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Items: 44

1.

Self-Assembling Nanoparticles Usher in a New Era of Vaccine Design.

Rappuoli R, Serruto D.

Cell. 2019 Mar 7;176(6):1245-1247. doi: 10.1016/j.cell.2019.02.008.

PMID:
30849370
2.

Monocyte-activation test to reliably measure the pyrogenic content of a vaccine: An in vitro pyrogen test to overcome in vivo limitations.

Valentini S, Santoro G, Baffetta F, Franceschi S, Paludi M, Brandini E, Gherardini L, Serruto D, Capecchi B.

Vaccine. 2018 Nov 14. pii: S0264-410X(18)31469-5. doi: 10.1016/j.vaccine.2018.10.082. [Epub ahead of print]

PMID:
30448065
3.

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.

4.

Global transcriptome analysis reveals small RNAs affecting Neisseria meningitidis bacteremia.

Fagnocchi L, Bottini S, Golfieri G, Fantappiè L, Ferlicca F, Antunes A, Guadagnuolo S, Del Tordello E, Siena E, Serruto D, Scarlato V, Muzzi A, Delany I.

PLoS One. 2015 May 7;10(5):e0126325. doi: 10.1371/journal.pone.0126325. eCollection 2015.

5.

Staphylococcal Esx proteins modulate apoptosis and release of intracellular Staphylococcus aureus during infection in epithelial cells.

Korea CG, Balsamo G, Pezzicoli A, Merakou C, Tavarini S, Bagnoli F, Serruto D, Unnikrishnan M.

Infect Immun. 2014 Oct;82(10):4144-53. doi: 10.1128/IAI.01576-14. Epub 2014 Jul 21.

6.

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.

Del Tordello E, Vacca I, Ram S, Rappuoli R, Serruto D.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):427-32. doi: 10.1073/pnas.1321556111. Epub 2013 Dec 23.

7.

Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins.

Cafardi V, Biagini M, Martinelli M, Leuzzi R, Rubino JT, Cantini F, Norais N, Scarselli M, Serruto D, Unnikrishnan M.

PLoS One. 2013 Nov 26;8(11):e81306. doi: 10.1371/journal.pone.0081306. eCollection 2013.

8.

Functional genomics studies of the human pathogen Neisseria meningitidis.

Del Tordello E, Serruto D.

Brief Funct Genomics. 2013 Jul;12(4):328-40. doi: 10.1093/bfgp/elt018. Epub 2013 May 30.

PMID:
23723380
9.

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment.

Vogel U, Taha MK, Vazquez JA, Findlow J, Claus H, Stefanelli P, Caugant DA, Kriz P, Abad R, Bambini S, Carannante A, Deghmane AE, Fazio C, Frosch M, Frosi G, Gilchrist S, Giuliani MM, Hong E, Ledroit M, Lovaglio PG, Lucidarme J, Musilek M, Muzzi A, Oksnes J, Rigat F, Orlandi L, Stella M, Thompson D, Pizza M, Rappuoli R, Serruto D, Comanducci M, Boccadifuoco G, Donnelly JJ, Medini D, Borrow R.

Lancet Infect Dis. 2013 May;13(5):416-25. doi: 10.1016/S1473-3099(13)70006-9. Epub 2013 Feb 13.

PMID:
23414709
10.

Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile.

Ðapa T, Leuzzi R, Ng YK, Baban ST, Adamo R, Kuehne SA, Scarselli M, Minton NP, Serruto D, Unnikrishnan M.

J Bacteriol. 2013 Feb;195(3):545-55. doi: 10.1128/JB.01980-12. Epub 2012 Nov 21.

11.

Analysis of the regulated transcriptome of Neisseria meningitidis in human blood using a tiling array.

Del Tordello E, Bottini S, Muzzi A, Serruto D.

J Bacteriol. 2012 Nov;194(22):6217-32. doi: 10.1128/JB.01055-12. Epub 2012 Sep 14.

12.

Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model.

Chiappini N, Seubert A, Telford JL, Grandi G, Serruto D, Margarit I, Janulczyk R.

PLoS One. 2012;7(7):e40411. doi: 10.1371/journal.pone.0040411. Epub 2012 Jul 27.

13.

Staphylococcus aureus FhuD2 is involved in the early phase of staphylococcal dissemination and generates protective immunity in mice.

Mishra RP, Mariotti P, Fiaschi L, Nosari S, Maccari S, Liberatori S, Fontana MR, Pezzicoli A, De Falco MG, Falugi F, Altindis E, Serruto D, Grandi G, Bagnoli F.

J Infect Dis. 2012 Oct 1;206(7):1041-9. doi: 10.1093/infdis/jis463. Epub 2012 Jul 24.

PMID:
22829645
14.

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens.

Serruto D, Bottomley MJ, Ram S, Giuliani MM, Rappuoli R.

Vaccine. 2012 May 30;30 Suppl 2:B87-97. doi: 10.1016/j.vaccine.2012.01.033. Review.

15.

Future challenges in the elimination of bacterial meningitis.

Bottomley MJ, Serruto D, Sáfadi MA, Klugman KP.

Vaccine. 2012 May 30;30 Suppl 2:B78-86. doi: 10.1016/j.vaccine.2011.12.099. Review.

PMID:
22607903
16.

Recombinant bacterial vaccines.

Unnikrishnan M, Rappuoli R, Serruto D.

Curr Opin Immunol. 2012 Jun;24(3):337-42. doi: 10.1016/j.coi.2012.03.013. Epub 2012 Apr 26. Review.

PMID:
22541723
17.

Structure of the C-terminal domain of Neisseria heparin binding antigen (NHBA), one of the main antigens of a novel vaccine against Neisseria meningitidis.

Esposito V, Musi V, de Chiara C, Veggi D, Serruto D, Scarselli M, Kelly G, Pizza M, Pastore A.

J Biol Chem. 2011 Dec 2;286(48):41767-75. doi: 10.1074/jbc.M111.289314. Epub 2011 Sep 29.

18.

A naturally occurring single-residue mutation in the translocator domain of Neisseria meningitidis NhhA affects trimerization, surface localization, and adhesive capabilities.

Echenique-Rivera H, Brunelli B, Scarselli M, Taddei AR, Pizza M, Aricò B, Serruto D.

Infect Immun. 2011 Nov;79(11):4308-21. doi: 10.1128/IAI.00198-11. Epub 2011 Aug 15.

19.

Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.

Echenique-Rivera H, Muzzi A, Del Tordello E, Seib KL, Francois P, Rappuoli R, Pizza M, Serruto D.

PLoS Pathog. 2011 May;7(5):e1002027. doi: 10.1371/journal.ppat.1002027. Epub 2011 May 5.

20.

Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.

Budroni S, Siena E, Dunning Hotopp JC, Seib KL, Serruto D, Nofroni C, Comanducci M, Riley DR, Daugherty SC, Angiuoli SV, Covacci A, Pizza M, Rappuoli R, Moxon ER, Tettelin H, Medini D.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4494-9. doi: 10.1073/pnas.1019751108. Epub 2011 Feb 28.

21.

A novel Hfq-dependent sRNA that is under FNR control and is synthesized in oxygen limitation in Neisseria meningitidis.

Fantappiè L, Oriente F, Muzzi A, Serruto D, Scarlato V, Delany I.

Mol Microbiol. 2011 Apr;80(2):507-23. doi: 10.1111/j.1365-2958.2011.07592.x. Epub 2011 Mar 7.

22.

Influence of sequence variability on bactericidal activity sera induced by Factor H binding protein variant 1.1.

Brunelli B, Del Tordello E, Palumbo E, Biolchi A, Bambini S, Comanducci M, Muzzi A, Pizza M, Rappuoli R, Donnelly JJ, Giuliani MM, Serruto D.

Vaccine. 2011 Jan 29;29(5):1072-81. doi: 10.1016/j.vaccine.2010.11.064. Epub 2010 Dec 3.

PMID:
21130753
23.

Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.

Donnelly J, Medini D, Boccadifuoco G, Biolchi A, Ward J, Frasch C, Moxon ER, Stella M, Comanducci M, Bambini S, Muzzi A, Andrews W, Chen J, Santos G, Santini L, Boucher P, Serruto D, Pizza M, Rappuoli R, Giuliani MM.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19490-5. doi: 10.1073/pnas.1013758107. Epub 2010 Oct 20.

24.

Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus.

Giuliani MM, Biolchi A, Serruto D, Ferlicca F, Vienken K, Oster P, Rappuoli R, Pizza M, Donnelly J.

Vaccine. 2010 Jul 12;28(31):5023-30. doi: 10.1016/j.vaccine.2010.05.014. Epub 2010 May 21.

PMID:
20493284
25.

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci.

Serruto D, Rappuoli R, Scarselli M, Gros P, van Strijp JA.

Nat Rev Microbiol. 2010 Jun;8(6):393-9. doi: 10.1038/nrmicro2366.

PMID:
20467445
26.

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.

Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Aricò B.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3770-5. doi: 10.1073/pnas.0915162107. Epub 2010 Feb 3.

27.

HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells.

Serruto D, Spadafina T, Scarselli M, Bambini S, Comanducci M, Höhle S, Kilian M, Veiga E, Cossart P, Oggioni MR, Savino S, Ferlenghi I, Taddei AR, Rappuoli R, Pizza M, Masignani V, Aricò B.

Cell Microbiol. 2009 Jul;11(7):1044-63. doi: 10.1111/j.1462-5822.2009.01306.x. Epub 2009 Mar 12.

PMID:
19290916
28.

Genome-based approaches to develop vaccines against bacterial pathogens.

Serruto D, Serino L, Masignani V, Pizza M.

Vaccine. 2009 May 26;27(25-26):3245-50. doi: 10.1016/j.vaccine.2009.01.072. Epub 2009 Feb 5. Review.

PMID:
19200820
29.

The Hfq-dependent small noncoding RNA NrrF directly mediates Fur-dependent positive regulation of succinate dehydrogenase in Neisseria meningitidis.

Metruccio MM, Fantappiè L, Serruto D, Muzzi A, Roncarati D, Donati C, Scarlato V, Delany I.

J Bacteriol. 2009 Feb;191(4):1330-42. doi: 10.1128/JB.00849-08. Epub 2008 Dec 5.

30.

Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.

Seib KL, Serruto D, Oriente F, Delany I, Adu-Bobie J, Veggi D, Aricò B, Rappuoli R, Pizza M.

Infect Immun. 2009 Jan;77(1):292-9. doi: 10.1128/IAI.01071-08. Epub 2008 Oct 13.

31.

Microbiology in the post-genomic era.

Medini D, Serruto D, Parkhill J, Relman DA, Donati C, Moxon R, Falkow S, Rappuoli R.

Nat Rev Microbiol. 2008 Jun;6(6):419-30. doi: 10.1038/nrmicro1901. Epub 2008 May 13. Review.

PMID:
18475305
32.

A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.

Tam VC, Serruto D, Dziejman M, Brieher W, Mekalanos JJ.

Cell Host Microbe. 2007 Apr 19;1(2):95-107.

33.

A universal vaccine for serogroup B meningococcus.

Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. Epub 2006 Jul 6.

34.

Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.

Scarselli M, Serruto D, Montanari P, Capecchi B, Adu-Bobie J, Veggi D, Rappuoli R, Pizza M, Aricò B.

Mol Microbiol. 2006 Aug;61(3):631-44. Epub 2006 Jun 27.

35.

Post-genomic vaccine development.

Serruto D, Rappuoli R.

FEBS Lett. 2006 May 22;580(12):2985-92. Epub 2006 May 4. Review.

36.

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system.

Dziejman M, Serruto D, Tam VC, Sturtevant D, Diraphat P, Faruque SM, Rahman MH, Heidelberg JF, Decker J, Li L, Montgomery KT, Grills G, Kucherlapati R, Mekalanos JJ.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3465-70. Epub 2005 Feb 22.

37.

Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens.

Serruto D, Adu-Bobie J, Capecchi B, Rappuoli R, Pizza M, Masignani V.

J Biotechnol. 2004 Sep 30;113(1-3):15-32. Review.

PMID:
15380644
38.

In silico identification of novel bacterial ADP-ribosyltransferases.

Masignani V, Balducci E, Serruto D, Veggi D, Aricò B, Comanducci M, Pizza M, Rappuoli R.

Int J Med Microbiol. 2004 Apr;293(7-8):471-8. Review.

PMID:
15149020
39.
40.

The genome revolution in vaccine research.

Capecchi B, Serruto D, Adu-Bobie J, Rappuoli R, Pizza M.

Curr Issues Mol Biol. 2004 Jan;6(1):17-27. Review.

41.

NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis.

Masignani V, Balducci E, Di Marcello F, Savino S, Serruto D, Veggi D, Bambini S, Scarselli M, Aricò B, Comanducci M, Adu-Bobie J, Giuliani MM, Rappuoli R, Pizza M.

Mol Microbiol. 2003 Nov;50(3):1055-67.

42.

Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity.

Serruto D, Adu-Bobie J, Scarselli M, Veggi D, Pizza M, Rappuoli R, Aricò B.

Mol Microbiol. 2003 Apr;48(2):323-34.

43.

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870.

Masignani V, Comanducci M, Giuliani MM, Bambini S, Adu-Bobie J, Arico B, Brunelli B, Pieri A, Santini L, Savino S, Serruto D, Litt D, Kroll S, Welsch JA, Granoff DM, Rappuoli R, Pizza M.

J Exp Med. 2003 Mar 17;197(6):789-99.

44.

Two years into reverse vaccinology.

Adu-Bobie J, Capecchi B, Serruto D, Rappuoli R, Pizza M.

Vaccine. 2003 Jan 30;21(7-8):605-10.

PMID:
12531326

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