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Items: 16

1.

A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer.

Piskol R, Huw L, Sergin I, Kljin C, Modrusan Z, Kim D, Kljavin N, Tam R, Patel R, Burton J, Penuel E, Qu X, Koeppen H, Sumiyoshi T, de Sauvage F, Lackner MR, de Sousa E Melo F, Kabbarah O.

Clin Cancer Res. 2019 Jul 15;25(14):4431-4442. doi: 10.1158/1078-0432.CCR-18-3032. Epub 2019 Apr 19.

PMID:
31004000
2.

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis.

Evans TD, Jeong SJ, Zhang X, Sergin I, Razani B.

Autophagy. 2018;14(4):724-726. doi: 10.1080/15548627.2018.1434373. Epub 2018 Mar 8.

3.

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damås JK, Razani B, Flo TH, Bjørkøy G.

Autophagy. 2017 Oct 3;13(10):1664-1678. doi: 10.1080/15548627.2017.1345411. Epub 2017 Aug 18.

4.

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.

Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B.

Nat Commun. 2017 Jun 7;8:15750. doi: 10.1038/ncomms15750.

5.

Target acquired: Selective autophagy in cardiometabolic disease.

Evans TD, Sergin I, Zhang X, Razani B.

Sci Signal. 2017 Feb 28;10(468). pii: eaag2298. doi: 10.1126/scisignal.aag2298. Review.

6.

Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization.

Sergin I, Jong YI, Harmon SK, Kumar V, O'Malley KL.

J Biol Chem. 2017 Mar 3;292(9):3637-3655. doi: 10.1074/jbc.M116.757724. Epub 2017 Jan 17.

7.

Anti-angiogenic Nanotherapy Inhibits Airway Remodeling and Hyper-responsiveness of Dust Mite Triggered Asthma in the Brown Norway Rat.

Lanza GM, Jenkins J, Schmieder AH, Moldobaeva A, Cui G, Zhang H, Yang X, Zhong Q, Keupp J, Sergin I, Paranandi KS, Eldridge L, Allen JS, Williams T, Scott MJ, Razani B, Wagner EM.

Theranostics. 2017 Jan 1;7(2):377-389. doi: 10.7150/thno.16627. eCollection 2017.

8.

Modulating Oxysterol Sensing to Control Macrophage Apoptosis and Atherosclerosis.

Evans TD, Sergin I, Zhang X, Razani B.

Circ Res. 2016 Dec 9;119(12):1258-1261. No abstract available.

9.

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.

Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, Fan D.

J Lipid Res. 2016 Jun;57(6):1006-16. doi: 10.1194/jlr.M065888. Epub 2016 Apr 10.

10.

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.

Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, Razani B.

Sci Signal. 2016 Jan 5;9(409):ra2. doi: 10.1126/scisignal.aad5614.

11.

Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.

Sergin I, Evans TD, Razani B.

Curr Opin Lipidol. 2015 Oct;26(5):394-404. doi: 10.1097/MOL.0000000000000213. Review.

12.

Hypoxia in plaque macrophages: a new danger signal for interleukin-1β activation?

Sergin I, Evans TD, Bhattacharya S, Razani B.

Circ Res. 2014 Oct 24;115(10):817-20. doi: 10.1161/CIRCRESAHA.114.305197. No abstract available.

13.

Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.

Jong YJ, Sergin I, Purgert CA, O'Malley KL.

Mol Pharmacol. 2014 Dec;86(6):774-85. doi: 10.1124/mol.114.094763. Epub 2014 Oct 17. Review.

14.

Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.

Emanuel R, Sergin I, Bhattacharya S, Turner J, Epelman S, Settembre C, Diwan A, Ballabio A, Razani B.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1942-1952. doi: 10.1161/ATVBAHA.114.303342. Epub 2014 Jul 24.

15.

Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis.

Sergin I, Razani B.

Trends Endocrinol Metab. 2014 May;25(5):225-34. doi: 10.1016/j.tem.2014.03.010. Epub 2014 Apr 17. Review.

16.

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.

Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL.

Immunity. 2014 Jan 16;40(1):91-104. doi: 10.1016/j.immuni.2013.11.019.

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