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Items: 1 to 50 of 518

1.

Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.

Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, Vedele F, Ghiglieri V, Picconi B, Di Lazzaro G, Schirinzi T, Sancesario G, Casadei N, Riess O, Bernardini S, Pisani A, Calabresi P, Viscomi MT, Serhan CN, Chiurchiù V, D'Amelio M, Mercuri NB.

Nat Commun. 2019 Oct 14;10(1):4725. doi: 10.1038/s41467-019-12538-2.

PMID:
31611555
2.

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

Jouvene CC, Shay AE, Soens MA, Norris PC, Haeggström JZ, Serhan CN.

FASEB J. 2019 Oct 5:fj201902003R. doi: 10.1096/fj.201902003R. [Epub ahead of print]

PMID:
31589826
3.

A tribute to Gerald Weissmann (1930-2019).

Abramson SB, Anderson PJ, Buyon JP, Cronstein BN, Pederson T, Philips MR, Serhan CN.

J Clin Invest. 2019 Oct 7. pii: 133490. doi: 10.1172/JCI133490. [Epub ahead of print] No abstract available.

4.

Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.

Dartt DA, Hodges RR, Serhan CN.

Adv Exp Med Biol. 2019;1161:13-25. doi: 10.1007/978-3-030-21735-8_3. Review.

PMID:
31562618
5.

Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys.

Becker F, Romero E, Goetzmann J, Hasselschwert DL, Dray B, Vanchiere J, Fontenot J, Yun JW, Norris PC, White L, Musso M, Serhan CN, Alexander JS, Gavins FNE.

Am J Pathol. 2019 Oct;189(10):1953-1972. doi: 10.1016/j.ajpath.2019.05.013.

PMID:
31547920
6.

Adipocytes promote ovarian cancer chemoresistance.

Yang J, Zaman MM, Vlasakov I, Roy R, Huang L, Martin CR, Freedman SD, Serhan CN, Moses MA.

Sci Rep. 2019 Sep 16;9(1):13316. doi: 10.1038/s41598-019-49649-1.

7.

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.

Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, Vedele F, Ghiglieri V, Picconi B, Di Lazzaro G, Schirinzi T, Sancesario G, Casadei N, Riess O, Bernardini S, Pisani A, Calabresi P, Viscomi MT, Serhan CN, Chiurchiù V, D'Amelio M, Mercuri NB.

Nat Commun. 2019 Sep 2;10(1):3945. doi: 10.1038/s41467-019-11928-w. Erratum in: Nat Commun. 2019 Oct 14;10(1):4725.

8.

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy.

Luo X, Gu Y, Tao X, Serhan CN, Ji RR.

Front Pharmacol. 2019 Jul 5;10:745. doi: 10.3389/fphar.2019.00745. eCollection 2019.

9.

Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.

Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN, Gerstmeier J, Werz O.

J Immunol. 2019 Aug 15;203(4):1031-1043. doi: 10.4049/jimmunol.1900236. Epub 2019 Jul 12.

PMID:
31300512
10.

Resolvin D4 attenuates the severity of pathological thrombosis in mice.

Cherpokova D, Jouvene CC, Libreros S, DeRoo E, Chu L, de la Rosa X, Norris P, Wagner DD, Serhan CN.

Blood. 2019 Jul 12. pii: blood.2018886317. doi: 10.1182/blood.2018886317. [Epub ahead of print]

PMID:
31300403
11.

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.

Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP.

J Clin Invest. 2019 Jun 17;129(7):2964-2979. doi: 10.1172/JCI127282. eCollection 2019 Jun 17.

12.

Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells.

Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA.

FASEB J. 2019 Jul;33(7):8468-8478. doi: 10.1096/fj.201802467R. Epub 2019 Apr 23.

PMID:
31013438
13.

Aspirin-triggered proresolving mediators stimulate resolution in cancer.

Gilligan MM, Gartung A, Sulciner ML, Norris PC, Sukhatme VP, Bielenberg DR, Huang S, Kieran MW, Serhan CN, Panigrahy D.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6292-6297. doi: 10.1073/pnas.1804000116. Epub 2019 Mar 12.

14.

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.

Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J.

FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8.

PMID:
30735438
15.

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes.

Hansen TV, Vik A, Serhan CN.

Front Pharmacol. 2019 Jan 17;9:1582. doi: 10.3389/fphar.2018.01582. eCollection 2018. Review.

16.

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.

Norris PC, Skulas-Ray AC, Riley I, Richter CK, Kris-Etherton PM, Jensen GL, Serhan CN, Maddipati KR.

Sci Rep. 2018 Dec 21;8(1):18050. doi: 10.1038/s41598-018-36679-4.

17.

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR.

Neuron. 2018 Dec 19;100(6):1292-1311. doi: 10.1016/j.neuron.2018.11.009. Review.

PMID:
30571942
18.

Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation.

Serhan CN, de la Rosa X, Jouvene C.

J Intern Med. 2019 Sep;286(3):240-258. doi: 10.1111/joim.12871. Epub 2019 Jan 18.

PMID:
30565762
19.

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, Serhan CN.

Cell Chem Biol. 2019 Feb 21;26(2):244-254.e4. doi: 10.1016/j.chembiol.2018.10.023. Epub 2018 Dec 13.

PMID:
30554914
20.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM.

JCI Insight. 2018 Dec 6;3(23). pii: 124039. doi: 10.1172/jci.insight.124039.

21.

Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells.

Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP, Serhan CN, Dartt DA.

Exp Eye Res. 2019 Mar;180:53-62. doi: 10.1016/j.exer.2018.11.018. Epub 2018 Dec 1.

PMID:
30513286
22.

Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA.

Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV.

Chemistry. 2019 Jan 28;25(6):1476-1480. doi: 10.1002/chem.201806029. Epub 2018 Dec 20.

PMID:
30511787
23.

Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1.

Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L.

Blood. 2019 Jan 17;133(3):252-265. doi: 10.1182/blood-2018-07-865378. Epub 2018 Nov 7.

PMID:
30404812
24.

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids.

Serhan CN, de la Rosa X, Jouvene CC.

J Immunol. 2018 Dec 1;201(11):3161-3165. doi: 10.4049/jimmunol.1800806. Epub 2018 Oct 24.

PMID:
30355784
25.

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.

Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA.

Mucosal Immunol. 2019 Jan;12(1):145-153. doi: 10.1038/s41385-018-0089-1. Epub 2018 Oct 2.

26.

Correction for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection".

Diaz LA, Altman NH, Khan WN, Serhan CN, Adkins B.

Infect Immun. 2018 Sep 21;86(10). pii: e00363-18. doi: 10.1128/IAI.00363-18. Print 2018 Oct. No abstract available.

27.

Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents.

Tungen JE, Aursnes M, Ramon S, Colas RA, Serhan CN, Olberg DE, Nuruddin S, Willoch F, Hansen TV.

Org Biomol Chem. 2018 Sep 19;16(36):6818-6823. doi: 10.1039/c8ob01232f.

28.

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.

Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23.

29.

Targeting lipid mediators in cancer biology.

Sulciner ML, Gartung A, Gilligan MM, Serhan CN, Panigrahy D.

Cancer Metastasis Rev. 2018 Sep;37(2-3):557-572. doi: 10.1007/s10555-018-9754-9. Review.

PMID:
30136088
30.

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

Zhang L, Terrando N, Xu ZZ, Bang S, Jordt SE, Maixner W, Serhan CN, Ji RR.

Front Pharmacol. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412. eCollection 2018.

31.

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.

Serhan CN, Levy BD.

J Clin Invest. 2018 Jul 2;128(7):2657-2669. doi: 10.1172/JCI97943. Epub 2018 May 14. Review.

32.

Identification of proresolving and inflammatory lipid mediators in human psoriasis.

Sorokin AV, Norris PC, English JT, Dey AK, Chaturvedi A, Baumer Y, Silverman J, Playford MP, Serhan CN, Mehta NN.

J Clin Lipidol. 2018 Jul - Aug;12(4):1047-1060. doi: 10.1016/j.jacl.2018.03.091. Epub 2018 Apr 6.

33.

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells.

Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA.

Exp Eye Res. 2018 Aug;173:64-72. doi: 10.1016/j.exer.2018.04.015. Epub 2018 Apr 25.

34.

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology.

Dalli J, Serhan CN.

Br J Pharmacol. 2019 Apr;176(8):1024-1037. doi: 10.1111/bph.14336. Epub 2018 Jun 3. Review.

35.

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

de la Rosa X, Norris PC, Chiang N, Rodriguez AR, Spur BW, Serhan CN.

Am J Pathol. 2018 Apr;188(4):950-966. doi: 10.1016/j.ajpath.2018.01.004.

36.

Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.

Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer RP, Serhan CN, Gilroy DW.

JCI Insight. 2018 Mar 22;3(6). pii: 94463. doi: 10.1172/jci.insight.94463.

37.

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.

Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M.

J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17.

38.

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

Norris PC, Serhan CN.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):553-561. doi: 10.1016/j.bbrc.2018.03.037. Epub 2018 Mar 15. Review.

39.

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

Sham HP, Walker KH, Abdulnour RE, Krishnamoorthy N, Douda DN, Norris PC, Barkas I, Benito-Figueroa S, Colby JK, Serhan CN, Levy BD.

J Immunol. 2018 Apr 15;200(8):2757-2766. doi: 10.4049/jimmunol.1602090. Epub 2018 Mar 9.

40.

Splenic leukocytes define the resolution of inflammation in heart failure.

Halade GV, Norris PC, Kain V, Serhan CN, Ingle KA.

Sci Signal. 2018 Mar 6;11(520). pii: eaao1818. doi: 10.1126/scisignal.aao1818.

41.

Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TE.

Sci Rep. 2018 Mar 2;8(1):4143. doi: 10.1038/s41598-018-22520-5.

42.

New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses.

Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CN.

FASEB J. 2018 Jul;32(7):4043-4052. doi: 10.1096/fj.201701493R. Epub 2018 Feb 28.

43.

Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure.

Halade GV, Kain V, Serhan CN.

FASEB J. 2018 Jul;32(7):3717-3729. doi: 10.1096/fj.201701173RR. Epub 2018 Feb 13.

44.

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.

Winkler JW, Libreros S, De La Rosa X, Sansbury BE, Norris PC, Chiang N, Fichtner D, Keyes GS, Wourms N, Spite M, Serhan CN.

J Leukoc Biol. 2018 Jan 29. doi: 10.1002/JLB.3MI0617-254R. [Epub ahead of print]

45.

Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.

Dalli J, Colas RA, Walker ME, Serhan CN.

Methods Mol Biol. 2018;1730:59-72. doi: 10.1007/978-1-4939-7592-1_4.

PMID:
29363065
46.

Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2.

Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, Matos Dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB.

Infect Immun. 2018 Mar 22;86(4). pii: e00688-17. doi: 10.1128/IAI.00688-17. Print 2018 Apr.

47.

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.

Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CN.

Nat Commun. 2018 Jan 4;9(1):59. doi: 10.1038/s41467-017-02538-5.

48.

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation.

Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R, Gilroy DW.

Clin Pharmacol Ther. 2018 Oct;104(4):675-686. doi: 10.1002/cpt.980. Epub 2018 Jan 30.

49.

Resolvins suppress tumor growth and enhance cancer therapy.

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D.

J Exp Med. 2018 Jan 2;215(1):115-140. doi: 10.1084/jem.20170681. Epub 2017 Nov 30.

50.

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.

Dalli J, Serhan CN.

Front Immunol. 2017 Nov 1;8:1400. doi: 10.3389/fimmu.2017.01400. eCollection 2017. Review.

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