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Shear Stress Attenuates Inward Remodeling in Cultured Mouse Thoracodorsal Arteries in an eNOS-Dependent, but Not Hemodynamic Manner, and Increases Cx37 Expression.

Looft-Wilson RC, Billig JE, Sessa WC.

J Vasc Res. 2019;56(6):284-295. doi: 10.1159/000502690. Epub 2019 Oct 1.


Caveolae: The FAQs.

Parton RG, Del Pozo MA, Vassilopoulos S, Nabi IR, Le Lay S, Lundmark R, Kenworthy AK, Camus A, Blouin CM, Sessa WC, Lamaze C.

Traffic. 2020 Jan;21(1):181-185. doi: 10.1111/tra.12689. Epub 2019 Sep 9.


Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.

Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C.

Circulation. 2019 Jul 16;140(3):225-239. doi: 10.1161/CIRCULATIONAHA.118.038571. Epub 2019 Jun 3.


Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.

Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR.

Matrix Biol. 2019 Sep;82:71-85. doi: 10.1016/j.matbio.2019.03.002. Epub 2019 Mar 13.


Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency.

Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):754-764. doi: 10.1161/ATVBAHA.119.312417.


Estrogen Reduces LDL (Low-Density Lipoprotein) Transcytosis.

Sessa WC.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2276-2277. doi: 10.1161/ATVBAHA.118.311620. No abstract available.


Endothelial NOS: perspective and recent developments.

Garcia V, Sessa WC.

Br J Pharmacol. 2019 Jan;176(2):189-196. doi: 10.1111/bph.14522. Epub 2018 Dec 9. Review.


Endothelial Transcytosis of Lipoproteins in Atherosclerosis.

Zhang X, Sessa WC, Fernández-Hernando C.

Front Cardiovasc Med. 2018 Sep 25;5:130. doi: 10.3389/fcvm.2018.00130. eCollection 2018. Review.


Lacteal junction zippering protects against diet-induced obesity.

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A.

Science. 2018 Aug 10;361(6402):599-603. doi: 10.1126/science.aap9331.


CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues.

Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC.

J Biol Chem. 2018 Jun 8;293(23):9126-9136. doi: 10.1074/jbc.RA117.000773. Epub 2018 Mar 27.


Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):870-879. doi: 10.1161/ATVBAHA.118.310748. Epub 2018 Feb 15.


Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin-stimulated, cAMP-mediated lipolysis.

Kuo A, Lee MY, Yang K, Gross RW, Sessa WC.

J Biol Chem. 2018 Jan 19;293(3):973-983. doi: 10.1074/jbc.RA117.000980. Epub 2017 Dec 4.


Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency.

Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A.

Sci Rep. 2017 Nov 13;7(1):15386. doi: 10.1038/s41598-017-13071-2.


Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.

Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA.

Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2311-2321. doi: 10.1161/ATVBAHA.117.310053. Epub 2017 Oct 12.


Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae.

Hoffmann R, Grabińska K, Guan Z, Sessa WC, Neiman AM.

Genetics. 2017 Dec;207(4):1371-1386. doi: 10.1534/genetics.117.300322. Epub 2017 Oct 4.


Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK.

Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10737-10742. doi: 10.1073/pnas.1706394114. Epub 2017 Sep 18.


A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity.

Grabińska KA, Edani BH, Park EJ, Kraehling JR, Sessa WC.

J Biol Chem. 2017 Oct 20;292(42):17351-17361. doi: 10.1074/jbc.M117.806034. Epub 2017 Aug 23.


HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.

MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR.

Matrix Biol. 2018 Jan;65:45-58. doi: 10.1016/j.matbio.2017.07.002. Epub 2017 Aug 5.


Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice.

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T.

J Allergy Clin Immunol. 2017 Aug;140(2):630-632.e9. doi: 10.1016/j.jaci.2017.02.030. Epub 2017 Apr 27. No abstract available.


Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression.

Luciano AK, Santana JM, Velazquez H, Sessa WC.

J Biol Rhythms. 2017 Jun;32(3):212-221. doi: 10.1177/0748730417704534. Epub 2017 Apr 28.


Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.

Kraehling JR, Sessa WC.

Circ Res. 2017 Mar 31;120(7):1174-1182. doi: 10.1161/CIRCRESAHA.117.303776. Review.


Lipid Droplet Biogenesis and Function in the Endothelium.

Kuo A, Lee MY, Sessa WC.

Circ Res. 2017 Apr 14;120(8):1289-1297. doi: 10.1161/CIRCRESAHA.116.310498. Epub 2017 Jan 24.


PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A.

Nat Commun. 2016 Nov 29;7:13650. doi: 10.1038/ncomms13650.


Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.

Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC.

Nat Commun. 2016 Nov 21;7:13516. doi: 10.1038/ncomms13516.


cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases.

Grabińska KA, Park EJ, Sessa WC.

J Biol Chem. 2016 Aug 26;291(35):18582-90. doi: 10.1074/jbc.R116.739490. Epub 2016 Jul 11. Review.


Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice.

Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC.

EMBO Mol Med. 2016 Jun 1;8(6):643-53. doi: 10.15252/emmm.201506031. Print 2016 Jun.


Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report.

Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):442-5. doi: 10.1161/ATVBAHA.115.306861. Epub 2016 Jan 21.


NgBR is essential for endothelial cell glycosylation and vascular development.

Park EJ, Grabińska KA, Guan Z, Sessa WC.

EMBO Rep. 2016 Feb;17(2):167-77. doi: 10.15252/embr.201540789. Epub 2016 Jan 11.


The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.

Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):370-9. doi: 10.1161/ATVBAHA.115.306942. Epub 2015 Dec 29.


Uncoupling Caveolae From Intracellular Signaling In Vivo.

Kraehling JR, Hao Z, Lee MY, Vinyard DJ, Velazquez H, Liu X, Stan RV, Brudvig GW, Sessa WC.

Circ Res. 2016 Jan 8;118(1):48-55. doi: 10.1161/CIRCRESAHA.115.307767. Epub 2015 Nov 24.


VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis.

Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y.

Circ Res. 2016 Jan 8;118(1):38-47. doi: 10.1161/CIRCRESAHA.115.307408. Epub 2015 Oct 15.


Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.

Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12812-7. doi: 10.1073/pnas.1507094112. Epub 2015 Sep 28.


Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.

Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC.

Sci Signal. 2015 Aug 18;8(390):ra81. doi: 10.1126/scisignal.aaa2819.


Enhanced eNOS Activation as the Fountain of Youth for Vascular Disease: Is BPIFB4 What Ponce de León Was Looking For?

Kraehling JR, Sessa WC.

Circ Res. 2015 Jul 31;117(4):309-10. doi: 10.1161/CIRCRESAHA.115.307020. No abstract available.


A randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation.

Patrick J, Dillaha L, Armas D, Sessa WC.

Postgrad Med. 2015 Aug;127(6):573-80. doi: 10.1080/00325481.2015.1050341. Epub 2015 May 22.


Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.

Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA.

Sci Signal. 2015 May 12;8(376):ra44. doi: 10.1126/scisignal.2005482.


Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis.

Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C.

Circ Res. 2015 May 22;116(11):1744-52. doi: 10.1161/CIRCRESAHA.116.305895. Epub 2015 Apr 13.


Endothelial glucocorticoid receptor suppresses atherogenesis--brief report.

Goodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):779-782. doi: 10.1161/ATVBAHA.114.304525. Epub 2015 Feb 19.


Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.

Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C.

FASEB J. 2015 Feb;29(2):597-610. doi: 10.1096/fj.14-262097. Epub 2014 Nov 12.


Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290(1):409-22. doi: 10.1074/jbc.M114.618421. Epub 2014 Nov 11.


Inflammation and the blood microvascular system.

Pober JS, Sessa WC.

Cold Spring Harb Perspect Biol. 2014 Oct 23;7(1):a016345. doi: 10.1101/cshperspect.a016345. Review.


Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS.

Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC.

PLoS One. 2014 Oct 9;9(10):e108126. doi: 10.1371/journal.pone.0108126. eCollection 2014.


Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12865-70. doi: 10.1073/pnas.1408472111. Epub 2014 Aug 18.


Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.

Park EJ, Grabińska KA, Guan Z, Stránecký V, Hartmannová H, Hodaňová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, Hůlková H, Wen R, Kmoch S, Sessa WC.

Cell Metab. 2014 Sep 2;20(3):448-57. doi: 10.1016/j.cmet.2014.06.016. Epub 2014 Jul 24.


Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis.

Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR.

Am J Pathol. 2014 May;184(5):1562-76. doi: 10.1016/j.ajpath.2014.01.009. Epub 2014 Mar 5.


Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC.

Development. 2014 Apr;141(7):1465-72. doi: 10.1242/dev.104539. Epub 2014 Mar 5.


Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry.

Jozsef L, Tashiro K, Kuo A, Park EJ, Skoura A, Albinsson S, Rivera-Molina F, Harrison KD, Iwakiri Y, Toomre D, Sessa WC.

J Biol Chem. 2014 Mar 28;289(13):9380-95. doi: 10.1074/jbc.M114.548602. Epub 2014 Feb 20.


The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.

Kondo Y, Jadlowiec CC, Muto A, Yi T, Protack C, Collins MJ, Tellides G, Sessa WC, Dardik A.

PLoS One. 2013 Nov 20;8(11):e81019. doi: 10.1371/journal.pone.0081019. eCollection 2013.


Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M.

J Biol Chem. 2014 Jan 3;289(1):510-9. doi: 10.1074/jbc.M113.506899. Epub 2013 Nov 14.


eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.

Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC.

J Cell Sci. 2013 Dec 15;126(Pt 24):5541-52. doi: 10.1242/jcs.115972. Epub 2013 Sep 17. Erratum in: J Cell Sci. 2014 May 1;127(Pt 9):2120.

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