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Items: 32


Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy.

Findlay EG, Currie AJ, Zhang A, Ovciarikova J, Young L, Stevens H, McHugh BJ, Canel M, Gray M, Milling SWF, Campbell JDM, Savill J, Serrels A, Davidson DJ.

Oncoimmunology. 2019 May 1;8(8):1608106. doi: 10.1080/2162402X.2019.1608106. eCollection 2019.


Development of a fluorescence-based cellular apoptosis reporter.

Balderstone LA, Dawson JC, Welman A, Serrels A, Wedge SR, Brunton VG.

Methods Appl Fluoresc. 2018 Oct 24;7(1):015001. doi: 10.1088/2050-6120/aae6f8.


Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy.

Tipping WJ, Lee M, Serrels A, Brunton VG, Hulme AN.

Chem Sci. 2017 Aug 1;8(8):5606-5615. doi: 10.1039/c7sc01837a. Epub 2017 May 24.


High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

Rubio-Ruiz B, Pérez-López AM, Bray TL, Lee M, Serrels A, Prieto M, Arruebo M, Carragher NO, Sebastián V, Unciti-Broceta A.

ACS Appl Mater Interfaces. 2018 Jan 31;10(4):3341-3348. doi: 10.1021/acsami.7b17282. Epub 2018 Jan 22.


IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, Quinn N, Taggart D, Von Kreigsheim A, Anderton SM, Serrels A, Frame MC.

Sci Signal. 2017 Dec 5;10(508). pii: eaan8355. doi: 10.1126/scisignal.aan8355.


Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Canel M, Byron A, Sims AH, Cartier J, Patel H, Frame MC, Brunton VG, Serrels B, Serrels A.

Cancer Res. 2017 Oct 1;77(19):5301-5312. doi: 10.1158/0008-5472.CAN-17-0418. Epub 2017 Aug 14.


FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer.

Symeonides SN, Anderton SM, Serrels A.

J Immunother Cancer. 2017 Feb 21;5:17. doi: 10.1186/s40425-017-0217-6. eCollection 2017.


Multiphoton Microscopy for Visualizing Lipids in Tissue.

Lee M, Serrels A.

Methods Mol Biol. 2016;1467:105-18. doi: 10.1007/978-1-4939-4023-3_9.


FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.

Serrels A, Frame MC.

Oncoimmunology. 2016 Jan 13;5(4):e1119356. eCollection 2016 Apr.


Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue.

Mendive-Tapia L, Zhao C, Akram AR, Preciado S, Albericio F, Lee M, Serrels A, Kielland N, Read ND, Lavilla R, Vendrell M.

Nat Commun. 2016 Mar 9;7:10940. doi: 10.1038/ncomms10940.


Stimulated Raman scattering microscopy: an emerging tool for drug discovery.

Tipping WJ, Lee M, Serrels A, Brunton VG, Hulme AN.

Chem Soc Rev. 2016 Apr 21;45(8):2075-89. doi: 10.1039/c5cs00693g. Epub 2016 Feb 3. Review.


Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.


In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy.

Lee M, Downes A, Chau YY, Serrels B, Hastie N, Elfick A, Brunton V, Frame M, Serrels A.

Intravital. 2015 Jun 8;4(1):e1055430. doi: 10.1080/21659087.2015.1055430. eCollection 2015 Jan-Apr.


FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

Frame MC, Serrels A.

Cancer Cell. 2015 Apr 13;27(4):429-31. doi: 10.1016/j.ccell.2015.03.013.


The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.

Sauter KA, Pridans C, Sehgal A, Bain CC, Scott C, Moffat L, Rojo R, Stutchfield BM, Davies CL, Donaldson DS, Renault K, McColl BW, Mowat AM, Serrels A, Frame MC, Mabbott NA, Hume DA.

PLoS One. 2014 Aug 19;9(8):e105429. doi: 10.1371/journal.pone.0105429. eCollection 2014.


Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.

Chau YY, Bandiera R, Serrels A, Martínez-Estrada OM, Qing W, Lee M, Slight J, Thornburn A, Berry R, McHaffie S, Stimson RH, Walker BR, Chapuli RM, Schedl A, Hastie N.

Nat Cell Biol. 2014 Apr;16(4):367-75. doi: 10.1038/ncb2922. Epub 2014 Mar 9.


E-cadherin-integrin crosstalk in cancer invasion and metastasis.

Canel M, Serrels A, Frame MC, Brunton VG.

J Cell Sci. 2013 Jan 15;126(Pt 2):393-401. doi: 10.1242/jcs.100115. Epub 2013 Mar 22. Review.


Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging.

Serrels A, Canel M, Brunton VG, Frame MC.

Cell Adh Migr. 2011 Jul-Aug;5(4):360-5. Epub 2011 Jul 1. Review.


The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells.

Serrels A, McLeod K, Canel M, Kinnaird A, Graham K, Frame MC, Brunton VG.

Int J Cancer. 2012 Jul 15;131(2):287-97. doi: 10.1002/ijc.26351. Epub 2011 Aug 30.


Live cell in vitro and in vivo imaging applications: accelerating drug discovery.

Isherwood B, Timpson P, McGhee EJ, Anderson KI, Canel M, Serrels A, Brunton VG, Carragher NO.

Pharmaceutics. 2011 Apr 4;3(2):141-70. doi: 10.3390/pharmaceutics3020141.


Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Canel M, Serrels A, Miller D, Timpson P, Serrels B, Frame MC, Brunton VG.

Cancer Res. 2010 Nov 15;70(22):9413-22. doi: 10.1158/0008-5472.CAN-10-1454. Epub 2010 Nov 2.


Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane.

Canel M, Serrels A, Anderson KI, Frame MC, Brunton VG.

Cell Adh Migr. 2010 Oct-Dec;4(4):491-501.


A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC.

Curr Biol. 2010 Jun 22;20(12):1086-92. doi: 10.1016/j.cub.2010.04.042. Epub 2010 May 20.


Two-color photoactivatable probe for selective tracking of proteins and cells.

Welman A, Serrels A, Brunton VG, Ditzel M, Frame MC.

J Biol Chem. 2010 Apr 9;285(15):11607-16. doi: 10.1074/jbc.M110.102392. Epub 2010 Feb 5.


Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Timpson P, Serrels A, Canel M, Frame MC, Brunton VG, Anderson KI.

Cell Adh Migr. 2009 Oct-Dec;3(4):351-4. Epub 2009 Oct 7. Review.


Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Serrels A, Timpson P, Canel M, Schwarz JP, Carragher NO, Frame MC, Brunton VG, Anderson KI.

Cancer Res. 2009 Apr 1;69(7):2714-9. doi: 10.1158/0008-5472.CAN-08-4308. Epub 2009 Mar 24.


Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.

Myssina S, Helgason GV, Serrels A, Jørgensen HG, Bhatia R, Modi H, Baird JW, Mountford JC, Hamilton A, Schemionek M, Koschmieder S, Brunton VG, Holyoake TL.

Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18.


A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.

Serrels B, Serrels A, Mason SM, Baldeschi C, Ashton GH, Canel M, Mackintosh LJ, Doyle B, Green TP, Frame MC, Sansom OJ, Brunton VG.

Carcinogenesis. 2009 Feb;30(2):249-57. doi: 10.1093/carcin/bgn278. Epub 2008 Dec 5.


Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression.

Canel M, Secades P, Garzón-Arango M, Allonca E, Suarez C, Serrels A, Frame M, Brunton V, Chiara MD.

Br J Cancer. 2008 Apr 8;98(7):1274-84. doi: 10.1038/sj.bjc.6604286. Epub 2008 Mar 18.


Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.

Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC.

Nat Cell Biol. 2007 Sep;9(9):1046-56. Epub 2007 Aug 26.


p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.

Macpherson IR, Hooper S, Serrels A, McGarry L, Ozanne BW, Harrington K, Frame MC, Sahai E, Brunton VG.

Oncogene. 2007 Aug 9;26(36):5214-28. Epub 2007 Mar 5.


Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib.

Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ, Ashton GH, Frame MC, Brunton VG.

Mol Cancer Ther. 2006 Dec;5(12):3014-22. Epub 2006 Dec 5.

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