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Items: 14

1.

Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations.

Seplyarskiy VB, Akkuratov EE, Akkuratova N, Andrianova MA, Nikolaev SI, Bazykin GA, Adameyko I, Sunyaev SR.

Nat Genet. 2019 Jan;51(1):36-41. doi: 10.1038/s41588-018-0285-7. Epub 2018 Dec 3.

PMID:
30510240
2.

Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence.

Goldmann JM, Seplyarskiy VB, Wong WSW, Vilboux T, Neerincx PB, Bodian DL, Solomon BD, Veltman JA, Deeken JF, Gilissen C, Niederhuber JE.

Nat Genet. 2018 Apr;50(4):487-492. doi: 10.1038/s41588-018-0071-6. Epub 2018 Mar 5.

PMID:
29507425
3.

Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours.

Andrianova MA, Chetan GK, Sibin MK, Mckee T, Merkler D, Narasinga RK, Ribaux P, Blouin JL, Makrythanasis P, Seplyarskiy VB, Antonarakis SE, Nikolaev SI.

J Pathol. 2017 Nov;243(3):331-341. doi: 10.1002/path.4957. Epub 2017 Sep 28.

PMID:
28805995
4.

Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.

Andrianova MA, Bazykin GA, Nikolaev SI, Seplyarskiy VB.

Genome Res. 2017 Aug;27(8):1336-1343. doi: 10.1101/gr.219915.116. Epub 2017 May 16.

5.

Evolution of Local Mutation Rate and Its Determinants.

Terekhanova NV, Seplyarskiy VB, Soldatov RA, Bazykin GA.

Mol Biol Evol. 2017 May 1;34(5):1100-1109. doi: 10.1093/molbev/msx060.

6.

APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.

Seplyarskiy VB, Andrianova MA, Bazykin GA.

Genome Res. 2017 Feb;27(2):175-184. doi: 10.1101/gr.210336.116. Epub 2016 Dec 9.

7.

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI.

Nat Genet. 2016 Apr;48(4):398-406. doi: 10.1038/ng.3525. Epub 2016 Mar 7.

PMID:
26950094
8.

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.

Seplyarskiy VB, Soldatov RA, Popadin KY, Antonarakis SE, Bazykin GA, Nikolaev SI.

Genome Res. 2016 Feb;26(2):174-82. doi: 10.1101/gr.197046.115. Epub 2016 Jan 11.

9.

Polymerase ΞΆ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures.

Seplyarskiy VB, Bazykin GA, Soldatov RA.

Mol Biol Evol. 2015 Dec;32(12):3158-72. doi: 10.1093/molbev/msv184. Epub 2015 Sep 15.

PMID:
26376651
10.

Extraordinary Genetic Diversity in a Wood Decay Mushroom.

Baranova MA, Logacheva MD, Penin AA, Seplyarskiy VB, Safonova YY, Naumenko SA, Klepikova AV, Gerasimov ES, Bazykin GA, James TY, Kondrashov AS.

Mol Biol Evol. 2015 Oct;32(10):2775-83. doi: 10.1093/molbev/msv153. Epub 2015 Jul 10.

11.

Gene age predicts the strength of purifying selection acting on gene expression variation in humans.

Popadin KY, Gutierrez-Arcelus M, Lappalainen T, Buil A, Steinberg J, Nikolaev SI, Lukowski SW, Bazykin GA, Seplyarskiy VB, Ioannidis P, Zdobnov EM, Dermitzakis ET, Antonarakis SE.

Am J Hum Genet. 2014 Dec 4;95(6):660-74. doi: 10.1016/j.ajhg.2014.11.003.

12.

Crossing-over in a hypervariable species preferentially occurs in regions of high local similarity.

Seplyarskiy VB, Logacheva MD, Penin AA, Baranova MA, Leushkin EV, Demidenko NV, Klepikova AV, Kondrashov FA, Kondrashov AS, James TY.

Mol Biol Evol. 2014 Nov;31(11):3016-25. doi: 10.1093/molbev/msu242. Epub 2014 Aug 18.

13.

Prevalence of multinucleotide replacements in evolution of primates and Drosophila.

Terekhanova NV, Bazykin GA, Neverov A, Kondrashov AS, Seplyarskiy VB.

Mol Biol Evol. 2013 Jun;30(6):1315-25. doi: 10.1093/molbev/mst036. Epub 2013 Feb 27.

14.

Heterogeneity of the transition/transversion ratio in Drosophila and Hominidae genomes.

Seplyarskiy VB, Kharchenko P, Kondrashov AS, Bazykin GA.

Mol Biol Evol. 2012 Aug;29(8):1943-55. doi: 10.1093/molbev/mss071. Epub 2012 Feb 15.

PMID:
22337862

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