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Items: 22


Potent LpxC Inhibitors with In Vitro Activity Against Multi-Drug Resistant Pseudomonas aeruginosa.

Krause KM, Haglund CM, Hebner C, Serio AW, Lee G, Nieto V, Cohen F, Kane TR, Machajewski TD, Hildebrandt D, Pillar C, Thwaites M, Hall D, Miesel L, Hackel M, Burek A, Andrews LD, Armstrong E, Swem L, Jubb A, Cirz RT.

Antimicrob Agents Chemother. 2019 Aug 26. pii: AAC.00977-19. doi: 10.1128/AAC.00977-19. [Epub ahead of print]


Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.

Andrews LD, Kane TR, Dozzo P, Haglund CM, Hilderbrandt DJ, Linsell MS, Machajewski T, McEnroe G, Serio AW, Wlasichuk KB, Neau DB, Pakhomova S, Waldrop GL, Sharp M, Pogliano J, Cirz RT, Cohen F.

J Med Chem. 2019 Aug 22;62(16):7489-7505. doi: 10.1021/acs.jmedchem.9b00625. Epub 2019 Aug 9.


Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.

Cohen F, Aggen JB, Andrews LD, Assar Z, Boggs J, Choi T, Dozzo P, Easterday AN, Haglund CM, Hildebrandt DJ, Holt MC, Joly K, Jubb A, Kamal Z, Kane TR, Konradi AW, Krause KM, Linsell MS, Machajewski TD, Miroshnikova O, Moser HE, Nieto V, Phan T, Plato C, Serio AW, Seroogy J, Shakhmin A, Stein AJ, Sun AD, Sviridov S, Wang Z, Wlasichuk K, Yang W, Zhou X, Zhu H, Cirz RT.

ChemMedChem. 2019 Aug 20;14(16):1560-1572. doi: 10.1002/cmdc.201900287. Epub 2019 Aug 5.


Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae.

Serio AW, Keepers T, Krause KM.

Open Forum Infect Dis. 2019 Mar 12;6(4):ofz123. doi: 10.1093/ofid/ofz123. eCollection 2019 Apr.


Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

McKinnell JA, Dwyer JP, Talbot GH, Connolly LE, Friedland I, Smith A, Jubb AM, Serio AW, Krause KM, Daikos GL; CARE Study Group.

N Engl J Med. 2019 Feb 21;380(8):791-793. doi: 10.1056/NEJMc1807634. No abstract available.


In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions.

Castanheira M, Davis AP, Serio AW, Krause KM, Mendes RE.

Diagn Microbiol Infect Dis. 2019 May;94(1):73-77. doi: 10.1016/j.diagmicrobio.2018.10.023. Epub 2018 Dec 5.


Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.

Serio AW, Keepers T, Andrews L, Krause KM.

EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018. Review.


Activity of plazomicin in combination with other antibiotics against multidrug-resistant Enterobacteriaceae.

Thwaites M, Hall D, Stoneburner A, Shinabarger D, Serio AW, Krause KM, Marra A, Pillar C.

Diagn Microbiol Infect Dis. 2018 Dec;92(4):338-345. doi: 10.1016/j.diagmicrobio.2018.07.006. Epub 2018 Jul 11.


Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae.

Thwaites M, Hall D, Shinabarger D, Serio AW, Krause KM, Marra A, Pillar C.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00236-18. doi: 10.1128/AAC.00236-18. Print 2018 Aug.


In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Isolates Collected from U.S. Hospitals and Comparative Activities of Aminoglycosides against Carbapenem-Resistant Enterobacteriaceae and Isolates Carrying Carbapenemase Genes.

Castanheira M, Davis AP, Mendes RE, Serio AW, Krause KM, Flamm RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00313-18. doi: 10.1128/AAC.00313-18. Print 2018 Aug.


Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD.

ACS Infect Dis. 2018 Jun 8;4(6):980-987. doi: 10.1021/acsinfecdis.8b00001. Epub 2018 Apr 19.


Antimicrobial activity of plazomicin against Enterobacteriaceae-producing carbapenemases from 50 Brazilian medical centers.

Martins AF, Bail L, Ito CAS, da Silva Nogueira K, Dalmolin TV, Martins AS, Rocha JLL, Serio AW, Tuon FF.

Diagn Microbiol Infect Dis. 2018 Mar;90(3):228-232. doi: 10.1016/j.diagmicrobio.2017.11.004. Epub 2017 Nov 10.


New Antimicrobial Agents  …  but No Susceptibility Tests!

Ambler JE, Krause KM, Steenbergen JN, Scangarella-Oman NE, Miller LA, Bhagwat SS, Serio AW, Chesnel L, Mahoney NM, Motyl MR, Critchley IA, Iaconis JP, Stone GG, Alder J, Xerri L, McCurdy SP, van Veenhuyzen DF, Grossman T, Echols RM, Williams G, Bradford PA.

Clin Infect Dis. 2016 Dec 1;63(11):1530-1531. Epub 2016 Aug 31. No abstract available.


Aminoglycosides: An Overview.

Krause KM, Serio AW, Kane TR, Connolly LE.

Cold Spring Harb Perspect Med. 2016 Jun 1;6(6). pii: a027029. doi: 10.1101/cshperspect.a027029. Review.


Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis.

Pechter KB, Meyer FM, Serio AW, Stülke J, Sonenshein AL.

J Bacteriol. 2013 Apr;195(7):1525-37. doi: 10.1128/JB.01690-12. Epub 2013 Jan 25.


Expression of an epitope-tagged virulence protein in Rickettsia parkeri using transposon insertion.

Welch MD, Reed SC, Lamason RL, Serio AW.

PLoS One. 2012;7(5):e37310. doi: 10.1371/journal.pone.0037310. Epub 2012 May 18.


Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway.

Reed SC, Serio AW, Welch MD.

Cell Microbiol. 2012 Apr;14(4):529-45. doi: 10.1111/j.1462-5822.2011.01739.x. Epub 2012 Jan 16.


Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.

Serio AW, Jeng RL, Haglund CM, Reed SC, Welch MD.

Cell Host Microbe. 2010 May 20;7(5):388-98. doi: 10.1016/j.chom.2010.04.008.


Expression of yeast mitochondrial aconitase in Bacillus subtilis.

Serio AW, Sonenshein AL.

J Bacteriol. 2006 Sep;188(17):6406-10.


Bacillus subtilis aconitase is required for efficient late-sporulation gene expression.

Serio AW, Pechter KB, Sonenshein AL.

J Bacteriol. 2006 Sep;188(17):6396-405. Erratum in: J Bacteriol. 2007 Jul;189(14):5403.


Metabolic imbalance and sporulation in an isocitrate dehydrogenase mutant of Bacillus subtilis.

Matsuno K, Blais T, Serio AW, Conway T, Henkin TM, Sonenshein AL.

J Bacteriol. 1999 Jun;181(11):3382-91.

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