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Items: 42

1.

Investigations of hydrazine cleavage of eltrombopag in humans.

Deng Y, Rogers M, Sychterz C, Talley K, Qian Y, Bershas D, Ho M, Shi W, Chen EP, Serabjit-Singh C, Gorycki PD.

Drug Metab Dispos. 2011 Sep;39(9):1747-54. doi: 10.1124/dmd.111.040188. Epub 2011 Jun 6.

PMID:
21646438
2.

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.

Xenobiotica. 2011 Jun;41(6):464-75. doi: 10.3109/00498254.2011.560295. Epub 2011 Mar 4.

PMID:
21370990
3.

The disposition and metabolism of GW695634: a non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS.

de Serres M, Moss L, Sigafoos J, Sefler A, Castellino S, Bowers G, Serabjit-Singh C.

Xenobiotica. 2010 Jun;40(6):437-45. doi: 10.3109/00498251003770578.

PMID:
20380622
4.

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

Polli JW, Humphreys JE, Harmon KA, Castellino S, O'Mara MJ, Olson KL, John-Williams LS, Koch KM, Serabjit-Singh CJ.

Drug Metab Dispos. 2008 Apr;36(4):695-701. doi: 10.1124/dmd.107.018374. Epub 2008 Jan 23.

PMID:
18216274
5.

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW.

Drug Metab Dispos. 2006 May;34(5):786-92. Epub 2006 Feb 2.

PMID:
16455806
6.
7.

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.

Mahar Doan KM, Wring SA, Shampine LJ, Jordan KH, Bishop JP, Kratz J, Yang E, Serabjit-Singh CJ, Adkison KK, Polli JW.

Pharmacology. 2004 Oct;72(2):92-8.

PMID:
15331914
8.

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ.

Drug Metab Dispos. 2004 Jul;32(7):722-6.

PMID:
15205387
9.

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

Gombar VK, Polli JW, Humphreys JE, Wring SA, Serabjit-Singh CS.

J Pharm Sci. 2004 Apr;93(4):957-68.

PMID:
14999732
10.

Drug interactions with herbal products and grapefruit juice: a conference report.

Huang SM, Hall SD, Watkins P, Love LA, Serabjit-Singh C, Betz JM, Hoffman FA, Honig P, Coates PM, Bull J, Chen ST, Kearns GL, Murray MD; Center for Drug Evaluation and Research and Office of Regulatory Affairs, Food and Drug Administration, Rockville, MD, USA.

Clin Pharmacol Ther. 2004 Jan;75(1):1-12. Review. No abstract available.

PMID:
14749688
11.

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Salisbury JA, Tippin TK, Serabjit-Singh CJ.

J Pharm Sci. 2003 Oct;92(10):2082-9.

PMID:
14502547
12.

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW.

J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37.

PMID:
12438524
13.

Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.

Wring SA, Silver IS, Serabjit-Singh CJ.

Methods Enzymol. 2002;357:285-95. No abstract available.

PMID:
12424918
14.

Rational use of in vitro P-glycoprotein assays in drug discovery.

Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS.

J Pharmacol Exp Ther. 2001 Nov;299(2):620-8.

PMID:
11602674
15.

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors.

Huang L, Wring SA, Woolley JL, Brouwer KR, Serabjit-Singh C, Polli JW.

Drug Metab Dispos. 2001 May;29(5):754-60.

PMID:
11302944
16.

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2.

17.

Shorter development of immunoassay for drugs: application of the novel RIMMS technique enables rapid production of monoclonal antibodies to ranitidine.

Wring SA, Kilpatrick KE, Hutchins JT, Witherspoon SM, Ellis B, Jenner WN, Serabjit-Singh C.

J Pharm Biomed Anal. 1999 Apr;19(5):695-707.

PMID:
10698534
18.

Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver.

Stewart RK, Serabjit-Singh CJ, Massey TE.

Toxicol Appl Pharmacol. 1996 Oct;140(2):499-507.

PMID:
8887467
19.

Recombinant baculovirus strategy for coexpression of functional human cytochrome P450 and P450 reductase.

Lee CA, Kost TA, Serabjit-Singh CJ.

Methods Enzymol. 1996;272:86-95. No abstract available.

PMID:
8791765
20.

Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans.

Dixon CM, Colthup PV, Serabjit-Singh CJ, Kerr BM, Boehlert CC, Park GR, Tarbit MH.

Drug Metab Dispos. 1995 Nov;23(11):1225-30.

PMID:
8591723
22.

Unique distribution profiles of glutathione S-transferases in regions of kidney, ureter, and bladder of rabbit.

Overby LH, Gardlik S, Philpot RM, Serabjit-Singh CJ.

Lab Invest. 1994 Apr;70(4):468-78.

PMID:
8176887
23.

Applications of molecular biology and in vitro technology to drug metabolism studies: an industrial perspective.

Tarbit MH, Bayliss MK, Herriott D, Hood SR, Hutson JL, Park GR, Serabjit-Singh CJ.

Biochem Soc Trans. 1993 Nov;21(4):1018-23. Review. No abstract available.

PMID:
8131890
24.

Diminished drug metabolism due to hormonal effects of cobalt mesoporphyrin on flavoproteins.

Yanni SB, Chism JP, Rickert DE, Serabjit-Singh CJ.

Chem Biol Interact. 1993 Oct;89(1):73-87.

PMID:
8221968
25.

The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation.

Gardlik S, Gasser R, Philpot RM, Serabjit-Singh CJ.

J Biol Chem. 1991 Oct 15;266(29):19681-7.

26.

Distribution of cytochrome P-450 monoxygenase enzymes in the nasal mucosa of hamster and rat.

Adams DR, Jones AM, Plopper CG, Serabjit-Singh CJ, Philpot RM.

Am J Anat. 1991 Mar;190(3):291-8.

PMID:
2048556
27.
28.

The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization.

Serabjit-Singh CJ, Nishio SJ, Philpot RM, Plopper CG.

Mol Pharmacol. 1988 Mar;33(3):279-89.

PMID:
3352593
29.

Immunohistochemical demonstration of cytochrome P-450 monooxygenase in Clara cells throughout the tracheobronchial airways of the rabbit.

Plopper CG, Cranz DL, Kemp L, Serabjit-Singh CJ, Philpot RM.

Exp Lung Res. 1987;13(1):59-68.

PMID:
3653045
30.

Metabolism of aflatoxin B1 in the upper airways of the rabbit: role of the nonciliated tracheal epithelial cell.

Coulombe RA Jr, Wilson DW, Hsieh DP, Plopper CG, Serabjit-Singh CJ.

Cancer Res. 1986 Aug;46(8):4091-6.

31.

Female-predominant expression of testosterone 16 alpha-hydroxylase ("I"-P-450(16)alpha) and its repression in strain 129/J.

Noshiro M, Serabjit-Singh CJ, Bend JR, Negishi M.

Arch Biochem Biophys. 1986 Feb 1;244(2):857-64.

PMID:
3753840
32.

Cytochrome P-450 monooxygenase system. Localization in smooth muscle of rabbit aorta.

Serabjit-Singh CJ, Bend JR, Philpot RM.

Mol Pharmacol. 1985 Jul;28(1):72-9.

PMID:
3927149
33.

The pulmonary uptake, accumulation, and metabolism of xenobiotics.

Bend JR, Serabjit-Singh CJ, Philpot RM.

Annu Rev Pharmacol Toxicol. 1985;25:97-125. Review. No abstract available.

PMID:
3890717
35.

Interactions between xenobiotics that increase or decrease the levels of cytochrome P-450 isozymes in rabbit lung and liver.

Serabjit-Singh CJ, Albro PW, Robertson IG, Philpot RM.

J Biol Chem. 1983 Nov 10;258(21):12827-34.

36.

Hepatic microsomal NADPH-cytochrome P-450 reductase from little skate, Raja erinacea. Comparison of thermolability and other molecular properties with a mammalian enzyme.

Pohl RJ, Serabjit-Singh CJ, Slaughter SR, Albro PW, Fouts JR, Philpot RM.

Chem Biol Interact. 1983 Aug 1;45(3):283-94.

PMID:
6411368
38.

Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.

Devereux TR, Serabjit-Singh CJ, Slaughter SR, Wolf CR, Philpot RM, Fouts JR.

Exp Lung Res. 1981 Aug;2(3):221-30.

PMID:
7028473
39.

Quantitation of two forms of pulmonary cytochrome P-450 in microsomes, using substrate specificities.

Franklin MR, Wolf CR, Serabjit-Singh C, Philpot RM.

Mol Pharmacol. 1980 May;17(3):415-20. No abstract available.

PMID:
7393217
40.

Cytochrome p-450: localization in rabbit lung.

Serabjit-Singh CJ, Wolf CR, Philpot RM, Plopper CG.

Science. 1980 Mar 28;207(4438):1469-70.

PMID:
6767272
41.
42.

The rabbit pulmonary monooxygenase system. Catalytic differences between two purified forms of cytochrome P-450 in the metabolism of benzo(a)pyrene.

Wolf CR, Smith BR, Ball LM, Serabjit-Singh C, Bend JR, Philpot RM.

J Biol Chem. 1979 May 10;254(9):3658-63. No abstract available.

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