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Items: 31

1.

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

Polli JW, Humphreys JE, Harmon KA, Castellino S, O'Mara MJ, Olson KL, John-Williams LS, Koch KM, Serabjit-Singh CJ.

Drug Metab Dispos. 2008 Apr;36(4):695-701. doi: 10.1124/dmd.107.018374. Epub 2008 Jan 23.

PMID:
18216274
2.

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW.

Drug Metab Dispos. 2006 May;34(5):786-92. Epub 2006 Feb 2.

PMID:
16455806
3.
4.

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.

Mahar Doan KM, Wring SA, Shampine LJ, Jordan KH, Bishop JP, Kratz J, Yang E, Serabjit-Singh CJ, Adkison KK, Polli JW.

Pharmacology. 2004 Oct;72(2):92-8.

PMID:
15331914
5.

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ.

Drug Metab Dispos. 2004 Jul;32(7):722-6.

PMID:
15205387
6.

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Salisbury JA, Tippin TK, Serabjit-Singh CJ.

J Pharm Sci. 2003 Oct;92(10):2082-9.

PMID:
14502547
7.

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW.

J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37.

PMID:
12438524
8.

Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.

Wring SA, Silver IS, Serabjit-Singh CJ.

Methods Enzymol. 2002;357:285-95. No abstract available.

PMID:
12424918
9.

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2.

10.

Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver.

Stewart RK, Serabjit-Singh CJ, Massey TE.

Toxicol Appl Pharmacol. 1996 Oct;140(2):499-507.

PMID:
8887467
11.

Recombinant baculovirus strategy for coexpression of functional human cytochrome P450 and P450 reductase.

Lee CA, Kost TA, Serabjit-Singh CJ.

Methods Enzymol. 1996;272:86-95. No abstract available.

PMID:
8791765
12.

Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans.

Dixon CM, Colthup PV, Serabjit-Singh CJ, Kerr BM, Boehlert CC, Park GR, Tarbit MH.

Drug Metab Dispos. 1995 Nov;23(11):1225-30.

PMID:
8591723
14.

Unique distribution profiles of glutathione S-transferases in regions of kidney, ureter, and bladder of rabbit.

Overby LH, Gardlik S, Philpot RM, Serabjit-Singh CJ.

Lab Invest. 1994 Apr;70(4):468-78.

PMID:
8176887
15.

Applications of molecular biology and in vitro technology to drug metabolism studies: an industrial perspective.

Tarbit MH, Bayliss MK, Herriott D, Hood SR, Hutson JL, Park GR, Serabjit-Singh CJ.

Biochem Soc Trans. 1993 Nov;21(4):1018-23. Review. No abstract available.

PMID:
8131890
16.

Diminished drug metabolism due to hormonal effects of cobalt mesoporphyrin on flavoproteins.

Yanni SB, Chism JP, Rickert DE, Serabjit-Singh CJ.

Chem Biol Interact. 1993 Oct;89(1):73-87.

PMID:
8221968
17.

The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation.

Gardlik S, Gasser R, Philpot RM, Serabjit-Singh CJ.

J Biol Chem. 1991 Oct 15;266(29):19681-7.

18.

Distribution of cytochrome P-450 monoxygenase enzymes in the nasal mucosa of hamster and rat.

Adams DR, Jones AM, Plopper CG, Serabjit-Singh CJ, Philpot RM.

Am J Anat. 1991 Mar;190(3):291-8.

PMID:
2048556
19.
20.

The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization.

Serabjit-Singh CJ, Nishio SJ, Philpot RM, Plopper CG.

Mol Pharmacol. 1988 Mar;33(3):279-89.

PMID:
3352593
21.

Immunohistochemical demonstration of cytochrome P-450 monooxygenase in Clara cells throughout the tracheobronchial airways of the rabbit.

Plopper CG, Cranz DL, Kemp L, Serabjit-Singh CJ, Philpot RM.

Exp Lung Res. 1987;13(1):59-68.

PMID:
3653045
22.

Metabolism of aflatoxin B1 in the upper airways of the rabbit: role of the nonciliated tracheal epithelial cell.

Coulombe RA Jr, Wilson DW, Hsieh DP, Plopper CG, Serabjit-Singh CJ.

Cancer Res. 1986 Aug;46(8):4091-6.

23.

Female-predominant expression of testosterone 16 alpha-hydroxylase ("I"-P-450(16)alpha) and its repression in strain 129/J.

Noshiro M, Serabjit-Singh CJ, Bend JR, Negishi M.

Arch Biochem Biophys. 1986 Feb 1;244(2):857-64.

PMID:
3753840
24.

Cytochrome P-450 monooxygenase system. Localization in smooth muscle of rabbit aorta.

Serabjit-Singh CJ, Bend JR, Philpot RM.

Mol Pharmacol. 1985 Jul;28(1):72-9.

PMID:
3927149
25.

The pulmonary uptake, accumulation, and metabolism of xenobiotics.

Bend JR, Serabjit-Singh CJ, Philpot RM.

Annu Rev Pharmacol Toxicol. 1985;25:97-125. Review. No abstract available.

PMID:
3890717
27.

Interactions between xenobiotics that increase or decrease the levels of cytochrome P-450 isozymes in rabbit lung and liver.

Serabjit-Singh CJ, Albro PW, Robertson IG, Philpot RM.

J Biol Chem. 1983 Nov 10;258(21):12827-34.

28.

Hepatic microsomal NADPH-cytochrome P-450 reductase from little skate, Raja erinacea. Comparison of thermolability and other molecular properties with a mammalian enzyme.

Pohl RJ, Serabjit-Singh CJ, Slaughter SR, Albro PW, Fouts JR, Philpot RM.

Chem Biol Interact. 1983 Aug 1;45(3):283-94.

PMID:
6411368
29.

Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.

Devereux TR, Serabjit-Singh CJ, Slaughter SR, Wolf CR, Philpot RM, Fouts JR.

Exp Lung Res. 1981 Aug;2(3):221-30.

PMID:
7028473
30.

Cytochrome p-450: localization in rabbit lung.

Serabjit-Singh CJ, Wolf CR, Philpot RM, Plopper CG.

Science. 1980 Mar 28;207(4438):1469-70.

PMID:
6767272
31.

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