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Items: 35

1.

Reference antigen-free and antibody-free LTD-IDMS assay for influenza H7N9 vaccine in vitro potency determination.

Morgenstern K, Xie Y, Palladino G, Barr JR, Settembre EC, Williams TL, Wen Y.

Vaccine. 2018 Oct 1;36(41):6144-6151. doi: 10.1016/j.vaccine.2018.08.065. Epub 2018 Sep 5.

PMID:
30194004
2.

Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine.

Ferdman J, Palladino G, Liao HX, Moody MA, Kepler TB, Del Giudice G, Dormitzer PR, Harrison SC, Settembre EC, Suphaphiphat P.

Vaccine. 2018 Aug 23;36(35):5325-5332. doi: 10.1016/j.vaccine.2018.06.054. Epub 2018 Jul 25.

3.

Inactivated influenza vaccine stress can affect in vitro potency assay relationship to immunogenicity.

Wen Y, Palladino G, Xie Y, Ferrari A, Settembre EC.

Vaccine. 2018 May 17;36(21):3010-3017. doi: 10.1016/j.vaccine.2018.04.021. Epub 2018 Apr 19.

PMID:
29680201
4.

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody.

Raymond DD, Bajic G, Ferdman J, Suphaphiphat P, Settembre EC, Moody MA, Schmidt AG, Harrison SC.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):168-173. doi: 10.1073/pnas.1715471115. Epub 2017 Dec 18.

5.

Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.

Penkert RR, Young NS, Surman SL, Sealy RE, Rosch J, Dormitzer PR, Settembre EC, Chandramouli S, Wong S, Hankins JS, Hurwitz JL.

Vaccine. 2017 Jun 22;35(29):3615-3620. doi: 10.1016/j.vaccine.2017.05.022. Epub 2017 May 26.

6.

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.

Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SC.

Nat Med. 2016 Dec;22(12):1465-1469. doi: 10.1038/nm.4223. Epub 2016 Nov 7.

7.

Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones.

Suphaphiphat P, Whittaker L, De Souza I, Daniels RS, Dormitzer PR, McCauley JW, Settembre EC.

Vaccine. 2016 Jul 12;34(32):3641-8. doi: 10.1016/j.vaccine.2016.05.031. Epub 2016 May 21.

8.

Trypsin pre-treatment corrects SRID over-estimation of immunologically active, pre-fusion HA caused by mixed immunoprecipitin rings.

Wen Y, Palladino G, Xie Y, Ferrari A, Ma X, Han L, Dormitzer PR, Settembre EC.

Vaccine. 2016 Jun 17;34(29):3388-95. doi: 10.1016/j.vaccine.2016.04.091. Epub 2016 May 4.

PMID:
27154389
9.

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.

Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A.

PLoS Pathog. 2015 Oct 20;11(10):e1005230. doi: 10.1371/journal.ppat.1005230. eCollection 2015 Oct.

10.

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody.

Chandramouli S, Ciferri C, Nikitin PA, Caló S, Gerrein R, Balabanis K, Monroe J, Hebner C, Lilja AE, Settembre EC, Carfi A.

Nat Commun. 2015 Sep 14;6:8176. doi: 10.1038/ncomms9176.

11.

Conformationally selective biophysical assay for influenza vaccine potency determination.

Wen Y, Han L, Palladino G, Ferrari A, Xie Y, Carfi A, Dormitzer PR, Settembre EC.

Vaccine. 2015 Oct 5;33(41):5342-5349. doi: 10.1016/j.vaccine.2015.08.077. Epub 2015 Sep 6.

PMID:
26348403
12.

Expression and Characterization of Recombinant, Tetrameric and Enzymatically Active Influenza Neuraminidase for the Setup of an Enzyme-Linked Lectin-Based Assay.

Prevato M, Ferlenghi I, Bonci A, Uematsu Y, Anselmi G, Giusti F, Bertholet S, Legay F, Telford JL, Settembre EC, Maione D, Cozzi R.

PLoS One. 2015 Aug 17;10(8):e0135474. doi: 10.1371/journal.pone.0135474. eCollection 2015.

13.

An Innovative Pseudotypes-Based Enzyme-Linked Lectin Assay for the Measurement of Functional Anti-Neuraminidase Antibodies.

Prevato M, Cozzi R, Pezzicoli A, Taddei AR, Ferlenghi I, Nandi A, Montomoli E, Settembre EC, Bertholet S, Bonci A, Legay F.

PLoS One. 2015 Aug 12;10(8):e0135383. doi: 10.1371/journal.pone.0135383. eCollection 2015.

14.

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.

Ciferri C, Chandramouli S, Donnarumma D, Nikitin PA, Cianfrocco MA, Gerrein R, Feire AL, Barnett SW, Lilja AE, Rappuoli R, Norais N, Settembre EC, Carfi A.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1767-72. doi: 10.1073/pnas.1424818112. Epub 2015 Jan 26.

15.

Bringing influenza vaccines into the 21st century.

Settembre EC, Dormitzer PR, Rappuoli R.

Hum Vaccin Immunother. 2014;10(3):600-4. Epub 2013 Dec 30.

16.

Active-site models for complexes of quinolinate synthase with substrates and intermediates.

Soriano EV, Zhang Y, Colabroy KL, Sanders JM, Settembre EC, Dorrestein PC, Begley TP, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1685-96. doi: 10.1107/S090744491301247X. Epub 2013 Aug 15.

17.

Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice.

Hekele A, Bertholet S, Archer J, Gibson DG, Palladino G, Brito LA, Otten GR, Brazzoli M, Buccato S, Bonci A, Casini D, Maione D, Qi ZQ, Gill JE, Caiazza NC, Urano J, Hubby B, Gao GF, Shu Y, De Gregorio E, Mandl CW, Mason PW, Settembre EC, Ulmer JB, Craig Venter J, Dormitzer PR, Rappuoli R, Geall AJ.

Emerg Microbes Infect. 2013 Aug;2(8):e52. doi: 10.1038/emi.2013.54. Epub 2013 Aug 14.

18.

Generation of a parvovirus B19 vaccine candidate.

Chandramouli S, Medina-Selby A, Coit D, Schaefer M, Spencer T, Brito LA, Zhang P, Otten G, Mandl CW, Mason PW, Dormitzer PR, Settembre EC.

Vaccine. 2013 Aug 20;31(37):3872-8. doi: 10.1016/j.vaccine.2013.06.062. Epub 2013 Jul 2.

PMID:
23827313
19.

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.

Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):264-9. doi: 10.1073/pnas.1218256109. Epub 2012 Nov 21.

20.

Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles.

Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC.

J Mol Biol. 2013 Jan 9;425(1):124-32. doi: 10.1016/j.jmb.2012.10.011. Epub 2012 Oct 23.

21.

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.

Lo Surdo P, Bottomley MJ, Calzetta A, Settembre EC, Cirillo A, Pandit S, Ni YG, Hubbard B, Sitlani A, Carfí A.

EMBO Rep. 2011 Dec 1;12(12):1300-5. doi: 10.1038/embor.2011.205.

22.

Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.

Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A.

PLoS Pathog. 2011 Sep;7(9):e1002277. doi: 10.1371/journal.ppat.1002277. Epub 2011 Sep 29.

23.

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.

Swanson KA, Settembre EC, Shaw CA, Dey AK, Rappuoli R, Mandl CW, Dormitzer PR, Carfi A.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9619-24. doi: 10.1073/pnas.1106536108. Epub 2011 May 17.

24.

Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines.

Settembre EC, Dormitzer PR, Rappuoli R.

J Mol Cell Biol. 2011 Jun;3(3):144-6. doi: 10.1093/jmcb/mjq046. Epub 2011 Mar 23.

PMID:
21430014
25.

Atomic model of an infectious rotavirus particle.

Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC.

EMBO J. 2011 Jan 19;30(2):408-16. doi: 10.1038/emboj.2010.322. Epub 2010 Dec 14.

26.

H1N1: can a pandemic cycle be broken?

Settembre EC, Dormitzer PR, Rappuoli R.

Sci Transl Med. 2010 Mar 24;2(24):24ps14. doi: 10.1126/scitranslmed.3000948.

PMID:
20375006
27.

Glycal formation in crystals of uridine phosphorylase.

Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE.

Biochemistry. 2010 Apr 27;49(16):3499-509. doi: 10.1021/bi902073b.

28.

Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs.

Nkolola JP, Peng H, Settembre EC, Freeman M, Grandpre LE, Devoy C, Lynch DM, La Porte A, Simmons NL, Bradley R, Montefiori DC, Seaman MS, Chen B, Barouch DH.

J Virol. 2010 Apr;84(7):3270-9. doi: 10.1128/JVI.02252-09. Epub 2010 Jan 6.

29.

Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab.

Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PR.

Science. 2009 Jun 12;324(5933):1444-7. doi: 10.1126/science.1170481.

30.

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM.

Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10644-8. doi: 10.1073/pnas.0904024106. Epub 2009 Jun 1.

31.

Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.

Bu W, Settembre EC, el Kouni MH, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):863-72. Epub 2005 Jun 24.

PMID:
15983408
32.

Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE).

Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004 Sep 23.

PMID:
15388921
33.

Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.

Settembre EC, Dorrestein PC, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE.

Biochemistry. 2004 Sep 21;43(37):11647-57.

PMID:
15362849
34.

Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.

Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL.

Biochemistry. 2004 May 11;43(18):5159-69.

PMID:
15122881
35.

Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.

Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE.

Biochemistry. 2003 Mar 18;42(10):2971-81.

PMID:
12627963

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