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Items: 1 to 50 of 107

1.

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.

Mamidi A, Prawiro C, Seymour PA, de Lichtenberg KH, Jackson A, Serup P, Semb H.

Nature. 2018 Dec;564(7734):114-118. doi: 10.1038/s41586-018-0762-2. Epub 2018 Nov 28.

PMID:
30487608
2.

Mesodermal induction of pancreatic fate commitment.

Seymour PA, Serup P.

Semin Cell Dev Biol. 2019 Aug;92:77-88. doi: 10.1016/j.semcdb.2018.08.008. Epub 2018 Aug 25. Review.

PMID:
30142440
3.

Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice.

Jørgensen MC, de Lichtenberg KH, Collin CA, Klinck R, Ekberg JH, Engelstoft MS, Lickert H, Serup P.

Development. 2018 Sep 3;145(17). pii: dev163568. doi: 10.1242/dev.163568.

4.

Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment.

Lauridsen FKB, Jensen TL, Rapin N, Aslan D, Wilhelmson AS, Pundhir S, Rehn M, Paul F, Giladi A, Hasemann MS, Serup P, Amit I, Porse BT.

Cell Rep. 2018 Jul 17;24(3):766-780. doi: 10.1016/j.celrep.2018.06.057.

5.

Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors.

Liu KC, Leuckx G, Sakano D, Seymour PA, Mattsson CL, Rautio L, Staels W, Verdonck Y, Serup P, Kume S, Heimberg H, Andersson O.

Diabetes. 2018 Jan;67(1):58-70. doi: 10.2337/db16-1587. Epub 2017 Oct 6.

6.

Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids.

Turner DA, Girgin M, Alonso-Crisostomo L, Trivedi V, Baillie-Johnson P, Glodowski CR, Hayward PC, Collignon J, Gustavsen C, Serup P, Steventon B, P Lutolf M, Arias AM.

Development. 2017 Nov 1;144(21):3894-3906. doi: 10.1242/dev.150391. Epub 2017 Sep 26.

7.

Parsing the Pancreas.

Grapin-Botton A, Serup P.

N Engl J Med. 2017 Mar 2;376(9):886-888. doi: 10.1056/NEJMcibr1616217. No abstract available.

PMID:
28249148
8.

Properties of embryoid bodies.

Brickman JM, Serup P.

Wiley Interdiscip Rev Dev Biol. 2017 Mar;6(2). doi: 10.1002/wdev.259. Epub 2016 Dec 2. Review.

PMID:
27911036
9.

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.

Stasiulewicz M, Gray SD, Mastromina I, Silva JC, Björklund M, Seymour PA, Booth D, Thompson C, Green RJ, Hall EA, Serup P, Dale JK.

Development. 2015 Jul 1;142(13):2291-303. doi: 10.1242/dev.125237. Epub 2015 May 20.

10.

The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube.

Hanotel J, Bessodes N, Thélie A, Hedderich M, Parain K, Van Driessche B, Brandão Kde O, Kricha S, Jorgensen MC, Grapin-Botton A, Serup P, Van Lint C, Perron M, Pieler T, Henningfeld KA, Bellefroid EJ.

Dev Biol. 2014 Feb 15;386(2):340-57. doi: 10.1016/j.ydbio.2013.12.024. Epub 2013 Dec 24.

11.

Bulking up on beta cells.

Seymour PA, Serup P.

N Engl J Med. 2013 Aug 22;369(8):777-9. doi: 10.1056/NEJMcibr1307038. No abstract available.

PMID:
23964941
12.

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.

Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, Magnuson MA, Zaret KS.

Dis Model Mech. 2012 Nov;5(6):956-66. doi: 10.1242/dmm.009696. Epub 2012 Aug 10.

13.

Signaling pathways regulating murine pancreatic development.

Serup P.

Semin Cell Dev Biol. 2012 Aug;23(6):663-72. doi: 10.1016/j.semcdb.2012.06.004. Epub 2012 Jun 21. Review.

PMID:
22728666
14.

Generation of animals allowing the conditional inactivation of the Pax4 gene.

Kordowich S, Serup P, Collombat P, Mansouri A.

Transgenic Res. 2012 Dec;21(6):1215-20. doi: 10.1007/s11248-012-9624-0. Epub 2012 Jun 21.

15.

Mind bomb 1 is required for pancreatic β-cell formation.

Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61. doi: 10.1073/pnas.1203605109. Epub 2012 Apr 23.

16.

A step closer to making beta cells.

Serup P.

Diabetologia. 2012 Mar;55(3):540-1. doi: 10.1007/s00125-011-2449-1. Epub 2012 Jan 13. No abstract available.

PMID:
22246379
17.

EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression.

Kalisz M, Winzi M, Bisgaard HC, Serup P.

Dev Biol. 2012 Feb 1;362(1):94-103. doi: 10.1016/j.ydbio.2011.11.017. Epub 2011 Dec 6.

18.

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.

Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P.

Development. 2012 Jan;139(1):33-45. doi: 10.1242/dev.071761. Epub 2011 Nov 17.

19.

Engineering artificial signaling centers to polarize embryoid body differentiation.

Petersen DR, Gustavsen C, Lindskog SR, Magnuson MA, Zaret KS, Serup P.

Stem Cells Dev. 2012 Mar 1;21(4):647-53. doi: 10.1089/scd.2011.0344. Epub 2011 Sep 29.

20.

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.

Kordowich S, Collombat P, Mansouri A, Serup P.

BMC Dev Biol. 2011 Aug 31;11:52. doi: 10.1186/1471-213X-11-52.

21.

Identification of a conserved cis-acting region driving expression of mouse Eomesodermin to the primitive streak, node, and definitive endoderm.

Wolf XA, Klein T, Garcia R, Hyttel P, Serup P.

Gene Expr Patterns. 2012 Jan-Feb;12(1-2):85-93. doi: 10.1016/j.gep.2011.06.003. Epub 2011 Jul 8.

PMID:
21763783
22.

A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos.

Klinck R, Füchtbauer EM, Ahnfelt-Rønne J, Serup P, Jensen JN, Jørgensen MC.

Gene Expr Patterns. 2011 Oct;11(7):415-26. doi: 10.1016/j.gep.2011.06.004. Epub 2011 Jul 2.

23.
24.

Three-dimensional immunohistochemical characterization of lineage commitment by localization of T and FOXA2 in porcine peri-implantation embryos.

Wolf XA, Serup P, Hyttel P.

Dev Dyn. 2011 Apr;240(4):890-7. doi: 10.1002/dvdy.22602. Epub 2011 Mar 10.

25.

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3.

Rubio-Cabezas O, Jensen JN, Hodgson MI, Codner E, Ellard S, Serup P, Hattersley AT.

Diabetes. 2011 Apr;60(4):1349-53. doi: 10.2337/db10-1008. Epub 2011 Mar 4.

26.

Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells.

Winzi MK, Hyttel P, Dale JK, Serup P.

Stem Cells Dev. 2011 Nov;20(11):1817-27. doi: 10.1089/scd.2011.0042. Epub 2011 Apr 6.

27.

Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos.

Wolf XA, Serup P, Hyttel P.

Dev Dyn. 2011 Jan;240(1):204-10. doi: 10.1002/dvdy.22491.

28.

Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

Sylvestersen KB, Herrera PL, Serup P, Rescan C.

Gene Expr Patterns. 2011 Jan-Feb;11(1-2):105-11. doi: 10.1016/j.gep.2010.10.001. Epub 2010 Oct 8.

PMID:
20934536
29.

Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling.

Engberg N, Kahn M, Petersen DR, Hansson M, Serup P.

Stem Cells. 2010 Sep;28(9):1498-509. doi: 10.1002/stem.479.

30.

Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.

Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J.

Eur J Histochem. 2010 Apr 15;54(2):e19.

31.

The transcriptional activity of Neurog3 affects migration and differentiation of ectopic endocrine cells in chicken endoderm.

Rosenberg LC, Lafon ML, Pedersen JK, Yassin H, Jensen JN, Serup P, Hecksher-Sørensen J.

Dev Dyn. 2010 Jul;239(7):1950-66. doi: 10.1002/dvdy.22329.

32.

Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development.

Ahnfelt-Rønne J, Ravassard P, Pardanaud-Glavieux C, Scharfmann R, Serup P.

Diabetes. 2010 Aug;59(8):1948-56. doi: 10.2337/db09-1010. Epub 2010 Jun 3.

33.

Immunohistochemistry of pancreatic development in cattle and pig.

Carlsson GL, Heller RS, Serup P, Hyttel P.

Anat Histol Embryol. 2010 Apr;39(2):107-19. doi: 10.1111/j.1439-0264.2009.00985.x.

PMID:
20028378
34.

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62. doi: 10.1016/j.cell.2009.05.035.

35.

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis.

Bayha E, Jørgensen MC, Serup P, Grapin-Botton A.

PLoS One. 2009 Jun 10;4(6):e5845. doi: 10.1371/journal.pone.0005845.

36.

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.

Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9715-20. doi: 10.1073/pnas.0904247106. Epub 2009 Jun 1.

37.

A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.

Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P.

Dev Biol. 2009 Jun 15;330(2):286-304. doi: 10.1016/j.ydbio.2009.03.026. Epub 2009 Apr 7.

38.

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS.

Pancreas. 2009 Jan;38(1):36-48. doi: 10.1097/MPA.0b013e3181816547.

PMID:
18665014
39.

Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.

Wang S, Hecksher-Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, Serup P, Gu G.

Dev Biol. 2008 May 15;317(2):531-40. doi: 10.1016/j.ydbio.2008.02.052. Epub 2008 Mar 12.

40.

Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.

Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD.

J Histochem Cytochem. 2008 Jun;56(6):587-95. doi: 10.1369/jhc.2008.950675. Epub 2008 Mar 17.

41.

Specificity of four monoclonal anti-NKx6-1 antibodies.

Klinck R, Serup P, Madsen OD, Jørgensen MC.

J Histochem Cytochem. 2008 Apr;56(4):415-24. doi: 10.1369/jhc.7A7350.2008. Epub 2008 Jan 22.

42.

An illustrated review of early pancreas development in the mouse.

Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

Endocr Rev. 2007 Oct;28(6):685-705. Epub 2007 Sep 19. Review.

PMID:
17881611
43.

Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.

Ahnfelt-Rønne J, Hald J, Bødker A, Yassin H, Serup P, Hecksher-Sørensen J.

BMC Dev Biol. 2007 Jun 7;7:63.

44.

An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.

Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

J Histochem Cytochem. 2007 Sep;55(9):925-30. Epub 2007 May 3.

PMID:
17478445
45.

Mutant neurogenin-3 in congenital malabsorptive diarrhea.

Jensen JN, Rosenberg LC, Hecksher-Sørensen J, Serup P.

N Engl J Med. 2007 Apr 26;356(17):1781-2; author reply 1782. No abstract available.

PMID:
17460236
46.

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A.

J Clin Invest. 2007 Apr;117(4):961-70.

47.

Towards cell therapy for diabetes.

Madsen OD, Serup P.

Nat Biotechnol. 2006 Dec;24(12):1481-3. No abstract available.

PMID:
17160042
48.

The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.

Petri A, Ahnfelt-Rønne J, Frederiksen KS, Edwards DG, Madsen D, Serup P, Fleckner J, Heller RS.

J Mol Endocrinol. 2006 Oct;37(2):301-16.

PMID:
17032746
49.

Embryonic stem cell-based diabetes therapy--a long road to travel.

Serup P.

Diabetologia. 2006 Nov;49(11):2537-40. Epub 2006 Sep 23. No abstract available.

PMID:
17019597
50.

Analysis of pancreatic endocrine development in GDF11-deficient mice.

Dichmann DS, Yassin H, Serup P.

Dev Dyn. 2006 Nov;235(11):3016-25.

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