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Insights into the cardioprotective properties of n-3 PUFAs against ischemic heart disease via modulation of the innate immune system.

Darwesh AM, Sosnowski DK, Lee TY, Keshavarz-Bahaghighat H, Seubert JM.

Chem Biol Interact. 2019 May 5;308:20-44. doi: 10.1016/j.cbi.2019.04.037. [Epub ahead of print] Review.


Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation.

Samokhvalov V, Jamieson KL, Darwesh AM, Keshavarz-Bahaghighat H, Lee TYT, Edin M, Lih F, Zeldin DC, Seubert JM.

Front Pharmacol. 2019 Jan 14;9:1572. doi: 10.3389/fphar.2018.01572. eCollection 2018.


Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain.

Dintica CS, Marseglia A, Rizzuto D, Wang R, Seubert J, Arfanakis K, Bennett DA, Xu W.

Neurology. 2019 Feb 12;92(7):e700-e709. doi: 10.1212/WNL.0000000000006919. Epub 2019 Jan 16.


Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation 1.

Darwesh AM, Jamieson KL, Wang C, Samokhvalov V, Seubert JM.

Can J Physiol Pharmacol. 2019 Jun;97(6):544-556. doi: 10.1139/cjpp-2018-0480. Epub 2018 Oct 16.


DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile.

Endo T, Samokhvalov V, Darwesh AM, Khey KMW, El-Sherbeni AA, Ei-Kadi AOS, Machida T, Hirafuji M, Seubert JM.

Cell Death Discov. 2018 Aug 20;4:29. doi: 10.1038/s41420-018-0090-1. eCollection 2018.


Prefrontal Control Over Occipital Responses to Crossmodal Overlap Varies Across the Congruency Spectrum.

Lundström JN, Regenbogen C, Ohla K, Seubert J.

Cereb Cortex. 2018 Jul 27. doi: 10.1093/cercor/bhy168. [Epub ahead of print]


Using the Deep Space Atomic Clock for Navigation and Science.

Ely TA, Burt EA, Prestage JD, Seubert JM, Tjoelker RL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jun;65(6):950-961. doi: 10.1109/TUFFC.2018.2808269.


Multisensory flavor perception: The relationship between congruency, pleasantness, and odor referral to the mouth.

Fondberg R, Lundström JN, Blöchl M, Olsson MJ, Seubert J.

Appetite. 2018 Jun 1;125:244-252. doi: 10.1016/j.appet.2018.02.012. Epub 2018 Feb 13.


Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD.

Biochem J. 2018 Mar 9;475(5):959-976. doi: 10.1042/BCJ20170823.


The intraparietal sulcus governs multisensory integration of audiovisual information based on task difficulty.

Regenbogen C, Seubert J, Johansson E, Finkelmeyer A, Andersson P, Lundström JN.

Hum Brain Mapp. 2018 Mar;39(3):1313-1326. doi: 10.1002/hbm.23918. Epub 2017 Dec 12.


STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line.

Soleymani Abyaneh H, Gupta N, Radziwon-Balicka A, Jurasz P, Seubert J, Lai R, Lavasanifar A.

Cancers (Basel). 2017 Oct 14;9(10). pii: E137. doi: 10.3390/cancers9100137.


Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation.

Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Santos-Martinez MJ, Radomski MW, Velazquez-Martinez CA, Winship IR, Jurasz P.

Cardiovasc Res. 2017 Dec 1;113(14):1719-1731. doi: 10.1093/cvr/cvx179. Review.


Cytochrome P450-derived eicosanoids and heart function.

Jamieson KL, Endo T, Darwesh AM, Samokhvalov V, Seubert JM.

Pharmacol Ther. 2017 Nov;179:47-83. doi: 10.1016/j.pharmthera.2017.05.005. Epub 2017 May 25. Review.


Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study.

Seubert J, Laukka EJ, Rizzuto D, Hummel T, Fratiglioni L, Bäckman L, Larsson M.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1072-1079. doi: 10.1093/gerona/glx054.


Phantom Smells: Prevalence and Correlates in a Population-Based Sample of Older Adults.

Sjölund S, Larsson M, Olofsson JK, Seubert J, Laukka EJ.

Chem Senses. 2017 May 1;42(4):309-318. doi: 10.1093/chemse/bjx006.


Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.

Sung MM, Byrne NJ, Robertson IM, Kim TT, Samokhvalov V, Levasseur J, Soltys CL, Fung D, Tyreman N, Denou E, Jones KE, Seubert JM, Schertzer JD, Dyck JR.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H842-H853. doi: 10.1152/ajpheart.00455.2016. Epub 2017 Feb 3.


Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice.

Jamieson KL, Samokhvalov V, Akhnokh MK, Lee K, Cho WJ, Takawale A, Wang X, Kassiri Z, Seubert JM.

Prostaglandins Other Lipid Mediat. 2017 Sep;132:47-58. doi: 10.1016/j.prostaglandins.2017.01.001. Epub 2017 Jan 16. Review.


A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1.

Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, Wang X, Fernandez-Patron C, Seubert JM, Oudit GY, Kassiri Z.

Hypertension. 2016 Oct;68(4):937-48. doi: 10.1161/HYPERTENSIONAHA.116.07566. Epub 2016 Aug 22.


Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.

El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM.

PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016.


Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM.

Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016.


SIRT Is Required for EDP-Mediated Protective Responses toward Hypoxia-Reoxygenation Injury in Cardiac Cells.

Samokhvalov V, Jamieson KL, Fedotov I, Endo T, Seubert JM.

Front Pharmacol. 2016 May 17;7:124. doi: 10.3389/fphar.2016.00124. eCollection 2016.


CYP-epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity Through SIRT1.

Samokhvalov V, Jamieson KL, Vriend J, Quan S, Seubert JM.

Cell Death Discov. 2015 Nov 23;1. doi: 10.1038/cddiscovery.2015.54.


Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype.

Larsson M, Hedner M, Papenberg G, Seubert J, Bäckman L, Laukka EJ.

Neurobiol Aging. 2016 Feb;38:118-126. doi: 10.1016/j.neurobiolaging.2015.11.012. Epub 2015 Nov 26.


Cardiovascular safety of sulphonylureas: over 40 years of continuous controversy without an answer.

Abdelmoneim AS, Eurich DT, Light PE, Senior PA, Seubert JM, Makowsky MJ, Simpson SH.

Diabetes Obes Metab. 2015 Jun;17(6):523-32. doi: 10.1111/dom.12456. Epub 2015 Mar 20. Review.


Neural responses to dynamic multimodal stimuli and pathology-specific impairments of social cognition in schizophrenia and depression.

Regenbogen C, Kellermann T, Seubert J, Schneider DA, Gur RE, Derntl B, Schneider F, Habel U.

Br J Psychiatry. 2015 Mar;206(3):198-205. doi: 10.1192/bjp.bp.113.143040. Epub 2015 Jan 8.


Superadditive opercular activation to food flavor is mediated by enhanced temporal and limbic coupling.

Seubert J, Ohla K, Yokomukai Y, Kellermann T, Lundström JN.

Hum Brain Mapp. 2015 May;36(5):1662-76. doi: 10.1002/hbm.22728. Epub 2014 Dec 26.


PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS.

Samokhvalov V, Vriend J, Jamieson KL, Akhnokh MK, Manne R, Falck JR, Seubert JM.

Front Pharmacol. 2014 Nov 11;5:242. doi: 10.3389/fphar.2014.00242. eCollection 2014.


Neural processing of emotion in multimodal settings.

Klasen M, Kreifelts B, Chen YH, Seubert J, Mathiak K.

Front Hum Neurosci. 2014 Oct 21;8:822. doi: 10.3389/fnhum.2014.00822. eCollection 2014. No abstract available.


PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.

Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM.

Toxicol Lett. 2015 Jan 5;232(1):10-20. doi: 10.1016/j.toxlet.2014.09.029. Epub 2014 Oct 6.


Epoxyeicosatrienoic acids and cardioprotection: the road to translation.

Oni-Orisan A, Alsaleh N, Lee CR, Seubert JM.

J Mol Cell Cardiol. 2014 Sep;74:199-208. doi: 10.1016/j.yjmcc.2014.05.016. Epub 2014 Jun 2. Review.


Odor valence linearly modulates attractiveness, but not age assessment, of invariant facial features in a memory-based rating task.

Seubert J, Gregory KM, Chamberland J, Dessirier JM, Lundström JN.

PLoS One. 2014 May 29;9(5):e98347. doi: 10.1371/journal.pone.0098347. eCollection 2014.


Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy.

Falamarzian A, Aliabadi HM, Molavi O, Seubert JM, Lai R, Uludağ H, Lavasanifar A.

J Biomed Mater Res A. 2014 Sep;102(9):3216-28. doi: 10.1002/jbm.a.34992. Epub 2013 Oct 25.


Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response.

Samokhvalov V, Alsaleh N, El-Sikhry HE, Jamieson KL, Chen CB, Lopaschuk DG, Carter C, Light PE, Manne R, Falck JR, Seubert JM.

Cell Death Dis. 2013 Oct 24;4:e885. doi: 10.1038/cddis.2013.418.


Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice.

Zou Z, Bellenger S, Massey KA, Nicolaou A, Geissler A, Bidu C, Bonnotte B, Pierre AS, Minville-Walz M, Rialland M, Seubert J, Kang JX, Lagrost L, Narce M, Bellenger J.

J Lipid Res. 2013 Dec;54(12):3453-63. doi: 10.1194/jlr.M042754. Epub 2013 Sep 19.


Risk of acute coronary events associated with glyburide compared with gliclazide use in patients with type 2 diabetes: a nested case-control study.

Abdelmoneim AS, Eurich DT, Gamble JM, Johnson JA, Seubert JM, Qiu W, Simpson SH.

Diabetes Obes Metab. 2014 Jan;16(1):22-9. doi: 10.1111/dom.12173. Epub 2013 Jul 19.


A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies.

Bhardwaj A, Huang Z, Kaur J, Yang F, Seubert JM, Knaus EE.

Bioorg Med Chem Lett. 2013 May 1;23(9):2769-74. doi: 10.1016/j.bmcl.2013.02.040. Epub 2013 Feb 22.


Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells.

Qadhi R, Alsaleh N, Samokhvalov V, El-Sikhry H, Bellenger J, Seubert JM.

Toxicol Lett. 2013 Jun 7;219(3):288-97. doi: 10.1016/j.toxlet.2013.03.010. Epub 2013 Mar 21.


Effect of ischemia reperfusion injury and epoxyeicosatrienoic acids on caveolin expression in mouse myocardium.

Chaudhary KR, Cho WJ, Yang F, Samokhvalov V, El-Sikhry HE, Daniel EE, Seubert JM.

J Cardiovasc Pharmacol. 2013 Mar;61(3):258-63. doi: 10.1097/FJC.0b013e31827afcee.


Pharmacologic protein kinase Cα inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation.

Moncada de la Rosa C, Radziwon-Balicka A, El-Sikhry H, Seubert J, Ruvolo PP, Radomski MW, Jurasz P.

J Pharmacol Exp Ther. 2013 Apr;345(1):15-24. doi: 10.1124/jpet.112.200881. Epub 2013 Feb 5.


Rapid, Affordable, and Point-of-Care Water Monitoring Via a Microfluidic DNA Sensor and a Mobile Interface for Global Health.

Kim U, Ghanbari S, Ravikumar A, Seubert J, Figueira S.

IEEE J Transl Eng Health Med. 2013 Sep 16;1:3700207. doi: 10.1109/JTEHM.2013.2281819. eCollection 2013.


Statistical localization of human olfactory cortex.

Seubert J, Freiherr J, Djordjevic J, Lundström JN.

Neuroimage. 2013 Feb 1;66:333-42. doi: 10.1016/j.neuroimage.2012.10.030. Epub 2012 Oct 24.


Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.

Samokhvalov V, Ussher JR, Fillmore N, Armstrong IK, Keung W, Moroz D, Lopaschuk DG, Seubert J, Lopaschuk GD.

Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1459-68. doi: 10.1152/ajpendo.00018.2012. Epub 2012 Oct 16.


Engineered peptides for the development of actively tumor targeted liposomal carriers of doxorubicin.

Shahin M, Soudy R, El-Sikhry H, Seubert JM, Kaur K, Lavasanifar A.

Cancer Lett. 2013 Jul 1;334(2):284-92. doi: 10.1016/j.canlet.2012.10.007. Epub 2012 Oct 13.


O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.

Huang Z, Kaur J, Bhardwaj A, Alsaleh N, Reisz JA, DuMond JF, King SB, Seubert JM, Zhang Y, Knaus EE.

J Med Chem. 2012 Nov 26;55(22):10262-71. doi: 10.1021/jm301303p. Epub 2012 Oct 24.


Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice.

Chaudhary KR, Zordoky BN, Edin ML, Alsaleh N, El-Kadi AO, Zeldin DC, Seubert JM.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:8-17. doi: 10.1016/j.prostaglandins.2012.08.001. Epub 2012 Aug 16.


Orbitofrontal cortex and olfactory bulb volume predict distinct aspects of olfactory performance in healthy subjects.

Seubert J, Freiherr J, Frasnelli J, Hummel T, Lundström JN.

Cereb Cortex. 2013 Oct;23(10):2448-56. doi: 10.1093/cercor/bhs230. Epub 2012 Aug 8.


Mitochondria and the aging heart.

Chaudhary KR, El-Sikhry H, Seubert JM.

J Geriatr Cardiol. 2011 Sep;8(3):159-67. doi: 10.3724/SP.J.1263.2011.00159.


Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model.

Bhardwaj A, Batchu SN, Kaur J, Huang Z, Seubert JM, Knaus EE.

ChemMedChem. 2012 Aug;7(8):1365-8. doi: 10.1002/cmdc.201200234. Epub 2012 Jun 11. No abstract available.


Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress.

Batchu SN, Lee SB, Samokhvalov V, Chaudhary KR, El-Sikhry H, Weldon SM, Seubert JM.

Can J Physiol Pharmacol. 2012 Jun;90(6):811-23. doi: 10.1139/y2012-082. Epub 2012 May 24.


Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection.

Batchu SN, Chaudhary KR, El-Sikhry H, Yang W, Light PE, Oudit GY, Seubert JM.

J Mol Cell Cardiol. 2012 Jul;53(1):43-52. doi: 10.1016/j.yjmcc.2012.04.008. Epub 2012 Apr 27.


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