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Items: 1 to 50 of 503

1.

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.

Norris PC, Skulas-Ray AC, Riley I, Richter CK, Kris-Etherton PM, Jensen GL, Serhan CN, Maddipati KR.

Sci Rep. 2018 Dec 21;8(1):18050. doi: 10.1038/s41598-018-36679-4.

2.

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR.

Neuron. 2018 Dec 19;100(6):1292-1311. doi: 10.1016/j.neuron.2018.11.009. Review.

PMID:
30571942
3.

Novel Mediators and Mechanisms in the Resolution of Infectious Inflammation: Evidence for Vagus Regulation.

Serhan CN, de la Rosa X, Jouvene C.

J Intern Med. 2018 Dec 19. doi: 10.1111/joim.12871. [Epub ahead of print]

PMID:
30565762
4.

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, Serhan CN.

Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. doi: 10.1016/j.chembiol.2018.10.023. [Epub ahead of print]

PMID:
30554914
5.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM.

JCI Insight. 2018 Dec 6;3(23). pii: 124039. doi: 10.1172/jci.insight.124039. [Epub ahead of print]

6.

Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells.

Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP, Serhan CN, Dartt DA.

Exp Eye Res. 2018 Dec 1;180:53-62. doi: 10.1016/j.exer.2018.11.018. [Epub ahead of print]

PMID:
30513286
7.

Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA.

Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV.

Chemistry. 2018 Dec 4. doi: 10.1002/chem.201806029. [Epub ahead of print]

PMID:
30511787
8.

Resolution of sickle cell disease associated inflammation and tissue damage with 17R-Resolvin D1.

Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L.

Blood. 2018 Nov 7. pii: blood-2018-07-865378. doi: 10.1182/blood-2018-07-865378. [Epub ahead of print]

PMID:
30404812
9.

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids.

Serhan CN, de la Rosa X, Jouvene CC.

J Immunol. 2018 Dec 1;201(11):3161-3165. doi: 10.4049/jimmunol.1800806. Epub 2018 Oct 24.

PMID:
30355784
10.

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.

Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA.

Mucosal Immunol. 2019 Jan;12(1):145-153. doi: 10.1038/s41385-018-0089-1. Epub 2018 Oct 2.

PMID:
30279513
11.

Correction for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection".

Diaz LA, Altman NH, Khan WN, Serhan CN, Adkins B.

Infect Immun. 2018 Sep 21;86(10). pii: e00363-18. doi: 10.1128/IAI.00363-18. Print 2018 Oct. No abstract available.

12.

Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents.

Tungen JE, Aursnes M, Ramon S, Colas RA, Serhan CN, Olberg DE, Nuruddin S, Willoch F, Hansen TV.

Org Biomol Chem. 2018 Sep 19;16(36):6818-6823. doi: 10.1039/c8ob01232f.

PMID:
30204204
13.

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23.

PMID:
30139917
14.

Targeting lipid mediators in cancer biology.

Sulciner ML, Gartung A, Gilligan MM, Serhan CN, Panigrahy D.

Cancer Metastasis Rev. 2018 Sep;37(2-3):557-572. doi: 10.1007/s10555-018-9754-9.

PMID:
30136088
15.

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

Zhang L, Terrando N, Xu ZZ, Bang S, Jordt SE, Maixner W, Serhan CN, Ji RR.

Front Pharmacol. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412. eCollection 2018.

16.

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.

Serhan CN, Levy BD.

J Clin Invest. 2018 Jul 2;128(7):2657-2669. doi: 10.1172/JCI97943. Epub 2018 May 14. Review.

17.

Identification of proresolving and inflammatory lipid mediators in human psoriasis.

Sorokin AV, Norris PC, English JT, Dey AK, Chaturvedi A, Baumer Y, Silverman J, Playford MP, Serhan CN, Mehta NN.

J Clin Lipidol. 2018 Jul - Aug;12(4):1047-1060. doi: 10.1016/j.jacl.2018.03.091. Epub 2018 Apr 6.

PMID:
29730187
18.

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells.

Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA.

Exp Eye Res. 2018 Aug;173:64-72. doi: 10.1016/j.exer.2018.04.015. Epub 2018 Apr 25.

PMID:
29702100
19.

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology.

Dalli J, Serhan CN.

Br J Pharmacol. 2018 Apr 21. doi: 10.1111/bph.14336. [Epub ahead of print] Review.

PMID:
29679485
20.

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

de la Rosa X, Norris PC, Chiang N, Rodriguez AR, Spur BW, Serhan CN.

Am J Pathol. 2018 Apr;188(4):950-966. doi: 10.1016/j.ajpath.2018.01.004.

PMID:
29571326
21.

Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.

Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer RP, Serhan CN, Gilroy DW.

JCI Insight. 2018 Mar 22;3(6). pii: 94463. doi: 10.1172/jci.insight.94463. [Epub ahead of print]

22.

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.

Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M.

J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17.

PMID:
29559341
23.

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

Norris PC, Serhan CN.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):553-561. doi: 10.1016/j.bbrc.2018.03.037. Epub 2018 Mar 15.

PMID:
29524409
24.

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

Sham HP, Walker KH, Abdulnour RE, Krishnamoorthy N, Douda DN, Norris PC, Barkas I, Benito-Figueroa S, Colby JK, Serhan CN, Levy BD.

J Immunol. 2018 Apr 15;200(8):2757-2766. doi: 10.4049/jimmunol.1602090. Epub 2018 Mar 9.

PMID:
29523657
25.

Splenic leukocytes define the resolution of inflammation in heart failure.

Halade GV, Norris PC, Kain V, Serhan CN, Ingle KA.

Sci Signal. 2018 Mar 6;11(520). pii: eaao1818. doi: 10.1126/scisignal.aao1818.

26.

Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TE.

Sci Rep. 2018 Mar 2;8(1):4143. doi: 10.1038/s41598-018-22520-5.

27.

New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses.

Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CN.

FASEB J. 2018 Jul;32(7):4043-4052. doi: 10.1096/fj.201701493R. Epub 2018 Feb 28.

PMID:
29490167
28.

Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure.

Halade GV, Kain V, Serhan CN.

FASEB J. 2018 Jul;32(7):3717-3729. doi: 10.1096/fj.201701173RR. Epub 2018 Feb 13.

PMID:
29455574
29.

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.

Winkler JW, Libreros S, De La Rosa X, Sansbury BE, Norris PC, Chiang N, Fichtner D, Keyes GS, Wourms N, Spite M, Serhan CN.

J Leukoc Biol. 2018 Jan 29. doi: 10.1002/JLB.3MI0617-254R. [Epub ahead of print]

PMID:
29377345
30.

Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.

Dalli J, Colas RA, Walker ME, Serhan CN.

Methods Mol Biol. 2018;1730:59-72. doi: 10.1007/978-1-4939-7592-1_4.

PMID:
29363065
31.

Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2.

Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, Matos Dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB.

Infect Immun. 2018 Mar 22;86(4). pii: e00688-17. doi: 10.1128/IAI.00688-17. Print 2018 Apr.

32.

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.

Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CN.

Nat Commun. 2018 Jan 4;9(1):59. doi: 10.1038/s41467-017-02538-5.

33.

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation.

Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R, Gilroy DW.

Clin Pharmacol Ther. 2018 Oct;104(4):675-686. doi: 10.1002/cpt.980. Epub 2018 Jan 30.

34.

Resolvins suppress tumor growth and enhance cancer therapy.

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D.

J Exp Med. 2018 Jan 2;215(1):115-140. doi: 10.1084/jem.20170681. Epub 2017 Nov 30.

35.

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.

Dalli J, Serhan CN.

Front Immunol. 2017 Nov 1;8:1400. doi: 10.3389/fimmu.2017.01400. eCollection 2017. Review.

36.

Immunoresolvents signaling molecules at intersection between the brain and immune system.

Dalli J, Serhan CN.

Curr Opin Immunol. 2018 Feb;50:48-54. doi: 10.1016/j.coi.2017.10.007. Epub 2017 Nov 16. Review.

37.

Atherosclerosis, Periodontal Disease, and Treatment with Resolvins.

Hamilton JA, Hasturk H, Kantarci A, Serhan CN, Van Dyke T.

Curr Atheroscler Rep. 2017 Nov 6;19(12):57. doi: 10.1007/s11883-017-0696-4. Review.

PMID:
29110146
38.

Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming.

Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia D.

Nat Biomed Eng. 2017;1. pii: 0094. doi: 10.1038/s41551-017-0094. Epub 2017 Jun 30.

39.

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TE.

Sci Rep. 2017 Oct 9;7(1):12848. doi: 10.1038/s41598-017-13185-7. Erratum in: Sci Rep. 2018 Mar 2;8(1):4143.

40.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

41.

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways.

Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4530-4544. doi: 10.1167/iovs.17-21914.

42.

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration.

Serhan CN, Chiang N, Dalli J.

Mol Aspects Med. 2018 Dec;64:1-17. doi: 10.1016/j.mam.2017.08.002. Epub 2017 Sep 1. Review.

PMID:
28802833
43.

A cluster of immunoresolvents links coagulation to innate host defense in human blood.

Norris PC, Libreros S, Chiang N, Serhan CN.

Sci Signal. 2017 Aug 1;10(490). pii: eaan1471. doi: 10.1126/scisignal.aan1471.

44.

Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection.

Diaz LA, Altman NH, Khan W, Serhan CN, Adkins B.

Infect Immun. 2017 Sep 20;85(10). pii: e00464-17. doi: 10.1128/IAI.00464-17. Print 2017 Oct. Erratum in: Infect Immun. 2018 Sep 21;86(10):.

45.

The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions.

Hansen TV, Dalli J, Serhan CN.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:103-110. doi: 10.1016/j.prostaglandins.2017.06.003. Epub 2017 Jun 7. Review.

46.

Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.

Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti M.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3963-3968. doi: 10.1073/pnas.1617290114. Epub 2017 Mar 29.

47.

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors.

Chiang N, Serhan CN.

Mol Aspects Med. 2017 Dec;58:114-129. doi: 10.1016/j.mam.2017.03.005. Epub 2017 Mar 31. Review.

48.

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology.

Serhan CN.

Mol Aspects Med. 2017 Dec;58:1-11. doi: 10.1016/j.mam.2017.03.001. Epub 2017 Mar 3. Review.

49.

NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4 Synthesis.

Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AMK.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):713-726. doi: 10.1164/rccm.201604-0892OC.

50.

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.

English JT, Norris PC, Hodges RR, Dartt DA, Serhan CN.

Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:17-27. doi: 10.1016/j.plefa.2017.01.004. Epub 2017 Jan 19.

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