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Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion.

Schramm A, Schweda F, Sequeira-Lopez MLS, Hofmann F, Sandner P, Schlossmann J.

Front Pharmacol. 2019 Jul 18;10:800. doi: 10.3389/fphar.2019.00800. eCollection 2019.


Stromal prorenin receptor is critical for normal kidney development.

Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R640-R650. doi: 10.1152/ajpregu.00320.2018. Epub 2019 Apr 3.


Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.

Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA.

Dis Model Mech. 2018 Dec 18;11(12). pii: dmm036731. doi: 10.1242/dmm.036731.


Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction.

Nagalakshmi VK, Li M, Shah S, Gigliotti JC, Klibanov AL, Epstein FH, Chevalier RL, Gomez RA, Sequeira-Lopez MLS.

Clin Sci (Lond). 2018 Dec 5;132(23):2519-2545. doi: 10.1042/CS20180623. Print 2018 Dec 12.


Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis.

Martinez MF, Medrano S, Brown EA, Tufan T, Shang S, Bertoncello N, Guessoum O, Adli M, Belyea BC, Sequeira-Lopez MLS, Gomez RA.

J Clin Invest. 2018 Nov 1;128(11):4787-4803. doi: 10.1172/JCI121361. Epub 2018 Oct 2.


Preserving kidney health during intensive blood pressure control.

Sequeira-Lopez MLS, Gomez RA.

Nat Rev Nephrol. 2018 Sep;14(9):537-538. doi: 10.1038/s41581-018-0034-2. No abstract available.


Development of the renal vasculature.

Mohamed T, Sequeira-Lopez MLS.

Semin Cell Dev Biol. 2019 Jul;91:132-146. doi: 10.1016/j.semcdb.2018.06.001. Epub 2018 Jun 6. Review.


Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo?

Neubauer B, Schrankl J, Steppan D, Neubauer K, Sequeira-Lopez ML, Pan L, Gomez RA, Coffman TM, Gross KW, Kurtz A, Wagner C.

Hypertension. 2018 Jun;71(6):1075-1082. doi: 10.1161/HYPERTENSIONAHA.117.10357. Epub 2018 Apr 16.


Renin cells in homeostasis, regeneration and immune defence mechanisms.

Gomez RA, Sequeira-Lopez MLS.

Nat Rev Nephrol. 2018 Apr;14(4):231-245. doi: 10.1038/nrneph.2017.186. Epub 2018 Jan 30. Review.


Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney.

Hickmann L, Steglich A, Gerlach M, Al-Mekhlafi M, Sradnick J, Lachmann P, Sequeira-Lopez MLS, Gomez RA, Hohenstein B, Hugo C, Todorov VT.

Kidney Int. 2017 Dec;92(6):1419-1432. doi: 10.1016/j.kint.2017.04.014. Epub 2017 Jul 6.


Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development.

Hu Y, Belyea BC, Li M, Göthert JR, Gomez RA, Sequeira-Lopez ML.

Sci Rep. 2017 Mar 24;7:45205. doi: 10.1038/srep45205.


Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging.

Kaverina NV, Kadoya H, Eng DG, Rusiniak ME, Sequeira-Lopez ML, Gomez RA, Pippin JW, Gross KW, Peti-Peterdi J, Shankland SJ.

PLoS One. 2017 Mar 22;12(3):e0173891. doi: 10.1371/journal.pone.0173891. eCollection 2017.


Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension.

Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD.

Hypertension. 2016 Dec;68(6):1385-1392. Epub 2016 Oct 17.


New insights into precursors of renal endothelium.

Sequeira-Lopez MLS, Torban E.

Kidney Int. 2016 Aug;90(2):244-246. doi: 10.1016/j.kint.2016.03.043.


Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression.

Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD.

Hypertension. 2016 May;67(5):992-9. doi: 10.1161/HYPERTENSIONAHA.115.07082. Epub 2016 Feb 29.


Novel Functions of Renin Precursors in Homeostasis and Disease.

Gomez RA, Sequeira-Lopez ML.

Physiology (Bethesda). 2016 Jan;31(1):25-33. doi: 10.1152/physiol.00039.2015. Review.


Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis.

Belyea BC, Xu F, Sequeira-Lopez ML, Ariel Gomez R.

Physiol Rep. 2015 Nov;3(11). pii: e12544. doi: 10.14814/phy2.12544.


Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development.

Hu Y, Li M, Göthert JR, Gomez RA, Sequeira-Lopez ML.

J Am Soc Nephrol. 2016 Jul;27(7):1984-95. doi: 10.1681/ASN.2015060610. Epub 2015 Nov 3.


Vascular versus tubular renin: role in kidney development.

Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. doi: 10.1152/ajpregu.00313.2015. Epub 2015 Aug 5.


Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.

Lin EE, Pentz ES, Sequeira-Lopez ML, Gomez RA.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R576-84. doi: 10.1152/ajpregu.00222.2015. Epub 2015 Jul 15.


The earliest metanephric arteriolar progenitors and their role in kidney vascular development.

Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA.

Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R138-49. doi: 10.1152/ajpregu.00428.2014. Epub 2014 Nov 26.


Deletion of the miR-143/145 cluster leads to hydronephrosis in mice.

Medrano S, Sequeira-Lopez ML, Gomez RA.

Am J Pathol. 2014 Dec;184(12):3226-38. doi: 10.1016/j.ajpath.2014.08.012. Epub 2014 Oct 7.


Renin lineage cells repopulate the glomerular mesangium after injury.

Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp JB, Sequeira-Lopez ML, Gomez RA, Hohenstein B, Todorov VT, Hugo CP.

J Am Soc Nephrol. 2015 Jan;26(1):48-54. doi: 10.1681/ASN.2014030265. Epub 2014 Jun 5.


Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression.

Castellanos-Rivera RM, Pentz ES, Lin E, Gross KW, Medrano S, Yu J, Sequeira-Lopez ML, Gomez RA.

J Am Soc Nephrol. 2015 Jan;26(1):67-80. doi: 10.1681/ASN.2013101045. Epub 2014 Jun 5.


Local renal circadian clocks control fluid-electrolyte homeostasis and BP.

Tokonami N, Mordasini D, Pradervand S, Centeno G, Jouffe C, Maillard M, Bonny O, Gachon F, Gomez RA, Sequeira-Lopez ML, Firsov D.

J Am Soc Nephrol. 2014 Jul;25(7):1430-9. doi: 10.1681/ASN.2013060641. Epub 2014 Mar 20.


Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia.

Belyea BC, Xu F, Pentz ES, Medrano S, Li M, Hu Y, Turner S, Legallo R, Jones CA, Tario JD, Liang P, Gross KW, Sequeira-Lopez ML, Gomez RA.

Nat Commun. 2014;5:3273. doi: 10.1038/ncomms4273.


Fate and plasticity of renin precursors in development and disease.

Gomez RA, Belyea B, Medrano S, Pentz ES, Sequeira-Lopez ML.

Pediatr Nephrol. 2014 Apr;29(4):721-6. doi: 10.1007/s00467-013-2688-0. Epub 2013 Dec 15. Review.


Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling.

Neubauer B, Machura K, Rupp V, Tallquist MD, Betsholtz C, Sequeira-Lopez ML, Ariel Gomez R, Wagner C.

Physiol Rep. 2013 Oct;1(5):e00132. doi: 10.1002/phy2.132. Epub 2013 Oct 24.


RBP-J in FOXD1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells.

Lin EE, Sequeira-Lopez ML, Gomez RA.

Am J Physiol Renal Physiol. 2014 Jan;306(2):F249-58. doi: 10.1152/ajprenal.00313.2013. Epub 2013 Nov 13.


Pericytes synthesize renin.

Berg AC, Chernavvsky-Sequeira C, Lindsey J, Gomez RA, Sequeira-Lopez ML.

World J Nephrol. 2013 Feb 6;2(1):11-6. doi: 10.5527/wjn.v2.i1.11.


Two oldies join forces to guard homeostasis.

Gomez RA, Sequeira-Lopez ML.

Am J Physiol Renal Physiol. 2013 Dec 1;305(11):F1546. doi: 10.1152/ajprenal.00496.2013. Epub 2013 Sep 18. No abstract available.


Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.

Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, Sequeira-Lopez ML, Bachmann S, Gomez RA, Eckardt KU, Kurtz A.

J Am Soc Nephrol. 2013 Feb;24(3):433-44. doi: 10.1681/ASN.2012080791. Epub 2013 Feb 7.


Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype.

Pentz ES, Cordaillat M, Carretero OA, Tucker AE, Sequeira Lopez ML, Gomez RA.

Am J Physiol Heart Circ Physiol. 2012 Jun 15;302(12):H2545-52. doi: 10.1152/ajpheart.00782.2011. Epub 2012 Apr 20.


Development of the renal arterioles.

Sequeira Lopez ML, Gomez RA.

J Am Soc Nephrol. 2011 Dec;22(12):2156-65. doi: 10.1681/ASN.2011080818. Epub 2011 Nov 3. Review.


Genes that confer the identity of the renin cell.

Brunskill EW, Sequeira-Lopez ML, Pentz ES, Lin E, Yu J, Aronow BJ, Potter SS, Gomez RA.

J Am Soc Nephrol. 2011 Dec;22(12):2213-25. doi: 10.1681/ASN.2011040401. Epub 2011 Oct 27. Erratum in: J Am Soc Nephrol. 2012 Mar;23(3):567.


Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype.

Medrano S, Monteagudo MC, Sequeira-Lopez ML, Pentz ES, Gomez RA.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F29-37. doi: 10.1152/ajprenal.00460.2011. Epub 2011 Oct 12.


Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

Castellanos Rivera RM, Monteagudo MC, Pentz ES, Glenn ST, Gross KW, Carretero O, Sequeira-Lopez ML, Gomez RA.

Physiol Genomics. 2011 Sep 8;43(17):1021-8. doi: 10.1152/physiolgenomics.00061.2011. Epub 2011 Jul 12.


Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells.

Kurt B, Kurtz L, Sequeira-Lopez ML, Gomez RA, Willecke K, Wagner C, Kurtz A.

Am J Physiol Renal Physiol. 2011 Mar;300(3):F743-8. doi: 10.1152/ajprenal.00647.2010. Epub 2011 Jan 5.


Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.

Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD.

Physiol Genomics. 2011 Mar 29;43(6):286-94. doi: 10.1152/physiolgenomics.00208.2010. Epub 2010 Dec 28.


Renal failure in mice with Gsalpha deletion in juxtaglomerular cells.

Chen L, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J.

Am J Nephrol. 2010;32(1):83-94. doi: 10.1159/000314635. Epub 2010 Jun 11.


Novel mechanisms for the control of renin synthesis and release.

Sequeira Lopez ML, Gomez RA.

Curr Hypertens Rep. 2010 Feb;12(1):26-32. doi: 10.1007/s11906-009-0080-z. Review.


Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.

Chen L, Kim SM, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Schnermann J, Briggs JP.

J Am Soc Nephrol. 2010 Jun;21(6):986-92. doi: 10.1681/ASN.2009030307. Epub 2010 Apr 15.


Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.

Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT.

Hypertension. 2010 Mar;55(3):660-6. doi: 10.1161/HYPERTENSIONAHA.109.138800. Epub 2010 Jan 11.


The microRNA-processing enzyme dicer maintains juxtaglomerular cells.

Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA.

J Am Soc Nephrol. 2010 Mar;21(3):460-7. doi: 10.1681/ASN.2009090964. Epub 2010 Jan 7.


Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway.

Neubauer B, Machura K, Chen M, Weinstein LS, Oppermann M, Sequeira-Lopez ML, Gomez RA, Schnermann J, Castrop H, Kurtz A, Wagner C.

Am J Physiol Renal Physiol. 2009 May;296(5):F1006-12. doi: 10.1152/ajprenal.90448.2008. Epub 2009 Mar 4.


CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

Gomez RA, Pentz ES, Jin X, Cordaillat M, Sequeira Lopez ML.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1255-62. doi: 10.1152/ajpheart.01266.2008. Epub 2009 Feb 27.


Who and where is the renal baroreceptor?: the connexin hypothesis.

Gomez RA, Sequeira Lopez ML.

Kidney Int. 2009 Mar;75(5):460-2. doi: 10.1038/ki.2008.536.


Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

Makhanova N, Sequeira-Lopez ML, Gomez RA, Kim HS, Smithies O.

Hypertension. 2006 Dec;48(6):1151-9. Epub 2006 Oct 30.


Kidney function in mice lacking aldosterone.

Makhanova N, Lee G, Takahashi N, Sequeira Lopez ML, Gomez RA, Kim HS, Smithies O.

Am J Physiol Renal Physiol. 2006 Jan;290(1):F61-9. Epub 2005 Aug 23.


Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.

Sequeira López ML, Pentz ES, Nomasa T, Smithies O, Gomez RA.

Dev Cell. 2004 May;6(5):719-28.

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