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Items: 1 to 50 of 85

1.

Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.

Borgs L, Peyre E, Alix P, Hanon K, Grobarczyk B, Godin JD, Purnelle A, Krusy N, Maquet P, Lefebvre P, Seutin V, Malgrange B, Nguyen L.

Sci Rep. 2016 Sep 19;6:33377. doi: 10.1038/srep33377.

2.

Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons.

Philippart F, Destreel G, Merino-Sepúlveda P, Henny P, Engel D, Seutin V.

J Neurosci. 2016 Jul 6;36(27):7234-45. doi: 10.1523/JNEUROSCI.0459-16.2016.

3.

Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels.

de Vrind V, Scuvée-Moreau J, Drion G, Hmaied C, Philippart F, Engel D, Seutin V.

Eur J Pharmacol. 2016 Oct 5;788:274-279. doi: 10.1016/j.ejphar.2016.06.046. Epub 2016 Jun 27.

PMID:
27364758
4.

[Mechanisms of caffeine-induced diuresis].

Marx B, Scuvée É, Scuvée-Moreau J, Seutin V, Jouret F.

Med Sci (Paris). 2016 May;32(5):485-90. doi: 10.1051/medsci/20163205015. Epub 2016 May 25. Review. French.

5.

Activation of D2 autoreceptors alters cocaine-induced locomotion and slows down local field oscillations in the rat ventral tegmental area.

Koulchitsky S, Delairesse C, Beeken T, Monteforte A, Dethier J, Quertemont E, Findeisen R, Bullinger E, Seutin V.

Neuropharmacology. 2016 Sep;108:120-7. doi: 10.1016/j.neuropharm.2016.04.034. Epub 2016 Apr 27.

6.

High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons.

Engel D, Seutin V.

J Physiol. 2015 Nov 15;593(22):4905-22. doi: 10.1113/JP271052. Epub 2015 Oct 12.

7.

Correlation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol.

Didone V, Masson S, Quoilin C, Seutin V, Quertemont E.

Addict Biol. 2016 Mar;21(2):387-96. doi: 10.1111/adb.12216. Epub 2014 Dec 24.

PMID:
25545401
8.

Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration.

Badarau E, Dilly S, Wouters J, Seutin V, Liégeois JF.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5616-5620. doi: 10.1016/j.bmcl.2014.10.083. Epub 2014 Nov 6.

PMID:
25466186
9.

Bis-(1,2,3,4-tetrahydroisoquinolinium): a chiral scaffold for developing high-affinity ligands for SK channels.

Liégeois JF, Wouters J, Seutin V, Dilly S.

ChemMedChem. 2014 Apr;9(4):737-40.

PMID:
24829978
10.

Mechanism of the medium-duration afterhyperpolarization in rat serotonergic neurons.

Alix P, Venkatesan K, Scuvée-Moreau J, Massotte L, Nguyen Trung ML, Cornil CA, Seutin V.

Eur J Neurosci. 2014 Jan;39(2):186-96. doi: 10.1111/ejn.12408. Epub 2013 Nov 4.

PMID:
24188044
11.

[Principles of the pharmacological treatment of drug addiction].

Saadan M, Scuvée-Moreau J, Seutin V.

Rev Med Liege. 2013 May-Jun;68(5-6):245-51. French.

12.

A balance equation determines a switch in neuronal excitability.

Franci A, Drion G, Seutin V, Sepulchre R.

PLoS Comput Biol. 2013;9(5):e1003040. doi: 10.1371/journal.pcbi.1003040. Epub 2013 May 23.

13.

The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels.

Dilly S, Philippart F, Lamy C, Poncin S, Snyders D, Seutin V, Liégeois JF.

Biochem Pharmacol. 2013 Feb 15;85(4):560-9. doi: 10.1016/j.bcp.2012.12.015. Epub 2012 Dec 24.

PMID:
23270990
14.

A novel phase portrait for neuronal excitability.

Drion G, Franci A, Seutin V, Sepulchre R.

PLoS One. 2012;7(8):e41806. doi: 10.1371/journal.pone.0041806. Epub 2012 Aug 8.

15.

Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.

Venkatesan K, Alix P, Marquet A, Doupagne M, Niespodziany I, Rogister B, Seutin V.

J Neurosci Res. 2012 Dec;90(12):2317-27. doi: 10.1002/jnr.23111. Epub 2012 Jul 30.

PMID:
22847229
16.

[Physiology, pharmacology and modelling of potassium channels: focus on SK channels].

Dilly S, Poncin S, Lamy C, Liégeois JF, Seutin V.

Med Sci (Paris). 2012 Apr;28(4):395-402. doi: 10.1051/medsci/2012284017. Epub 2012 Apr 25. Review. French.

17.

Differential effects of cocaine on dopamine neuron firing in awake and anesthetized rats.

Koulchitsky S, De Backer B, Quertemont E, Charlier C, Seutin V.

Neuropsychopharmacology. 2012 Jun;37(7):1559-71. doi: 10.1038/npp.2011.339. Epub 2012 Feb 1.

18.

Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels.

Weatherall KL, Seutin V, Liégeois JF, Marrion NV.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18494-9. doi: 10.1073/pnas.1110724108. Epub 2011 Oct 24.

19.

Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.

Badarau E, Dilly S, Dufour F, Poncin S, Seutin V, Liégeois JF.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6756-9. doi: 10.1016/j.bmcl.2011.09.043. Epub 2011 Sep 16.

PMID:
21978678
20.

Ion-channel modulators: more diversity than previously thought.

Dilly S, Lamy C, Marrion NV, Liégeois JF, Seutin V.

Chembiochem. 2011 Aug 16;12(12):1808-12. doi: 10.1002/cbic.201100236. Epub 2011 Jul 1. Review.

PMID:
21726033
21.

How modeling can reconcile apparently discrepant experimental results: the case of pacemaking in dopaminergic neurons.

Drion G, Massotte L, Sepulchre R, Seutin V.

PLoS Comput Biol. 2011 May;7(5):e1002050. doi: 10.1371/journal.pcbi.1002050. Epub 2011 May 26.

22.

11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.

Kaminski RM, Fu Z, Venkatesan K, Mazzuferi M, Leclercq K, Seutin V, Vicini S.

Neuropharmacology. 2011 Jun;60(7-8):1098-108. doi: 10.1016/j.neuropharm.2010.09.021. Epub 2010 Sep 29.

23.

Allosteric block of KCa2 channels by apamin.

Lamy C, Goodchild SJ, Weatherall KL, Jane DE, Liégeois JF, Seutin V, Marrion NV.

J Biol Chem. 2010 Aug 27;285(35):27067-77. doi: 10.1074/jbc.M110.110072. Epub 2010 Jun 18.

24.

The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines.

Lamy C, Scuvée-Moreau J, Dilly S, Liégeois JF, Seutin V.

Eur J Pharmacol. 2010 Sep 1;641(1):23-8. doi: 10.1016/j.ejphar.2010.05.008. Epub 2010 May 26.

PMID:
20546722
25.

Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra.

Seutin V, Engel D.

J Neurophysiol. 2010 Jun;103(6):3099-114. doi: 10.1152/jn.00513.2009. Epub 2010 Mar 31.

26.

M-type channels selectively control bursting in rat dopaminergic neurons.

Drion G, Bonjean M, Waroux O, Scuvée-Moreau J, Liégeois JF, Sejnowski TJ, Sepulchre R, Seutin V.

Eur J Neurosci. 2010 Mar;31(5):827-35. doi: 10.1111/j.1460-9568.2010.07107.x.

27.

Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues.

Goodchild SJ, Lamy C, Seutin V, Marrion NV.

J Gen Physiol. 2009 Oct;134(4):295-308. doi: 10.1085/jgp.200910252.

28.

[Regulation of the activity of monoaminergic neurons by ion channels: an opportunity for new therapeutic approaches?].

Seutin V.

Bull Mem Acad R Med Belg. 2008;163(5):213-22; discussion 223-4. French.

PMID:
19245101
29.

SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons.

Rouchet N, Waroux O, Lamy C, Massotte L, Scuvée-Moreau J, Liégeois JF, Seutin V.

Eur J Neurosci. 2008 Sep;28(6):1108-15. doi: 10.1111/j.1460-9568.2008.06430.x. Epub 2008 Sep 9.

PMID:
18783364
30.

[Endocannabinoid system in the brain...and elsewhere].

Scheen AJ, Seutin V, Van Gaal LF.

Rev Med Liege. 2008 May-Jun;63(5-6):364-71. French.

31.

[Pharmacological strategies in the modulation of central nervous system activity].

Phan-Ba R, Scuvée-Moreau J, Seutin V.

Rev Med Liege. 2008 May-Jun;63(5-6):238-44. French.

32.

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers.

Graulich A, Lamy C, Alleva L, Dilly S, Chavatte P, Wouters J, Seutin V, Liégeois JF.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3440-5. doi: 10.1016/j.bmcl.2008.03.069. Epub 2008 Mar 29. Erratum in: Bioorg Med Chem Lett. 2010 Jan 1;20(1):422.

PMID:
18436444
33.

Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.

Hansen HH, Waroux O, Seutin V, Jentsch TJ, Aznar S, Mikkelsen JD.

J Physiol. 2008 Apr 1;586(7):1823-32. doi: 10.1113/jphysiol.2007.149450. Epub 2008 Jan 3. Review.

34.

Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers.

Graulich A, Dilly S, Farce A, Scuvée-Moreau J, Waroux O, Lamy C, Chavatte P, Seutin V, Liégeois JF.

J Med Chem. 2007 Oct 18;50(21):5070-5. Epub 2007 Sep 15.

PMID:
17867663
35.

Characterization of 4-(2-hydroxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-fluorobenzamido]ethyl]piperazine (p-DMPPF) as a new potent 5-HT1A antagonist.

Defraiteur C, Plenevaux A, Scuvée-Moreau J, Rouchet N, Goblet D, Luxen A, Seutin V.

Br J Pharmacol. 2007 Nov;152(6):952-8. Epub 2007 Aug 20.

36.

Metaplastic effect of apamin on LTP and paired-pulse facilitation.

Ris L, Capron B, Sclavons C, Liégeois JF, Seutin V, Godaux E.

Learn Mem. 2007 Jun 5;14(6):390-9. Print 2007 Jun.

37.

SK channels are on the move.

Seutin V, Liégeois JF.

Br J Pharmacol. 2007 Jul;151(5):568-70. Epub 2007 May 8.

38.

Characterization of the neurotoxicity induced by the extract of Magnistipula butayei (Chrysobalanaceae) in rat: effects of a new natural convulsive agent.

Karangwa C, Esters V, Tits M, Minet A, Boland A, Seutin V, Noirfalise A, Angenot L, Grisar T, Foidart A.

Toxicon. 2007 Jun 15;49(8):1109-19. Epub 2007 Feb 16. Erratum in: Toxicon. 2010 Feb-Mar;55(2-3):675.

PMID:
17395230
39.

Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.

Graulich A, Scuvée-Moreau J, Alleva L, Lamy C, Waroux O, Seutin V, Liégeois JF.

J Med Chem. 2006 Nov 30;49(24):7208-14.

PMID:
17125273
40.

The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat.

Hansen HH, Ebbesen C, Mathiesen C, Weikop P, Rønn LC, Waroux O, Scuvée-Moreau J, Seutin V, Mikkelsen JD.

J Pharmacol Exp Ther. 2006 Sep;318(3):1006-19. Epub 2006 Jun 14.

41.

Identification of a pharmacophore of SKCa channel blockers.

Dilly S, Graulich A, Farce A, Seutin V, Liegeois JF, Chavatte P.

J Enzyme Inhib Med Chem. 2005 Dec;20(6):517-23.

PMID:
16408787
42.

SK channels control the firing pattern of midbrain dopaminergic neurons in vivo.

Waroux O, Massotte L, Alleva L, Graulich A, Thomas E, Liégeois JF, Scuvée-Moreau J, Seutin V.

Eur J Neurosci. 2005 Dec;22(12):3111-21.

PMID:
16367777
44.

Dopaminergic neurones: much more than dopamine?

Seutin V.

Br J Pharmacol. 2005 Sep;146(2):167-9. Review.

45.

Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function.

Adamantidis A, Thomas E, Foidart A, Tyhon A, Coumans B, Minet A, Tirelli E, Seutin V, Grisar T, Lakaye B.

Eur J Neurosci. 2005 May;21(10):2837-44.

PMID:
15926931
46.

[Coenzyme Q10: biochemistry, pathophysiology of its deficiency and potential benefit of an increased intake].

Malchair P, Van Overmeire L, Boland A, Salmon E, Pierard L, Seutin V.

Rev Med Liege. 2005 Jan;60(1):45-51. Review. French.

47.

Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers.

Graulich A, Mercier F, Scuvée-Moreau J, Seutin V, Liégeois JF.

Bioorg Med Chem. 2005 Feb 15;13(4):1201-9.

PMID:
15670929
48.
49.

Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices.

Scuvée-Moreau J, Boland A, Graulich A, Van Overmeire L, D'hoedt D, Graulich-Lorge F, Thomas E, Abras A, Stocker M, Liégeois JF, Seutin V.

Br J Pharmacol. 2004 Nov;143(6):753-64. Epub 2004 Oct 25.

50.

Mechanisms of actions of inhaled anesthetics.

Seutin VM.

N Engl J Med. 2003 Aug 28;349(9):909-10; author reply 909-10. No abstract available.

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