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Items: 1 to 50 of 95

1.

TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours.

Saito Y, Takahashi T, Obata Y, Nishida T, Ohkubo S, Nakagawa F, Serada S, Fujimoto M, Ohkawara T, Nishigaki T, Sugase T, Koh M, Ishida T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Hirota S, Naka T, Mori M, Doki Y.

Br J Cancer. 2019 Dec 20. doi: 10.1038/s41416-019-0688-y. [Epub ahead of print]

PMID:
31857719
2.

Copper ions are novel therapeutic agents for uterine leiomyosarcoma.

Kakuda M, Matsuzaki S, Ueda Y, Shiomi M, Matsuzaki S, Kimura T, Fujita M, Egawa-Takata T, Kobayashi E, Serada S, Yoshino K, Naka T, Kimura T.

Am J Obstet Gynecol. 2020 Jan;222(1):64.e1-64.e16. doi: 10.1016/j.ajog.2019.07.030. Epub 2019 Jul 24.

PMID:
31351063
3.

Erratum: Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T.

J Crohns Colitis. 2019 Dec 10;13(12):1590. doi: 10.1093/ecco-jcc/jjz100. No abstract available.

4.

Myosin heavy chain, a novel allergen for fish allergy in patients with atopic dermatitis.

Shibata Y, Serada S, Fujimoto M, Oishi T, Ohko K, Fujieda M, Naka T, Sano S.

Br J Dermatol. 2019 Dec;181(6):1322-1324. doi: 10.1111/bjd.18226. Epub 2019 Aug 22. No abstract available.

PMID:
31209867
5.

Overexpression of SOCS3 mediated by adenovirus vector in mouse and human castration-resistant prostate cancer cells increases the sensitivity to NK cells in vitro and in vivo.

Yoneda T, Kunimura N, Kitagawa K, Fukui Y, Saito H, Narikiyo K, Ishiko M, Otsuki N, Nibu KI, Fujisawa M, Serada S, Naka T, Shirakawa T.

Cancer Gene Ther. 2019 Nov;26(11-12):388-399. doi: 10.1038/s41417-018-0075-5. Epub 2019 Jan 4.

PMID:
30607005
6.

Epithelial-mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine-rich alpha-2 glycoprotein.

Otsuru T, Kobayashi S, Wada H, Takahashi T, Gotoh K, Iwagami Y, Yamada D, Noda T, Asaoka T, Serada S, Fujimoto M, Eguchi H, Mori M, Doki Y, Naka T.

Cancer Sci. 2019 Mar;110(3):985-996. doi: 10.1111/cas.13918. Epub 2019 Feb 4.

7.

Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles.

Egawa-Takata T, Yoshino K, Hiramatsu K, Nakagawa S, Serada S, Nakajima A, Endo H, Kubota S, Matsuzaki S, Kobayashi E, Ueda Y, Morii E, Inoue M, Naka T, Kimura T.

Int J Gynecol Cancer. 2018 Nov;28(9):1751-1757. doi: 10.1097/IGC.0000000000001354.

8.

Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer.

Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Koh M, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanazaki K, Mori M, Doki Y, Naka T.

Oncotarget. 2018 Aug 31;9(68):32917-32928. doi: 10.18632/oncotarget.25952. eCollection 2018 Aug 31.

9.

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.

Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, Fujii-Kuriyama Y, Sakamato S, Ito T, Handa H, Tanaka T, Yoshimura A, Suzuki H.

J Exp Med. 2018 Aug 6;215(8):2197-2209. doi: 10.1084/jem.20172024. Epub 2018 Jun 22.

10.

Intratumoral Delivery of an Adenoviral Vector Carrying the SOCS-1 Gene Enhances T-Cell-Mediated Antitumor Immunity By Suppressing PD-L1.

Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T.

Mol Cancer Ther. 2018 Sep;17(9):1941-1950. doi: 10.1158/1535-7163.MCT-17-0822. Epub 2018 Jun 11.

11.

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.

Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.

Gastric Cancer. 2018 Nov;21(6):968-976. doi: 10.1007/s10120-018-0822-1. Epub 2018 Apr 5.

PMID:
29623544
12.

Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.

Lee H, Fujimoto M, Ohkawara T, Honda H, Serada S, Terada Y, Naka T.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):1045-1051. doi: 10.1016/j.bbrc.2018.03.111. Epub 2018 Mar 17.

PMID:
29550485
13.

Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts.

Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T.

Physiol Rep. 2017 Dec;5(24). pii: e13556. doi: 10.14814/phy2.13556. Epub 2017 Dec 26.

14.

LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.

Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T.

Cancer Res. 2018 Jan 15;78(2):516-527. doi: 10.1158/0008-5472.CAN-17-0910. Epub 2017 Nov 29.

15.

Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer.

Matsuzaki S, Serada S, Hiramatsu K, Nojima S, Matsuzaki S, Ueda Y, Ohkawara T, Mabuchi S, Fujimoto M, Morii E, Yoshino K, Kimura T, Naka T.

Int J Cancer. 2018 Mar 1;142(5):1056-1066. doi: 10.1002/ijc.31124. Epub 2017 Oct 31.

16.

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma.

Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.

Cancer Res. 2017 Dec 15;77(24):6975-6986. doi: 10.1158/0008-5472.CAN-17-1525. Epub 2017 Oct 17.

17.

Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer.

Yamamoto M, Takahashi T, Serada S, Sugase T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Naka T, Mori M, Doki Y.

Cancer Sci. 2017 Oct;108(10):2052-2060. doi: 10.1111/cas.13329.

18.

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.

Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, Kawahata H, Serada S, Naka T.

Arthritis Res Ther. 2017 Jun 14;19(1):137. doi: 10.1186/s13075-017-1349-2.

19.

Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma.

Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.

Oncotarget. 2017 Apr 11;8(15):24741-24752. doi: 10.18632/oncotarget.15799.

20.

Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.

Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.

Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.

21.

Leucine-rich α-2 glycoprotein is an innovative biomarker for psoriasis.

Nakajima H, Serada S, Fujimoto M, Naka T, Sano S.

J Dermatol Sci. 2017 May;86(2):170-174. doi: 10.1016/j.jdermsci.2017.01.008. Epub 2017 Jan 29. No abstract available.

PMID:
28179066
22.

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.

Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Nakamura H, Nishigaki T, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M.

Genes Chromosomes Cancer. 2017 Apr;56(4):303-313. doi: 10.1002/gcc.22438. Epub 2017 Jan 23.

23.

Splicing factor proline/glutamine-rich is a novel autoantigen of dermatomyositis and associated with anti-melanoma differentiation-associated gene 5 antibody.

Hosono Y, Nakashima R, Serada S, Murakami K, Imura Y, Yoshifuji H, Ohmura K, Naka T, Mimori T.

J Autoimmun. 2017 Feb;77:116-122. doi: 10.1016/j.jaut.2016.11.006. Epub 2016 Dec 3.

PMID:
27919567
24.

Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.

Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T.

J Crohns Colitis. 2017 Jan;11(1):84-91. doi: 10.1093/ecco-jcc/jjw132. Epub 2016 Jul 27. Erratum in: J Crohns Colitis. 2019 Dec 10;13(12):1590.

25.

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma.

Honda H, Fujimoto M, Miyamoto S, Ishikawa N, Serada S, Hattori N, Nomura S, Kohno N, Yokoyama A, Naka T.

PLoS One. 2016 Sep 9;11(9):e0162672. doi: 10.1371/journal.pone.0162672. eCollection 2016.

26.

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.

Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.

Br J Cancer. 2016 Jun 28;115(1):66-75. doi: 10.1038/bjc.2016.183. Epub 2016 Jun 16.

27.

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation.

Han Y, Ripley B, Serada S, Naka T, Fujimoto M.

PLoS One. 2016 Apr 12;11(4):e0153399. doi: 10.1371/journal.pone.0153399. eCollection 2016.

28.

Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.

Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T.

Br J Cancer. 2016 Mar 1;114(5):554-61. doi: 10.1038/bjc.2016.27. Epub 2016 Feb 18.

29.

Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.

Yamada K, Miyamoto Y, Tsujii A, Moriyama T, Ikuno Y, Shiromizu T, Serada S, Fujimoto M, Tomonaga T, Naka T, Yoneda Y, Oka M.

Sci Rep. 2016 Feb 18;6:21410. doi: 10.1038/srep21410.

30.

Large-scale proteome analysis of abscisic acid and ABSCISIC ACID INSENSITIVE3-dependent proteins related to desiccation tolerance in Physcomitrella patens.

Yotsui I, Serada S, Naka T, Saruhashi M, Taji T, Hayashi T, Quatrano RS, Sakata Y.

Biochem Biophys Res Commun. 2016 Mar 18;471(4):589-95. doi: 10.1016/j.bbrc.2016.02.024. Epub 2016 Feb 8.

PMID:
26869511
31.

Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin.

Yang L, Murota H, Shindo S, Yang F, Serada S, Fujimoto M, Naka T, Katayama I.

J Dermatol Sci. 2016 Apr;82(1):57-9. doi: 10.1016/j.jdermsci.2016.01.004. Epub 2016 Jan 8. No abstract available.

PMID:
26827264
32.

Human herpesvirus 6 U11 protein is critical for virus infection.

Mahmoud NF, Kawabata A, Tang H, Wakata A, Wang B, Serada S, Naka T, Mori Y.

Virology. 2016 Feb;489:151-7. doi: 10.1016/j.virol.2015.12.011. Epub 2016 Jan 4.

33.

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

Kumagai S, Nakayama H, Fujimoto M, Honda H, Serada S, Ishibashi-Ueda H, Kasai A, Obana M, Sakata Y, Sawa Y, Fujio Y, Naka T.

Cardiovasc Res. 2016 Feb 1;109(2):272-82. doi: 10.1093/cvr/cvv273. Epub 2015 Dec 17.

PMID:
26678356
34.

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody.

Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, Enomoto T, Kimura T, Naka T.

Cancer Sci. 2015 Oct;106(10):1474-8. doi: 10.1111/cas.12738.

35.

CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: Comparison with blockade of interleukin-6.

Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, Nishida K, Naka T.

Exp Eye Res. 2015 Nov;140:53-64. doi: 10.1016/j.exer.2015.08.012. Epub 2015 Aug 20.

PMID:
26297802
36.

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis.

Natatsuka R, Takahashi T, Serada S, Fujimoto M, Ookawara T, Nishida T, Hara H, Nishigaki T, Harada E, Murakami T, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.

Br J Cancer. 2015 Jul 28;113(3):433-42. doi: 10.1038/bjc.2015.229. Epub 2015 Jul 16.

37.

Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells.

Tagami-Nagata N, Serada S, Fujimoto M, Tanemura A, Nakatsuka R, Ohkawara T, Murota H, Kishimoto T, Katayama I, Naka T.

Exp Dermatol. 2015 Nov;24(11):864-71. doi: 10.1111/exd.12802. Epub 2015 Sep 3.

PMID:
26173926
38.

Leucine-rich α2 -glycoprotein as a potential biomarker for joint inflammation during anti-interleukin-6 biologic therapy in rheumatoid arthritis.

Fujimoto M, Serada S, Suzuki K, Nishikawa A, Ogata A, Nanki T, Hattori K, Kohsaka H, Miyasaka N, Takeuchi T, Naka T.

Arthritis Rheumatol. 2015 May;67(8):2056-60. doi: 10.1002/art.39164.

39.

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.

Takemoto N, Serada S, Fujimoto M, Honda H, Ohkawara T, Takahashi T, Nomura S, Inohara H, Naka T.

Oncotarget. 2015 May 10;6(13):11009-22.

40.

Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner.

Morimoto A, Serada S, Enomoto T, Kim A, Matsuzaki S, Takahashi T, Ueda Y, Yoshino K, Fujita M, Fujimoto M, Kimura T, Naka T.

Oncotarget. 2014 Sep 15;5(17):7776-87.

41.

Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells.

Kawabata A, Serada S, Naka T, Mori Y.

J Gen Virol. 2014 Dec;95(Pt 12):2769-77. doi: 10.1099/vir.0.069336-0. Epub 2014 Sep 10.

PMID:
25209806
42.

Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.

Yang L, Fujimoto M, Murota H, Serada S, Fujimoto M, Honda H, Yamada K, Suzuki K, Nishikawa A, Hosono Y, Yoneda Y, Takehara K, Imura Y, Mimori T, Takeuchi T, Katayama I, Naka T.

Rheumatology (Oxford). 2015 Feb;54(2):349-58. doi: 10.1093/rheumatology/keu325. Epub 2014 Aug 28.

PMID:
25172934
43.

Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses.

Azuma K, Serada S, Takamatsu S, Terao N, Takeishi S, Kamada Y, Naka T, Miyoshi E.

J Proteome Res. 2014 Nov 7;13(11):4869-77. doi: 10.1021/pr5004399. Epub 2014 Sep 5.

PMID:
25158113
44.

Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer.

Furukawa K, Kawamoto K, Eguchi H, Tanemura M, Tanida T, Tomimaru Y, Akita H, Hama N, Wada H, Kobayashi S, Nonaka Y, Takamatsu S, Shinzaki S, Kumada T, Satomura S, Ito T, Serada S, Naka T, Mori M, Doki Y, Miyoshi E, Nagano H.

Pancreas. 2015 Jan;44(1):93-8. doi: 10.1097/MPA.0000000000000205.

PMID:
25058884
45.
46.

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment.

Kotobuki Y, Yang L, Serada S, Tanemura A, Yang F, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T.

Pigment Cell Melanoma Res. 2014 Jul;27(4):630-9. doi: 10.1111/pcmr.12245. Epub 2014 Apr 22.

PMID:
24674392
47.

Histamine contributes to tissue remodeling via periostin expression.

Yang L, Murota H, Serada S, Fujimoto M, Kudo A, Naka T, Katayama I.

J Invest Dermatol. 2014 Aug;134(8):2105-2113. doi: 10.1038/jid.2014.120. Epub 2014 Feb 27.

48.

Expression of MHC class I molecule in HHV-6B-infected cells.

Ota M, Serada S, Naka T, Mori Y.

Microbiol Immunol. 2014 Feb;58(2):Februarycover. doi: 10.1111/1348-0421.12142. No abstract available.

49.

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers.

Matsuzaki S, Serada S, Morimoto A, Ueda Y, Yoshino K, Kimura T, Naka T.

Expert Opin Ther Targets. 2014 Apr;18(4):403-14. doi: 10.1517/14728222.2014.882323. Epub 2014 Jan 30. Review.

PMID:
24479491
50.

MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.

Ota M, Serada S, Naka T, Mori Y.

Microbiol Immunol. 2014 Feb;58(2):119-25. doi: 10.1111/1348-0421.12121.

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