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Items: 1 to 50 of 69

1.

A Clinical Review of Diabetic Foot Infections.

Chastain CA, Klopfenstein N, Serezani CH, Aronoff DM.

Clin Podiatr Med Surg. 2019 Jul;36(3):381-395. doi: 10.1016/j.cpm.2019.02.004. Epub 2019 Apr 6. Review.

PMID:
31079605
2.

Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection.

Braga Filho JAF, Abreu AG, Rios CEP, Trovão LO, Silva DLF, Cysne DN, Nascimento JR, Fortes TS, Silva LA, Guerra RNM, Maciel MCG, Serezani CH, Nascimento FRF.

Front Immunol. 2018 Sep 21;9:2137. doi: 10.3389/fimmu.2018.02137. eCollection 2018.

3.

Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice.

Brandt SL, Wang S, Dejani NN, Klopfenstein N, Winfree S, Filgueiras L, McCarthy BP, Territo PR, Serezani CH.

JCI Insight. 2018 Sep 6;3(17). pii: 120220. doi: 10.1172/jci.insight.120220. eCollection 2018 Sep 6.

4.

Intestinal host defense outcome is dictated by PGE2 production during efferocytosis of infected cells.

Dejani NN, Orlando AB, Niño VE, Penteado LA, Verdan FF, Bazzano JMR, Codo AC, Salina ACG, Saraiva AC, Avelar MR, Spolidorio LC, Serezani CH, Medeiros AI.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8469-E8478. doi: 10.1073/pnas.1722016115. Epub 2018 Aug 20.

5.

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.

Brandt SL, Klopfenstein N, Wang S, Winfree S, McCarthy BP, Territo PR, Miller L, Serezani CH.

PLoS Pathog. 2018 Aug 13;14(8):e1007244. doi: 10.1371/journal.ppat.1007244. eCollection 2018 Aug.

6.

Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections.

Brandt SL, Putnam NE, Cassat JE, Serezani CH.

J Immunol. 2018 Jun 15;200(12):3871-3880. doi: 10.4049/jimmunol.1701574. Review.

7.

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

Sisti F, Wang S, Brandt SL, Glosson-Byers N, Mayo LD, Son YM, Sturgeon S, Filgueiras L, Jancar S, Wong H, Dela Cruz CS, Andrews N, Alves-Filho JC, Cunha FQ, Serezani CH.

Sci Signal. 2018 May 1;11(528). pii: eaai9085. doi: 10.1126/scisignal.aai9085.

PMID:
29717063
8.

Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease.

Brandt SL, Serezani CH.

Semin Immunol. 2017 Oct;33:37-43. doi: 10.1016/j.smim.2017.08.006. Review.

9.

SOCS1 is a negative regulator of metabolic reprogramming during sepsis.

Piñeros Alvarez AR, Glosson-Byers N, Brandt S, Wang S, Wong H, Sturgeon S, McCarthy BP, Territo PR, Alves-Filho JC, Serezani CH.

JCI Insight. 2017 Jul 6;2(13). pii: 92530. doi: 10.1172/jci.insight.92530. eCollection 2017 Jul 6.

10.

Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection.

Salina AC, Souza TP, Serezani CH, Medeiros AI.

Innate Immun. 2017 Apr;23(3):219-227. doi: 10.1177/1753425916684934. Epub 2016 Dec 20.

PMID:
28359217
11.

Imbalance between HDAC and HAT activities drives aberrant STAT1/MyD88 expression in macrophages from type 1 diabetic mice.

Filgueiras LR, Brandt SL, Ramalho TR, Jancar S, Serezani CH.

J Diabetes Complications. 2017 Feb;31(2):334-339. doi: 10.1016/j.jdiacomp.2016.08.001. Epub 2016 Aug 7.

12.

Topical Prostaglandin E Analog Restores Defective Dendritic Cell-Mediated Th17 Host Defense Against Methicillin-Resistant Staphylococcus Aureus in the Skin of Diabetic Mice.

Dejani NN, Brandt SL, Piñeros A, Glosson-Byers NL, Wang S, Son YM, Medeiros AI, Serezani CH.

Diabetes. 2016 Dec;65(12):3718-3729. Epub 2016 Sep 7.

13.

PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages.

Ishizuka EK, Filgueiras LR, Rios FJ, Serezani CH, Jancar S.

Sci Rep. 2016 Aug 24;6:32092. doi: 10.1038/srep32092.

14.

Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation.

Li XJ, Deng L, Brandt SL, Goodwin CB, Ma P, Yang Z, Mali RS, Liu Z, Kapur R, Serezani CH, Chan RJ.

Oncotarget. 2016 Apr 26;7(17):23096-105. doi: 10.18632/oncotarget.8500.

15.

Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.

Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH.

Nat Commun. 2016 Feb 23;7:10760. doi: 10.1038/ncomms10760.

16.

Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.

Ribeiro LR, Loures FV, de Araújo EF, Feriotti C, Costa TA, Serezani CH, Jancar S, Calich VL.

Mediators Inflamm. 2015;2015:852574. doi: 10.1155/2015/852574. Epub 2015 Oct 8.

17.

Leukotriene B4 as a Potential Therapeutic Target for the Treatment of Metabolic Disorders.

Filgueiras LR, Serezani CH, Jancar S.

Front Immunol. 2015 Oct 8;6:515. doi: 10.3389/fimmu.2015.00515. eCollection 2015. Review. No abstract available.

18.

Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.

Carrasco SE, Troxell B, Yang Y, Brandt SL, Li H, Sandusky GE, Condon KW, Serezani CH, Yang XF.

Infect Immun. 2015 Dec;83(12):4848-60. doi: 10.1128/IAI.01215-15. Epub 2015 Oct 5.

19.

MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.

Wang Z, Brandt S, Medeiros A, Wang S, Wu H, Dent A, Serezani CH.

PLoS One. 2015 Feb 23;10(2):e0115855. doi: 10.1371/journal.pone.0115855. eCollection 2015.

20.

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.

Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH.

Sci Signal. 2015 Jan 27;8(361):ra10. doi: 10.1126/scisignal.2005568.

21.

Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages.

Morato CI, da Silva IA Jr, Borges AF, Dorta ML, Oliveira MA, Jancar S, Serezani CH, Ribeiro-Dias F.

Microbes Infect. 2014 Nov;16(11):945-53. doi: 10.1016/j.micinf.2014.08.015. Epub 2014 Sep 6.

22.

Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages.

da Silva-Souza HA, Lira MN, Costa-Junior HM, da Cruz CM, Vasconcellos JS, Mendes AN, Pimenta-Reis G, Alvarez CL, Faccioli LH, Serezani CH, Schachter J, Persechini PM.

Biochim Biophys Acta. 2014 Jul;1838(7):1967-77. doi: 10.1016/j.bbamem.2014.04.006. Epub 2014 Apr 15.

23.

PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.

Ferreira AE, Sisti F, Sônego F, Wang S, Filgueiras LR, Brandt S, Serezani AP, Du H, Cunha FQ, Alves-Filho JC, Serezani CH.

J Immunol. 2014 Mar 1;192(5):2357-65. doi: 10.4049/jimmunol.1302375. Epub 2014 Jan 31.

24.

Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation.

Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH.

J Immunol. 2014 Mar 1;192(5):2349-56. doi: 10.4049/jimmunol.1302982. Epub 2014 Jan 29.

25.

The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.

Secatto A, Soares EM, Locachevic GA, Assis PA, Paula-Silva FW, Serezani CH, de Medeiros AI, Faccioli LH.

PLoS One. 2014 Jan 21;9(1):e85083. doi: 10.1371/journal.pone.0085083. eCollection 2014.

26.

EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii.

Rogers LM, Thelen T, Fordyce K, Bourdonnay E, Lewis C, Yu H, Zhang J, Xie J, Serezani CH, Peters-Golden M, Aronoff DM.

Am J Reprod Immunol. 2014 Jan;71(1):34-43. doi: 10.1111/aji.12153. Epub 2013 Aug 1.

27.

Proinflammatory responses of heme in alveolar macrophages: repercussion in lung hemorrhagic episodes.

Simões RL, Arruda MA, Canetti C, Serezani CH, Fierro IM, Barja-Fidalgo C.

Mediators Inflamm. 2013;2013:946878. doi: 10.1155/2013/946878. Epub 2013 Apr 17.

28.

Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant.

Domingo-Gonzalez R, Katz S, Serezani CH, Moore TA, Levine AM, Moore BB.

J Immunol. 2013 Jun 1;190(11):5809-17. doi: 10.4049/jimmunol.1203274. Epub 2013 Apr 29.

29.

Differential stem- and progenitor-cell trafficking by prostaglandin E2.

Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM.

Nature. 2013 Mar 21;495(7441):365-9. doi: 10.1038/nature11929. Epub 2013 Mar 13.

30.

Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.

Soares EM, Mason KL, Rogers LM, Serezani CH, Faccioli LH, Aronoff DM.

J Immunol. 2013 Feb 15;190(4):1614-22. doi: 10.4049/jimmunol.1202932. Epub 2013 Jan 16.

31.

Murine colitis is mediated by vimentin.

Mor-Vaknin N, Legendre M, Yu Y, Serezani CH, Garg SK, Jatzek A, Swanson MD, Gonzalez-Hernandez MJ, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Peters-Golden M, Kao JY, Markovitz DM.

Sci Rep. 2013;3:1045. doi: 10.1038/srep01045. Epub 2013 Jan 9.

32.

Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation.

Filgueiras LR Jr, Martins JO, Serezani CH, Capelozzi VL, Montes MB, Jancar S.

PLoS One. 2012;7(9):e44987. Epub 2012 Sep 14.

33.

Prostaglandin E2 and the suppression of phagocyte innate immune responses in different organs.

Medeiros A, Peres-Buzalaf C, Fortino Verdan F, Serezani CH.

Mediators Inflamm. 2012;2012:327568. Epub 2012 Sep 13. Review.

34.

Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.

Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M.

J Immunol. 2012 Jul 15;189(2):906-15. doi: 10.4049/jimmunol.1200257. Epub 2012 Jun 13.

35.

Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia.

Mancuso P, Myers MG Jr, Goel D, Serezani CH, O'Brien E, Goldberg J, Aronoff DM, Peters-Golden M.

J Immunol. 2012 Jul 15;189(2):867-75. doi: 10.4049/jimmunol.1200465. Epub 2012 Jun 8.

36.

Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2.

Bourdonnay E, Serezani CH, Aronoff DM, Peters-Golden M.

J Leukoc Biol. 2012 Jul;92(1):219-31. doi: 10.1189/jlb.1211590. Epub 2012 Apr 27.

37.

5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.

Secatto A, Rodrigues LC, Serezani CH, Ramos SG, Dias-Baruffi M, Faccioli LH, Medeiros AI.

PLoS One. 2012;7(3):e31701. doi: 10.1371/journal.pone.0031701. Epub 2012 Mar 20.

38.

PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi.

Serezani CH, Kane S, Medeiros AI, Cornett AM, Kim SH, Marques MM, Lee SP, Lewis C, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M.

Sci Signal. 2012 Feb 7;5(210):ra12. doi: 10.1126/scisignal.2002448.

39.

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling.

Zaslona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M.

Blood. 2012 Mar 8;119(10):2358-67. doi: 10.1182/blood-2011-08-374207. Epub 2012 Jan 10.

40.

Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity.

Morato-Marques M, Campos MR, Kane S, Rangel AP, Lewis C, Ballinger MN, Kim SH, Peters-Golden M, Jancar S, Serezani CH.

J Biol Chem. 2011 Aug 19;286(33):28902-13. doi: 10.1074/jbc.M111.235309. Epub 2011 Jun 29.

41.

Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages.

Kim SH, Serezani CH, Okunishi K, Zaslona Z, Aronoff DM, Peters-Golden M.

J Biol Chem. 2011 Mar 18;286(11):8875-83. doi: 10.1074/jbc.M110.187815. Epub 2011 Jan 19.

42.

Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression.

Serezani CH, Lewis C, Jancar S, Peters-Golden M.

J Clin Invest. 2011 Feb;121(2):671-82. doi: 10.1172/JCI43302. Epub 2011 Jan 4.

43.

The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.

Thelen T, Hao Y, Medeiros AI, Curtis JL, Serezani CH, Kobzik L, Harris LH, Aronoff DM.

J Immunol. 2010 Oct 1;185(7):4328-35. doi: 10.4049/jimmunol.1000989. Epub 2010 Sep 1.

44.

Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia.

Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M.

Infect Immun. 2010 May;78(5):2264-71. doi: 10.1128/IAI.01323-09. Epub 2010 Mar 15.

45.

FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions.

Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M.

Blood. 2009 Oct 8;114(15):3316-24. doi: 10.1182/blood-2009-01-199919. Epub 2009 Aug 5.

46.

E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection.

Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P.

J Immunol. 2009 Aug 15;183(4):2642-9. doi: 10.4049/jimmunol.0900129. Epub 2009 Jul 27.

47.

Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4.

Campos MR, Serezani CH, Peters-Golden M, Jancar S.

Mol Immunol. 2009 Mar;46(6):1204-11. doi: 10.1016/j.molimm.2008.11.024. Epub 2009 Feb 14.

PMID:
19223078
48.

Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling.

Medeiros AI, Serezani CH, Lee SP, Peters-Golden M.

J Exp Med. 2009 Jan 16;206(1):61-8. doi: 10.1084/jem.20082058. Epub 2009 Jan 5.

49.

Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP.

Lee SP, Serezani CH, Medeiros AI, Ballinger MN, Peters-Golden M.

J Immunol. 2009 Jan 1;182(1):530-7.

50.

Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells.

Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, Sorgi CA, Serezani CH, Deepe GS Jr, Faccioli LH.

J Immunol. 2008 Dec 15;181(12):8544-51.

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