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Items: 37


Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease.

Kizilay Mancini O, Lora M, Cuillerier A, Shum-Tim D, Hamdy R, Burelle Y, Servant MJ, Stochaj U, Colmegna I.

Circ Res. 2018 Jan 19;122(2):255-266. doi: 10.1161/CIRCRESAHA.117.311400. Epub 2017 Nov 7.


Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway.

Khan KA, Dô F, Marineau A, Doyon P, Clément JF, Woodgett JR, Doble BW, Servant MJ.

Mol Cell Biol. 2015 Sep 1;35(17):3029-43. doi: 10.1128/MCB.00344-15. Epub 2015 Jun 22.


Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor.

Arts MR, Baron M, Chokr N, Fritzler MJ; Canadian Scleroderma Research Group (CSRG), Servant MJ.

PLoS One. 2014 Jun 13;9(6):e100035. doi: 10.1371/journal.pone.0100035. eCollection 2014.


TNF-α expression in neutrophils and its regulation by glycogen synthase kinase-3: a potentiating role for lithium.

Giambelluca MS, Bertheau-Mailhot G, Laflamme C, Rollet-Labelle E, Servant MJ, Pouliot M.

FASEB J. 2014 Aug;28(8):3679-90. doi: 10.1096/fj.14-251900. Epub 2014 May 6.


Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

Grandvaux N, Guan X, Yoboua F, Zucchini N, Fink K, Doyon P, Martin L, Servant MJ, Chartier S.

J Innate Immun. 2014;6(5):650-62. doi: 10.1159/000360764. Epub 2014 Apr 30.


Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.

Jossart C, Mulumba M, Granata R, Gallo D, Ghigo E, Marleau S, Servant MJ, Ong H.

Mol Endocrinol. 2014 Jan;28(1):65-79. doi: 10.1210/me.2013-1027. Epub 2013 Jan 1.


Role of IκB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo.

Doyon P, van Zuylen WJ, Servant MJ.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2850-7. doi: 10.1161/ATVBAHA.113.302487. Epub 2013 Oct 17.


Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.

van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ.

PLoS Pathog. 2012;8(7):e1002747. doi: 10.1371/journal.ppat.1002747. Epub 2012 Jul 5.


Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.

Doyon P, Servant MJ.

J Biol Chem. 2010 Oct 1;285(40):30708-18. doi: 10.1074/jbc.M110.126433. Epub 2010 Jul 21. Erratum in: J Biol Chem. 2011 Mar 25;286(12):10888.


GPR103b functions in the peripheral regulation of adipogenesis.

Mulumba M, Jossart C, Granata R, Gallo D, Escher E, Ghigo E, Servant MJ, Marleau S, Ong H.

Mol Endocrinol. 2010 Aug;24(8):1615-25. doi: 10.1210/me.2010-0010. Epub 2010 Jun 9.


Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.

Wang TT, Dabbas B, Laperriere D, Bitton AJ, Soualhine H, Tavera-Mendoza LE, Dionne S, Servant MJ, Bitton A, Seidman EG, Mader S, Behr MA, White JH.

J Biol Chem. 2010 Jan 22;285(4):2227-31. doi: 10.1074/jbc.C109.071225. Epub 2009 Nov 30.


Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.

Halawani D, LeBlanc AC, Rouiller I, Michnick SW, Servant MJ, Latterich M.

Mol Cell Biol. 2009 Aug;29(16):4484-94. doi: 10.1128/MCB.00252-09. Epub 2009 Jun 8.


Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.

Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen TL, Zhao T, Shestakova EA, Zaari S, Bibeau-Poirier A, Servant MJ, Lin R, Meurs EF, Hiscott J.

Mol Cell Biol. 2009 Jun;29(12):3401-12. doi: 10.1128/MCB.00880-08. Epub 2009 Apr 20.


The IKK-related kinases: from innate immunity to oncogenesis.

Clément JF, Meloche S, Servant MJ.

Cell Res. 2008 Sep;18(9):889-99. doi: 10.1038/cr.2008.273. Review.


Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.

Bibeau-Poirier A, Servant MJ.

Cytokine. 2008 Sep;43(3):359-67. doi: 10.1016/j.cyto.2008.07.012. Epub 2008 Aug 15. Review.


Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.

Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ.

J Virol. 2008 Apr;82(8):3984-96. doi: 10.1128/JVI.02526-07. Epub 2008 Feb 13.


Signaling pathways involved in the cardioprotective effects of cannabinoids.

Lépicier P, Bibeau-Poirier A, Lagneux C, Servant MJ, Lamontagne D.

J Pharmacol Sci. 2006 Oct;102(2):155-66. Epub 2006 Oct 7. Review.


Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.

Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ.

J Immunol. 2006 Oct 15;177(8):5059-67. Erratum in: J Immunol. 2006 Dec 15;177(12):8878-9.


Endothelin is a dose-dependent trophic factor and a mitogen in small arteries in vivo.

Dao HH, Bouvet C, Moreau S, Beaucage P, Larivière R, Servant MJ, de Champlain J, Moreau P.

Cardiovasc Res. 2006 Jul 1;71(1):61-8. Epub 2006 Mar 3.


The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex.

Douillette A, Bibeau-Poirier A, Gravel SP, Clément JF, Chénard V, Moreau P, Servant MJ.

J Biol Chem. 2006 May 12;281(19):13275-84. Epub 2006 Mar 2.


Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.

Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R.

Ann N Y Acad Sci. 2003 Dec;1010:237-48. Review.


Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J.

J Biol Chem. 2003 Mar 14;278(11):9441-7. Epub 2003 Jan 10.


Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

Servant MJ, Grandvaux N, Hiscott J.

Biochem Pharmacol. 2002 Sep;64(5-6):985-92. Review.


The interferon antiviral response: from viral invasion to evasion.

Grandvaux N, tenOever BR, Servant MJ, Hiscott J.

Curr Opin Infect Dis. 2002 Jun;15(3):259-67. Review.


Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.

Grandvaux N, Servant MJ, tenOever B, Sen GC, Balachandran S, Barber GN, Lin R, Hiscott J.

J Virol. 2002 Jun;76(11):5532-9.


Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.

tenOever BR, Servant MJ, Grandvaux N, Lin R, Hiscott J.

J Virol. 2002 Apr;76(8):3659-69. Erratum in: J Virol 2002 Jun;76(12):6413.


Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function.

Servant MJ, Tenoever B, Lin R.

J Interferon Cytokine Res. 2002 Jan;22(1):49-58. Review.


Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells.

Meloche S, Pelletier S, Servant MJ.

Mol Cell Biochem. 2000 Sep;212(1-2):99-109. Review.


Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.

Servant MJ, ten Oever B, LePage C, Conti L, Gessani S, Julkunen I, Lin R, Hiscott J.

J Biol Chem. 2001 Jan 5;276(1):355-63.


The IRF-3 transcription factor mediates Sendai virus-induced apoptosis.

Heylbroeck C, Balachandran S, Servant MJ, DeLuca C, Barber GN, Lin R, Hiscott J.

J Virol. 2000 Apr;74(8):3781-92.


Interferon regulatory factors: the next generation.

Mamane Y, Heylbroeck C, Génin P, Algarté M, Servant MJ, LePage C, DeLuca C, Kwon H, Lin R, Hiscott J.

Gene. 1999 Sep 3;237(1):1-14. Review.


Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression.

Scimeca JC, Servant MJ, Dyer JO, Meloche S.

Oncogene. 1997 Aug 7;15(6):717-25.


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