Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 63

1.

Circular RNA CpG island hypermethylation-associated silencing in human cancer.

Ferreira HJ, Davalos V, de Moura MC, Soler M, Perez-Salvia M, Bueno-Costa A, Setien F, Moran S, Villanueva A, Esteller M.

Oncotarget. 2018 Jun 26;9(49):29208-29219. doi: 10.18632/oncotarget.25673. eCollection 2018 Jun 26.

2.

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma.

Perez-Salvia M, Aldaba E, Vara Y, Fabre M, Ferrer C, Masdeu C, Zubia A, San Sebastian E, Otaegui D, Llinàs-Arias P, Rosselló-Tortella M, Berdasco M, Moutinho C, Setien F, Villanueva A, González-Barca E, Muncunill J, Navarro JT, Piris MA, Cossio FP, Esteller M.

Haematologica. 2018 Jun 7. pii: haematol.2018.189241. doi: 10.3324/haematol.2018.189241. [Epub ahead of print] No abstract available.

3.

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis.

Mur P, De Voer RM, Olivera-Salguero R, Rodríguez-Perales S, Pons T, Setién F, Aiza G, Valdés-Mas R, Bertini A, Pineda M, Vreede L, Navarro M, Iglesias S, González S, Brunet J, Valencia A, Esteller M, Lázaro C, Kops GJPL, Urioste M, Puente XS, Capellá G, Valle L.

Mol Cancer. 2018 Feb 15;17(1):23. doi: 10.1186/s12943-018-0762-8.

4.

DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders.

Berdasco M, Gómez A, Rubio MJ, Català-Mora J, Zanón-Moreno V, Lopez M, Hernández C, Yoshida S, Nakama T, Ishikawa K, Ishibashi T, Boubekeur AM, Louhibi L, Pujana MA, Sayols S, Setien F, Corella D, de Torres C, Parareda A, Mora J, Zhao L, Zhang K, Lleonart ME, Alonso J, Simó R, Caminal JM, Esteller M.

Sci Rep. 2017 Sep 18;7(1):11762. doi: 10.1038/s41598-017-12084-1.

5.

Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer.

Pérez-Salvia M, Simó-Riudalbas L, Llinàs-Arias P, Roa L, Setien F, Soler M, de Moura MC, Bradner JE, Gonzalez-Suarez E, Moutinho C, Esteller M.

Oncotarget. 2017 May 29;8(31):51621-51629. doi: 10.18632/oncotarget.18255. eCollection 2017 Aug 1.

6.

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.

Anadón C, van Tetering G, Ferreira HJ, Moutinho C, Martínez-Cardús A, Villanueva A, Soler M, Heyn H, Moran S, Castro de Moura M, Setien F, Vidal A, Genescà E, Ribera JM, Nomdedeu JF, Guil S, Esteller M.

Leukemia. 2017 Jul;31(7):1622-1625. doi: 10.1038/leu.2017.99. Epub 2017 Mar 27. No abstract available.

7.

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.

Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, Galán M, Sala N, Akiyama Y, Martínez-Iniesta M, Farré L, Villanueva A, Gross M, Diederichs S, Guil S, Esteller M.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7535-E7544. Epub 2016 Nov 7.

8.

Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.

Vaclová T, Woods NT, Megías D, Gomez-Lopez S, Setién F, García Bueno JM, Macías JA, Barroso A, Urioste M, Esteller M, Monteiro ANA, Benítez J, Osorio A.

Hum Mol Genet. 2016 Dec 15;25(24):5287-5299. doi: 10.1093/hmg/ddw343.

9.

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

Anadón C, Guil S, Simó-Riudalbas L, Moutinho C, Setien F, Martínez-Cardús A, Moran S, Villanueva A, Calaf M, Vidal A, Lazo PA, Zondervan I, Savola S, Kohno T, Yokota J, Ribas de Pouplana L, Esteller M.

Oncogene. 2016 Aug 18;35(33):4422. doi: 10.1038/onc.2016.27. Epub 2016 Jun 27. No abstract available.

10.

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

Anadón C, Guil S, Simó-Riudalbas L, Moutinho C, Setien F, Martínez-Cardús A, Moran S, Villanueva A, Calaf M, Vidal A, Lazo PA, Zondervan I, Savola S, Kohno T, Yokota J, Ribas de Pouplana L, Esteller M.

Oncogene. 2016 Aug 18;35(33):4407-13. doi: 10.1038/onc.2015.469. Epub 2015 Dec 7. Erratum in: Oncogene. 2016 Aug 18;35(33):4422.

11.

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families.

Calvete O, Martinez P, Garcia-Pavia P, Benitez-Buelga C, Paumard-Hernández B, Fernandez V, Dominguez F, Salas C, Romero-Laorden N, Garcia-Donas J, Carrillo J, Perona R, Triviño JC, Andrés R, Cano JM, Rivera B, Alonso-Pulpon L, Setien F, Esteller M, Rodriguez-Perales S, Bougeard G, Frebourg T, Urioste M, Blasco MA, Benítez J.

Nat Commun. 2015 Sep 25;6:8383. doi: 10.1038/ncomms9383.

12.

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Simó-Riudalbas L, Pérez-Salvia M, Setien F, Villanueva A, Moutinho C, Martínez-Cardús A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barceló-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura CS, Carneiro F, Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M.

Cancer Res. 2015 Sep 15;75(18):3936-45. doi: 10.1158/0008-5472.CAN-14-3702. Epub 2015 Jul 24.

13.

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers.

Vaclová T, Gómez-López G, Setién F, Bueno JM, Macías JA, Barroso A, Urioste M, Esteller M, Benítez J, Osorio A.

Breast Cancer Res Treat. 2015 Jul;152(2):271-82. doi: 10.1007/s10549-015-3459-3. Epub 2015 Jun 14.

PMID:
26071757
14.

A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies.

Agrelo R, Sutz MA, Setien F, Aldunate F, Esteller M, Da Costa V, Achenbach R.

Epigenetics. 2015;10(4):329-41. doi: 10.1080/15592294.2015.1027853.

15.

Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene.

Cascón A, Comino-Méndez I, Currás-Freixes M, de Cubas AA, Contreras L, Richter S, Peitzsch M, Mancikova V, Inglada-Pérez L, Pérez-Barrios A, Calatayud M, Azriel S, Villar-Vicente R, Aller J, Setién F, Moran S, Garcia JF, Río-Machín A, Letón R, Gómez-Graña Á, Apellániz-Ruiz M, Roncador G, Esteller M, Rodríguez-Antona C, Satrústegui J, Eisenhofer G, Urioste M, Robledo M.

J Natl Cancer Inst. 2015 Mar 11;107(5). pii: djv053. doi: 10.1093/jnci/djv053.

PMID:
25766404
16.

DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes.

Portela A, Liz J, Nogales V, Setién F, Villanueva A, Esteller M.

Oncogene. 2013 Nov 21;32(47):5421-8. doi: 10.1038/onc.2013.162. Epub 2013 May 20.

17.

A demonstration of the Storz C-CAM in endoscopic imagery projection for far forward battlefield telemetric support and training.

Boedeker BH, Bernhagen MA, Derrick DC, Abadia de Barbara AH, Del Real Colomo A, Hillan Garcia L, Setién F, Nicholas TA 4th.

Stud Health Technol Inform. 2013;184:51-5.

PMID:
23400129
18.

Virtual simulation training using the Storz C-HUB to support distance airway training for the Spanish Medical Corps and NATO partners.

Abadia de Barbara AH, Nicholas Iv TA, Del Real Colomo A, Boedeker D, Bernhagen MA, Hillan Garcia L, Setién F, Boedeker BH.

Stud Health Technol Inform. 2012;182:1-9.

PMID:
23138073
19.

DNA methylation plasticity of human adipose-derived stem cells in lineage commitment.

Berdasco M, Melguizo C, Prados J, Gómez A, Alaminos M, Pujana MA, Lopez M, Setien F, Ortiz R, Zafra I, Aranega A, Esteller M.

Am J Pathol. 2012 Dec;181(6):2079-93. doi: 10.1016/j.ajpath.2012.08.016. Epub 2012 Sep 29.

20.

Distinct DNA methylomes of newborns and centenarians.

Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valencia A, Gut IG, Wang J, Esteller M.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10522-7. doi: 10.1073/pnas.1120658109. Epub 2012 Jun 11.

21.

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.

Romero OA, Setien F, John S, Gimenez-Xavier P, Gómez-López G, Pisano D, Condom E, Villanueva A, Hager GL, Sanchez-Cespedes M.

EMBO Mol Med. 2012 Jul;4(7):603-16. doi: 10.1002/emmm.201200236. Epub 2012 Apr 11.

22.

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.

Espada J, Peinado H, Lopez-Serra L, Setién F, Lopez-Serra P, Portela A, Renart J, Carrasco E, Calvo M, Juarranz A, Cano A, Esteller M.

Nucleic Acids Res. 2011 Nov;39(21):9194-205. doi: 10.1093/nar/gkr658. Epub 2011 Aug 16.

23.

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.

Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S, Ropero S, Kalluri R, Croce CM, Calin GA, Esteller M.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9. doi: 10.1073/pnas.1014720108. Epub 2011 Feb 28. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 17;:.

24.

The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome.

Martinez M, Ichaso N, Setien F, Durany N, Qiu X, Roesler W.

Lipids Health Dis. 2010 Sep 9;9:98. doi: 10.1186/1476-511X-9-98.

25.

BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors.

Veeck J, Ropero S, Setien F, Gonzalez-Suarez E, Osorio A, Benitez J, Herman JG, Esteller M.

J Clin Oncol. 2010 Oct 10;28(29):e563-4; author reply e565-6. doi: 10.1200/JCO.2010.30.1010. Epub 2010 Aug 2. No abstract available.

PMID:
20679605
26.

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.

Berdasco M, Ropero S, Setien F, Fraga MF, Lapunzina P, Losson R, Alaminos M, Cheung NK, Rahman N, Esteller M.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21830-5. doi: 10.1073/pnas.0906831106. Epub 2009 Dec 14.

27.

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.

Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M.

Cancer Res. 2009 Nov 1;69(21):8447-54. doi: 10.1158/0008-5472.CAN-09-0551. Epub 2009 Oct 27.

28.

The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa.

Gozalbo-López B, Gómez del Moral M, Campos-Martín Y, Setién F, Martín P, Bellas C, Regueiro JR, Martínez-Naves E.

Histol Histopathol. 2009 Nov;24(11):1439-49. doi: 10.14670/HH-24.1439.

PMID:
19760593
29.

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP.

Exp Mol Pathol. 2008 Dec;85(3):201-6. doi: 10.1016/j.yexmp.2008.09.006. Epub 2008 Oct 11.

PMID:
18977219
30.

Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.

Fraga MF, Berdasco M, Ballestar E, Ropero S, Lopez-Nieva P, Lopez-Serra L, Martín-Subero JI, Calasanz MJ, Lopez de Silanes I, Setien F, Casado S, Fernandez AF, Siebert R, Stifani S, Esteller M.

Cancer Res. 2008 Jun 1;68(11):4116-22. doi: 10.1158/0008-5472.CAN-08-0085.

31.

Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas.

Sánchez A, Setién F, Martinez N, Oliva JL, Herranz M, Fraga MF, Alaminos M, Esteller M, Rojas JM.

Oncogene. 2008 Aug 21;27(36):4969-72. doi: 10.1038/onc.2008.129. Epub 2008 Apr 21.

PMID:
18427547
32.

Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins.

Lopez-Serra L, Ballestar E, Ropero S, Setien F, Billard LM, Fraga MF, Lopez-Nieva P, Alaminos M, Guerrero D, Dante R, Esteller M.

Oncogene. 2008 Jun 5;27(25):3556-66. doi: 10.1038/sj.onc.1211022. Epub 2008 Jan 28.

PMID:
18223687
33.

Combinatorial effects of splice variants modulate function of Aiolos.

Caballero R, Setien F, Lopez-Serra L, Boix-Chornet M, Fraga MF, Ropero S, Megias D, Alaminos M, Sanchez-Tapia EM, Montoya MC, Esteller M, Gonzalez-Sarmiento R, Ballestar E.

J Cell Sci. 2007 Aug 1;120(Pt 15):2619-30.

34.

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.

Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setién F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Git A, Spiteri I, Das PP, Caldas C, Miska E, Esteller M.

Cancer Res. 2007 Feb 15;67(4):1424-9. Erratum in: Cancer Res. 2007 Apr 1;67(7):3492. Gitt, Anna [corrected to Git, Anna].

35.

CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.

Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, Esteller M.

Carcinogenesis. 2007 Jun;28(6):1264-8. Epub 2007 Feb 1.

PMID:
17272309
36.

A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer.

Lopez-Serra L, Ballestar E, Fraga MF, Alaminos M, Setien F, Esteller M.

Cancer Res. 2006 Sep 1;66(17):8342-6.

37.

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.

Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8822-7. Epub 2006 May 24.

38.

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S Jr, Esteller M.

Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16.

PMID:
16642021
39.

Epigenetic differences arise during the lifetime of monozygotic twins.

Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. Epub 2005 Jul 11.

40.

Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.

Agrelo R, Setien F, Espada J, Artiga MJ, Rodriguez M, Pérez-Rosado A, Sanchez-Aguilera A, Fraga MF, Piris MA, Esteller M.

J Clin Oncol. 2005 Jun 10;23(17):3940-7. Epub 2005 May 2.

PMID:
15867203
41.

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.

Alaminos M, Dávalos V, Ropero S, Setién F, Paz MF, Herranz M, Fraga MF, Mora J, Cheung NK, Gerald WL, Esteller M.

Cancer Res. 2005 Apr 1;65(7):2565-71.

42.

Proteolytic regulation of activated STAT6 by calpains.

Zamorano J, Rivas MD, Setien F, Perez-G M.

J Immunol. 2005 Mar 1;174(5):2843-8.

43.

The impact of MECP2 mutations in the expression patterns of Rett syndrome patients.

Ballestar E, Ropero S, Alaminos M, Armstrong J, Setien F, Agrelo R, Fraga MF, Herranz M, Avila S, Pineda M, Monros E, Esteller M.

Hum Genet. 2005 Jan;116(1-2):91-104. Epub 2004 Nov 11.

PMID:
15549394
44.

Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.

Ropero S, Setien F, Espada J, Fraga MF, Herranz M, Asp J, Benassi MS, Franchi A, Patiño A, Ward LS, Bovee J, Cigudosa JC, Wim W, Esteller M.

Hum Mol Genet. 2004 Nov 15;13(22):2753-65. Epub 2004 Sep 22.

PMID:
15385438
45.

Characterization of the MHC class I-related MR1 locus in nonhuman primates.

Parra-Cuadrado JF, Gómez del Moral M, García-Pavía P, Setién F, Martínez-Naves E.

Immunogenetics. 2001 Oct;53(8):643-8. Epub 2001 Nov 6.

PMID:
11797097
46.

Structural characterization of two CD1A allelic variants.

Oteo M, Arribas P, Setién F, Parra JF, Mirones I, Gómez del Moral M, Martínez-Naves E.

Hum Immunol. 2001 Oct;62(10):1137-41.

PMID:
11600221
47.

A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.

Parra-Cuadrado JF, Navarro P, Mirones I, Setién F, Oteo M, Martínez-Naves E.

Tissue Antigens. 2000 Aug;56(2):170-2.

PMID:
11019920
48.

Single strand conformational polymorphism analysis of human CD1 genes in different ethnic groups.

Oteo M, Parra JF, Mirones I, Giménez LI, Setién F, Martínez-Naves E.

Tissue Antigens. 1999 Jun;53(6):545-50.

PMID:
10395104
49.

Genetic structure and organization of the membrane attack complement components.

Gonzalez S, Setién F, Coto E, López-Larrea C.

Eur J Immunogenet. 1996 Jun;23(3):181-97. Review. No abstract available.

PMID:
8803531
50.

Characterization of interleukin-8 receptors in non-human primates.

Alvarez V, Coto E, Setién F, Gonzalez S, Gonzalez-Roces S, López-Larrea C.

Immunogenetics. 1996;43(5):261-7.

PMID:
9110929

Supplemental Content

Loading ...
Support Center