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Items: 1 to 50 of 66

1.

Painful interactions: Microbial compounds and visceral pain.

van Thiel IAM, Botschuijver S, de Jonge WJ, Seppen J.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165534. doi: 10.1016/j.bbadis.2019.165534. Epub 2019 Oct 18. Review.

2.

Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis.

Willemze RA, Brinkman DJ, Welting O, van Hamersveld PHP, Verseijden C, Luyer MD, Wildenberg ME, Seppen J, de Jonge WJ.

Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G557-G568. doi: 10.1152/ajpgi.00067.2019. Epub 2019 Jul 19.

PMID:
31322912
3.

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing.

Végh AMD, den Haan AD, Cócera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ.

Molecules. 2019 Jan 5;24(1). pii: E181. doi: 10.3390/molecules24010181.

4.

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis.

Willemze RA, Welting O, van Hamersveld P, Verseijden C, Nijhuis LE, Hilbers FW, Meijer SL, Heesters BA, Folgering JHA, Darwinkel H, Blancou P, Vervoordeldonk MJ, Seppen J, Heinsbroek SEM, de Jonge WJ.

Mol Med. 2019 Jan 7;25(1):1. doi: 10.1186/s10020-018-0068-8.

5.

Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.

Botschuijver S, Welting O, Levin E, Maria-Ferreira D, Koch E, Montijn RC, Seppen J, Hakvoort TBM, Schuren FHJ, de Jonge WJ, van den Wijngaard RM.

Neurogastroenterol Motil. 2018 Jun;30(6):e13299. doi: 10.1111/nmo.13299. Epub 2018 Jan 31.

PMID:
29383802
6.

Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.

Willemze RA, Welting O, van Hamersveld HP, Meijer SL, Folgering JHA, Darwinkel H, Witherington J, Sridhar A, Vervoordeldonk MJ, Seppen J, de Jonge WJ.

Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13163. Epub 2017 Jul 26.

PMID:
28745812
7.

Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.

Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM.

Gastroenterology. 2017 Oct;153(4):1026-1039. doi: 10.1053/j.gastro.2017.06.004. Epub 2017 Jun 15.

PMID:
28624575
8.

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.

van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Elferink RO, Beuers U, Bosma PJ.

Sci Rep. 2017 May 10;7(1):1646. doi: 10.1038/s41598-017-01602-w.

9.

Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity.

Dhawan S, De Palma G, Willemze RA, Hilbers FW, Verseijden C, Luyer MD, Nuding S, Wehkamp J, Souwer Y, de Jong EC, Seppen J, van den Wijngaard RM, Wehner S, Verdu E, Bercik P, de Jonge WJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G920-G933. doi: 10.1152/ajpgi.00114.2016. Epub 2016 Aug 11.

10.

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

Schilderink R, Verseijden C, Seppen J, Muncan V, van den Brink GR, Lambers TT, van Tol EA, de Jonge WJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1138-46. doi: 10.1152/ajpgi.00411.2015. Epub 2016 May 5.

11.

Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model.

Kingma SD, Wagemans T, IJlst L, Seppen J, Gijbels MJ, Wijburg FA, van Vlies N.

JIMD Rep. 2015;23:77-83. doi: 10.1007/8904_2015_432. Epub 2015 Apr 9.

12.

Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications.

van Wenum M, Chamuleau RA, van Gulik TM, Siliakus A, Seppen J, Hoekstra R.

Expert Opin Biol Ther. 2014 Dec;14(12):1745-60. doi: 10.1517/14712598.2014.950651. Epub 2014 Nov 4. Review.

PMID:
25366164
13.

Human fetal liver cells for regulated ex vivo erythropoietin gene therapy.

El Filali E, Duijst S, Hiralall JK, Legrand N, van Gulik T, Hoekstra R, Seppen J.

Mol Ther Methods Clin Dev. 2014 Mar 12;1:14003. doi: 10.1038/mtm.2014.3. eCollection 2014.

14.

Specific gene delivery to liver sinusoidal and artery endothelial cells.

Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Münch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schüttrumpf J, Müller UC, Seppen J, Ott M, Buchholz CJ.

Blood. 2013 Sep 19;122(12):2030-8. doi: 10.1182/blood-2012-11-468579. Epub 2013 Jul 24.

PMID:
23884859
15.

Lynch syndrome: the patients' perspective.

Seppen J, Bruzzone L.

Fam Cancer. 2013 Jun;12(2):341-5. doi: 10.1007/s10689-013-9630-2. Review.

PMID:
23532831
16.

Phase 1 and phase 2 drug metabolism and bile acid production of HepaRG cells in a bioartificial liver in absence of dimethyl sulfoxide.

Hoekstra R, Nibourg GA, van der Hoeven TV, Plomer G, Seppen J, Ackermans MT, Camus S, Kulik W, van Gulik TM, Elferink RP, Chamuleau RA.

Drug Metab Dispos. 2013 Mar;41(3):562-7. doi: 10.1124/dmd.112.049098. Epub 2012 Dec 13.

PMID:
23238784
17.

Bilirubin, the gold within.

Seppen J, Bosma P.

Circulation. 2012 Nov 27;126(22):2547-9. doi: 10.1161/CIRCULATIONAHA.112.147082. Epub 2012 Oct 30. No abstract available.

PMID:
23110861
18.

Human liver endothelial cells, but not macrovascular or microvascular endothelial cells, engraft in the mouse liver.

Filali EE, Hiralall JK, van Veen HA, Stolz DB, Seppen J.

Cell Transplant. 2013;22(10):1801-11. doi: 10.3727/096368912X657594. Epub 2012 Oct 3.

PMID:
23044355
19.

A diet containing the soy phytoestrogen genistein causes infertility in female rats partially deficient in UDP glucuronyltransferase.

Seppen J.

Toxicol Appl Pharmacol. 2012 Nov 1;264(3):335-42. doi: 10.1016/j.taap.2012.09.013. Epub 2012 Sep 20.

PMID:
23000043
20.

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

Bakker ML, Boink GJ, Boukens BJ, Verkerk AO, van den Boogaard M, den Haan AD, Hoogaars WM, Buermans HP, de Bakker JM, Seppen J, Tan HL, Moorman AF, 't Hoen PA, Christoffels VM.

Cardiovasc Res. 2012 Jun 1;94(3):439-49. doi: 10.1093/cvr/cvs120. Epub 2012 Mar 14.

PMID:
22419669
21.

Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases.

Folmer DE, Mok KS, de Wee SW, Duijst S, Hiralall JK, Seppen J, Oude Elferink RP, Paulusma CC.

J Histochem Cytochem. 2012 Mar;60(3):205-18. doi: 10.1369/0022155411435705. Epub 2012 Jan 17.

22.

DLK1, a serum marker for hepatoblastoma in young infants.

Falix FA, Aronson DC, Lamers WH, Hiralall JK, Seppen J.

Pediatr Blood Cancer. 2012 Oct;59(4):743-5. doi: 10.1002/pbc.24024. Epub 2011 Dec 16.

PMID:
22180200
23.

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042. Epub 2011 Aug 4.

PMID:
21820390
24.

[Gluttony and penance--laxatives and 'liver stones'].

van Hooft J, Oude Elferink R, Seppen J.

Ned Tijdschr Geneeskd. 2010;154(51-52):A2645. Dutch.

PMID:
21211072
25.

Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats.

Markusic DM, de Waart DR, Seppen J.

PLoS One. 2010 Apr 1;5(4):e9974. doi: 10.1371/journal.pone.0009974.

26.

Doxycycline regulated lentiviral vectors.

Markusic D, Seppen J.

Methods Mol Biol. 2010;614:69-76. doi: 10.1007/978-1-60761-533-0_4.

PMID:
20225036
27.

Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes.

Deurholt T, van Til NP, Chhatta AA, ten Bloemendaal L, Schwartlander R, Payne C, Plevris JN, Sauer IM, Chamuleau RA, Elferink RP, Seppen J, Hoekstra R.

BMC Biotechnol. 2009 Oct 21;9:89. doi: 10.1186/1472-6750-9-89.

28.

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain.

Markusic DM, van Til NP, Hiralall JK, Elferink RP, Seppen J.

BMC Biotechnol. 2009 Oct 7;9:85. doi: 10.1186/1472-6750-9-85.

29.

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

Centlivre M, Zhou X, Pouw SM, Weijer K, Kleibeuker W, Das AT, Blom B, Seppen J, Berkhout B, Legrand N.

Gene Ther. 2010 Jan;17(1):14-25. doi: 10.1038/gt.2009.109. Epub 2009 Sep 3.

PMID:
19727135
30.

Synthetic gene regulation circuits for control of cell expansion.

May T, Butueva M, Bantner S, Markusic D, Seppen J, MacLeod RA, Weich H, Hauser H, Wirth D.

Tissue Eng Part A. 2010 Feb;16(2):441-52. doi: 10.1089/ten.TEA.2009.0184.

PMID:
19705962
31.

Small animal models of hepatocyte transplantation.

Seppen J, Filali EE, Elferink RO.

Methods Mol Biol. 2009;481:75-82. doi: 10.1007/978-1-59745-201-4_7. Review.

PMID:
19096792
32.

Biological pacing by gene and cell therapy.

Boink GJ, Seppen J, de Bakker JM, Tan HL.

Neth Heart J. 2007;15(9):318-22.

33.

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer.

Boink GJ, Verkerk AO, van Amersfoorth SC, Tasseron SJ, van der Rijt R, Bakker D, Linnenbank AC, van der Meulen J, de Bakker JM, Seppen J, Tan HL.

J Gene Med. 2008 May;10(5):487-97. doi: 10.1002/jgm.1172.

PMID:
18383475
34.

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity.

van Til NP, Heutinck KM, van der Rijt R, Paulusma CC, van Wijland M, Markusic DM, Elferink RP, Seppen J.

Retrovirology. 2008 Feb 1;5:14. doi: 10.1186/1742-4690-5-14.

35.

The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux.

Vrins C, Vink E, Vandenberghe KE, Frijters R, Seppen J, Groen AK.

FEBS Lett. 2007 Oct 2;581(24):4616-20. Epub 2007 Aug 31.

36.

Domain-wide regulation of gene expression in the human genome.

Gierman HJ, Indemans MH, Koster J, Goetze S, Seppen J, Geerts D, van Driel R, Versteeg R.

Genome Res. 2007 Sep;17(9):1286-95. Epub 2007 Aug 10.

37.

Preferential gene transfer of lentiviral vectors to liver-derived cells, using a hepatitis B peptide displayed on GP64.

Markusic DM, Kanitz A, Oude-Elferink RP, Seppen J.

Hum Gene Ther. 2007 Jul;18(7):673-9.

PMID:
17630838
38.

In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

Deurholt T, ten Bloemendaal L, Chhatta AA, van Wijk AC, Weijer K, Seppen J, Elferink RP, Chamuleau RA, Hoekstra R.

Cell Transplant. 2006;15(8-9):811-22.

PMID:
17269451
39.

Gene therapy to create biological pacemakers.

Boink GJ, Seppen J, de Bakker JM, Tan HL.

Med Biol Eng Comput. 2007 Feb;45(2):167-76. Epub 2006 Oct 18. Review.

PMID:
17048028
40.

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.

Bonta PI, van Tiel CM, Vos M, Pols TW, van Thienen JV, Ferreira V, Arkenbout EK, Seppen J, Spek CA, van der Poll T, Pannekoek H, de Vries CJ.

Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2288-94. Epub 2006 Jul 27.

PMID:
16873729
41.

Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats.

Seppen J, Bakker C, de Jong B, Kunne C, van den Oever K, Vandenberghe K, de Waart R, Twisk J, Bosma P.

Mol Ther. 2006 Jun;13(6):1085-92. Epub 2006 Apr 3.

42.

Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats.

Seppen J, van Til NP, van der Rijt R, Hiralall JK, Kunne C, Elferink RP.

Gene Ther. 2006 Apr;13(8):672-7.

PMID:
16267566
43.

Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes.

Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJ, Biessen EA, van Berkel TJ, Pannekoek H, Horrevoets AJ.

Am J Pathol. 2005 Aug;167(2):609-18.

44.

Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery.

Barry S, Brzezinski M, Yanay O, Seppen JE, Osborne WR.

J Gene Med. 2005 Dec;7(12):1510-6.

PMID:
16041689
45.

Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo.

Bot I, Guo J, Van Eck M, Van Santbrink PJ, Groot PH, Hildebrand RB, Seppen J, Van Berkel TJ, Biessen EA.

Blood. 2005 Aug 15;106(4):1147-53. Epub 2005 May 10.

PMID:
15886324
46.

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter.

Markusic D, Oude-Elferink R, Das AT, Berkhout B, Seppen J.

Nucleic Acids Res. 2005 Apr 4;33(6):e63.

47.

Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes.

van Til NP, Markusic DM, van der Rijt R, Kunne C, Hiralall JK, Vreeling H, Frederiks WM, Oude-Elferink RP, Seppen J.

Mol Ther. 2005 Jan;11(1):26-34.

48.

Unedited inhibition of HBV replication by APOBEC3G.

Seppen J.

J Hepatol. 2004 Dec;41(6):1068-9. No abstract available.

PMID:
15582148
49.

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes.

Carlotti F, Bazuine M, Kekarainen T, Seppen J, Pognonec P, Maassen JA, Hoeben RC.

Mol Ther. 2004 Feb;9(2):209-17.

50.

Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer.

Seppen J, van der Rijt R, Looije N, van Til NP, Lamers WH, Oude Elferink RP.

Mol Ther. 2003 Oct;8(4):593-9.

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