clin Med. 2019 Aug 28;8(9). pii: E1332. doi: 10.3390/jcm8091332. Review.


Alginate Nanoparticles for Drug Delivery and Targeting.

Severino P, da Silva CF, Andrade LN, de Lima Oliveira D, Campos J, Souto EB.

Curr Pharm Des. 2019;25(11):1312-1334. doi: 10.2174/1381612825666190425163424.


Correction to: Structural and myocardial dysfunction in heart failure beyond ejection fraction.

Severino P, Maestrini V, Mariani MV, Birtolo LI, Scarpati R, Mancone M, Fedele F.

Heart Fail Rev. 2019 Aug 24. doi: 10.1007/s10741-019-09845-7. [Epub ahead of print]


Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems.

Souto EB, Dias-Ferreira J, Craveiro SA, Severino P, Sanchez-Lopez E, Garcia ML, Silva AM, Souto SB, Mahant S.

Pathogens. 2019 Aug 1;8(3). pii: E119. doi: 10.3390/pathogens8030119. Review.


Futility in cardiology: the need for a change in perspectives.

Severino P, Mariani MV, Fedele F.

Eur J Heart Fail. 2019 Jul 29. doi: 10.1002/ejhf.1576. [Epub ahead of print] No abstract available.


The Influence of Polysaccharide Coating on the Physicochemical Parameters and Cytotoxicity of Silica Nanoparticles for Hydrophilic Biomolecules Delivery.

Andreani T, Fangueiro JF, Severino P, Souza ALR, Martins-Gomes C, Fernandes PMV, Calpena AC, Gremião MP, Souto EB, Silva AM.

Nanomaterials (Basel). 2019 Jul 27;9(8). pii: E1081. doi: 10.3390/nano9081081.


Mutagenesis Induced by Sub-Lethal Doses of Ciprofloxacin: Genotypic and Phenotypic Differences Between the Pseudomonas aeruginosa Strain PA14 and Clinical Isolates.

Migliorini LB, Brüggemann H, de Sales RO, Koga PCM, de Souza AV, Martino MDV, Galhardo RS, Severino P.

Front Microbiol. 2019 Jul 10;10:1553. doi: 10.3389/fmicb.2019.01553. eCollection 2019.


Structural and myocardial dysfunction in heart failure beyond ejection fraction.

Severino P, Maestrini V, Mariani MV, Birtolo LI, Scarpati R, Mancone M, Fedele F.

Heart Fail Rev. 2019 Jul 17. doi: 10.1007/s10741-019-09828-8. [Epub ahead of print] Review. Erratum in: Heart Fail Rev. 2019 Aug 24;:.


Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency.

Severino P, Netti L, Mariani MV, Maraone A, D'Amato A, Scarpati R, Infusino F, Pucci M, Lavalle C, Maestrini V, Mancone M, Fedele F.

Cardiol Res Pract. 2019 May 2;2019:4874921. doi: 10.1155/2019/4874921. eCollection 2019. Review.


Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow.

Severino P, D'Amato A, Netti L, Pucci M, Infusino F, Maestrini V, Mancone M, Fedele F.

J Diabetes Res. 2019 Apr 4;2019:9489826. doi: 10.1155/2019/9489826. eCollection 2019. Review.


Use of pharmaceutical nanotechnology for the treatment of leishmaniasis.

Marques CSF, Machado Júnior JB, Andrade LRM, Andrade LN, Santos ALSD, Cruz MDSPE, Chaud M, Fricks AT, Severino P.

Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180246. doi: 10.1590/0037-8682-0246-2018. Portuguese.


Triggers for Atrial Fibrillation: The Role of Anxiety.

Severino P, Mariani MV, Maraone A, Piro A, Ceccacci A, Tarsitani L, Maestrini V, Mancone M, Lavalle C, Pasquini M, Fedele F.

Cardiol Res Pract. 2019 Feb 18;2019:1208505. doi: 10.1155/2019/1208505. eCollection 2019. Review.


Giant right atrium and subvalvular pulmonary stenosis: A case report of an interesting combination.

Maestrini V, Birtolo LI, Cimino S, Severino P, Mancone M, Francone M, Banypersad SM, Ventriglia F, Tritapepe L, Miraldi F, Fedele F.

Echocardiography. 2019 May;36(5):992-995. doi: 10.1111/echo.14311. Epub 2019 Mar 14.


Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions.

Hamasaki MY, Severino P, Puga RD, Koike MK, Hernandes C, Barbeiro HV, Barbeiro DF, Machado MCC, Reis EM, Pinheiro da Silva F.

Inflammation. 2019 Jun;42(3):1023-1031. doi: 10.1007/s10753-019-00964-9.


Chitosan/Copaiba oleoresin films for would dressing application.

Debone HS, Lopes PS, Severino P, Yoshida CMP, Souto EB, da Silva CF.

Int J Pharm. 2019 Jan 30;555:146-152. doi: 10.1016/j.ijpharm.2018.11.054. Epub 2018 Nov 22.


Solid Lipid Nanoparticles for Dibucaine Sustained Release.

de M Barbosa R, Ribeiro LNM, Casadei BR, da Silva CMG, Queiróz VA, Duran N, de Araújo DR, Severino P, de Paula E.

Pharmaceutics. 2018 Nov 14;10(4). pii: E231. doi: 10.3390/pharmaceutics10040231.


Linseed Essential Oil - Source of Lipids as Active Ingredients for Pharmaceuticals and Nutraceuticals.

Campos JR, Severino P, Ferreira CS, Zielinska A, Santini A, Souto SB, Souto EB.

Curr Med Chem. 2019;26(24):4537-4558. doi: 10.2174/0929867325666181031105603. Review.


Electron Paramagnetic Resonance and Small-Angle X-ray Scattering Characterization of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Dibucaine Encapsulation.

Barbosa RM, Casadei BR, Duarte EL, Severino P, Barbosa LRS, Duran N, de Paula E.

Langmuir. 2018 Nov 6;34(44):13296-13304. doi: 10.1021/acs.langmuir.8b02559. Epub 2018 Oct 24.


Natural Products as a Source for New Leads in Cancer Research and Treatment.

Cabral C, Efferth T, Pires IM, Severino P, Lemos MFL.

Evid Based Complement Alternat Med. 2018 Jul 15;2018:8243680. doi: 10.1155/2018/8243680. eCollection 2018. No abstract available.


Linalool bioactive properties and potential applicability in drug delivery systems.

Pereira I, Severino P, Santos AC, Silva AM, Souto EB.

Colloids Surf B Biointerfaces. 2018 Nov 1;171:566-578. doi: 10.1016/j.colsurfb.2018.08.001. Epub 2018 Aug 3. Review.


Solid lipid nanoparticles optimized by 22 factorial design for skin administration: Cytotoxicity in NIH3T3 fibroblasts.

Rigon RB, Gonçalez ML, Severino P, Alves DA, Santana MHA, Souto EB, Chorilli M.

Colloids Surf B Biointerfaces. 2018 Nov 1;171:501-505. doi: 10.1016/j.colsurfb.2018.07.065. Epub 2018 Jul 30.


Comparative Genomics of Nonoutbreak Pseudomonas aeruginosa Strains Underlines Genome Plasticity and Geographic Relatedness of the Global Clone ST235.

Brüggemann H, Migliorini LB, Sales RO, Koga PCM, Souza AV, Jensen A, Poehlein A, Brzuszkiewicz E, Doi AM, Pasternak J, Martino MDV, Severino P.

Genome Biol Evol. 2018 Jul 1;10(7):1852-1857. doi: 10.1093/gbe/evy139.


Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review.

Santos RS, Loureiro KC, Rezende PS, Andrade LN, de Melo Barbosa R, Santini A, Santos AC, Ferreira da Silva C, Souto EB, de Sousa DP, Amaral RG, Severino P.

J Dermatolog Treat. 2019 Sep;30(6):617-626. doi: 10.1080/09546634.2018.1479726. Epub 2019 Apr 16.


Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art.

Campos JR, Fernandes AR, Severino P, Gracia ML, Souto SB, Souto EB.

Curr Pharm Des. 2018;24(21):2508-2512. doi: 10.2174/1381612824666180522092740. Review.


Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels.

Severino P, D'Amato A, Netti L, Pucci M, De Marchis M, Palmirotta R, Volterrani M, Mancone M, Fedele F.

Int J Mol Sci. 2018 Mar 10;19(3). pii: E802. doi: 10.3390/ijms19030802. Review.


Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1.

Severino PF, Silva M, Carrascal M, Malagolini N, Chiricolo M, Venturi G, Barbaro Forleo R, Astolfi A, Catera M, Videira PA, Dall'Olio F.

BMC Cancer. 2018 Feb 17;18(1):198. doi: 10.1186/s12885-018-4107-1.


Crystalline Ethylene Oxide and Propylene Oxide Triblock Copolymer Solid Dispersion Enhance Solubility, Stability and Promoting Time- Controllable Release of Curcumin.

Alves TFR, das Neves Lopes FCC, Rebelo MA, Souza JF, da Silva Pontes K, Santos C, Severino P, Junior JMO, Komatsu D, Chaud MV.

Recent Pat Drug Deliv Formul. 2018;12(1):65-74. doi: 10.2174/1872211312666180118104920.


Cervical intramedullary spinal cord lipoma.

Severino R, Severino P.

Surg Neurol Int. 2017 Oct 24;8:255. doi: 10.4103/sni.sni_257_17. eCollection 2017.


Surgery or not? A case of ventriculus terminalis in an adult patient.

Severino R, Severino P.

J Spine Surg. 2017 Sep;3(3):475-480. doi: 10.21037/jss.2017.06.22.


Expression of sialyl-Tn sugar antigen in bladder cancer cells affects response to Bacillus Calmette Guérin (BCG) and to oxidative damage.

Severino PF, Silva M, Carrascal M, Malagolini N, Chiricolo M, Venturi G, Astolfi A, Catera M, Videira PA, Dall'Olio F.

Oncotarget. 2017 Apr 17;8(33):54506-54517. doi: 10.18632/oncotarget.17138. eCollection 2017 Aug 15.


Fronto-orbital mucocele with intracranial extension: a case report.

Severino R, Severino P.

J Surg Case Rep. 2017 Jun 14;2017(6):rjx107. doi: 10.1093/jscr/rjx107. eCollection 2017 Jun.


Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture.

Severino P, Ariga SK, Barbeiro HV, de Lima TM, de Paula Silva E, Barbeiro DF, Machado MCC, Nizet V, Pinheiro da Silva F.

J Mol Med (Berl). 2017 Sep;95(9):995-1003. doi: 10.1007/s00109-017-1555-z. Epub 2017 Jun 16.


Antimicrobial activity of polymyxin-loaded solid lipid nanoparticles (PLX-SLN): Characterization of physicochemical properties and in vitro efficacy.

Severino P, Silveira EF, Loureiro K, Chaud MV, Antonini D, Lancellotti M, Sarmento VH, da Silva CF, Santana MHA, Souto EB.

Eur J Pharm Sci. 2017 Aug 30;106:177-184. doi: 10.1016/j.ejps.2017.05.063. Epub 2017 May 30.


Post-sternotomy pain syndrome following cardiac surgery: case report.

Bordoni B, Marelli F, Morabito B, Sacconi B, Severino P.

J Pain Res. 2017 May 15;10:1163-1169. doi: 10.2147/JPR.S129394. eCollection 2017.


Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review.

Hernandes C, Pereira AMS, Severino P.

Curr Genomics. 2017 Feb;18(1):60-74. doi: 10.2174/1389202917666160803160934. Review.


Reasons why a second radiological opinion is advisable: a case report of a misreported crural synovial cell sarcoma.

Severino R, Severino P.

J Surg Case Rep. 2017 Mar 9;2017(3):rjx046. doi: 10.1093/jscr/rjx046. eCollection 2017 Mar.


d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity.

Teixeira MC, Severino P, Andreani T, Boonme P, Santini A, Silva AM, Souto EB.

Saudi Pharm J. 2017 Feb;25(2):231-235. doi: 10.1016/j.jsps.2016.06.004. Epub 2016 Jun 22.


Human Lymph Node-Derived Fibroblastic and Double-Negative Reticular Cells Alter Their Chemokines and Cytokines Expression Profile Following Inflammatory Stimuli.

Severino P, Palomino DT, Alvarenga H, Almeida CB, Pasqualim DC, Cury A, Salvalaggio PR, De Vasconcelos Macedo AL, Andrade MC, Aloia T, Bromberg S, Rizzo LV, Rocha FA, Marti LC.

Front Immunol. 2017 Feb 14;8:141. doi: 10.3389/fimmu.2017.00141. eCollection 2017.


Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures.

de Oliveira GG, Feitosa A, Loureiro K, Fernandes AR, Souto EB, Severino P.

Saudi Pharm J. 2017 Jan;25(1):99-103. doi: 10.1016/j.jsps.2016.05.001. Epub 2016 May 7.


Insights into the Function of Long Noncoding RNAs in Sepsis Revealed by Gene Co-Expression Network Analysis.

Pellegrina DVDS, Severino P, Barbeiro HV, de Souza HP, Machado MCC, Pinheiro-da-Silva F, Reis EM.

Noncoding RNA. 2017 Jan 26;3(1). pii: E5. doi: 10.3390/ncrna3010005.


Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.

Muñoz M, Craske M, Severino P, de Lima TM, Labhart P, Chammas R, Velasco IT, Machado MC, Egan B, Nakaya HI, Pinheiro da Silva F.

J Cancer. 2016 Nov 26;7(15):2341-2345. eCollection 2016.


Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction: The Misleading Definition of the New Guidelines.

Fedele F, Mancone M, Adamo F, Severino P.

Cardiol Rev. 2017 Jan/Feb;25(1):4-5. No abstract available.


Preparation of Thermosensitive Gel for Controlled Release of Levofloxacin and Their Application in the Treatment of Multidrug-Resistant Bacteria.

Alves DA, Machado D, Melo A, Pereira RF, Severino P, de Hollanda LM, Araújo DR, Lancellotti M.

Biomed Res Int. 2016;2016:9702129. Epub 2016 Sep 5.


Influence of different surfactants on the physicochemical properties of elastic liposomes.

Barbosa RM, Severino P, Preté PS, Santana MH.

Pharm Dev Technol. 2017 May;22(3):360-369. doi: 10.3109/10837450.2016.1163387. Epub 2016 Apr 6.


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