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Items: 46

1.

Differential Responses of Human Dendritic Cells to Live or Inactivated Staphylococcus aureus: Impact on Cytokine Production and T Helper Expansion.

Cruciani M, Sandini S, Etna MP, Giacomini E, Camilli R, Severa M, Rizzo F, Bagnoli F, Hiscott J, Coccia EM.

Front Immunol. 2019 Nov 12;10:2622. doi: 10.3389/fimmu.2019.02622. eCollection 2019.

2.

A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis.

Severa M, Rizzo F, Srinivasan S, Di Dario M, Giacomini E, Buscarinu MC, Cruciani M, Etna MP, Sandini S, Mechelli R, Farina A, Trivedi P, Hertzog PJ, Salvetti M, Farina C, Coccia EM.

J Autoimmun. 2019 Jul;101:1-16. doi: 10.1016/j.jaut.2019.04.006. Epub 2019 Apr 30.

PMID:
31047767
3.

Thymosins in multiple sclerosis and its experimental models: moving from basic to clinical application.

Severa M, Zhang J, Giacomini E, Rizzo F, Etna MP, Cruciani M, Garaci E, Chopp M, Coccia EM.

Mult Scler Relat Disord. 2019 Jan;27:52-60. doi: 10.1016/j.msard.2018.09.035. Epub 2018 Oct 2. Review.

PMID:
30317071
4.

Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients.

Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M, Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A, Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G.

J Neuroimmunol. 2018 Nov 15;324:165-171. doi: 10.1016/j.jneuroim.2018.09.005. Epub 2018 Sep 15.

PMID:
30270021
5.

Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas.

Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ.

Leukemia. 2019 Jan;33(1):132-147. doi: 10.1038/s41375-018-0178-x. Epub 2018 Jun 26.

6.

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.

Pacella I, Procaccini C, Focaccetti C, Miacci S, Timperi E, Faicchia D, Severa M, Rizzo F, Coccia EM, Bonacina F, Mitro N, Norata GD, Rossetti G, Ranzani V, Pagani M, Giorda E, Wei Y, Matarese G, Barnaba V, Piconese S.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6546-E6555. doi: 10.1073/pnas.1720113115. Epub 2018 Jun 25.

7.

Author Correction: Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis.

Srinivasan S, Severa M, Rizzo F, Menon R, Brini E, Mechelli R, Martinelli V, Hertzog P, Salvetti M, Furlan R, Martino G, Comi G, Coccia EM, Farina C.

Sci Rep. 2018 May 11;8(1):7615. doi: 10.1038/s41598-018-24987-8.

8.

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.

Etna MP, Sinigaglia A, Grassi A, Giacomini E, Romagnoli A, Pardini M, Severa M, Cruciani M, Rizzo F, Anastasiadou E, Di Camillo B, Barzon L, Fimia GM, Manganelli R, Coccia EM.

PLoS Pathog. 2018 Jan 4;14(1):e1006790. doi: 10.1371/journal.ppat.1006790. eCollection 2018 Jan.

9.

Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis.

Srinivasan S, Severa M, Rizzo F, Menon R, Brini E, Mechelli R, Martinelli V, Hertzog P, Salvetti M, Furlan R, Martino G, Comi G, Coccia EM, Farina C.

Sci Rep. 2017 Aug 21;7(1):8981. doi: 10.1038/s41598-017-09286-y. Erratum in: Sci Rep. 2018 May 11;8(1):7615.

10.

Staphylococcus aureus Esx Factors Control Human Dendritic Cell Functions Conditioning Th1/Th17 Response.

Cruciani M, Etna MP, Camilli R, Giacomini E, Percario ZA, Severa M, Sandini S, Rizzo F, Brandi V, Balsamo G, Polticelli F, Affabris E, Pantosti A, Bagnoli F, Coccia EM.

Front Cell Infect Microbiol. 2017 Jul 21;7:330. doi: 10.3389/fcimb.2017.00330. eCollection 2017.

11.

Thymosin-α1 expands deficient IL-10-producing regulatory B cell subsets in relapsing-remitting multiple sclerosis patients.

Giacomini E, Rizzo F, Etna MP, Cruciani M, Mechelli R, Buscarinu MC, Pica F, D'Agostini C, Salvetti M, Coccia EM, Severa M.

Mult Scler. 2018 Feb;24(2):127-139. doi: 10.1177/1352458517695892. Epub 2017 Feb 1.

PMID:
28273784
12.

Interferon-β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS-mediated apoptosis.

Rizzo F, Giacomini E, Mechelli R, Buscarinu MC, Salvetti M, Severa M, Coccia EM.

Immunol Cell Biol. 2016 Oct;94(9):886-894. doi: 10.1038/icb.2016.55. Epub 2016 Jun 6.

PMID:
27265253
13.

IFN-α promotes rapid human Treg contraction and late Th1-like Treg decrease.

Pacella I, Timperi E, Accapezzato D, Martire C, Labbadia G, Cavallari EN, D'Ettorre G, Calvo L, Rizzo F, Severa M, Coccia EM, Vullo V, Barnaba V, Piconese S.

J Leukoc Biol. 2016 Sep;100(3):613-23. doi: 10.1189/jlb.5A0415-140R. Epub 2016 Feb 26.

PMID:
26921346
14.

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions.

Etna MP, Giacomini E, Pardini M, Severa M, Bottai D, Cruciani M, Rizzo F, Calogero R, Brosch R, Coccia EM.

Sci Rep. 2015 Nov 25;5:17078. doi: 10.1038/srep17078.

15.

Apoptotic Epitope-Specific CD8+ T Cells and Interferon Signaling Intersect in Chronic Hepatitis C Virus Infection.

Martini H, Citro A, Martire C, D'Ettorre G, Labbadia G, Accapezzato D, Piconese S, De Marzio P, Cavallari EN, Calvo L, Rizzo F, Severa M, Coccia EM, Grazi GL, Di Filippo S, Sidney J, Vullo V, Sette A, Barnaba V.

J Infect Dis. 2016 Feb 15;213(4):674-83. doi: 10.1093/infdis/jiv460. Epub 2015 Sep 19.

PMID:
26386427
16.

Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists.

Giacomini E, Severa M, Cruciani M, Etna MP, Rizzo F, Pardini M, Scagnolari C, Garaci E, Coccia EM.

Expert Opin Biol Ther. 2015;15 Suppl 1:S59-70. doi: 10.1517/14712598.2015.1019460. Epub 2015 Jun 22.

PMID:
26096650
17.

IFN-β Therapy Regulates TLR7-Mediated Response in Plasmacytoid Dendritic Cells of Multiple Sclerosis Patients Influencing an Anti-Inflammatory Status.

Severa M, Rizzo F, Giacomini E, Annibali V, Gafa V, Romano S, Buscarinu MC, Fornasiero A, Salvetti M, Coccia EM.

J Interferon Cytokine Res. 2015 Sep;35(9):668-81. doi: 10.1089/jir.2014.0207. Epub 2015 Apr 29.

PMID:
25923141
18.

IFN-β and multiple sclerosis: cross-talking of immune cells and integration of immunoregulatory networks.

Severa M, Rizzo F, Giacomini E, Salvetti M, Coccia EM.

Cytokine Growth Factor Rev. 2015 Apr;26(2):229-39. doi: 10.1016/j.cytogfr.2014.11.005. Epub 2014 Nov 22. Review.

PMID:
25498525
19.

Pro- and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis.

Etna MP, Giacomini E, Severa M, Coccia EM.

Semin Immunol. 2014 Dec;26(6):543-51. doi: 10.1016/j.smim.2014.09.011. Epub 2014 Nov 8. Review.

PMID:
25453229
20.

A human dendritic cell-based in vitro model to assess Mycobacterium tuberculosis SO2 vaccine immunogenicity.

Etna MP, Giacomini E, Severa M, Pardini M, Aguilo N, Martin C, Coccia EM.

ALTEX. 2014;31(4):397-406. doi: 10.14573/altex.1311041. Epub 2014 May 20.

21.

The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA.

J Immunol. 2014 Mar 1;192(5):2291-304. doi: 10.4049/jimmunol.1301799. Epub 2014 Jan 29.

22.

IFN-β therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients.

Giacomini E, Severa M, Rizzo F, Mechelli R, Annibali V, Ristori G, Riccieri V, Salvetti M, Coccia EM.

Eur J Immunol. 2013 Jul;43(7):1963-72. doi: 10.1002/eji.201243212. Epub 2013 May 28.

23.

Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis.

Angelini DF, Serafini B, Piras E, Severa M, Coccia EM, Rosicarelli B, Ruggieri S, Gasperini C, Buttari F, Centonze D, Mechelli R, Salvetti M, Borsellino G, Aloisi F, Battistini L.

PLoS Pathog. 2013;9(4):e1003220. doi: 10.1371/journal.ppat.1003220. Epub 2013 Apr 11.

24.

Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis.

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM, Migliorini P, Aloisi F, Pitzalis C.

Ann Rheum Dis. 2013 Sep 1;72(9):1559-68. doi: 10.1136/annrheumdis-2012-202352. Epub 2012 Dec 25.

PMID:
23268369
25.

EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape.

Severa M, Giacomini E, Gafa V, Anastasiadou E, Rizzo F, Corazzari M, Romagnoli A, Trivedi P, Fimia GM, Coccia EM.

Eur J Immunol. 2013 Jan;43(1):147-58. doi: 10.1002/eji.201242552. Epub 2012 Oct 30.

26.

Differential regulation of miR-21 and miR-146a by Epstein-Barr virus-encoded EBNA2.

Rosato P, Anastasiadou E, Garg N, Lenze D, Boccellato F, Vincenti S, Severa M, Coccia EM, Bigi R, Cirone M, Ferretti E, Campese AF, Hummel M, Frati L, Presutti C, Faggioni A, Trivedi P.

Leukemia. 2012 Nov;26(11):2343-52. doi: 10.1038/leu.2012.108. Epub 2012 Apr 19.

27.

Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies.

Cappelletti C, Baggi F, Zolezzi F, Biancolini D, Beretta O, Severa M, Coccia EM, Confalonieri P, Morandi L, Mora M, Mantegazza R, Bernasconi P.

Neurology. 2011 Jun 14;76(24):2079-88. doi: 10.1212/WNL.0b013e31821f440a.

PMID:
21670437
28.

Bystander inhibition of dendritic cell differentiation by Mycobacterium tuberculosis-induced IL-10.

Remoli ME, Giacomini E, Petruccioli E, Gafa V, Severa M, Gagliardi MC, Iona E, Pine R, Nisini R, Coccia EM.

Immunol Cell Biol. 2011 Mar;89(3):437-46. doi: 10.1038/icb.2010.106. Epub 2010 Aug 31.

PMID:
20805841
29.

Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.

van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA.

J Virol. 2010 Oct;84(20):10802-11. doi: 10.1128/JVI.00063-10. Epub 2010 Aug 4.

30.

Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation.

Serafini B, Severa M, Columba-Cabezas S, Rosicarelli B, Veroni C, Chiappetta G, Magliozzi R, Reynolds R, Coccia EM, Aloisi F.

J Neuropathol Exp Neurol. 2010 Jul;69(7):677-93. doi: 10.1097/NEN.0b013e3181e332ec.

PMID:
20535037
31.

Enhancement of anti-Aspergillus T helper type 1 response by interferon-β-conditioned dendritic cells.

Gafa V, Remoli ME, Giacomini E, Severa M, Grillot R, Coccia EM.

Immunology. 2010 Oct;131(2):282-8. doi: 10.1111/j.1365-2567.2010.03302.x.

32.

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.

Geeraedts F, Goutagny N, Hornung V, Severa M, de Haan A, Pool J, Wilschut J, Fitzgerald KA, Huckriede A.

PLoS Pathog. 2008 Aug 29;4(8):e1000138. doi: 10.1371/journal.ppat.1000138.

33.

Plasmacytoid dendritic cells in multiple sclerosis: intracerebral recruitment and impaired maturation in response to interferon-beta.

Lande R, Gafa V, Serafini B, Giacomini E, Visconti A, Remoli ME, Severa M, Parmentier M, Ristori G, Salvetti M, Aloisi F, Coccia EM.

J Neuropathol Exp Neurol. 2008 May;67(5):388-401. doi: 10.1097/NEN.0b013e31816fc975.

PMID:
18431257
34.

IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression.

Remoli ME, Gafa V, Giacomini E, Severa M, Lande R, Coccia EM.

Eur J Immunol. 2007 Dec;37(12):3499-508.

35.

TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war.

Severa M, Fitzgerald KA.

Curr Top Microbiol Immunol. 2007;316:167-92. Review.

PMID:
17969448
36.

In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment.

Gafa V, Remoli ME, Giacomini E, Gagliardi MC, Lande R, Severa M, Grillot R, Coccia EM.

Microbes Infect. 2007 Jul;9(8):971-80. Epub 2007 Apr 11.

PMID:
17556001
37.

Sensitization to TLR7 agonist in IFN-beta-preactivated dendritic cells.

Severa M, Remoli ME, Giacomini E, Annibali V, Gafa V, Lande R, Tomai M, Salvetti M, Coccia EM.

J Immunol. 2007 May 15;178(10):6208-16.

38.

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.

Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM.

J Leukoc Biol. 2007 Jan;81(1):355-63. Epub 2006 Oct 17.

PMID:
17046972
39.

Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.

Severa M, Coccia EM, Fitzgerald KA.

J Biol Chem. 2006 Sep 8;281(36):26188-95. Epub 2006 Jul 18.

40.

Pin-ning down immune responses to RNA viruses.

Goutagny N, Severa M, Fitzgerald KA.

Nat Immunol. 2006 Jun;7(6):555-7. No abstract available.

PMID:
16715065
41.

Infection of human dendritic cells with a Mycobacterium tuberculosis sigE mutant stimulates production of high levels of interleukin-10 but low levels of CXCL10: impact on the T-cell response.

Giacomini E, Sotolongo A, Iona E, Severa M, Remoli ME, Gafa V, Lande R, Fattorini L, Smith I, Manganelli R, Coccia EM.

Infect Immun. 2006 Jun;74(6):3296-304.

42.

Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression.

Severa M, Remoli ME, Giacomini E, Ragimbeau J, Lande R, Uzé G, Pellegrini S, Coccia EM.

J Leukoc Biol. 2006 Jun;79(6):1286-94. Epub 2006 Apr 19.

PMID:
16624932
43.

Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.

Matikainen S, Sirén J, Tissari J, Veckman V, Pirhonen J, Severa M, Sun Q, Lin R, Meri S, Uzé G, Hiscott J, Julkunen I.

J Virol. 2006 Apr;80(7):3515-22.

44.

Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response.

Gafa V, Lande R, Gagliardi MC, Severa M, Giacomini E, Remoli ME, Nisini R, Ramoni C, Di Francesco P, Aldebert D, Grillot R, Coccia EM.

Infect Immun. 2006 Mar;74(3):1480-9.

45.

Inhibition of interleukin-12 expression in diltiazem-treated dendritic cells through the reduction of nuclear factor-kappa B transcriptional activity.

Severa M, D'Ambrosio A, Giordani L, Quintieri F, Coccia E.

Biochem Pharmacol. 2005 Feb 1;69(3):425-32. Epub 2004 Dec 9.

PMID:
15652234
46.

Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells.

Coccia EM, Severa M, Giacomini E, Monneron D, Remoli ME, Julkunen I, Cella M, Lande R, Uzé G.

Eur J Immunol. 2004 Mar;34(3):796-805. doi: 10.1002/eji.200324610.

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