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Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness.

Kowalski-Chauvel A, Gouaze-Andersson V, Baricault L, Martin E, Delmas C, Toulas C, Cohen-Jonathan-Moyal E, Seva C.

Cancers (Basel). 2019 Mar 22;11(3). pii: E406. doi: 10.3390/cancers11030406.


Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1.

Kowalski-Chauvel A, Modesto A, Gouaze-Andersson V, Baricault L, Gilhodes J, Delmas C, Lemarie A, Toulas C, Cohen-Jonathan-Moyal E, Seva C.

Cell Death Dis. 2018 Aug 29;9(9):872. doi: 10.1038/s41419-018-0853-x.


By modulating α2β1 integrin signalling, gastrin increases adhesion oF AGS-GR gastric cancer cells.

Kowalski-Chauvel A, Teissier G, Toulas C, Cohen-Jonathan-Moyal E, Seva C.

Exp Cell Res. 2018 Jan 15;362(2):498-503. doi: 10.1016/j.yexcr.2017.12.014. Epub 2017 Dec 15.


Targeting progastrin enhances radiosensitization of colorectal cancer cells.

Kowalski-Chauvel A, Gouaze-Andersson V, Vignolle-Vidoni A, Delmas C, Toulas C, Cohen-Jonathan-Moyal E, Seva C.

Oncotarget. 2017 Apr 20;8(35):58587-58600. doi: 10.18632/oncotarget.17274. eCollection 2017 Aug 29.


The Bad, the Good and eIF3e/INT6.

Sesen J, Casaos J, Scotland SJ, Seva C, Eisinger-Mathason TS, Skuli N.

Front Biosci (Landmark Ed). 2017 Jan 1;22:1-20. Review.


Progastrin a new pro-angiogenic factor in colorectal cancer.

Najib S, Kowalski-Chauvel A, Do C, Roche S, Cohen-Jonathan-Moyal E, Seva C.

Oncogene. 2015 Jun 11;34(24):3120-30. doi: 10.1038/onc.2014.255. Epub 2014 Aug 11.


Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.

Sesen J, Cammas A, Scotland SJ, Elefterion B, Lemarié A, Millevoi S, Mathew LK, Seva C, Toulas C, Moyal EC, Skuli N.

Int J Mol Sci. 2014 Jan 29;15(2):2172-90. doi: 10.3390/ijms15022172.


Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.

Do C, Bertrand C, Palasse J, Delisle MB, Cohen-Jonathan-Moyal E, Seva C.

BMC Cancer. 2013 Nov 8;13:531. doi: 10.1186/1471-2407-13-531.


Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.

Kowalski-Chauvel A, Najib S, Tikhonova IG, Huc L, Lopez F, Martinez LO, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

J Biol Chem. 2012 Nov 30;287(49):41458-68. doi: 10.1074/jbc.M112.382465. Epub 2012 Oct 10.


A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.

Do C, Bertrand C, Palasse J, Delisle MB, Shulkes A, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

Cancer Prev Res (Phila). 2012 Apr;5(4):675-84. doi: 10.1158/1940-6207.CAPR-11-0408. Epub 2012 Feb 24.


αv integrin: a new gastrin target in human pancreatic cancer cells.

Cayrol C, Bertrand C, Kowalski-Chauvel A, Daulhac L, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

World J Gastroenterol. 2011 Oct 28;17(40):4488-95. doi: 10.3748/wjg.v17.i40.4488.


Phosphorylation of spinal N-methyl-d-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy.

Daulhac L, Maffre V, Mallet C, Etienne M, Privat AM, Kowalski-Chauvel A, Seva C, Fialip J, Eschalier A.

Eur J Pain. 2011 Feb;15(2):169.e1-169.e12. doi: 10.1016/j.ejpain.2010.06.003. Epub 2010 Jul 1.


A gastrin precursor, gastrin-gly, upregulates VEGF expression in colonic epithelial cells through an HIF-1-independent mechanism.

Bertrand C, Kowalski-Chauvel A, Do C, Résa C, Najib S, Daulhac L, Wang TC, Ferrand A, Seva C.

Int J Cancer. 2010 Jun 15;126(12):2847-57. doi: 10.1002/ijc.25001.


Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas.

Gigoux V, Clerc P, Sanchez D, Coll MG, Corominola H, Leung-Theung-Long S, Pénicaud L, Gomis R, Seva C, Fourmy D, Dufresne M.

Regul Pept. 2008 Feb 7;146(1-3):88-98. Epub 2007 Aug 31.


Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.

Clerc P, Coll Constans MG, Lulka H, Broussaud S, Guigné C, Leung-Theung-Long S, Perrin C, Knauf C, Carpéné C, Pénicaud L, Seva C, Burcelin R, Valet P, Fourmy D, Dufresne M.

Endocrinology. 2007 Mar;148(3):1039-49. Epub 2006 Nov 22.


An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.

Vatinel S, Ferrand A, Lopez F, Kowalski-Chauvel A, Estève JP, Fourmy D, Dufresne M, Seva C.

Biochim Biophys Acta. 2006 Oct;1763(10):1098-107. Epub 2006 Jul 21.


Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas.

Ferrand A, Vatinel S, Kowalski-Chauvel A, Bertrand C, Escrieut C, Fourmy D, Dufresne M, Seva C.

World J Gastroenterol. 2006 Jul 28;12(28):4498-503.


Cholecystokinin and gastrin receptors.

Dufresne M, Seva C, Fourmy D.

Physiol Rev. 2006 Jul;86(3):805-47. Review.


Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.

Ferrand A, Kowalski-Chauvel A, Pannequin J, Bertrand C, Fourmy D, Dufresne M, Seva C.

World J Gastroenterol. 2006 Mar 28;12(12):1859-64.


Cholecystokinin-2 receptor modulates cell adhesion through beta 1-integrin in human pancreatic cancer cells.

Cayrol C, Clerc P, Bertrand C, Gigoux V, Portolan G, Fourmy D, Dufresne M, Seva C.

Oncogene. 2006 Jul 27;25(32):4421-8. Epub 2006 Mar 20.


Partial agonism, neutral antagonism, and inverse agonism at the human wild-type and constitutively active cholecystokinin-2 receptors.

Foucaud M, Tikhonova IG, Langer I, Escrieut C, Dufresne M, Seva C, Maigret B, Fourmy D.

Mol Pharmacol. 2006 Mar;69(3):680-90. Epub 2005 Nov 17.


Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

Ferrand A, Bertrand C, Portolan G, Cui G, Carlson J, Pradayrol L, Fourmy D, Dufresne M, Wang TC, Seva C.

Cancer Res. 2005 Apr 1;65(7):2770-7.


Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation.

Mathieu A, Clerc P, Portolan G, Bierkamp C, Lulka H, Pradayrol L, Seva C, Fourmy D, Dufresne M.

Int J Cancer. 2005 May 20;115(1):46-54.


A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, Pradayrol L, Fourmy D, Dufresne M, Seva C.

J Biol Chem. 2005 Mar 18;280(11):10710-5. Epub 2005 Jan 7.


Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor.

Archer-Lahlou E, Tikhonova I, Escrieut C, Dufresne M, Seva C, Pradayrol L, Moroder L, Maigret B, Fourmy D.

J Med Chem. 2005 Jan 13;48(1):180-91.


Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor.

Archer-Lahlou E, Escrieut C, Clerc P, Martinez J, Moroder L, Logsdon C, Kopin A, Seva C, Dufresne M, Pradayrol L, Maigret B, Fourmy D.

J Biol Chem. 2005 Mar 18;280(11):10664-74. Epub 2005 Jan 4.


Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells.

Leung-Theung-Long S, Roulet E, Clerc P, Escrieut C, Marchal-Victorion S, Ritz-Laser B, Philippe J, Pradayrol L, Seva C, Fourmy D, Dufresne M.

J Biol Chem. 2005 Mar 4;280(9):7976-84. Epub 2004 Dec 14.


Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo.

Bierkamp C, Bonhoure S, Mathieu A, Clerc P, Fourmy D, Pradayrol L, Seva C, Dufresne M.

Am J Pathol. 2004 Dec;165(6):2135-45.


Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin.

Ferrand A, Kowalski-Chauvel A, Bertrand C, Pradayrol L, Fourmy D, Dufresne M, Seva C.

Exp Cell Res. 2004 Dec 10;301(2):128-38.


The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.

Arnould M, Tassa A, Ferrand A, Archer E, Estève JP, Pénalba V, Portolan G, Escherich A, Moroder L, Fourmy D, Seva C, Dufresne M.

FEBS Lett. 2004 Jun 18;568(1-3):89-93.


Gastrin mediated cholecystokinin-2 receptor activation induces loss of cell adhesion and scattering in epithelial MDCK cells.

Bierkamp C, Kowalski-Chauvel A, Dehez S, Fourmy D, Pradayrol L, Seva C.

Oncogene. 2002 Oct 31;21(50):7656-70.


c-Jun NH(2)-terminal kinase pathway in growth-promoting effect of the G protein-coupled receptor cholecystokinin B receptor: a protein kinase C/Src-dependent-mechanism.

Dehez S, Bierkamp C, Kowalski-Chauvel A, Daulhac L, Escrieut C, Susini C, Pradayrol L, Fourmy D, Seva C.

Cell Growth Differ. 2002 Aug;13(8):375-85.


Activation of c-Jun N-terminal kinase 1 (JNK-1) after amino acid deficiency in HeLa cells.

Aubel C, Dehez S, Chabanon H, Seva C, Ferrara M, Brachet P.

Cell Signal. 2001 Jun;13(6):417-23.


Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca(2+) and Src-dependent mechanisms.

Dehez S, Daulhac L, Kowalski-Chauvel A, Fourmy D, Pradayrol L, Seva C.

FEBS Lett. 2001 May 4;496(1):25-30.


Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor.

Galés C, Kowalski-Chauvel A, Dufour MN, Seva C, Moroder L, Pradayrol L, Vaysse N, Fourmy D, Silvente-Poirot S.

J Biol Chem. 2000 Jun 9;275(23):17321-7.


Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors.

Daulhac L, Kowalski-Chauvel A, Pradayrol L, Vaysse N, Seva C.

J Biol Chem. 1999 Jul 16;274(29):20657-63.


Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathway.

Daulhac L, Kowalski-Chauvel A, Pradayrol L, Vaysse N, Seva C.

FEBS Lett. 1999 Feb 26;445(2-3):251-5.


Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA.

Pyronnet S, Gingras AC, Bouisson M, Kowalski-Chauvel A, Seva C, Vaysse N, Sonenberg N, Pradayrol L.

Oncogene. 1998 Apr 30;16(17):2219-27.


Wortmannin-sensitive activation of p70S6-kinase and MAP-kinase by the G protein-coupled receptor, G/CCKB.

Seva C, Kowalski-Chauvel A, Daulhac L, Barthez C, Vaysse N, Pradayrol L.

Biochem Biophys Res Commun. 1997 Sep 8;238(1):202-6.


Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors.

Kowalski-Chauvel A, Pradayrol L, Vaysse N, Seva C.

Biochem Biophys Res Commun. 1997 Jul 30;236(3):687-92.


Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complex.

Seva C, Kowalski-Chauvel A, Blanchet JS, Vaysse N, Pradayrol L.

FEBS Lett. 1996 Jan 2;378(1):74-8.


Gastrin and glycine-extended progastrin processing intermediates induce different programs of early gene activation.

Todisco A, Takeuchi Y, Seva C, Dickinson CJ, Yamada T.

J Biol Chem. 1995 Nov 24;270(47):28337-41.


Somatostatin inhibits AP-1 function via multiple protein phosphatases.

Todisco A, Seva C, Takeuchi Y, Dickinson CJ, Yamada T.

Am J Physiol. 1995 Jul;269(1 Pt 1):G160-6.


Glycine-extended progastrin processing intermediates induce H+,K(+)-ATPase alpha-subunit gene expression through a novel receptor.

Kaise M, Muraoka A, Seva C, Takeda H, Dickinson CJ, Yamada T.

J Biol Chem. 1995 May 12;270(19):11155-60.


Growth-promoting effects of glycine-extended progastrin.

Seva C, Dickinson CJ, Yamada T.

Science. 1994 Jul 15;265(5170):410-2.


Coupling of pancreatic gastrin/cholecystokinin-B (G/CCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells.

Seva C, Scemama JL, Pradayrol L, Sarfati PD, Vaysse N.

Regul Pept. 1994 Jun 16;52(1):31-8.


Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J).

Pradel P, Estival A, Seva C, Wicker-Planquart C, Puigserver A, Vaysse N, Clemente F.

Biochem J. 1993 Feb 15;290 ( Pt 1):219-24.


Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide.

Buscail L, Cambillau C, Seva C, Scemama JL, De Neef P, Robberecht P, Christophe J, Susini C, Vaysse N.

Gastroenterology. 1992 Sep;103(3):1002-8.


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