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Items: 1 to 50 of 292

1.

FOLFOXIRI Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study (AIO KRK0109).

Modest DP, Martens UM, Riera-Knorrenschild J, Greeve J, Florschütz A, Wessendorf S, Ettrich T, Kanzler S, Nörenberg D, Ricke J, Seidensticker M, Held S, Buechner-Steudel P, Atzpodien J, Heinemann V, Seufferlein T, Tannapfel A, Reinacher-Schick AC, Geissler M.

J Clin Oncol. 2019 Oct 14:JCO1901340. doi: 10.1200/JCO.19.01340. [Epub ahead of print]

PMID:
31609637
2.

Molecular Approaches to Metastatic Colorectal Cancer: Better Diagnosis - Better Treatment?

Seufferlein T, Simões C, Kude F, Ettrich TJ.

Visc Med. 2019 Aug;35(4):259-264. doi: 10.1159/000500617. Epub 2019 Jul 11. Review.

PMID:
31602389
3.

Novel Concepts in the Management of Colorectal Cancer.

Seufferlein T, Weitz J.

Visc Med. 2019 Aug;35(4):245. doi: 10.1159/000501750. Epub 2019 Jul 30. No abstract available.

PMID:
31602386
4.

An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.

Cancers (Basel). 2019 Sep 21;11(10). pii: E1410. doi: 10.3390/cancers11101410.

5.

Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information.

Ettrich TJ, Schwerdel D, Dolnik A, Beuter F, Blätte TJ, Schmidt SA, Stanescu-Siegmund N, Steinacker J, Marienfeld R, Kleger A, Bullinger L, Seufferlein T, Berger AW.

Sci Rep. 2019 Sep 13;9(1):13261. doi: 10.1038/s41598-019-49860-0.

6.

MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.

Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B Jr, Siveke JT, Rodriguez-Aznar E, Hermann PC.

Stem Cells Int. 2019 Jun 2;2019:8475389. doi: 10.1155/2019/8475389. eCollection 2019.

7.

Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks.

Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO.

Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019.

8.

Optimizing the management of locally advanced pancreatic cancer with a focus on induction chemotherapy: Expert opinion based on a review of current evidence.

Seufferlein T, Hammel P, Delpero JR, Macarulla T, Pfeiffer P, Prager GW, Reni M, Falconi M, Philip PA, Van Cutsem E.

Cancer Treat Rev. 2019 Jul;77:1-10. doi: 10.1016/j.ctrv.2019.05.007. Epub 2019 May 29. Review.

PMID:
31163334
9.

Effect of a Single Aspirin Dose Prior to Fecal Immunochemical Testing on Test Sensitivity for Detecting Advanced Colorectal Neoplasms: A Randomized Clinical Trial.

Brenner H, Calderazzo S, Seufferlein T, Ludwig L, Dikopoulos N, Mangold J, Böck W, Stolz T, Eisenbach T, Block T, Kopp-Schneider A, Czock D, Tikk K.

JAMA. 2019 May 7;321(17):1686-1692. doi: 10.1001/jama.2019.4755.

PMID:
31063574
10.

Variant classification in precision oncology.

Leichsenring J, Horak P, Kreutzfeldt S, Heining C, Christopoulos P, Volckmar AL, Neumann O, Kirchner M, Ploeger C, Budczies J, Heilig CE, Hutter B, Fröhlich M, Uhrig S, Kazdal D, Allgäuer M, Harms A, Rempel E, Lehmann U, Thomas M, Pfarr N, Azoitei N, Bonzheim I, Marienfeld R, Möller P, Werner M, Fend F, Boerries M, von Bubnoff N, Lassmann S, Longerich T, Bitzer M, Seufferlein T, Malek N, Weichert W, Schirmacher P, Penzel R, Endris V, Brors B, Klauschen F, Glimm H, Fröhling S, Stenzinger A.

Int J Cancer. 2019 Dec 1;145(11):2996-3010. doi: 10.1002/ijc.32358. Epub 2019 May 21.

PMID:
31008532
11.

Treatment of pancreatic cancer-neoadjuvant treatment in resectable pancreatic cancer (PDAC).

Seufferlein T, Ettrich TJ.

Transl Gastroenterol Hepatol. 2019 Mar 27;4:21. doi: 10.21037/tgh.2019.03.05. eCollection 2019. Review.

12.

Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance.

D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, Martin-Hijano L, Valle S, Earl J, Cassiano C, Lombardia L, Feliu J, Monti MC, Seufferlein T, García-Bermejo L, Martinelli P, Carrato A, Sainz B Jr.

Oncogene. 2019 Jul;38(27):5469-5485. doi: 10.1038/s41388-019-0803-9. Epub 2019 Apr 1.

PMID:
30936462
13.

A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer.

Berger AW, Schwerdel D, Reinacher-Schick A, Uhl W, Algül H, Friess H, Janssen KP, König A, Ghadimi M, Gallmeier E, Bartsch DK, Geissler M, Staib L, Tannapfel A, Kleger A, Beutel A, Schulte LA, Kornmann M, Ettrich TJ, Seufferlein T.

Theranostics. 2019 Feb 12;9(5):1280-1287. doi: 10.7150/thno.29247. eCollection 2019.

14.

Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone.

Bekeschus S, Lippert M, Diepold K, Chiosis G, Seufferlein T, Azoitei N.

Sci Rep. 2019 Mar 11;9(1):4112. doi: 10.1038/s41598-019-38580-0.

15.

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline.

Hassan C, Wysocki PT, Fuccio L, Seufferlein T, Dinis-Ribeiro M, Brandão C, Regula J, Frazzoni L, Pellise M, Alfieri S, Dekker E, Jover R, Rosati G, Senore C, Spada C, Gralnek I, Dumonceau JM, van Hooft JE, van Cutsem E, Ponchon T.

Endoscopy. 2019 Mar;51(3):C1. doi: 10.1055/a-0854-5925. Epub 2019 Feb 14.

PMID:
30763965
16.

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline.

Hassan C, Wysocki PT, Fuccio L, Seufferlein T, Dinis-Ribeiro M, Brandão C, Regula J, Frazzoni L, Pellise M, Alfieri S, Dekker E, Jover R, Rosati G, Senore C, Spada C, Gralnek I, Dumonceau JM, van Hooft JE, van Cutsem E, Ponchon T.

Endoscopy. 2019 Mar;51(3):266-277. doi: 10.1055/a-0831-2522. Epub 2019 Feb 5.

17.

Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination.

Krieger J, Riedl P, Stifter K, Roman-Sosa G, Seufferlein T, Wagner M, Schirmbeck R.

Mol Ther. 2019 Mar 6;27(3):661-672. doi: 10.1016/j.ymthe.2019.01.011. Epub 2019 Jan 22.

18.

Systemic treatment of pancreatic cancer revisited.

Ducreux M, Seufferlein T, Van Laethem JL, Laurent-Puig P, Smolenschi C, Malka D, Boige V, Hollebecque A, Conroy T.

Semin Oncol. 2019 Feb;46(1):28-38. doi: 10.1053/j.seminoncol.2018.12.003. Epub 2018 Dec 27. Review.

19.

Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group.

Ettrich TJ, Berger AW, Perkhofer L, Daum S, König A, Dickhut A, Wittel U, Wille K, Geissler M, Algül H, Gallmeier E, Atzpodien J, Kornmann M, Muche R, Prasnikar N, Tannapfel A, Reinacher-Schick A, Uhl W, Seufferlein T.

BMC Cancer. 2018 Dec 29;18(1):1298. doi: 10.1186/s12885-018-5183-y.

20.

New and Recurrent Colorectal Cancers After Resection: a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies.

Fuccio L, Rex D, Ponchon T, Frazzoni L, Dinis-Ribeiro M, Bhandari P, Dekker E, Pellisè M, Correale L, van Hooft J, Jover R, Libanio D, Radaelli F, Alfieri S, Bazzoli F, Senore C, Regula J, Seufferlein T, Rösch T, Sharma P, Repici A, Hassan C.

Gastroenterology. 2019 Apr;156(5):1309-1323.e3. doi: 10.1053/j.gastro.2018.12.006. Epub 2018 Dec 13.

PMID:
30553914
21.

Ultrasound point shear wave elastography of the pancreas: comparison of patients with type 1 diabetes and healthy volunteers - results from a pilot study.

Püttmann S, Koch J, Steinacker JP, Schmidt SA, Seufferlein T, Kratzer W, Schmidberger J, Manfras B.

BMC Med Imaging. 2018 Dec 13;18(1):52. doi: 10.1186/s12880-018-0295-z.

22.

Invitation to Screening Colonoscopy in the Population at Familial Risk for Colorectal Cancer.

Bauer A, Riemann JF, Seufferlein T, Reinshagen M, Hollerbach S, Haug U, Unverzagt S, Boese S, Ritter-Herschbach M, Jahn P, Frese T, Harris M, Landenberger M.

Dtsch Arztebl Int. 2018 Oct 26;115(43):715-722. doi: 10.3238/arztebl.2018.0715.

23.

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion.

Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A.

Int J Mol Sci. 2018 Nov 29;19(12). pii: E3801. doi: 10.3390/ijms19123801.

24.

IgG4-Related Diseases in the Gastrointestinal Tract: Clinical Presentation, Diagnosis and Treatment Challenges.

Backhus J, Seufferlein T, Perkhofer L, Hermann PC, Kleger A.

Digestion. 2019;100(1):1-14. doi: 10.1159/000492814. Epub 2018 Nov 1. Review.

PMID:
30384361
25.

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.

Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.

J Clin Invest. 2018 Nov 1;128(11):5056-5072. doi: 10.1172/JCI97912. Epub 2018 Oct 15.

26.

Regorafenib.

Ettrich TJ, Seufferlein T.

Recent Results Cancer Res. 2018;211:45-56. doi: 10.1007/978-3-319-91442-8_3. Review.

PMID:
30069758
27.

Organoidomics - falling star or new galaxy in pancreatic cancer?

Seufferlein T, Kleger A.

Nat Rev Gastroenterol Hepatol. 2018 Oct;15(10):586-587. doi: 10.1038/s41575-018-0052-3. No abstract available.

PMID:
30046146
28.

Time trends in dyspepsia and association with H. pylori and work-related stress-An observational study in white collar employees in 1996 and 2015.

Braig S, Berger S, Rothenbacher D, Schmid S, Seufferlein T, Brenner H, Rothenbacher D, Gündel H.

PLoS One. 2018 Jun 22;13(6):e0199533. doi: 10.1371/journal.pone.0199533. eCollection 2018.

29.

Adverse Drug Reactions (ADR) and Emergencies.

Schurig AM, Böhme M, Just KS, Scholl C, Dormann H, Plank-Kiegele B, Seufferlein T, Gräff I, Schwab M, Stingl JC.

Dtsch Arztebl Int. 2018 Apr 13;115(15):251-258. doi: 10.3238/arztebl.2018.0251.

30.

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma.

Wille C, Eiseler T, Langenberger ST, Richter J, Mizuno K, Radermacher P, Knippschild U, Huber-Lang M, Seufferlein T, Paschke S.

J Leukoc Biol. 2018 Sep;104(3):615-630. doi: 10.1002/JLB.4A0617-251RR. Epub 2018 Apr 14.

PMID:
29656400
31.

[ASCO- and ESMO-update 2017 - highlights of the 53. meeting of the American Society of Clinical Oncology/ASCO 2017 and European Society for Medical Oncology/ESMO congress 2017].

Ettrich TJ, Ebert M, Lorenzen S, Moehler M, Vogel A, Witkowski L, Seufferlein T, Reinacher-Schick A.

Z Gastroenterol. 2018 Apr;56(4):384-397. doi: 10.1055/s-0044-101757. Epub 2018 Apr 11. German.

PMID:
29642252
32.

[Laryngopharyngeal Reflux].

Reiter R, Heyduck A, Seufferlein T, Hoffmann T, Pickhard A.

Laryngorhinootologie. 2018 Apr;97(4):238-245. doi: 10.1055/s-0044-100794. Epub 2018 Apr 10. Review. German.

PMID:
29635668
33.

Barriers and Facilitating Factors for Research Involvement in Cancer Centers: A Survey of Colorectal Cancer Center Coordinators in Germany, Austria, and Switzerland.

Kowalski C, Post S, Seufferlein T, Benz SR, Ferencz J, Wesselmann S.

Cancer Control. 2018 Jan-Mar;25(1):1073274818765475. doi: 10.1177/1073274818765475.

PMID:
29592528
34.

Chemotherapeutic agents eligible for prior dosing in pancreatic cancer patients requiring hemodialysis: a systematic review
.

Hann A, Nosalski E, Hermann PC, Egger J, Seufferlein T, Keller F.

Clin Nephrol. 2018 Aug;90(2):125-141. doi: 10.5414/CN109327. Review.

PMID:
29578402
35.

Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study.

Berger AW, Raedler K, Langner C, Ludwig L, Dikopoulos N, Becker KF, Slotta-Huspenina J, Quante M, Schwerdel D, Perkhofer L, Kleger A, Zizer E, Oswald F, Seufferlein T, Meining A.

United European Gastroenterol J. 2018 Mar;6(2):290-299. doi: 10.1177/2050640617723810. Epub 2017 Jul 28.

36.

Population nutrikinetics of green tea extract.

Scholl C, Lepper A, Lehr T, Hanke N, Schneider KL, Brockmöller J, Seufferlein T, Stingl JC.

PLoS One. 2018 Feb 21;13(2):e0193074. doi: 10.1371/journal.pone.0193074. eCollection 2018.

37.

ECCO essential requirements for quality cancer care: Oesophageal and gastric cancer.

Allum W, Lordick F, Alsina M, Andritsch E, Ba-Ssalamah A, Beishon M, Braga M, Caballero C, Carneiro F, Cassinello F, Dekker JW, Delgado-Bolton R, Haustermans K, Henning G, Hutter B, Lövey J, Netíková IŠ, Obermannová R, Oberst S, Rostoft S, Saarto T, Seufferlein T, Sheth S, Wynter-Blyth V, Costa A, Naredi P.

Crit Rev Oncol Hematol. 2018 Feb;122:179-193. doi: 10.1016/j.critrevonc.2017.12.019. Epub 2018 Jan 2. Review.

38.

Targeted deep sequencing of circulating tumor DNA in metastatic pancreatic cancer.

Berger AW, Schwerdel D, Ettrich TJ, Hann A, Schmidt SA, Kleger A, Marienfeld R, Seufferlein T.

Oncotarget. 2017 Dec 16;9(2):2076-2085. doi: 10.18632/oncotarget.23330. eCollection 2018 Jan 5.

39.

CabaGast: multicentre, Phase II study with cabazitaxel in previously treated patients with advanced or metastatic adenocarcinoma of the esophagogastric junction and stomach.

Schmalenberg H, Al-Batran SE, Pauligk C, Zander T, Reichart A, Lindig U, Kleiß M, Müller L, Bolling C, Seufferlein T, Reichardt P, Kullmann F, Eschenburg H, Schmittel A, Egger M, Block A, Goetze TO.

J Cancer Res Clin Oncol. 2018 Mar;144(3):559-569. doi: 10.1007/s00432-017-2565-5. Epub 2017 Dec 28.

PMID:
29285668
40.

Protein kinase D2: a versatile player in cancer biology.

Azoitei N, Cobbaut M, Becher A, Van Lint J, Seufferlein T.

Oncogene. 2018 Mar;37(10):1263-1278. doi: 10.1038/s41388-017-0052-8. Epub 2017 Dec 20. Review.

PMID:
29259300
41.

Shifting cancer care towards Multidisciplinarity: the cancer center certification program of the German cancer society.

Kowalski C, Graeven U, von Kalle C, Lang H, Beckmann MW, Blohmer JU, Burchardt M, Ehrenfeld M, Fichtner J, Grabbe S, Hoffmann H, Iro H, Post S, Scharl A, Schlegel U, Seufferlein T, Stummer W, Ukena D, Ferencz J, Wesselmann S.

BMC Cancer. 2017 Dec 14;17(1):850. doi: 10.1186/s12885-017-3824-1.

42.

Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals.

Bansal V, Gassenhuber J, Phillips T, Oliveira G, Harbaugh R, Villarasa N, Topol EJ, Seufferlein T, Boehm BO.

BMC Med. 2017 Dec 6;15(1):213. doi: 10.1186/s12916-017-0977-3.

43.

Reprogramming to pluripotency does not require transition through a primitive streak-like state.

Raab S, Klingenstein M, Möller A, Illing A, Tosic J, Breunig M, Kuales G, Linta L, Seufferlein T, Arnold SJ, Kleger A, Liebau S.

Sci Rep. 2017 Nov 29;7(1):16543. doi: 10.1038/s41598-017-15187-x.

44.

Direct-acting antiviral agents in the treatment of chronic Hepatitis C - "Real-life" experience from an academic centre and two specialized clinical practices.

Groß MJ, Härter G, Backhus J, Zizer E, Seufferlein T, Ludwig L, Dikopoulos N.

Z Gastroenterol. 2018 Apr;56(4):351-360. doi: 10.1055/s-0043-121892. Epub 2017 Nov 7.

PMID:
29113004
45.

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway.

Liu Y, Steinestel K, Rouhi A, Armacki M, Diepold K, Chiosis G, Simmet T, Seufferlein T, Azoitei N.

Oncotarget. 2017 Aug 24;8(44):77474-77488. doi: 10.18632/oncotarget.20535. eCollection 2017 Sep 29.

46.

Clinical relevance of molecular diagnostics in gastrointestinal (GI) cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 17th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal Cancer, Barcelona.

Baraniskin A, Van Laethem JL, Wyrwicz L, Guller U, Wasan HS, Matysiak-Budnik T, Gruenberger T, Ducreux M, Carneiro F, Van Cutsem E, Seufferlein T, Schmiegel W.

Eur J Cancer. 2017 Nov;86:305-317. doi: 10.1016/j.ejca.2017.09.021. Epub 2017 Oct 21. Review.

PMID:
29065378
47.

[Cystic pancreatic tumors: diagnostics and new biomarkers].

Berger AW, Seufferlein T, Kleger A.

Chirurg. 2017 Nov;88(11):905-912. doi: 10.1007/s00104-017-0493-1. Review. German.

PMID:
28831506
48.

Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis.

Hohwieler M, Perkhofer L, Liebau S, Seufferlein T, Müller M, Illing A, Kleger A.

United European Gastroenterol J. 2017 Aug;5(5):609-624. doi: 10.1177/2050640616670565. Epub 2016 Sep 21. Review.

49.

The armadillo protein p0071 controls KIF3 motor transport.

Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, Hatzfeld M, Seufferlein T.

J Cell Sci. 2017 Oct 1;130(19):3374-3387. doi: 10.1242/jcs.200170. Epub 2017 Aug 14.

50.

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.

Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A.

Cancer Res. 2017 Oct 15;77(20):5576-5590. doi: 10.1158/0008-5472.CAN-17-0634. Epub 2017 Aug 8.

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