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Items: 1 to 50 of 139

1.

BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway.

Green AL, DeSisto J, Flannery P, Lemma R, Knox A, Lemieux M, Sanford B, O'Rourke R, Ramkissoon S, Jones K, Perry J, Hui X, Moroze E, Balakrishnan I, O'Neill AF, Dunn K, DeRyckere D, Danis E, Safadi A, Gilani A, Hubbell-Engler B, Nuss Z, Levy JMM, Serkova N, Venkataraman S, Graham DK, Foreman N, Ligon K, Jones K, Kung AL, Vibhakar R.

Oncogene. 2019 Dec 16. doi: 10.1038/s41388-019-1125-7. [Epub ahead of print]

PMID:
31844250
2.

Electromagnetic wave propagation in a fast pulse line ion accelerator.

Behbahani RA, Diot Q, Kavanagh B, Serkova NJ, Miften M, Westerly DC.

Med Phys. 2019 Dec;46(12):5714-5721. doi: 10.1002/mp.13875. Epub 2019 Nov 4.

PMID:
31622500
3.

Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II.

Wang G, Serkova NJ, Groman EV, Scheinman RI, Simberg D.

Mol Pharm. 2019 Oct 7;16(10):4274-4281. doi: 10.1021/acs.molpharmaceut.9b00632. Epub 2019 Sep 26.

PMID:
31556296
4.

Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma.

Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM.

Neuro Oncol. 2019 Dec 17;21(12):1540-1551. doi: 10.1093/neuonc/noz116.

PMID:
31276586
5.

Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer.

Dhar D, Raina K, Kant R, Wempe MF, Serkova NJ, Agarwal C, Agarwal R.

Carcinogenesis. 2019 Jun 13. pii: bgz114. doi: 10.1093/carcin/bgz114. [Epub ahead of print]

PMID:
31194859
6.

Quantitative NMR-Based Metabolomics on Tissue Biomarkers and Its Translation into In Vivo Magnetic Resonance Spectroscopy.

Serkova NJ, Davis DM, Steiner J, Agarwal R.

Methods Mol Biol. 2019;1978:369-387. doi: 10.1007/978-1-4939-9236-2_23.

PMID:
31119675
7.

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment.

Oweida AJ, Bhatia S, Van Court B, Darragh L, Serkova N, Karam SD.

J Vis Exp. 2019 Apr 22;(146). doi: 10.3791/59195.

8.

Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers.

Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD.

Cancer Res. 2019 May 15;79(10):2722-2735. doi: 10.1158/0008-5472.CAN-18-3257. Epub 2019 Mar 20.

PMID:
30894369
9.

Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. doi: 10.1152/ajpregu.00359.2018. Epub 2019 Feb 13.

PMID:
30758974
10.

Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.

Keenan KE, Biller JR, Delfino JG, Boss MA, Does MD, Evelhoch JL, Griswold MA, Gunter JL, Hinks RS, Hoffman SW, Kim G, Lattanzi R, Li X, Marinelli L, Metzger GJ, Mukherjee P, Nordstrom RJ, Peskin AP, Perez E, Russek SE, Sahiner B, Serkova N, Shukla-Dave A, Steckner M, Stupic KF, Wilmes LJ, Wu HH, Zhang H, Jackson EF, Sullivan DC.

J Magn Reson Imaging. 2019 Jun;49(7):e26-e39. doi: 10.1002/jmri.26598. Epub 2019 Jan 24.

PMID:
30680836
11.

Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma.

Veo B, Danis E, Pierce A, Sola I, Wang D, Foreman NK, Jin J, Ma A, Serkova N, Venkataraman S, Vibhakar R.

JCI Insight. 2019 Jan 10;4(1). pii: 122933. doi: 10.1172/jci.insight.122933. [Epub ahead of print]

12.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT.

Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27.

13.

Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.

Scott AJ, Arcaroli JJ, Bagby SM, Yahn R, Huber KM, Serkova NJ, Nguyen A, Kim J, Thorburn A, Vogel J, Quackenbush KS, Capasso A, Schreiber A, Blatchford P, Klauck PJ, Pitts TM, Eckhardt SG, Messersmith WA.

Mol Cancer Ther. 2018 Oct;17(10):2112-2122. doi: 10.1158/1535-7163.MCT-17-0131. Epub 2018 Jul 19.

14.

Cooperation Between Pten and Smad4 in Murine Salivary Gland Tumor Formation and Progression.

Cao Y, Liu H, Gao L, Lu L, Du L, Bai H, Li J, Said S, Wang XJ, Song J, Serkova N, Wei M, Xiao J, Lu SL.

Neoplasia. 2018 Aug;20(8):764-774. doi: 10.1016/j.neo.2018.05.009. Epub 2018 Jun 27.

15.

The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact.

Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA.

Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27.

16.

Design considerations for a pulse line ion accelerator (PLIA)-based PET isotope generator.

Westerly DC, Behbahani RA, Kavanagh B, Liu A, Miften M, Serkova NJ, Diot Q.

Med Phys. 2018 Jun 15. doi: 10.1002/mp.13050. [Epub ahead of print]

PMID:
29905959
17.

Unique Heterogeneous Topological Pattern of the Metabolic Landscape in Rabbit Fetal Lungs following Tracheal Occlusion.

Marwan AI, Shabeka U, Reisz JA, Zheng C, Serkova NJ, Dobrinskikh E.

Fetal Diagn Ther. 2019;45(3):145-154. doi: 10.1159/000487752. Epub 2018 Apr 18.

18.

Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases.

Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM.

Front Oncol. 2017 Nov 2;7:252. doi: 10.3389/fonc.2017.00252. eCollection 2017.

19.

Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.

Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD.

Oncoimmunology. 2017 Aug 3;6(10):e1356153. doi: 10.1080/2162402X.2017.1356153. eCollection 2017.

20.

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK.

Cancer Cell. 2017 Sep 11;32(3):392. doi: 10.1016/j.ccell.2017.08.008. No abstract available.

21.

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.

Henry CJ, Nemkov T, Casás-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J.

Haematologica. 2017 Dec;102(12):1985-1994. doi: 10.3324/haematol.2017.171074. Epub 2017 Sep 7.

22.

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK.

Cancer Cell. 2017 Jul 10;32(1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. Erratum in: Cancer Cell. 2017 Sep 11;32(3):392.

23.

Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation.

Serkova NJ.

Front Immunol. 2017 May 22;8:590. doi: 10.3389/fimmu.2017.00590. eCollection 2017. Review.

24.

Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions.

Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D.

ACS Nano. 2017 Jan 24;11(1):12-18. doi: 10.1021/acsnano.6b08244. Epub 2017 Jan 9.

25.

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. Epub 2016 Oct 10.

26.

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldovan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Caánovas A, Medrano JF, Thomas MG, Iloska D, Plecitá-Hlavatá L, Ježek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR.

Circulation. 2016 Oct 11;134(15):1105-1121. Epub 2016 Aug 25. Erratum in: Circulation. 2019 Jan 8;139(2):e1. Moldvan, Radu [corrected to Moldovan, Radu].

27.

Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics.

Deep G, Kumar R, Nambiar DK, Jain AK, Ramteke AM, Serkova NJ, Agarwal C, Agarwal R.

Mol Carcinog. 2017 Mar;56(3):833-848. doi: 10.1002/mc.22537. Epub 2016 Sep 5.

28.

Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents.

Serkova NJ, Eckhardt SG.

Front Oncol. 2016 Jul 15;6:152. doi: 10.3389/fonc.2016.00152. eCollection 2016. Review.

29.

Clinical translation of ferumoxytol-based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population.

Fredrickson J, Serkova NJ, Wyatt SK, Carano RA, Pirzkall A, Rhee I, Rosen LS, Bessudo A, Weekes C, de Crespigny A.

Magn Reson Med. 2017 Feb;77(2):814-825. doi: 10.1002/mrm.26167. Epub 2016 Feb 26.

30.

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J.

J Clin Invest. 2015 Dec;125(12):4666-80. doi: 10.1172/JCI83024. Epub 2015 Nov 9.

31.

Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism.

Sartorius CA, Hanna CT, Gril B, Cruz H, Serkova NJ, Huber KM, Kabos P, Schedin TB, Borges VF, Steeg PS, Cittelly DM.

Oncogene. 2016 Jun 2;35(22):2881-92. doi: 10.1038/onc.2015.353. Epub 2015 Sep 28.

32.

Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus.

Thurman JM, Serkova NJ.

Version 2. F1000Res. 2015 Jun 16 [revised 2015 Jan 1];4:153. doi: 10.12688/f1000research.6587.2. eCollection 2015. Review.

33.

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 1;309(5):L435-40. doi: 10.1152/ajplung.00169.2015. Epub 2015 Jun 26.

34.

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts.

Schlaepfer IR, Glodé LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH.

Mol Imaging Biol. 2015 Aug;17(4):529-38. doi: 10.1007/s11307-014-0814-4.

35.

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J.

Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29.

36.

High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties.

Wang G, Inturi S, Serkova NJ, Merkulov S, McCrae K, Russek SE, Banda NK, Simberg D.

ACS Nano. 2014 Dec 23;8(12):12437-49. doi: 10.1021/nn505126b. Epub 2014 Nov 26.

37.

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.

Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G.

Mol Carcinog. 2015 Nov;54(11):1417-29. doi: 10.1002/mc.22220. Epub 2014 Sep 22.

38.

1H-NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators.

Bogren LK, Murphy CJ, Johnston EL, Sinha N, Serkova NJ, Drew KL.

PLoS One. 2014 Sep 11;9(9):e107493. doi: 10.1371/journal.pone.0107493. eCollection 2014.

39.

Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

Rudolph MC, Wellberg EA, Lewis AS, Terrell KL, Merz AL, Maluf NK, Serkova NJ, Anderson SM.

J Lipid Res. 2014 Jun;55(6):1052-65. doi: 10.1194/jlr.M044487. Epub 2014 Apr 25.

40.

Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits.

Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA.

Exp Neurol. 2014 Jun;256:7-16. doi: 10.1016/j.expneurol.2014.03.008. Epub 2014 Mar 25.

41.

Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging.

Thurman JM, Serkova NJ.

Adv Chronic Kidney Dis. 2013 Nov;20(6):488-99. doi: 10.1053/j.ackd.2013.06.001. Review.

42.

ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury.

Frey L, Lepkin A, Schickedanz A, Huber K, Brown MS, Serkova N.

Neurol Res. 2014 Jan;36(1):26-37. doi: 10.1179/1743132813Y.0000000269. Epub 2013 Dec 6.

43.

Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.

Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW.

PLoS One. 2013 Sep 18;8(9):e74809. doi: 10.1371/journal.pone.0074809. eCollection 2013.

44.

Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.

Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW.

PLoS One. 2013 Aug 15;8(8):e73267. doi: 10.1371/journal.pone.0073267. eCollection 2013.

45.

Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis.

Wilson J, Higgins D, Hutting H, Serkova N, Baird C, Khailova L, Queensland K, Vu Tran Z, Weitzel L, Wischmeyer PE.

Crit Care. 2013 Sep 10;17(5):R195. doi: 10.1186/cc12889.

46.

Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.

Derry MM, Raina K, Balaiya V, Jain AK, Shrotriya S, Huber KM, Serkova NJ, Agarwal R, Agarwal C.

Cancer Prev Res (Phila). 2013 Jul;6(7):625-33. doi: 10.1158/1940-6207.CAPR-13-0053. Epub 2013 May 2.

47.

Left ventricular assist device effects on metabolic substrates in the failing heart.

Weitzel LB, Ambardekar AV, Brieke A, Cleveland JC, Serkova NJ, Wischmeyer PE, Lowes BD.

PLoS One. 2013;8(4):e60292. doi: 10.1371/journal.pone.0060292. Epub 2013 Apr 1.

48.

Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.

Bradshaw-Pierce EL, Pitts TM, Kulikowski G, Selby H, Merz AL, Gustafson DL, Serkova NJ, Eckhardt SG, Weekes CD.

PLoS One. 2013;8(3):e58089. doi: 10.1371/journal.pone.0058089. Epub 2013 Mar 8.

49.

Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.

Raina K, Agarwal C, Wadhwa R, Serkova NJ, Agarwal R.

Autophagy. 2013 May;9(5):697-713. doi: 10.4161/auto.23960. Epub 2013 Feb 27.

50.

First-in-human phase I trial of two schedules of OSI-930, a novel multikinase inhibitor, incorporating translational proof-of-mechanism studies.

Yap TA, Arkenau HT, Camidge DR, George S, Serkova NJ, Gwyther SJ, Spratlin JL, Lal R, Spicer J, Desouza NM, Leach MO, Chick J, Poondru S, Boinpally R, Gedrich R, Brock K, Stephens A, Eckhardt SG, Kaye SB, Demetri G, Scurr M.

Clin Cancer Res. 2013 Feb 15;19(4):909-19. doi: 10.1158/1078-0432.CCR-12-2258. Epub 2013 Feb 12.

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