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Clinical spectrum and pleiotropic nature of CDH1 germline mutations.

Figueiredo J, Melo S, Carneiro P, Moreira AM, Fernandes MS, Ribeiro AS, Guilford P, Paredes J, Seruca R.

J Med Genet. 2019 Apr;56(4):199-208. doi: 10.1136/jmedgenet-2018-105807. Epub 2019 Jan 19.


Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer.

Fernandes MS, Sanches JM, Seruca R.

Adv Exp Med Biol. 2018;1110:35-53. doi: 10.1007/978-3-030-02771-1_4.


SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells.

Ribeiro AS, Nobre AR, Mendes N, Almeida J, Vieira AF, Sousa B, Carvalho FA, Monteiro J, Polónia A, Fonseca M, Sanches JM, Santos NC, Seruca R, Paredes J.

Cell Commun Signal. 2018 Nov 7;16(1):75. doi: 10.1186/s12964-018-0286-2.


E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer.

Figueiredo J, Melo S, Gamet K, Godwin T, Seixas S, Sanches JM, Guilford P, Seruca R.

Mol Cancer. 2018 Aug 1;17(1):112. doi: 10.1186/s12943-018-0859-0.


Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept.

Figueiredo J, Rodrigues I, Ribeiro J, Fernandes MS, Melo S, Sousa B, Paredes J, Seruca R, Sanches JM.

Sci Rep. 2018 Jul 6;8(1):10266. doi: 10.1038/s41598-018-28570-z.


Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect.

Corso G, Figueiredo J, La Vecchia C, Veronesi P, Pravettoni G, Macis D, Karam R, Lo Gullo R, Provenzano E, Toesca A, Mazzocco K, Carneiro F, Seruca R, Melo S, Schmitt F, Roviello F, De Scalzi AM, Intra M, Feroce I, De Camilli E, Villardita MG, Trentin C, De Lorenzi F, Bonanni B, Galimberti V.

J Med Genet. 2018 Jul;55(7):431-441. doi: 10.1136/jmedgenet-2018-105337. Epub 2018 Jun 21.


Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer.

Pena-Couso L, Perea J, Melo S, Mercadillo F, Figueiredo J, Sanches JM, Sánchez-Ruiz A, Robles L, Seruca R, Urioste M.

Eur J Hum Genet. 2018 Sep;26(9):1348-1353. doi: 10.1038/s41431-018-0173-8. Epub 2018 May 16.


Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.

Melo S, Figueiredo J, Fernandes MS, Gonçalves M, Morais-de-Sá E, Sanches JM, Seruca R.

Int J Mol Sci. 2017 Dec 12;18(12). pii: E2687. doi: 10.3390/ijms18122687. Review.


Blue intensity matters for cell cycle profiling in fluorescence DAPI-stained images.

Ferro A, Mestre T, Carneiro P, Sahumbaiev I, Seruca R, Sanches JM.

Lab Invest. 2017 May;97(5):615-625. doi: 10.1038/labinvest.2017.13. Epub 2017 Mar 6.


Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells.

Ribeiro AS, Carvalho FA, Figueiredo J, Carvalho R, Mestre T, Monteiro J, Guedes AF, Fonseca M, Sanches J, Seruca R, Santos NC, Paredes J.

Nanoscale. 2016 Nov 24;8(46):19390-19401.


Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers.

Fernandes MS, Melo S, Velho S, Carneiro P, Carneiro F, Seruca R.

Oncotarget. 2016 Oct 18;7(42):68546-68558. doi: 10.18632/oncotarget.11843.


O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer.

Carvalho S, Oliveira T, Bartels MF, Miyoshi E, Pierce M, Taniguchi N, Carneiro F, Seruca R, Reis CA, Strahl S, Pinho SS.

Oncotarget. 2016 Oct 4;7(40):65231-65246. doi: 10.18632/oncotarget.11245.


Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation.

Pinto AT, Pinto ML, Velho S, Pinto MT, Cardoso AP, Figueira R, Monteiro A, Marques M, Seruca R, Barbosa MA, Mareel M, Oliveira MJ, Rocha S.

PLoS One. 2016 Aug 11;11(8):e0160891. doi: 10.1371/journal.pone.0160891. eCollection 2016.


Corrigendum: Quantification of topological features in cell meshes to explore E-cadherin dysfunction.

Mestre T, Figueiredo J, Ribeiro AS, Paredes J, Seruca R, Sanches JM.

Sci Rep. 2016 Jul 27;6:30222. doi: 10.1038/srep30222. No abstract available.


CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness.

Branco da Cunha C, Klumpers DD, Koshy ST, Weaver JC, Chaudhuri O, Seruca R, Carneiro F, Granja PL, Mooney DJ.

Biomaterials. 2016 Aug;98:152-62. doi: 10.1016/j.biomaterials.2016.04.016. Epub 2016 May 3.


Quantification of topological features in cell meshes to explore E-cadherin dysfunction.

Mestre T, Figueiredo J, Ribeiro AS, Paredes J, Seruca R, Sanches JM.

Sci Rep. 2016 May 6;6:25101. doi: 10.1038/srep25101. Erratum in: Sci Rep. 2016 Jul 27;6:30222.


Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.

Teresa Pinto A, Laranjeiro Pinto M, Patrícia Cardoso A, Monteiro C, Teixeira Pinto M, Filipe Maia A, Castro P, Figueira R, Monteiro A, Marques M, Mareel M, Dos Santos SG, Seruca R, Adolfo Barbosa M, Rocha S, José Oliveira M.

Sci Rep. 2016 Jan 6;6:18765. doi: 10.1038/srep18765.


Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A.

Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021.


Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation.

Pinheiro M, Pinto C, Peixoto A, Veiga I, Lopes P, Henrique R, Baldaia H, Carneiro F, Seruca R, Tomlinson I, Kovac M, Heinimann K, Teixeira MR.

Br J Cancer. 2015 Aug 11;113(4):686-92. doi: 10.1038/bjc.2015.281. Epub 2015 Aug 6.


E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade.

Caldeira J, Figueiredo J, Brás-Pereira C, Carneiro P, Moreira AM, Pinto MT, Relvas JB, Carneiro F, Barbosa M, Casares F, Janody F, Seruca R.

Hum Mol Genet. 2015 Oct 15;24(20):5891-900. doi: 10.1093/hmg/ddv312. Epub 2015 Aug 5.


Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.

Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS.

Oncogene. 2016 Mar 31;35(13):1619-31. doi: 10.1038/onc.2015.225. Epub 2015 Jul 20.


Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate.

Brito LA, Yamamoto GL, Melo S, Malcher C, Ferreira SG, Figueiredo J, Alvizi L, Kobayashi GS, Naslavsky MS, Alonso N, Felix TM, Zatz M, Seruca R, Passos-Bueno MR.

Hum Mutat. 2015 Nov;36(11):1029-33. doi: 10.1002/humu.22827. Epub 2015 Aug 3.


Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour.

Cardoso AP, Pinto ML, Pinto AT, Pinto MT, Monteiro C, Oliveira MI, Santos SG, Relvas JB, Seruca R, Mantovani A, Mareel M, Barbosa MA, Oliveira MJ.

BMC Cancer. 2015 Jun 5;15:456. doi: 10.1186/s12885-015-1466-8.


Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, Hoogerbrugge N, Caldas C, Schreiber KE, Hardwick RH, Ausems MG, Bardram L, Benusiglio PR, Bisseling TM, Blair V, Bleiker E, Boussioutas A, Cats A, Coit D, DeGregorio L, Figueiredo J, Ford JM, Heijkoop E, Hermens R, Humar B, Kaurah P, Keller G, Lai J, Ligtenberg MJ, O'Donovan M, Oliveira C, Pinheiro H, Ragunath K, Rasenberg E, Richardson S, Roviello F, Schackert H, Seruca R, Taylor A, Ter Huurne A, Tischkowitz M, Joe ST, van Dijck B, van Grieken NC, van Hillegersberg R, van Sandick JW, Vehof R, van Krieken JH, Fitzgerald RC.

J Med Genet. 2015 Jun;52(6):361-74. doi: 10.1136/jmedgenet-2015-103094. Epub 2015 May 15. Review.


The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation.

Zhang L, Xiao A, Ruggeri J, Bacares R, Somar J, Melo S, Figueiredo J, Simões-Correia J, Seruca R, Shah MA.

Mutat Res. 2014 Dec;770:106-11. doi: 10.1016/j.mrfmmm.2014.10.001. Epub 2014 Oct 13. Erratum in: Mutat Res. 2015 Apr;774():59.


Familial gastric cancer: genetic susceptibility, pathology, and implications for management.

Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F.

Lancet Oncol. 2015 Feb;16(2):e60-70. doi: 10.1016/S1470-2045(14)71016-2. Review.


Causes and consequences of microsatellite instability in gastric carcinogenesis.

Velho S, Fernandes MS, Leite M, Figueiredo C, Seruca R.

World J Gastroenterol. 2014 Nov 28;20(44):16433-42. doi: 10.3748/wjg.v20.i44.16433. Review.


Hereditary diffuse gastric cancer - pathophysiology and clinical management.

Pinheiro H, Oliveira C, Seruca R, Carneiro F.

Best Pract Res Clin Gastroenterol. 2014 Dec;28(6):1055-68. doi: 10.1016/j.bpg.2014.09.007. Epub 2014 Sep 28. Review.


Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants.

Sanches JM, Figueiredo J, Fonseca M, Durães C, Melo S, Esménio S, Seruca R.

Eur J Hum Genet. 2015 Aug;23(8):1072-9. doi: 10.1038/ejhg.2014.240. Epub 2014 Nov 12.


E-cadherin germline mutation carriers: clinical management and genetic implications.

Corso G, Figueiredo J, Biffi R, Trentin C, Bonanni B, Feroce I, Serrano D, Cassano E, Annibale B, Melo S, Seruca R, De Lorenzi F, Ferrara F, Piagnerelli R, Roviello F, Galimberti V.

Cancer Metastasis Rev. 2014 Dec;33(4):1081-94. doi: 10.1007/s10555-014-9528-y. Review.


New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers.

Ferreira AM, Tuominen I, Sousa S, Gerbens F, van Dijk-Bos K, Osinga J, Kooi KA, Sanjabi B, Esendam C, Oliveira C, Terpstra P, Hardonk M, van der Sluis T, Zazula M, Stachura J, van der Zee AG, Hollema H, Sijmons RH, Aaltonen LA, Seruca R, Hofstra RM, Westers H.

Hum Mutat. 2014 Dec;35(12):1514-23. doi: 10.1002/humu.22700.


The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.

Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE.

Int J Cancer. 2015 Feb 15;136(4):844-53. doi: 10.1002/ijc.29039. Epub 2014 Jun 28.


Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation.

Velho S, Pinto A, Licastro D, Oliveira MJ, Sousa F, Stupka E, Seruca R.

BMC Cancer. 2014 Mar 14;14:182. doi: 10.1186/1471-2407-14-182.


High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin.

Bernardes N, Ribeiro AS, Abreu S, Vieira AF, Carreto L, Santos M, Seruca R, Paredes J, Fialho AM.

Int J Biochem Cell Biol. 2014 May;50:1-9. doi: 10.1016/j.biocel.2014.01.023. Epub 2014 Feb 6.


Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?

Durães C, Almeida GM, Seruca R, Oliveira C, Carneiro F.

Virchows Arch. 2014 Mar;464(3):367-78. doi: 10.1007/s00428-013-1533-y. Epub 2014 Feb 1. Review.


Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid.

Correia M, Casal S, Vinagre J, Seruca R, Figueiredo C, Touati E, Machado JC.

Int J Med Microbiol. 2014 May;304(3-4):314-20. doi: 10.1016/j.ijmm.2013.11.018. Epub 2013 Dec 1.


DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo.

Simões-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girão H, Pereira P, Seruca R.

Hum Mol Genet. 2014 Apr 15;23(8):2094-105. doi: 10.1093/hmg/ddt602. Epub 2013 Nov 29.


Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin.

de-Freitas-Junior JC, Carvalho S, Dias AM, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Díaz JA, Reis CA, Pinho SS.

PLoS One. 2013 Nov 25;8(11):e81579. doi: 10.1371/journal.pone.0081579. eCollection 2013.


Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells.

Machado AM, Desler C, Bøggild S, Strickertsson JA, Friis-Hansen L, Figueiredo C, Seruca R, Rasmussen LJ.

Mech Ageing Dev. 2013 Oct;134(10):460-6. doi: 10.1016/j.mad.2013.08.004. Epub 2013 Sep 3.


Therapeutic targets associated to E-cadherin dysfunction in gastric cancer.

Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R.

Expert Opin Ther Targets. 2013 Oct;17(10):1187-201. doi: 10.1517/14728222.2013.827174. Epub 2013 Aug 19. Review.


Gastric cancer: adding glycosylation to the equation.

Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA.

Trends Mol Med. 2013 Nov;19(11):664-76. doi: 10.1016/j.molmed.2013.07.003. Epub 2013 Aug 8. Review.


The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models.

Bernardes N, Ribeiro AS, Abreu S, Mota B, Matos RG, Arraiano CM, Seruca R, Paredes J, Fialho AM.

PLoS One. 2013 Jul 19;8(7):e69023. doi: 10.1371/journal.pone.0069023. Print 2013.


E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.

Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA.

Biochim Biophys Acta. 2013 Mar;1830(3):2690-700.


Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.

Cardoso AP, Pinto ML, Pinto AT, Oliveira MI, Pinto MT, Gonçalves R, Relvas JB, Figueiredo C, Seruca R, Mantovani A, Mareel M, Barbosa MA, Oliveira MJ.

Oncogene. 2014 Apr 17;33(16):2123-33. doi: 10.1038/onc.2013.154. Epub 2013 May 6.


Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.

Correia M, Michel V, Osório H, El Ghachi M, Bonis M, Boneca IG, De Reuse H, Matos AA, Lenormand P, Seruca R, Figueiredo C, Machado JC, Touati E.

PLoS One. 2013;8(4):e60657. doi: 10.1371/journal.pone.0060657. Epub 2013 Apr 5.


E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer.

Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F.

Prog Mol Biol Transl Sci. 2013;116:337-59. doi: 10.1016/B978-0-12-394311-8.00015-7. Review.


CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development.

van der Werf CS, Hsiao NH, Conroy S, Paredes J, Ribeiro AS, Sribudiani Y, Seruca R, Hofstra RM, Westers H, van Ijzendoorn SC.

PLoS One. 2013;8(2):e54649. doi: 10.1371/journal.pone.0054649. Epub 2013 Feb 27.


Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC).

Oliveira C, Seruca R, Hoogerbrugge N, Ligtenberg M, Carneiro F.

Eur J Hum Genet. 2013 Aug;21(8). doi: 10.1038/ejhg.2012.247. Epub 2013 Feb 27. No abstract available.


CCAAT/enhancer binding protein β (C/EBPβ) isoforms as transcriptional regulators of the pro-invasive CDH3/P-cadherin gene in human breast cancer cells.

Albergaria A, Resende C, Nobre AR, Ribeiro AS, Sousa B, Machado JC, Seruca R, Paredes J, Schmitt F.

PLoS One. 2013;8(2):e55749. doi: 10.1371/journal.pone.0055749. Epub 2013 Feb 6.


Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer.

Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C.

J Clin Oncol. 2013 Mar 1;31(7):868-75. doi: 10.1200/JCO.2012.44.4612. Epub 2013 Jan 22.


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