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Items: 1 to 50 of 76

1.

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

Melnyk P, Vingtdeux V, Burlet S, Eddarkaoui S, Grosjean ME, Larchanché PE, Hochart G, Sergheraert C, Estrella C, Barrier M, Poix V, Plancq P, Lannoo C, Hamdane M, Delacourte A, Verwaerde P, Buée L, Sergeant N.

ACS Chem Neurosci. 2015 Apr 15;6(4):559-69. doi: 10.1021/cn5003013. Epub 2015 Feb 6.

PMID:
25611616
2.

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.

Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P.

Eur J Med Chem. 2008 Oct;43(10):2045-55. doi: 10.1016/j.ejmech.2007.11.003. Epub 2007 Nov 19.

PMID:
18226428
3.

Synthesis and antimalarial activity of new analogues of amodiaquine.

Delarue-Cochin S, Paunescu E, Maes L, Mouray E, Sergheraert C, Grellier P, Melnyk P.

Eur J Med Chem. 2008 Feb;43(2):252-60. Epub 2007 Apr 3.

PMID:
17485145
4.

Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase.

Mouray E, Moutiez M, Girault S, Sergheraert C, Florent I, Grellier P.

Biochimie. 2007 Mar;89(3):337-46. Epub 2006 Nov 27.

PMID:
17166645
5.

Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.

Helleboid-Chapman A, Helleboid S, Jakel H, Timmerman C, Sergheraert C, Pattou F, Fruchart-Najib J, Fruchart JC.

Cell Res. 2006 Jul;16(7):661-70.

6.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators.

Charton J, Girault-Mizzi S, Debreu-Fontaine MA, Foufelle F, Hainault I, Bizot-Espiard JG, Caignard DH, Sergheraert C.

Bioorg Med Chem. 2006 Jul 1;14(13):4490-518. Epub 2006 Mar 2.

PMID:
16513356
7.

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.

Melnyk P, Leroux V, Sergheraert C, Grellier P.

Bioorg Med Chem Lett. 2006 Jan 1;16(1):31-5. Epub 2005 Nov 2.

PMID:
16263280
8.

Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.

Ryckebusch A, Gilleron P, Millet R, Houssin R, Lemoine A, Pommery N, Grellier P, Sergheraert C, Hénichart JP.

Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1324-6.

9.

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1.

Charton J, Cazenave Gassiot A, Girault-Mizzi S, Debreu-Fontaine MA, Melnyk P, Sergheraert C.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4833-7.

PMID:
16140011
10.

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 2.

Cazenave Gassiot A, Charton J, Girault-Mizzi S, Gilleron P, Debreu-Fontaine MA, Sergheraert C, Melnyk P.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4828-32.

PMID:
16140009
11.

Conversion of sterically hindered diacylated 1,2-phenylenediamines into 2-substituted benzimidazoles.

Charton J, Girault-Mizzi S, Sergheraert C.

Chem Pharm Bull (Tokyo). 2005 May;53(5):492-7.

12.

Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.

Ryckebusch A, Debreu-Fontaine MA, Mouray E, Grellier P, Sergheraert C, Melnyk P.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):297-302.

PMID:
15603943
13.

Design, synthesis and antimalarial activity of a glyoxylylhydrazone library.

Ryckebusch A, Fruchart JS, Cattiaux L, Rousselot-Paillet P, Leroux V, Melnyk O, Grellier P, Mouray E, Sergheraert C, Melnyk P.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4439-43.

PMID:
15357968
14.

Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin.

Temmerman S, Pethe K, Parra M, Alonso S, Rouanet C, Pickett T, Drowart A, Debrie AS, Delogu G, Menozzi FD, Sergheraert C, Brennan MJ, Mascart F, Locht C.

Nat Med. 2004 Sep;10(9):935-41. Epub 2004 Aug 8.

15.

Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.

Guillon J, Grellier P, Labaied M, Sonnet P, Léger JM, Déprez-Poulain R, Forfar-Bares I, Dallemagne P, Lemaître N, Péhourcq F, Rochette J, Sergheraert C, Jarry C.

J Med Chem. 2004 Apr 8;47(8):1997-2009.

PMID:
15055999
16.

Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.

Soulère L, Delplace P, Davioud-Charvet E, Py S, Sergheraert C, Périé J, Ricard I, Hoffmann P, Dive D.

Bioorg Med Chem. 2003 Nov 17;11(23):4941-4.

PMID:
14604655
17.

Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.

Ryckebusch A, Deprez-Poulain R, Debreu-Fontaine MA, Vandaele R, Mouray E, Grellier P, Sergheraert C.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3783-7.

PMID:
14552779
18.

Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.

Flipo M, Florent I, Grellier P, Sergheraert C, Deprez-Poulain R.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2659-62.

PMID:
12873488
19.

Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach.

Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C, Wattez A, David JP, Vanmechelen E, Sergheraert C, Delacourte A.

J Neurochem. 2003 Jun;85(6):1581-91.

20.

Characterization of boar sperm cytoskeletal cylicin II as an actin-binding protein.

Rousseaux-Prévost R, Lécuyer C, Drobecq H, Sergheraert C, Dacheux JL, Rousseaux J.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):182-9.

PMID:
12646184
21.

Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.

Ryckebusch A, Deprez-Poulain R, Maes L, Debreu-Fontaine MA, Mouray E, Grellier P, Sergheraert C.

J Med Chem. 2003 Feb 13;46(4):542-57.

PMID:
12570376
22.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3601-4.

PMID:
12443785
23.

Parallel synthesis and anti-malarial activity of a sulfonamide library.

Ryckebusch A, Déprez-Poulain R, Debreu-Fontaine MA, Vandaele R, Mouray E, Grellier P, Sergheraert C.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2595-8.

PMID:
12182868
24.

Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis.

Pethe K, Bifani P, Drobecq H, Sergheraert C, Debrie AS, Locht C, Menozzi FD.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10759-64. Epub 2002 Jul 29.

25.

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.

Vendeville S, Goossens F, Debreu-Fontaine MA, Landry V, Davioud-Charvet E, Grellier P, Scharpe S, Sergheraert C.

Bioorg Med Chem. 2002 Jun;10(6):1719-29.

PMID:
11937331
26.

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Boehme CC, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K.

J Med Chem. 2001 Nov 22;44(24):4268-76.

PMID:
11708927
27.

Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.

Grellier P, Vendeville S, Joyeau R, Bastos IM, Drobecq H, Frappier F, Teixeira AR, Schrével J, Davioud-Charvet E, Sergheraert C, Santana JM.

J Biol Chem. 2001 Dec 14;276(50):47078-86. Epub 2001 Oct 11.

28.

"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.

Delarue S, Girault S, Dali Ali F, Maes L, Grellier P, Sergheraert C.

Chem Pharm Bull (Tokyo). 2001 Aug;49(8):933-7.

29.

Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.

Delarue S, Girault S, Maes L, Debreu-Fontaine MA, Labaeïd M, Grellier P, Sergheraert C.

J Med Chem. 2001 Aug 16;44(17):2827-33.

PMID:
11495593
30.

Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines).

Girault S, Delarue S, Grellier P, Berecibar A, Maes L, Quirijnen L, Lemiere P, Debreu-Fontaine MA, Sergheraert C.

J Pharm Pharmacol. 2001 Jul;53(7):935-8.

PMID:
11480542
31.

A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.

Xu KP, Zoukhri D, Zieske JD, Dartt DA, Sergheraert C, Loing E, Yu FS.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C603-14.

32.

Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.

Girault S, Grellier P, Berecibar A, Maes L, Lemière P, Mouray E, Davioud-Charvet E, Sergheraert C.

J Med Chem. 2001 May 24;44(11):1658-65.

PMID:
11356101
33.

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies.

Girault S, Davioud-Charvet TE, Maes L, Dubremetz JF, Debreu MA, Landry V, Sergheraert C.

Bioorg Med Chem. 2001 Apr;9(4):837-46.

PMID:
11354666
34.

Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis.

Matias I, Bisogno T, Melck D, Vandenbulcke F, Verger-Bocquet M, De Petrocellis L, Sergheraert C, Breton C, Di Marzo V, Salzet M.

Brain Res Mol Brain Res. 2001 Mar 5;87(2):145-59.

PMID:
11245916
35.

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Salmon-Chemin L, Buisine E, Yardley V, Kohler S, Debreu MA, Landry V, Sergheraert C, Croft SL, Krauth-Siegel RL, Davioud-Charvet E.

J Med Chem. 2001 Feb 15;44(4):548-65.

PMID:
11170645
36.

Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification using the antiplasmodial inhibitor 1,4-bis[3-[N-(cyclohexyl methyl)amino]propyl]piperazine..

Florent I, Mouray E, Dali Ali F, Drobecq H, Girault S, Schrével J, Sergheraert C, Grellier P.

FEBS Lett. 2000 Nov 10;484(3):246-52. Erratum in: FEBS Lett 2001 Feb 9;490(1-2):102. Florenta, I [corrected to Florent, I].

37.

Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series.

Bonnet B, Soullez D, Girault S, Maes L, Landry V, Davioud-Charvet E, Sergheraert C.

Bioorg Med Chem. 2000 Jan;8(1):95-103.

PMID:
10968268
38.

Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.

Girault S, Grellier P, Berecibar A, Maes L, Mouray E, Lemière P, Debreu MA, Davioud-Charvet E, Sergheraert C.

J Med Chem. 2000 Jul 13;43(14):2646-54.

PMID:
10893302
39.

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.

Salmon-Chemin L, Lemaire A, De Freitas S, Deprez B, Sergheraert C, Davioud-Charvet E.

Bioorg Med Chem Lett. 2000 Apr 3;10(7):631-5.

PMID:
10762041
40.

Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.

Zoukhri D, Hodges RR, Sergheraert C, Dartt DA.

Invest Ophthalmol Vis Sci. 2000 Feb;41(2):386-92.

PMID:
10670466
41.

Characterization of aggregates of hepatitis C virus glycoproteins.

Choukhi A, Pillez A, Drobecq H, Sergheraert C, Wychowski C, Dubuisson J.

J Gen Virol. 1999 Dec;80 ( Pt 12):3099-107.

PMID:
10567640
42.

Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis.

Thiam K, Loing E, Zoukhri D, Rommens C, Hodges R, Dartt D, Verwaerde C, Auriault C, Gras-Masse H, Sergheraert C.

FEBS Lett. 1999 Oct 15;459(3):285-90.

43.

Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets.

Davioud-Charvet E, Berecibar A, Girault S, Landry V, Drobecq H, Sergheraert C.

Bioorg Med Chem Lett. 1999 Jun 7;9(11):1567-72.

PMID:
10386937
44.

Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.

Vendeville S, Bourel L, Davioud-Charvet E, Grellier P, Deprez B, Sergheraert C.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):437-42.

PMID:
10091698
45.

Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library.

Vendeville S, Buisine E, Williard X, Schrevel J, Grellier P, Santana J, Sergheraert C.

Chem Pharm Bull (Tokyo). 1999 Feb;47(2):194-8.

PMID:
10071854
46.
47.

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.

Girault S, Davioud-Charvet E, Salmon L, Berecibar A, Debreu MA, Sergheraert C.

Bioorg Med Chem Lett. 1998 May 19;8(10):1175-80.

PMID:
9871730
48.

Protein kinase C isoforms differentially control lacrimal gland functions.

Zoukhri D, Hodges RR, Sergheraert C, Dartt DA.

Adv Exp Med Biol. 1998;438:181-6. No abstract available.

PMID:
9634884
49.

Lacrimal gland functions are differentially controlled by protein kinase C isoforms.

Zoukhri D, Hodges RR, Sergheraert C, Dartt DA.

Ann N Y Acad Sci. 1998 Apr 15;842:217-20.

PMID:
9599315
50.

A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.

Salmon L, Landry V, Melnyk O, Maes L, Sergheraert C, Davioud-Charvet E.

Chem Pharm Bull (Tokyo). 1998 Apr;46(4):707-10.

PMID:
9579046

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