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Items: 1 to 50 of 83

1.

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity.

Budaitis BG, Jariwala S, Reinemann DN, Schimert KI, Scarabelli G, Grant BJ, Sept D, Lang MJ, Verhey KJ.

Elife. 2019 May 14;8. pii: e44146. doi: 10.7554/eLife.44146.

2.

Entropic effects enable life at extreme temperatures.

Kim YH, Leriche G, Diraviyam K, Koyanagi T, Gao K, Onofrei D, Patterson J, Guha A, Gianneschi N, Holland GP, Gilson MK, Mayer M, Sept D, Yang J.

Sci Adv. 2019 May 1;5(5):eaaw4783. doi: 10.1126/sciadv.aaw4783. eCollection 2019 May.

3.

The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth.

Chaaban S, Jariwala S, Hsu CT, Redemann S, Kollman JM, Müller-Reichert T, Sept D, Bui KH, Brouhard GJ.

Dev Cell. 2018 Oct 22;47(2):191-204.e8. doi: 10.1016/j.devcel.2018.08.023. Epub 2018 Sep 20.

PMID:
30245157
4.

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division.

Chen C, Cummings R, Mordovanakis A, Hunt AJ, Mayer M, Sept D, Yamashita YM.

Elife. 2018 Mar 26;7. pii: e33685. doi: 10.7554/eLife.33685.

5.

Frequency-Based Analysis of Gramicidin A Nanopores Enabling Detection of Small Molecules with Picomolar Sensitivity.

Kim YH, Hang L, Cifelli JL, Sept D, Mayer M, Yang J.

Anal Chem. 2018 Feb 6;90(3):1635-1642. doi: 10.1021/acs.analchem.7b02961. Epub 2018 Jan 16.

PMID:
29266927
6.

An electric-eel-inspired soft power source from stacked hydrogels.

Schroeder TBH, Guha A, Lamoureux A, VanRenterghem G, Sept D, Shtein M, Yang J, Mayer M.

Nature. 2017 Dec 13;552(7684):214-218. doi: 10.1038/nature24670.

7.

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia.

Krtková J, Xu J, Lalle M, Steele-Ogus M, Alas GCM, Sept D, Paredez AR.

mSphere. 2017 Sep 13;2(5). pii: e00248-17. doi: 10.1128/mSphere.00248-17. eCollection 2017 Sep-Oct.

8.

Hybrid Lipids Inspired by Extremophiles and Eukaryotes Afford Serum-Stable Membranes with Low Leakage.

Koyanagi T, Cao KJ, Leriche G, Onofrei D, Holland GP, Mayer M, Sept D, Yang J.

Chemistry. 2017 May 17;23(28):6757-6762. doi: 10.1002/chem.201701378. Epub 2017 Apr 20.

9.

Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine.

Castle BT, McCubbin S, Prahl LS, Bernens JN, Sept D, Odde DJ.

Mol Biol Cell. 2017 May 1;28(9):1238-1257. doi: 10.1091/mbc.E16-08-0567. Epub 2017 Mar 15.

10.

Real-time shape approximation and fingerprinting of single proteins using a nanopore.

Yusko EC, Bruhn BR, Eggenberger OM, Houghtaling J, Rollings RC, Walsh NC, Nandivada S, Pindrus M, Hall AR, Sept D, Li J, Kalonia DS, Mayer M.

Nat Nanotechnol. 2017 May;12(4):360-367. doi: 10.1038/nnano.2016.267. Epub 2016 Dec 19.

PMID:
27992411
11.

Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure.

Jepsen L, Kruth KA, Rubenstein PA, Sept D.

Biophys J. 2016 Jul 26;111(2):323-332. doi: 10.1016/j.bpj.2016.06.012.

12.

Effects of Lipid Tethering in Extremophile-Inspired Membranes on H(+)/OH(-) Flux at Room Temperature.

Schroeder TBH, Leriche G, Koyanagi T, Johnson MA, Haengel KN, Eggenberger OM, Wang CL, Kim YH, Diraviyam K, Sept D, Yang J, Mayer M.

Biophys J. 2016 Jun 7;110(11):2430-2440. doi: 10.1016/j.bpj.2016.04.044.

13.

Novel α-tubulin mutation disrupts neural development and tubulin proteostasis.

Gartz Hanson M, Aiken J, Sietsema DV, Sept D, Bates EA, Niswander L, Moore JK.

Dev Biol. 2016 Jan 15;409(2):406-19. doi: 10.1016/j.ydbio.2015.11.022. Epub 2015 Nov 30.

14.

Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.

Horger KS, Liu H, Rao DK, Shukla S, Sept D, Ambudkar SV, Mayer M.

Biochim Biophys Acta. 2015 Feb;1848(2):643-53. doi: 10.1016/j.bbamem.2014.10.023. Epub 2014 Nov 4.

15.

A method for multiprotein assembly in cells reveals independent action of kinesins in complex.

Norris SR, Soppina V, Dizaji AS, Schimert KI, Sept D, Cai D, Sivaramakrishnan S, Verhey KJ.

J Cell Biol. 2014 Nov 10;207(3):393-406. doi: 10.1083/jcb.201407086. Epub 2014 Nov 3.

16.

Capping protein regulators fine-tune actin assembly dynamics.

Edwards M, Zwolak A, Schafer DA, Sept D, Dominguez R, Cooper JA.

Nat Rev Mol Cell Biol. 2014 Oct;15(10):677-89. doi: 10.1038/nrm3869. Epub 2014 Sep 10. Review. Erratum in: Nat Rev Mol Cell Biol. 2014 Nov;15(11):701.

17.

Modeling large-scale dynamic processes in the cell: polarization, waves, and division.

Sept D, Carlsson AE.

Q Rev Biophys. 2014 Aug;47(3):221-48. doi: 10.1017/S0033583514000079. Review.

PMID:
25124728
18.

Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails.

Aiken J, Sept D, Costanzo M, Boone C, Cooper JA, Moore JK.

Curr Biol. 2014 Jun 16;24(12):1295-1303. doi: 10.1016/j.cub.2014.03.078. Epub 2014 May 15.

19.

Assessing the barriers to image-guided drug delivery.

Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):1-14. doi: 10.1002/wnan.1247. Epub 2013 Oct 31. Review.

20.

Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii.

Ma CI, Diraviyam K, Maier ME, Sept D, Sibley LD.

J Nat Prod. 2013 Sep 27;76(9):1565-72. doi: 10.1021/np400196w. Epub 2013 Sep 10.

21.

Multisite Ion Models That Improve Coordination and Free Energy Calculations in Molecular Dynamics Simulations.

Saxena A, Sept D.

J Chem Theory Comput. 2013 Aug 13;9(8):3538-42. doi: 10.1021/ct400177g. Epub 2013 Jul 18.

PMID:
26584110
22.

The unusual dynamics of parasite actin result from isodesmic polymerization.

Skillman KM, Ma CI, Fremont DH, Diraviyam K, Cooper JA, Sept D, Sibley LD.

Nat Commun. 2013;4:2285. doi: 10.1038/ncomms3285.

23.

Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.

Collier TS, Diraviyam K, Monsey J, Shen W, Sept D, Bose R.

J Biol Chem. 2013 Aug 30;288(35):25254-64. doi: 10.1074/jbc.M113.474882. Epub 2013 Jul 10.

24.

A model for the interfacial kinetics of phospholipase D activity on long-chain lipids.

Majd S, Yusko EC, Yang J, Sept D, Mayer M.

Biophys J. 2013 Jul 2;105(1):146-53. doi: 10.1016/j.bpj.2013.05.018.

25.

Mechanical properties of doubly stabilized microtubule filaments.

Hawkins TL, Sept D, Mogessie B, Straube A, Ross JL.

Biophys J. 2013 Apr 2;104(7):1517-28. doi: 10.1016/j.bpj.2013.02.026.

26.

Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity.

Prangkio P, Yusko EC, Sept D, Yang J, Mayer M.

PLoS One. 2012;7(10):e47261. doi: 10.1371/journal.pone.0047261. Epub 2012 Oct 15.

27.

Microtubules: sizing up the GTP cap.

Brouhard G, Sept D.

Curr Biol. 2012 Sep 25;22(18):R802-3. doi: 10.1016/j.cub.2012.07.050.

28.

Single-particle characterization of Aβ oligomers in solution.

Yusko EC, Prangkio P, Sept D, Rollings RC, Li J, Mayer M.

ACS Nano. 2012 Jul 24;6(7):5909-19. doi: 10.1021/nn300542q. Epub 2012 Jun 21.

29.

Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

Kim T, Ravilious GE, Sept D, Cooper JA.

J Biol Chem. 2012 May 4;287(19):15251-62. doi: 10.1074/jbc.M112.345447. Epub 2012 Mar 12.

30.

Synthesis of chondramide A analogues with modified β-tyrosine and their biological evaluation.

Zhdanko A, Schmauder A, Ma CI, Sibley LD, Sept D, Sasse F, Maier ME.

Chemistry. 2011 Nov 18;17(47):13349-57. doi: 10.1002/chem.201101978. Epub 2011 Oct 20.

31.

Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites.

Skillman KM, Diraviyam K, Khan A, Tang K, Sept D, Sibley LD.

PLoS Pathog. 2011 Oct;7(10):e1002280. doi: 10.1371/journal.ppat.1002280. Epub 2011 Oct 6.

32.

The interaction of cofilin with the actin filament.

Wong DY, Sept D.

J Mol Biol. 2011 Oct 14;413(1):97-105. doi: 10.1016/j.jmb.2011.08.039. Epub 2011 Aug 22.

33.

Drug-like leads for steric discrimination between substrate and inhibitors of human acetylcholinesterase.

Wildman SA, Zheng X, Sept D, Auletta JT, Rosenberry TL, Marshall GR.

Chem Biol Drug Des. 2011 Oct;78(4):495-504. doi: 10.1111/j.1747-0285.2011.01157.x. Epub 2011 Aug 22.

34.

An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins.

Paredez AR, Assaf ZJ, Sept D, Timofejeva L, Dawson SC, Wang CJ, Cande WZ.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6151-6. doi: 10.1073/pnas.1018593108. Epub 2011 Mar 28.

35.

Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and not influx, as the bigger hurdle in cancer drug therapy.

Sim H, Bibee K, Wickline S, Sept D.

Cancer Res. 2011 Feb 1;71(3):686-92. doi: 10.1158/0008-5472.CAN-10-2666. Epub 2010 Dec 1.

36.

The interaction of capping protein with the barbed end of the actin filament.

Kim T, Cooper JA, Sept D.

J Mol Biol. 2010 Dec 17;404(5):794-802. doi: 10.1016/j.jmb.2010.10.017. Epub 2010 Oct 20.

37.

An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.

Yang J, Krishnamoorthy G, Saxena A, Zhang G, Shi J, Yang H, Delaloye K, Sept D, Cui J.

Neuron. 2010 Jun 24;66(6):871-83. doi: 10.1016/j.neuron.2010.05.009.

38.

The kinetics of cooperative cofilin binding reveals two states of the cofilin-actin filament.

De La Cruz EM, Sept D.

Biophys J. 2010 May 19;98(9):1893-901. doi: 10.1016/j.bpj.2010.01.023.

39.

An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.

Goley ED, Rammohan A, Znameroski EA, Firat-Karalar EN, Sept D, Welch MD.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8159-64. doi: 10.1073/pnas.0911668107. Epub 2010 Apr 19.

40.

Microtubule elasticity: connecting all-atom simulations with continuum mechanics.

Sept D, MacKintosh FC.

Phys Rev Lett. 2010 Jan 8;104(1):018101. Epub 2010 Jan 4.

PMID:
20366396
41.

Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo.

Lin MC, Galletta BJ, Sept D, Cooper JA.

J Cell Sci. 2010 Apr 15;123(Pt 8):1329-42. doi: 10.1242/jcs.065698. Epub 2010 Mar 23.

42.

Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.

Ma C, Tran J, Gu F, Ochoa R, Li C, Sept D, Werbovetz K, Morrissette N.

Antimicrob Agents Chemother. 2010 Apr;54(4):1453-60. doi: 10.1128/AAC.01150-09. Epub 2010 Feb 9.

43.

F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin.

Oztug Durer ZA, Diraviyam K, Sept D, Kudryashov DS, Reisler E.

J Mol Biol. 2010 Jan 22;395(3):544-57. doi: 10.1016/j.jmb.2009.11.001. Epub 2009 Nov 6.

44.

The basic concepts of molecular modeling.

Saxena A, Wong D, Diraviyam K, Sept D.

Methods Enzymol. 2009;467:307-334. doi: 10.1016/S0076-6879(09)67012-9.

PMID:
19897098
45.

Protein-protein interactions: making drug design second nature.

Sackett DL, Sept D.

Nat Chem. 2009 Nov;1(8):596-7. doi: 10.1038/nchem.427. No abstract available.

PMID:
21378947
46.

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.

Silva JR, Pan H, Wu D, Nekouzadeh A, Decker KF, Cui J, Baker NA, Sept D, Rudy Y.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11102-6. doi: 10.1073/pnas.0904505106. Epub 2009 Jun 22.

47.

A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB.

Bean GJ, Flickinger ST, Westler WM, McCully ME, Sept D, Weibel DB, Amann KJ.

Biochemistry. 2009 Jun 9;48(22):4852-7. doi: 10.1021/bi900014d.

48.

Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.

Moore JK, Sept D, Cooper JA.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5147-52. doi: 10.1073/pnas.0810828106. Epub 2009 Mar 11.

49.

Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging.

Neubauer AM, Sim H, Winter PM, Caruthers SD, Williams TA, Robertson JD, Sept D, Lanza GM, Wickline SA.

Magn Reson Med. 2008 Dec;60(6):1353-61. doi: 10.1002/mrm.21795.

50.

Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules.

Mitra A, Sept D.

Biophys J. 2008 Oct;95(7):3252-8. doi: 10.1529/biophysj.108.133884. Epub 2008 Jul 11.

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