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Items: 1 to 50 of 84

1.

Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics.

Koistinen VM, da Silva AB, Abrankó L, Low D, Villalba RG, Barberán FT, Landberg R, Savolainen O, Alvarez-Acero I, de Pascual-Teresa S, Van Poucke C, Almeida C, Petrásková L, Valentová K, Durand S, Wiczkowski W, Szawara-Nowak D, González-Domínguez R, Llorach R, Andrés-Lacueva C, Aura AM, Seppänen-Laakso T, Hanhineva K, Manach C, Bronze MR.

Metabolites. 2018 Aug 24;8(3). pii: E46. doi: 10.3390/metabo8030046.

2.

In Vitro Gut Metabolism of [U-13 C]-Quinic Acid, The Other Hydrolysis Product of Chlorogenic Acid.

Naranjo Pinta M, Montoliu I, Aura AM, Seppänen-Laakso T, Barron D, Moco S.

Mol Nutr Food Res. 2018 Aug 16:e1800396. doi: 10.1002/mnfr.201800396. [Epub ahead of print]

PMID:
30113130
3.

Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period.

Qin N, Kokkonen T, Salin S, Seppänen-Laakso T, Taponen J, Vanhatalo A, Elo K.

J Dairy Sci. 2018 Oct;101(10):8929-8943. doi: 10.3168/jds.2017-13153. Epub 2018 Aug 1.

PMID:
30077441
4.

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions.

Wang Y, Seppänen-Laakso T, Rischer H, Wiebe MG.

PLoS One. 2018 Apr 12;13(4):e0195329. doi: 10.1371/journal.pone.0195329. eCollection 2018.

5.

Plant cells as food - A concept taking shape.

Nordlund E, Lille M, Silventoinen P, Nygren H, Seppänen-Laakso T, Mikkelson A, Aura AM, Heiniö RL, Nohynek L, Puupponen-Pimiä R, Rischer H.

Food Res Int. 2018 May;107:297-305. doi: 10.1016/j.foodres.2018.02.045. Epub 2018 Feb 19.

6.

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis.

Shikov AN, Laakso I, Pozharitskaya ON, Seppänen-Laakso T, Krishtopina AS, Makarova MN, Vuorela H, Makarov V.

Mar Drugs. 2017 Nov 24;15(12). pii: E365. doi: 10.3390/md15120365.

7.

UPLC-ELSD Analysis of Algal Lipid Classes and Derivatization of Bound and Free Fatty Acids and Sterols for GC-MS Methods.

Seppänen-Laakso T, Nygren H, Rischer H.

Methods Mol Biol. 2017 Nov 21. doi: 10.1007/7651_2017_109. [Epub ahead of print]

PMID:
29159730
8.

Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Analysis of Molecular Lipids in Algae Samples.

Nygren H, Seppänen-Laakso T, Rischer H.

Methods Mol Biol. 2017 Nov 21. doi: 10.1007/7651_2017_108. [Epub ahead of print]

PMID:
29159726
9.

Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids.

Krogerus K, Seppänen-Laakso T, Castillo S, Gibson B.

Microb Cell Fact. 2017 Apr 21;16(1):66. doi: 10.1186/s12934-017-0679-8.

10.

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species.

Suvanto J, Nohynek L, Seppänen-Laakso T, Rischer H, Salminen JP, Puupponen-Pimiä R.

Planta. 2017 Aug;246(2):227-241. doi: 10.1007/s00425-017-2686-8. Epub 2017 Apr 5.

11.

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia.

Hotti H, Gopalacharyulu P, Seppänen-Laakso T, Rischer H.

PLoS One. 2017 Feb 21;12(2):e0171078. doi: 10.1371/journal.pone.0171078. eCollection 2017.

12.

Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction.

Castillo S, Barth D, Arvas M, Pakula TM, Pitkänen E, Blomberg P, Seppanen-Laakso T, Nygren H, Sivasiddarthan D, Penttilä M, Oja M.

Biotechnol Biofuels. 2016 Nov 21;9:252. eCollection 2016.

13.

A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention.

Lankinen M, Schwab U, Kolehmainen M, Paananen J, Nygren H, Seppänen-Laakso T, Poutanen K, Hyötyläinen T, Risérus U, Savolainen MJ, Hukkanen J, Brader L, Marklund M, Rosqvist F, Hermansen K, Cloetens L, Önning G, Thorsdottir I, Gunnarsdottir I, Åkesson B, Dragsted LO, Uusitupa M, Orešič M.

J Nutr. 2016 Mar 9. pii: jn220459. [Epub ahead of print]

PMID:
26962194
14.

Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry.

Akhgari A, Laakso I, Seppänen-Laakso T, Yrjönen T, Vuorela H, Oksman-Caldentey KM, Rischer H.

Molecules. 2015 Dec 17;20(12):22621-34. doi: 10.3390/molecules201219873.

15.

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures.

Häkkinen ST, Seppänen-Laakso T, Oksman-Caldentey KM, Rischer H.

Front Plant Sci. 2015 Nov 24;6:1035. doi: 10.3389/fpls.2015.01035. eCollection 2015.

16.

Polyketide synthases from poison hemlock (Conium maculatum L.).

Hotti H, Seppänen-Laakso T, Arvas M, Teeri TH, Rischer H.

FEBS J. 2015 Nov;282(21):4141-56. doi: 10.1111/febs.13410. Epub 2015 Sep 11.

17.

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS.

Akhgari A, Laakso I, Seppänen-Laakso T, Yrjönen T, Vuorela H, Oksman-Caldentey KM, Rischer H.

Phytochem Anal. 2015 Sep-Oct;26(5):331-8. doi: 10.1002/pca.2567. Epub 2015 Jun 11.

PMID:
26095837
18.

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.

Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15.

19.

Analysis of beers from an 1840s' shipwreck.

Londesborough J, Dresel M, Gibson B, Juvonen R, Holopainen U, Mikkelson A, Seppänen-Laakso T, Viljanen K, Virtanen H, Wilpola A, Hofmann T, Wilhelmson A.

J Agric Food Chem. 2015 Mar 11;63(9):2525-36. doi: 10.1021/jf5052943. Epub 2015 Feb 26.

PMID:
25664918
20.

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.

Ritala A, Dong L, Imseng N, Seppänen-Laakso T, Vasilev N, van der Krol S, Rischer H, Maaheimo H, Virkki A, Brändli J, Schillberg S, Eibl R, Bouwmeester H, Oksman-Caldentey KM.

J Biotechnol. 2014 Apr 20;176:20-8. doi: 10.1016/j.jbiotec.2014.01.031. Epub 2014 Feb 14.

PMID:
24530945
21.

[Fatty fish modifies HDL particle size and lipid concentrations].

Joukamo L, Lankinen M, Schwab U, Soininen P, Kangas AJ, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Oresic M, Ala-Korpela M, Uusitupa M.

Duodecim. 2013;129(24):2661-70. Finnish.

PMID:
24471210
22.

Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients.

Hilvo M, Gade S, Hyötyläinen T, Nekljudova V, Seppänen-Laakso T, Sysi-Aho M, Untch M, Huober J, von Minckwitz G, Denkert C, Orešič M, Loibl S.

Int J Cancer. 2014 Apr 1;134(7):1725-33. doi: 10.1002/ijc.28491. Epub 2013 Oct 8.

23.

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.

Puupponen-Pimiä R, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, Leppänen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tómas-Barberán FA, Espín JC, Oksman-Caldentey KM.

Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12.

PMID:
23934737
24.

Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes.

La Torre D, Seppänen-Laakso T, Larsson HE, Hyötyläinen T, Ivarsson SA, Lernmark A, Oresic M; DiPiS Study Group.

Diabetes. 2013 Nov;62(11):3951-6. doi: 10.2337/db13-0215. Epub 2013 Aug 8.

25.

Plant cells as pharmaceutical factories.

Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Miralpeix B, Capell T, Christou P, Oksman-Caldentey KM.

Curr Pharm Des. 2013;19(31):5640-60. Review.

PMID:
23394561
26.

Metabolic engineering of plant secondary products: which way forward?

Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM, Capell T, Christou P.

Curr Pharm Des. 2013;19(31):5622-39. Review.

PMID:
23394556
27.

T-cell activation induces selective changes of cellular lipidome.

Lonnberg T, Yetukuri L, Seppanen-Laakso T, Lahesmaa R, Oresic M.

Front Biosci (Elite Ed). 2013 Jan 1;5:558-73.

PMID:
23277012
28.

Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction.

Ylipaasto P, Smura T, Gopalacharyulu P, Paananen A, Seppänen-Laakso T, Kaijalainen S, Ahlfors H, Korsgren O, Lakey JR, Lahesmaa R, Piemonti L, Oresic M, Galama J, Roivainen M.

Diabetologia. 2012 Dec;55(12):3273-83. doi: 10.1007/s00125-012-2713-z. Epub 2012 Sep 16.

PMID:
22983635
29.

Insulin signaling regulates fatty acid catabolism at the level of CoA activation.

Xu X, Gopalacharyulu P, Seppänen-Laakso T, Ruskeepää AL, Aye CC, Carson BP, Mora S, Orešič M, Teleman AA.

PLoS Genet. 2012 Jan;8(1):e1002478. doi: 10.1371/journal.pgen.1002478. Epub 2012 Jan 19.

30.

Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia.

Orešič M, Seppänen-Laakso T, Sun D, Tang J, Therman S, Viehman R, Mustonen U, van Erp TG, Hyötyläinen T, Thompson P, Toga AW, Huttunen MO, Suvisaari J, Kaprio J, Lönnqvist J, Cannon TD.

Genome Med. 2012 Jan 18;4(1):1. doi: 10.1186/gm300.

31.

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.

Vainio P, Lehtinen L, Mirtti T, Hilvo M, Seppänen-Laakso T, Virtanen J, Sankila A, Nordling S, Lundin J, Rannikko A, Orešič M, Kallioniemi O, Iljin K.

Oncotarget. 2011 Dec;2(12):1176-90.

32.

Metabolic regulation in progression to autoimmune diabetes.

Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M.

PLoS Comput Biol. 2011 Oct;7(10):e1002257. doi: 10.1371/journal.pcbi.1002257. Epub 2011 Oct 27.

33.

Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes.

Pflueger M, Seppänen-Laakso T, Suortti T, Hyötyläinen T, Achenbach P, Bonifacio E, Orešič M, Ziegler AG.

Diabetes. 2011 Nov;60(11):2740-7. doi: 10.2337/db10-1652.

34.

Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study.

Lankinen M, Schwab U, Kolehmainen M, Paananen J, Poutanen K, Mykkänen H, Seppänen-Laakso T, Gylling H, Uusitupa M, Orešič M.

PLoS One. 2011;6(8):e22646. doi: 10.1371/journal.pone.0022646. Epub 2011 Aug 25.

35.

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M.

PLoS Biol. 2011 Jun;9(6):e1000623. doi: 10.1371/journal.pbio.1000623. Epub 2011 Jun 7.

36.

Human tear fluid lipidome: from composition to function.

Rantamäki AH, Seppänen-Laakso T, Oresic M, Jauhiainen M, Holopainen JM.

PLoS One. 2011 May 5;6(5):e19553. doi: 10.1371/journal.pone.0019553.

37.

Metabolome in schizophrenia and other psychotic disorders: a general population-based study.

Orešič M, Tang J, Seppänen-Laakso T, Mattila I, Saarni SE, Saarni SI, Lönnqvist J, Sysi-Aho M, Hyötyläinen T, Perälä J, Suvisaari J.

Genome Med. 2011 Mar 23;3(3):19. doi: 10.1186/gm233.

38.

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression.

Hilvo M, Denkert C, Lehtinen L, Müller B, Brockmöller S, Seppänen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, Berg E, Nygren H, Sysi-Aho M, Griffin JL, Fiehn O, Loibl S, Richter-Ehrenstein C, Radke C, Hyötyläinen T, Kallioniemi O, Iljin K, Oresic M.

Cancer Res. 2011 May 1;71(9):3236-45. doi: 10.1158/0008-5472.CAN-10-3894. Epub 2011 Mar 17.

39.

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy.

Sysi-Aho M, Koikkalainen J, Seppänen-Laakso T, Kaartinen M, Kuusisto J, Peuhkurinen K, Kärkkäinen S, Antila M, Lauerma K, Reissell E, Jurkko R, Lötjönen J, Heliö T, Orešič M.

PLoS One. 2011 Jan 20;6(1):e15744. doi: 10.1371/journal.pone.0015744.

40.

Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues.

Nygren H, Seppänen-Laakso T, Castillo S, Hyötyläinen T, Orešič M.

Methods Mol Biol. 2011;708:247-57. doi: 10.1007/978-1-61737-985-7_15.

PMID:
21207295
41.

Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women.

Lankinen M, Schwab U, Seppänen-Laakso T, Mattila I, Juntunen K, Mykkänen H, Poutanen K, Gylling H, Oresic M.

J Nutr. 2011 Jan;141(1):31-6. doi: 10.3945/jn.110.131656. Epub 2010 Nov 17.

PMID:
21084654
42.

Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs.

Leskinen T, Rinnankoski-Tuikka R, Rintala M, Seppänen-Laakso T, Pöllänen E, Alen M, Sipilä S, Kaprio J, Kovanen V, Rahkila P, Oresic M, Kainulainen H, Kujala UM.

PLoS One. 2010 Sep 16;5(9). pii: e12609. doi: 10.1371/journal.pone.0012609.

43.

Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.

Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttilä J, Seppänen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Orešič M, Yki-Järvinen H.

Gastroenterology. 2010 Dec;139(6):1961-1971.e1. doi: 10.1053/j.gastro.2010.06.064. Epub 2010 Jun 27.

PMID:
20600015
44.

Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol.

Yetukuri L, Söderlund S, Koivuniemi A, Seppänen-Laakso T, Niemelä PS, Hyvönen M, Taskinen MR, Vattulainen I, Jauhiainen M, Oresic M.

J Lipid Res. 2010 Aug;51(8):2341-51. doi: 10.1194/jlr.M006494. Epub 2010 Apr 29.

45.

Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil.

Seppänen-Laakso T, Laakso I, Lehtimäki T, Rontu R, Moilanen E, Solakivi T, Seppo L, Vanhanen H, Kiviranta K, Hiltunen R.

Prostaglandins Leukot Essent Fatty Acids. 2010 Jul;83(1):45-54. doi: 10.1016/j.plefa.2010.02.001. Epub 2010 Mar 4.

PMID:
20206485
46.

Ketogenic diet slows down mitochondrial myopathy progression in mice.

Ahola-Erkkilä S, Carroll CJ, Peltola-Mjösund K, Tulkki V, Mattila I, Seppänen-Laakso T, Oresic M, Tyynismaa H, Suomalainen A.

Hum Mol Genet. 2010 May 15;19(10):1974-84. doi: 10.1093/hmg/ddq076. Epub 2010 Feb 17.

PMID:
20167576
47.

Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome.

Kajander K, Myllyluoma E, Kyrönpalo S, Rasmussen M, Sipponen P, Mattila I, Seppänen-Laakso T, Vapaatalo H, Oresic M, Korpela R.

World J Gastroenterol. 2009 Dec 28;15(48):6068-74.

48.

Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum.

Kotronen A, Seppänen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää AL, Yki-Järvinen H, Oresic M.

Obesity (Silver Spring). 2010 May;18(5):937-44. doi: 10.1038/oby.2009.326. Epub 2009 Oct 1.

49.

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease.

de Mello VD, Lankinen M, Schwab U, Kolehmainen M, Lehto S, Seppänen-Laakso T, Oresic M, Pulkkinen L, Uusitupa M, Erkkilä AT.

Diabetologia. 2009 Dec;52(12):2612-5. doi: 10.1007/s00125-009-1482-9. Epub 2009 Aug 11.

PMID:
19669729
50.

Gut microbiota affects lens and retinal lipid composition.

Oresic M, Seppänen-Laakso T, Yetukuri L, Bäckhed F, Hänninen V.

Exp Eye Res. 2009 Nov;89(5):604-7. doi: 10.1016/j.exer.2009.06.018. Epub 2009 Jul 8.

PMID:
19591827

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