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Items: 31

1.

A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Dawson JC, Serrels B, Byron A, Muir MT, Makda A, García-Muñoz A, von Kriegsheim A, Lietha D, Carragher NO, Frame MC.

Mol Cancer Ther. 2019 Nov 29. pii: molcanther.0330.2019. doi: 10.1158/1535-7163.MCT-19-0330. [Epub ahead of print]

PMID:
31784455
2.

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.

Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM.

Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12.

PMID:
31189647
3.

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation.

Felton JM, Lucas CD, Dorward DA, Duffin R, Kipari T, Vermeren S, Robb CT, MacLeod KG, Serrels B, Schwarze J, Haslett C, Dransfield I, Rossi AG.

J Allergy Clin Immunol. 2018 Dec;142(6):1884-1893.e6. doi: 10.1016/j.jaci.2018.01.029. Epub 2018 Feb 8.

4.

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, Quinn N, Taggart D, Von Kreigsheim A, Anderton SM, Serrels A, Frame MC.

Sci Signal. 2017 Dec 5;10(508). pii: eaan8355. doi: 10.1126/scisignal.aan8355.

5.

Reverse Phase Protein Arrays and Drug Discovery.

Macleod KG, Serrels B, Carragher NO.

Methods Mol Biol. 2017;1647:153-169. doi: 10.1007/978-1-4939-7201-2_10.

PMID:
28809001
6.

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Canel M, Byron A, Sims AH, Cartier J, Patel H, Frame MC, Brunton VG, Serrels B, Serrels A.

Cancer Res. 2017 Oct 1;77(19):5301-5312. doi: 10.1158/0008-5472.CAN-17-0418. Epub 2017 Aug 14.

7.

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.

Alexopoulou AN, Lees DM, Bodrug N, Lechertier T, Fernandez I, D'Amico G, Dukinfield M, Batista S, Tavora B, Serrels B, Hodivala-Dilke K.

J Pathol. 2017 Jul;242(3):358-370. doi: 10.1002/path.4911. Epub 2017 Jun 1.

8.

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Schoenherr C, Byron A, Sandilands E, Paliashvili K, Baillie GS, Garcia-Munoz A, Valacca C, Cecconi F, Serrels B, Frame MC.

Elife. 2017 Mar 31;6. pii: e23172. doi: 10.7554/eLife.23172.

9.

Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.

Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A.

Cell Death Discov. 2017 Mar 6;3:16077. doi: 10.1038/cddiscovery.2016.77. eCollection 2017.

10.

Dual role of pericyte α6β1-integrin in tumour blood vessels.

Reynolds LE, D'Amico G, Lechertier T, Papachristodoulou A, Muñoz-Félix JM, De Arcangelis A, Baker M, Serrels B, Hodivala-Dilke KM.

J Cell Sci. 2017 May 1;130(9):1583-1595. doi: 10.1242/jcs.197848. Epub 2017 Mar 13.

11.

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.

Creedon H, Gómez-Cuadrado L, Tarnauskaitė Ž, Balla J, Canel M, MacLeod KG, Serrels B, Fraser C, Unciti-Broceta A, Tracey N, Le Bihan T, Klinowska T, Sims AH, Byron A, Brunton VG.

Oncotarget. 2016 Mar 8;7(10):11539-52. doi: 10.18632/oncotarget.7317.

12.

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.

Villari G, Jayo A, Zanet J, Fitch B, Serrels B, Frame M, Stramer BM, Goult BT, Parsons M.

J Cell Sci. 2015 Dec 15;128(24):4601-14. doi: 10.1242/jcs.175760. Epub 2015 Nov 5.

13.

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.

14.

In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy.

Lee M, Downes A, Chau YY, Serrels B, Hastie N, Elfick A, Brunton V, Frame M, Serrels A.

Intravital. 2015 Jun 8;4(1):e1055430. doi: 10.1080/21659087.2015.1055430. eCollection 2015 Jan-Apr.

15.

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

Schoenherr C, Serrels B, Proby C, Cunningham DL, Findlay JE, Baillie GS, Heath JK, Frame MC.

J Cell Sci. 2014 Dec 15;127(Pt 24):5303-16. doi: 10.1242/jcs.157560. Epub 2014 Oct 29.

16.

Generation of point-mutant FAK knockin mice.

Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B, Hodivala-Dilke K.

Genesis. 2014 Nov;52(11):907-15. doi: 10.1002/dvg.22823. Epub 2014 Sep 30.

PMID:
25242698
17.

Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society.

Akbani R, Becker KF, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF 3rd, Pollard HB, Serrels B, Zhu J.

Mol Cell Proteomics. 2014 Jul;13(7):1625-43. doi: 10.1074/mcp.O113.034918. Epub 2014 Apr 28.

18.

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Patel H, Zich J, Serrels B, Rickman C, Hardwick KG, Frame MC, Brunton VG.

Nat Commun. 2013;4:2056. doi: 10.1038/ncomms3056.

PMID:
23804033
19.

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

Ridgway RA, Serrels B, Mason S, Kinnaird A, Muir M, Patel H, Muller WJ, Sansom OJ, Brunton VG.

Carcinogenesis. 2012 Dec;33(12):2369-76. doi: 10.1093/carcin/bgs284. Epub 2012 Sep 12.

PMID:
22971575
20.

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.

Sandilands E, Serrels B, Wilkinson S, Frame MC.

EMBO Rep. 2012 Aug;13(8):733-40. doi: 10.1038/embor.2012.92. Epub 2012 Jun 26. Erratum in: EMBO Rep. 2012 Sep;13(9):867.

21.

FAK and talin: who is taking whom to the integrin engagement party?

Serrels B, Frame MC.

J Cell Biol. 2012 Jan 23;196(2):185-7. doi: 10.1083/jcb.201112128.

22.

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC.

Nat Cell Biol. 2011 Dec 4;14(1):51-60. doi: 10.1038/ncb2386.

PMID:
22138575
23.

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1.

Serrels B, Sandilands E, Frame MC.

Small GTPases. 2011 Jan;2(1):54-61.

24.

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Canel M, Serrels A, Miller D, Timpson P, Serrels B, Frame MC, Brunton VG.

Cancer Res. 2010 Nov 15;70(22):9413-22. doi: 10.1158/0008-5472.CAN-10-1454. Epub 2010 Nov 2.

25.

The FERM domain: organizing the structure and function of FAK.

Frame MC, Patel H, Serrels B, Lietha D, Eck MJ.

Nat Rev Mol Cell Biol. 2010 Nov;11(11):802-14. doi: 10.1038/nrm2996. Review.

PMID:
20966971
26.

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC.

Curr Biol. 2010 Jun 22;20(12):1086-92. doi: 10.1016/j.cub.2010.04.042. Epub 2010 May 20.

27.

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.

Serrels B, Serrels A, Mason SM, Baldeschi C, Ashton GH, Canel M, Mackintosh LJ, Doyle B, Green TP, Frame MC, Sansom OJ, Brunton VG.

Carcinogenesis. 2009 Feb;30(2):249-57. doi: 10.1093/carcin/bgn278. Epub 2008 Dec 5.

PMID:
19060248
28.

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.

Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC.

Nat Cell Biol. 2007 Sep;9(9):1046-56. Epub 2007 Aug 26.

PMID:
17721515
29.
30.

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC.

Genes Dev. 2004 Dec 15;18(24):2998-3003.

31.

SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.

Westhoff MA, Serrels B, Fincham VJ, Frame MC, Carragher NO.

Mol Cell Biol. 2004 Sep;24(18):8113-33.

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