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Items: 46


Evaluation of protective and immune responses following vaccination with recombinant MIP and CPAF from Chlamydia abortus as novel vaccines for enzootic abortion of ewes.

O'Neill LM, Keane OM, Ross PJ, Nally JE, Seshu J, Markey B.

Vaccine. 2019 Aug 23;37(36):5428-5438. doi: 10.1016/j.vaccine.2019.06.088. Epub 2019 Jul 30.


The Lyme disease spirochete's BpuR DNA/RNA-binding protein is differentially expressed during the mammal-tick infectious cycle, which affects translation of the SodA superoxide dismutase.

Jutras BL, Savage CR, Arnold WK, Lethbridge KG, Carroll DW, Tilly K, Bestor A, Zhu H, Seshu J, Zückert WR, Stewart PE, Rosa PA, Brissette CA, Stevenson B.

Mol Microbiol. 2019 Sep;112(3):973-991. doi: 10.1111/mmi.14336. Epub 2019 Jul 7.


Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete.

Arnold WK, Savage CR, Lethbridge KG, Smith TC 2nd, Brissette CA, Seshu J, Stevenson B.

PLoS One. 2018 Aug 30;13(8):e0203286. doi: 10.1371/journal.pone.0203286. eCollection 2018.


Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A.

Ketter PM, Yu JJ, Guentzel MN, May HC, Gupta R, Eppinger M, Klose KE, Seshu J, Chambers JP, Cap AP, Arulanandam BP.

MBio. 2018 Jul 10;9(4). pii: e01298-18. doi: 10.1128/mBio.01298-18.


Short-Chain Fatty Acids Alter Metabolic and Virulence Attributes of Borrelia burgdorferi.

Lin YH, Chen Y, Smith TC 2nd, Karna SLR, Seshu J.

Infect Immun. 2018 Aug 22;86(9). pii: e00217-18. doi: 10.1128/IAI.00217-18. Print 2018 Sep.


Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease.

Smith TC 2nd, Helm SM, Chen Y, Lin YH, Rajasekhar Karna SL, Seshu J.

Infect Immun. 2018 Jun 21;86(7). pii: e00057-18. doi: 10.1128/IAI.00057-18. Print 2018 Jul.


Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing.

Trivedi NH, Yu JJ, Hung CY, Doelger RP, Navara CS, Armitige LY, Seshu J, Sinai AP, Chambers JP, Guentzel MN, Arulanandam BP.

Innate Immun. 2018 Apr;24(3):152-162. doi: 10.1177/1753425918760180. Epub 2018 Feb 26.


The Borrelia burgdorferi Glycosaminoglycan Binding Protein Bgp in the B31 Strain Is Not Essential for Infectivity despite Facilitating Adherence and Tissue Colonization.

Schlachter S, Seshu J, Lin T, Norris S, Parveen N.

Infect Immun. 2018 Jan 22;86(2). pii: e00667-17. doi: 10.1128/IAI.00667-17. Print 2018 Feb.


Regulation of Gene and Protein Expression in the Lyme Disease Spirochete.

Stevenson B, Seshu J.

Curr Top Microbiol Immunol. 2018;415:83-112. doi: 10.1007/82_2017_49. Review.


Analysis of DNA and RNA Binding Properties of Borrelia burgdorferi Regulatory Proteins.

Seshu J, Smith TC 2nd, Lin YH, Karna SLR, Miller CL, Van Laar T.

Methods Mol Biol. 2018;1690:155-175. doi: 10.1007/978-1-4939-7383-5_13.


Pathogenic Leptospires Modulate Protein Expression and Post-translational Modifications in Response to Mammalian Host Signals.

Nally JE, Grassmann AA, Planchon S, Sergeant K, Renaut J, Seshu J, McBride AJ, Caimano MJ.

Front Cell Infect Microbiol. 2017 Aug 9;7:362. doi: 10.3389/fcimb.2017.00362. eCollection 2017.


Spermine and Spermidine Alter Gene Expression and Antigenic Profile of Borrelia burgdorferi.

Lin YH, Romo JA, Smith TC 2nd, Reyes AN, Karna SLR, Miller CL, Van Laar TA, Yendapally R, Chambers JP, Seshu J.

Infect Immun. 2017 Feb 23;85(3). pii: e00684-16. doi: 10.1128/IAI.00684-16. Print 2017 Mar.


RNA-Seq of Borrelia burgdorferi in Multiple Phases of Growth Reveals Insights into the Dynamics of Gene Expression, Transcriptome Architecture, and Noncoding RNAs.

Arnold WK, Savage CR, Brissette CA, Seshu J, Livny J, Stevenson B.

PLoS One. 2016 Oct 5;11(10):e0164165. doi: 10.1371/journal.pone.0164165. eCollection 2016.


Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.

Van Laar TA, Hole C, Rajasekhar Karna SL, Miller CL, Reddick R, Wormley FL, Seshu J.

Microbes Infect. 2016 Jun;18(6):430-435. doi: 10.1016/j.micinf.2016.03.004. Epub 2016 Mar 16.


Genome Sequences of Five Clinical Isolates of Klebsiella pneumoniae.

Lopez LL, Rusconi B, Gildersleeve H, Qi C, McLaughlin M, Scheetz MH, Seshu J, Eppinger M.

Genome Announc. 2016 Mar 10;4(2). pii: e00040-16. doi: 10.1128/genomeA.00040-16.


Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi.

Esteve-Gassent MD, Smith TC 2nd, Small CM, Thomas DP, Seshu J.

PLoS One. 2015 Aug 31;10(8):e0136707. doi: 10.1371/journal.pone.0136707. eCollection 2015.


Biological and physiological characterization of in vitro blood feeding in nymph and adult stages of Ornithodoros turicata (Acari: Argasidae).

Zheng H, Li AY, Teel PD, Pérez de León AA, Seshu J, Liu J.

J Insect Physiol. 2015 Apr;75:73-9. doi: 10.1016/j.jinsphys.2015.03.005. Epub 2015 Mar 14.


Contributions of environmental signals and conserved residues to the functions of carbon storage regulator A of Borrelia burgdorferi.

Karna SL, Prabhu RG, Lin YH, Miller CL, Seshu J.

Infect Immun. 2013 Aug;81(8):2972-85. doi: 10.1128/IAI.00494-13. Epub 2013 Jun 10.


Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.

Miller CL, Karna SL, Seshu J.

Mol Microbiol. 2013 Apr;88(1):105-24. doi: 10.1111/mmi.12171. Epub 2013 Mar 14.


A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi.

Aguirre JD, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab DJ, Seshu J, Hart PJ, Saito M, Culotta VC.

J Biol Chem. 2013 Mar 22;288(12):8468-78. doi: 10.1074/jbc.M112.433540. Epub 2013 Feb 2.


Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase.

Arulanandam BP, Chetty SL, Yu JJ, Leonard S, Klose K, Seshu J, Cap A, Valdes JJ, Chambers JP.

J Biol Chem. 2012 Oct 26;287(44):37185-94. doi: 10.1074/jbc.M112.404400. Epub 2012 Aug 24.


Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi.

Van Laar TA, Lin YH, Miller CL, Karna SL, Chambers JP, Seshu J.

PLoS One. 2012;7(5):e38171. doi: 10.1371/journal.pone.0038171. Epub 2012 May 31.


Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi.

Raju BV, Esteve-Gassent MD, Karna SL, Miller CL, Van Laar TA, Seshu J.

Infect Immun. 2011 Aug;79(8):3407-20. doi: 10.1128/IAI.05234-11. Epub 2011 May 31.


Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection.

Murthy AK, Li W, Chaganty BK, Kamalakaran S, Guentzel MN, Seshu J, Forsthuber TG, Zhong G, Arulanandam BP.

Infect Immun. 2011 Jul;79(7):2928-35. doi: 10.1128/IAI.05022-11. Epub 2011 May 2.


Evasion of IFN-γ signaling by Francisella novicida is dependent upon Francisella outer membrane protein C.

Nallaparaju KC, Yu JJ, Rodriguez SA, Zogaj X, Manam S, Guentzel MN, Seshu J, Murthy AK, Chambers JP, Klose KE, Arulanandam BP.

PLoS One. 2011 Mar 31;6(3):e18201. doi: 10.1371/journal.pone.0018201.


Immunization with dendritic cells pulsed ex vivo with recombinant chlamydial protease-like activity factor induces protective immunity against genital chlamydiamuridarum challenge.

Li W, Murthy AK, Chaganty BK, Guentzel MN, Seshu J, Chambers JP, Zhong G, Arulanandam BP.

Front Immunol. 2011 Dec 8;2:73. doi: 10.3389/fimmu.2011.00073. eCollection 2011.


A bacterial two-hybrid system that utilizes Gateway cloning for rapid screening of protein-protein interactions.

Karna SL, Zogaj X, Barker JR, Seshu J, Dove SL, Klose KE.

Biotechniques. 2010 Nov;49(5):831-3. doi: 10.2144/000113539.


CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi.

Karna SL, Sanjuan E, Esteve-Gassent MD, Miller CL, Maruskova M, Seshu J.

Infect Immun. 2011 Feb;79(2):732-44. doi: 10.1128/IAI.00882-10. Epub 2010 Nov 15.


Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge.

Li W, Murthy AK, Guentzel MN, Chambers JP, Forsthuber TG, Seshu J, Zhong G, Arulanandam BP.

Infect Immun. 2010 Sep;78(9):3942-9. doi: 10.1128/IAI.00346-10. Epub 2010 Jul 6.


Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of Borrelia burgdorferi.

Sanjuan E, Esteve-Gassent MD, Maruskova M, Seshu J.

Infect Immun. 2009 Nov;77(11):5149-62. doi: 10.1128/IAI.00673-09. Epub 2009 Sep 8.


Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.

Cong Y, Yu JJ, Guentzel MN, Berton MT, Seshu J, Klose KE, Arulanandam BP.

Vaccine. 2009 Sep 18;27(41):5554-61. doi: 10.1016/j.vaccine.2009.07.034. Epub 2009 Aug 3.


A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge.

Murthy AK, Chaganty BK, Li W, Guentzel MN, Chambers JP, Seshu J, Zhong G, Arulanandam BP.

FEMS Immunol Med Microbiol. 2009 Mar;55(2):271-9. doi: 10.1111/j.1574-695X.2008.00517.x.


sodA is essential for virulence of Borrelia burgdorferi in the murine model of Lyme disease.

Esteve-Gassent MD, Elliott NL, Seshu J.

Mol Microbiol. 2009 Feb;71(3):594-612. doi: 10.1111/j.1365-2958.2008.06549.x. Epub 2008 Nov 24.


Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease.

Maruskova M, Seshu J.

Infect Immun. 2008 Nov;76(11):5274-84. doi: 10.1128/IAI.00803-08. Epub 2008 Sep 2.


Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection.

Li W, Murthy AK, Guentzel MN, Seshu J, Forsthuber TG, Zhong G, Arulanandam BP.

J Immunol. 2008 Mar 1;180(5):3375-82.


Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease.

Maruskova M, Esteve-Gassent MD, Sexton VL, Seshu J.

Infect Immun. 2008 Jan;76(1):391-402. Epub 2007 Nov 5.


Induction of cross-serovar protection against genital chlamydial infection by a targeted multisubunit vaccination approach.

Li W, Guentzel MN, Seshu J, Zhong G, Murthy AK, Arulanandam BP.

Clin Vaccine Immunol. 2007 Dec;14(12):1537-44. Epub 2007 Oct 17.


Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

Seshu J, Esteve-Gassent MD, Labandeira-Rey M, Kim JH, Trzeciakowski JP, Höök M, Skare JT.

Mol Microbiol. 2006 Mar;59(5):1591-601.


A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.

Seshu J, Boylan JA, Hyde JA, Swingle KL, Gherardini FC, Skare JT.

Mol Microbiol. 2004 Dec;54(5):1352-63.


Dissolved oxygen levels alter gene expression and antigen profiles in Borrelia burgdorferi.

Seshu J, Boylan JA, Gherardini FC, Skare JT.

Infect Immun. 2004 Mar;72(3):1580-6. Erratum in: Infect Immun. 2004 Apr;72(4):2456.


Secretion of the virulence-associated Campylobacter invasion antigens from Campylobacter jejuni requires a stimulatory signal.

Rivera-Amill V, Kim BJ, Seshu J, Konkel ME.

J Infect Dis. 2001 Jun 1;183(11):1607-16. Epub 2001 May 1.


The many faces of Borrelia burgdorferi.

Seshu J, Skare JT.

J Mol Microbiol Biotechnol. 2000 Oct;2(4):463-72. Review.


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