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Items: 1 to 50 of 80

1.

Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.

Beck KR, Kanagaratnam S, Kratschmar DV, Birk J, Yamaguchi H, Sailer AW, Seuwen K, Odermatt A.

J Steroid Biochem Mol Biol. 2019 Jun;190:19-28. doi: 10.1016/j.jsbmb.2019.03.011. Epub 2019 Mar 19.

PMID:
30902677
2.

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B; Swiss IBD Cohort Study Group.

BMC Gastroenterol. 2019 Jan 7;19(1):2. doi: 10.1186/s12876-018-0922-8.

3.

Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease.

Tcymbarevich I, Richards SM, Russo G, Kühn-Georgijevic J, Cosin-Roger J, Baebler K, Lang S, Bengs S, Atrott K, Bettoni C, Gruber S, Frey-Wagner I, Scharl M, Misselwitz B, Wagner CA, Seuwen K, Rogler G, Ruiz PA, Spalinger M, de Vallière C.

J Crohns Colitis. 2019 Feb 1;13(2):245-258. doi: 10.1093/ecco-jcc/jjy152.

PMID:
30535144
4.

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.

Auberson M, Stadelmann S, Stoudmann C, Seuwen K, Koesters R, Thorens B, Bonny O.

Pflugers Arch. 2018 Dec;470(12):1739-1751. doi: 10.1007/s00424-018-2190-4. Epub 2018 Aug 13.

5.

CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S.

Neuropharmacology. 2018 Aug;138:381-392. doi: 10.1016/j.neuropharm.2018.06.007. Epub 2018 Jun 9.

6.

Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing.

Gauthier A, Fisch A, Seuwen K, Baumgarten B, Ruffner H, Aebi A, Rausch M, Kiessling F, Bartneck M, Weiskirchen R, Tacke F, Storm G, Lammers T, Ludwig MG.

Biomaterials. 2018 Sep;178:481-495. doi: 10.1016/j.biomaterials.2018.04.006. Epub 2018 Apr 5.

PMID:
29650255
7.

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Suply T, Hannedouche S, Carte N, Li J, Grosshans B, Schaefer M, Raad L, Beck V, Vidal S, Hiou-Feige A, Beluch N, Barbieri S, Wirsching J, Lageyre N, Hillger F, Debon C, Dawson J, Smith P, Lannoy V, Detheux M, Bitsch F, Falchetto R, Bouwmeester T, Porter J, Baumgarten B, Mansfield K, Carballido JM, Seuwen K, Bassilana F.

Sci Signal. 2017 Sep 12;10(496). pii: eaal0180. doi: 10.1126/scisignal.aal0180.

PMID:
28900043
8.

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.

Surdziel E, Clay I, Nigsch F, Thiemeyer A, Allard C, Hoffman G, Reece-Hoyes JS, Phadke T, Gambert R, Keller CG, Ludwig MG, Baumgarten B, Frederiksen M, Schübeler D, Seuwen K, Bouwmeester T, Fodor BD.

PLoS One. 2017 Aug 24;12(8):e0183679. doi: 10.1371/journal.pone.0183679. eCollection 2017.

9.

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Miltz W, Velcicky J, Dawson J, Littlewood-Evans A, Ludwig MG, Seuwen K, Feifel R, Oberhauser B, Meyer A, Gabriel D, Nash M, Loetscher P.

Bioorg Med Chem. 2017 Aug 15;25(16):4512-4525. doi: 10.1016/j.bmc.2017.06.050. Epub 2017 Jun 29.

PMID:
28689977
10.

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.

Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP.

JCI Insight. 2017 Jun 2;2(11). pii: 93700. doi: 10.1172/jci.insight.93700. eCollection 2017 Jun 2.

11.

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68).

de Vallière C, Cosin-Roger J, Simmen S, Atrott K, Melhem H, Zeitz J, Madanchi M, Tcymbarevich I, Fried M, Kullak-Ublick GA, Vavricka SR, Misselwitz B, Seuwen K, Wagner CA, Eloranta JJ, Rogler G, Ruiz PA.

Cell Mol Gastroenterol Hepatol. 2016 Jun 25;2(6):796-810. doi: 10.1016/j.jcmgh.2016.06.003. eCollection 2016 Nov.

12.

Adhesion GPCR Function in Pulmonary Development and Disease.

Ludwig MG, Seuwen K, Bridges JP.

Handb Exp Pharmacol. 2016;234:309-327. Review.

PMID:
27832494
13.

Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening.

Kiessling MK, Schuierer S, Stertz S, Beibel M, Bergling S, Knehr J, Carbone W, de Vallière C, Tchinda J, Bouwmeester T, Seuwen K, Rogler G, Roma G.

BMC Genomics. 2016 Sep 9;17(1):723. doi: 10.1186/s12864-016-3042-2.

14.

The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.

de Vallière C, Vidal S, Clay I, Jurisic G, Tcymbarevich I, Lang S, Ludwig MG, Okoniewski M, Eloranta JJ, Kullak-Ublick GA, Wagner CA, Rogler G, Seuwen K.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G475-90. doi: 10.1152/ajpgi.00408.2014. Epub 2015 Jul 23.

15.

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA.

Science. 2015 Jun 12;348(6240):1255-60. doi: 10.1126/science.aaa0922. Epub 2015 Jun 11.

16.

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.

de Vallière C, Wang Y, Eloranta JJ, Vidal S, Clay I, Spalinger MR, Tcymbarevich I, Terhalle A, Ludwig MG, Suply T, Fried M, Kullak-Ublick GA, Frey-Wagner I, Scharl M, Seuwen K, Wagner CA, Rogler G.

Inflamm Bowel Dis. 2015 Jun;21(6):1269-81. doi: 10.1097/MIB.0000000000000375.

17.

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women.

John MR, Harfst E, Loeffler J, Belleli R, Mason J, Bruin GJ, Seuwen K, Klickstein LB, Mindeholm L, Widler L, Kneissel M.

Bone. 2014 Jul;64:204-10. doi: 10.1016/j.bone.2014.04.015. Epub 2014 Apr 24.

PMID:
24769332
18.

Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.

Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA, Marsilje TH, Seuwen K, Nguyen DG, Sailer AW.

J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub 2014 Apr 15.

PMID:
24678947
19.

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

Bassilana F, Carlson A, DaSilva JA, Grosshans B, Vidal S, Beck V, Wilmeringwetter B, Llamas LA, Showalter TB, Rigollier P, Bourret A, Ramamurthy A, Wu X, Harbinski F, Plonsky S, Lee L, Ruffner H, Grandi P, Schirle M, Jenkins J, Sailer AW, Bouwmeester T, Porter JA, Myer V, Finan PM, Tallarico JA, Kelleher JF 3rd, Seuwen K, Jain RK, Luchansky SJ.

Nat Chem Biol. 2014 May;10(5):343-9. doi: 10.1038/nchembio.1481. Epub 2014 Mar 16.

PMID:
24633354
20.

Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages.

Preuss I, Ludwig MG, Baumgarten B, Bassilana F, Gessier F, Seuwen K, Sailer AW.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):663-8. doi: 10.1016/j.bbrc.2014.01.069. Epub 2014 Jan 27.

PMID:
24480442
21.

The proton-activated receptor GPR4 modulates glucose homeostasis by increasing insulin sensitivity.

Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA.

Cell Physiol Biochem. 2013;32(5):1403-16.

22.

Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.

Hannedouche S, Beck V, Leighton-Davies J, Beibel M, Roma G, Oakeley EJ, Lannoy V, Bernard J, Hamon J, Barbieri S, Preuss I, Lasbennes MC, Sailer AW, Suply T, Seuwen K, Parker CN, Bassilana F.

J Biol Chem. 2013 Sep 20;288(38):27434-43. doi: 10.1074/jbc.M113.497214. Epub 2013 Aug 12.

23.

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Quancard J, Bollbuck B, Janser P, Angst D, Berst F, Buehlmayer P, Streiff M, Beerli C, Brinkmann V, Guerini D, Smith PA, Seabrook TJ, Traebert M, Seuwen K, Hersperger R, Bruns C, Bassilana F, Bigaud M.

Chem Biol. 2012 Sep 21;19(9):1142-51. doi: 10.1016/j.chembiol.2012.07.016.

24.

The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.

Mohebbi N, Benabbas C, Vidal S, Daryadel A, Bourgeois S, Velic A, Ludwig MG, Seuwen K, Wagner CA.

Cell Physiol Biochem. 2012;29(3-4):313-24. doi: 10.1159/000338486. Epub 2012 Apr 3.

25.

Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.

Wyder L, Suply T, Ricoux B, Billy E, Schnell C, Baumgarten BU, Maira SM, Koelbing C, Ferretti M, Kinzel B, Müller M, Seuwen K, Ludwig MG.

Angiogenesis. 2011 Dec;14(4):533-44. doi: 10.1007/s10456-011-9238-9. Epub 2011 Nov 2.

PMID:
22045552
26.

Oxysterols direct immune cell migration via EBI2.

Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW.

Nature. 2011 Jul 27;475(7357):524-7. doi: 10.1038/nature10280.

27.

ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans.

John MR, Widler L, Gamse R, Buhl T, Seuwen K, Breitenstein W, Bruin GJ, Belleli R, Klickstein LB, Kneissel M.

Bone. 2011 Aug;49(2):233-41. doi: 10.1016/j.bone.2011.04.007. Epub 2011 Apr 14.

PMID:
21514409
28.

Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists).

Gerspacher M, Altmann E, Beerli R, Buhl T, Endres R, Gamse R, Kameni-Tcheudji J, Kneissel M, Krawinkler KH, Missbach M, Schmidt A, Seuwen K, Weiler S, Widler L.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5161-4. doi: 10.1016/j.bmcl.2010.07.016. Epub 2010 Aug 3.

PMID:
20685119
29.

1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists.

Widler L, Altmann E, Beerli R, Breitenstein W, Bouhelal R, Buhl T, Gamse R, Gerspacher M, Halleux C, John MR, Lehmann H, Kalb O, Kneissel M, Missbach M, Müller IR, Reidemeister S, Renaud J, Taillardat A, Tommasi R, Weiler S, Wolf RM, Seuwen K.

J Med Chem. 2010 Mar 11;53(5):2250-63. doi: 10.1021/jm901811v.

PMID:
20158186
30.

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

Mullershausen F, Zecri F, Cetin C, Billich A, Guerini D, Seuwen K.

Nat Chem Biol. 2009 Jun;5(6):428-34. doi: 10.1038/nchembio.173. Erratum in: Nat Chem Biol. 2009 Dec;5(12):954.

PMID:
19430484
31.

Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts.

Ribrioux S, Brüngger A, Baumgarten B, Seuwen K, John MR.

BMC Genomics. 2008 Mar 6;9:122. doi: 10.1186/1471-2164-9-122.

32.

Signaling of human frizzled receptors to the mating pathway in yeast.

Dirnberger D, Seuwen K.

PLoS One. 2007 Sep 26;2(9):e954.

33.

Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.

Mullershausen F, Craveiro LM, Shin Y, Cortes-Cros M, Bassilana F, Osinde M, Wishart WL, Guerini D, Thallmair M, Schwab ME, Sivasankaran R, Seuwen K, Dev KK.

J Neurochem. 2007 Aug;102(4):1151-61.

34.

Receptors for protons or lipid messengers or both?

Seuwen K, Ludwig MG, Wolf RM.

J Recept Signal Transduct Res. 2006;26(5-6):599-610. Review.

PMID:
17118800
35.

The 7 TM G-protein-coupled receptor target family.

Jacoby E, Bouhelal R, Gerspacher M, Seuwen K.

ChemMedChem. 2006 Aug;1(8):761-82. Review.

PMID:
16902930
36.

Multi-lineage potential of human mesenchymal stem cells following clonal expansion.

Halleux C, Sottile V, Gasser JA, Seuwen K.

J Musculoskelet Neuronal Interact. 2001 Sep;2(1):71-6.

37.

Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone).

Sottile V, Seuwen K, Kneissel M.

Calcif Tissue Int. 2004 Oct;75(4):329-37. Epub 2004 Jul 13.

PMID:
15549648
38.

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.

Miedlich SU, Gama L, Seuwen K, Wolf RM, Breitwieser GE.

J Biol Chem. 2004 Feb 20;279(8):7254-63. Epub 2003 Dec 2.

39.

Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.

Marrony S, Bassilana F, Seuwen K, Keller H.

Bone. 2003 Sep;33(3):426-33.

PMID:
13678785
40.

Proton-sensing G-protein-coupled receptors.

Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K.

Nature. 2003 Sep 4;425(6953):93-8.

PMID:
12955148
41.

Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.

Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P.

Mol Pharmacol. 2003 Mar;63(3):471-7.

PMID:
12606753
42.
43.

Stem cell characteristics of human trabecular bone-derived cells.

Sottile V, Halleux C, Bassilana F, Keller H, Seuwen K.

Bone. 2002 May;30(5):699-704.

PMID:
11996907
44.

A high-capacity screen for adipogenic differentiation.

Sottile V, Seuwen K.

Anal Biochem. 2001 Jun 1;293(1):124-8.

PMID:
11373088
46.

Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor.

Feuerbach D, Fehlmann D, Nunn C, Siehler S, Langenegger D, Bouhelal R, Seuwen K, Hoyer D.

Neuropharmacology. 2000 Jun 8;39(8):1451-62.

PMID:
10818261
47.

Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.

Siehler S, Seuwen K, Hoyer D.

Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):488-99.

PMID:
10598788
48.

Molecular cloning and pharmacological characterization of a somatostatin receptor subtype in the gymnotiform fish Apteronotus albifrons.

Zupanc GK, Siehler S, Jones EM, Seuwen K, Furuta H, Hoyer D, Yano H.

Gen Comp Endocrinol. 1999 Sep;115(3):333-45.

PMID:
10480984
49.

Characterisation of the fish sst3 receptor, a member of the SRIF1 receptor family: atypical pharmacological features.

Siehler S, Zupanc GK, Seuwen K, Hoyer D.

Neuropharmacology. 1999 Mar;38(3):449-62.

PMID:
10219983
50.

A novel calcium sensor stimulating inositol phosphate formation and [Ca2+]i signaling expressed by GCT23 osteoclast-like cells.

Seuwen K, Boddeke HG, Migliaccio S, Perez M, Taranta A, Teti A.

Proc Assoc Am Physicians. 1999 Jan-Feb;111(1):70-81.

PMID:
9893159

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