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Differential frontal alpha oscillations and mechanisms underlying loss of consciousness: a comparison between slow and fast propofol infusion rates.

Sepúlveda P, Cortinez LI, Irani M, Egaña JI, Contreras V, Sánchez Corzo A, Acosta I, Sitaram R.

Anaesthesia. 2019 Dec 1. doi: 10.1111/anae.14885. [Epub ahead of print]


Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension: A Double-Blind, Placebo-Controlled Study.

White RJ, Jerjes-Sanchez C, Bohns Meyer GM, Pulido T, Sepulveda P, Wang KY, Grünig E, Hiremath S, Yu Z, Gangcheng Z, Yip WLJ, Zhang S, Khan A, Deng CQ, Grover R, Tapson VF; FREEDOM-EV Investigators.

Am J Respir Crit Care Med. 2019 Nov 25. doi: 10.1164/rccm.201908-1640OC. [Epub ahead of print]


Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation.

Gil-Castell O, Badia JD, Ontoria-Oviedo I, Castellano D, Sepúlveda P, Ribes-Greus A.

Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110296. doi: 10.1016/j.msec.2019.110296. Epub 2019 Oct 14.


Refractory Myopic Retinal Detachment and Macular Hole Closure with Autologous Neurosensory Retinal Free Flap.

Sousa Neves F, Braga J, Sepúlveda P, Bilhoto M.

Case Rep Ophthalmol. 2019 May 23;10(2):160-164. doi: 10.1159/000500275. eCollection 2019 May-Aug.


Bartonella Infection in Stray Dogs from Central and Southern Chile (Linares and Puerto Montt).

Weinborn-Astudillo RM, Pau N, Tobar BZ, Jaffe DA, Boulouis HJ, Sepúlveda P, Müller A, Chomel BB.

Vector Borne Zoonotic Dis. 2019 Oct 29. doi: 10.1089/vbz.2019.2505. [Epub ahead of print]


Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.

Lewalle A, Land S, Merken JJ, Raafs A, Sepúlveda P, Heymans S, Kleinjans J, Niederer SA.

Biophys J. 2019 Jul 29. pii: S0006-3495(19)30622-8. doi: 10.1016/j.bpj.2019.07.033. [Epub ahead of print]


Trends of maxillofacial trauma: An update from the prospective register of a multicenter study in emergency services of Chile.

Werlinger F, Villalón M, Duarte V, Acevedo R, Aguilera R, Alcocer D, Badillo O, Briones R, Condal C, Del Río M, García R, Herrera M, Jaramillo J, Merchan F, Nasi M, Osbén R, Rivera A, Riviello S, Rojas P, Vidal C, Rodríguez G, Schild S, Arroyo E, Alvarado MJ, Sepúlveda P, Cortés J.

Med Oral Patol Oral Cir Bucal. 2019 Sep 1;24(5):e588-e594. doi: 10.4317/medoral.22985.


[Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension].

Sepúlveda P, Ortega J, Armijo G, Torres J, Ramírez P, Backhouse C, Vargas C, López L, González F, Puentes Á, Donoso H, Bellet A, Godoy D, Araya M, Andrade CL, Molina JP, Nazzal C.

Rev Med Chil. 2019 Apr;147(4):426-436. doi: 10.4067/S0034-98872019000400426. Spanish.


Postoperative Delirium and EEG Monitoring.

Lobo FA, Robba C, Romagnoli S, Naranjo M, Boveri H, Sepulveda P.

J Neurosurg Anesthesiol. 2019 Oct;31(4):446-447. doi: 10.1097/ANA.0000000000000618. No abstract available.


Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36.

Garcia NA, González-King H, Grueso E, Sánchez R, Martinez-Romero A, Jávega B, O'Connor JE, Simons PJ, Handberg A, Sepúlveda P.

PLoS One. 2019 May 29;14(5):e0217546. doi: 10.1371/journal.pone.0217546. eCollection 2019.


Synthesis and characterization of zeolite-based composites functionalized with nanoscale zero-valent iron for removing arsenic in the presence of selenium from water.

Suazo-Hernández J, Sepúlveda P, Manquián-Cerda K, Ramírez-Tagle R, Rubio MA, Bolan N, Sarkar B, Arancibia-Miranda N.

J Hazard Mater. 2019 Jul 5;373:810-819. doi: 10.1016/j.jhazmat.2019.03.125. Epub 2019 Apr 1.


Neural inertia and differences between loss of and recovery from consciousness during total intravenous anaesthesia: a narrative review.

Sepúlveda PO, Tapia LF, Monsalves S.

Anaesthesia. 2019 Jun;74(6):801-809. doi: 10.1111/anae.14609. Epub 2019 Mar 5. Review.


"Residents get no… satisfaction" a problem to face during internal medicine rotations: development and psychometric properties of the IMPRINT-15.

Díaz LA, Sepúlveda P, Abbott E, Fuentes-López E, Letelier LM, Riquelme A, Aizman A.

Postgrad Med J. 2019 Feb;95(1120):96-101. doi: 10.1136/postgradmedj-2018-136187. Epub 2019 Feb 20.


Electroencephalography in anaesthesia; opening minds to the future.

Sepúlveda PO, Naranjo M.

Rev Esp Anestesiol Reanim. 2019 Feb;66(2):59-61. doi: 10.1016/j.redar.2018.11.002. Epub 2018 Dec 4. English, Spanish. No abstract available.


Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility.

Ontoria-Oviedo I, Dorronsoro A, Sánchez R, Ciria M, Gómez-Ferrer M, Buigues M, Grueso E, Tejedor S, García-García F, González-King H, Garcia NA, Peiró-Molina E, Sepúlveda P.

Front Cardiovasc Med. 2018 Oct 25;5:152. doi: 10.3389/fcvm.2018.00152. eCollection 2018.


PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes.

Brown EL, Foletta VC, Wright CR, Sepulveda PV, Konstantopoulos N, Sanigorski A, Della Gatta P, Cameron-Smith D, Kralli A, Russell AP.

Front Physiol. 2018 Sep 25;9:1336. doi: 10.3389/fphys.2018.01336. eCollection 2018.


Cell wall and metabolite composition of berries of Vitis vinifera (L.) cv. Thompson Seedless with different firmness.

Zepeda B, Olmedo P, Ejsmentewicz T, Sepúlveda P, Balic I, Balladares C, Delgado-Rioseco J, Fuentealba C, Moreno AA, Defilippi BG, Meneses C, Pedreschi R, Campos-Vargas R.

Food Chem. 2018 Dec 1;268:492-497. doi: 10.1016/j.foodchem.2018.06.065. Epub 2018 Jun 15.


Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome.

Rojas E, Bermúdez V, Motlaghzadeh Y, Mathew J, Fidilio E, Faria J, Rojas J, de Bravo MC, Contreras J, Mantilla LP, Angarita L, Sepúlveda PA, Kuzmar I.

Curr Nutr Rep. 2018 Jul 11. doi: 10.1007/s13668-018-0228-z. [Epub ahead of print] Review.


As(V) removal capacity of FeCu bimetallic nanoparticles in aqueous solutions: The influence of Cu content and morphologic changes in bimetallic nanoparticles.

Sepúlveda P, Rubio MA, Baltazar SE, Rojas-Nunez J, Sánchez Llamazares JL, Garcia AG, Arancibia-Miranda N.

J Colloid Interface Sci. 2018 Aug 15;524:177-187. doi: 10.1016/j.jcis.2018.03.113. Epub 2018 Mar 31.


Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment.

Cortínez LI, Sepúlveda P, Rolle A, Cottin P, Guerrini A, Anderson BJ.

Anesth Analg. 2018 Oct;127(4):865-872. doi: 10.1213/ANE.0000000000002814.


"Candidatus Neoehrlichia chilensis" sp. nov.: Molecular detection and characterization of a novel Anaplasmataceae in wild rodents from Valdivia, southern Chile.

Müller A, Monti G, Otth C, Sepúlveda P, Bittencourt P, Nachum-Biala Y, Gutiérrez R, Harrus S.

Transbound Emerg Dis. 2018 Apr;65(2):357-362. doi: 10.1111/tbed.12815. Epub 2018 Jan 24.


Transcriptome analysis during ripening of table grape berry cv. Thompson Seedless.

Balic I, Vizoso P, Nilo-Poyanco R, Sanhueza D, Olmedo P, Sepúlveda P, Arriagada C, Defilippi BG, Meneses C, Campos-Vargas R.

PLoS One. 2018 Jan 10;13(1):e0190087. doi: 10.1371/journal.pone.0190087. eCollection 2018.


Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Hammam K, Saez-Ayala M, Rebuffet E, Gros L, Lopez S, Hajem B, Humbert M, Baudelet E, Audebert S, Betzi S, Lugari A, Combes S, Letard S, Casteran N, Mansfield C, Moussy A, De Sepulveda P, Morelli X, Dubreuil P.

Nat Commun. 2017 Nov 10;8(1):1420. doi: 10.1038/s41467-017-01582-5.


Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.

Martinez VG, Ontoria-Oviedo I, Ricardo CP, Harding SE, Sacedon R, Varas A, Zapata A, Sepulveda P, Vicente A.

Stem Cell Res Ther. 2017 Sep 29;8(1):208. doi: 10.1186/s13287-017-0659-2.


Intravitreal Injections of Bevacizumab: The Impact of Needle Size in Intraocular Pressure and Pain.

Loureiro M, Matos R, Sepulveda P, Meira D.

J Curr Glaucoma Pract. 2017 May-Aug;11(2):38-41. doi: 10.5005/jp-journals-10028-1220. Epub 2017 Aug 5.


Evidence of hysteresis in propofol pharmacodynamics.

Sepúlveda PO 5th, Carrasco E, Tapia LF, Ramos M, Cruz F, Conget P, Olivares QFB, Cortínez I.

Anaesthesia. 2018 Jan;73(1):40-48. doi: 10.1111/anae.14009. Epub 2017 Sep 5.


Gene expression of Vibrio parahaemolyticus growing in laboratory isolation conditions compared to those common in its natural ocean environment.

García K, Yáñez C, Plaza N, Peña F, Sepúlveda P, Pérez-Reytor D, Espejo RT.

BMC Microbiol. 2017 May 19;17(1):118. doi: 10.1186/s12866-017-1030-6.


Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways.

Ciria M, García NA, Ontoria-Oviedo I, González-King H, Carrero R, De La Pompa JL, Montero JA, Sepúlveda P.

Stem Cells Dev. 2017 Jul 1;26(13):973-985. doi: 10.1089/scd.2016.0331. Epub 2017 May 18.


Carbon allocation to growth and storage in two evergreen species of contrasting successional status.

Piper FI, Sepúlveda P, Bustos-Salazar A, Zúñiga-Feest A.

Am J Bot. 2017 May;104(5):654-662. doi: 10.3732/ajb.1700057. Epub 2017 May 10.


Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model.

Garcia NA, Moncayo-Arlandi J, Vazquez A, Genovés P, Calvo CJ, Millet J, Martí N, Aguado C, Knecht E, Valiente-Alandi I, Montero JA, Díez-Juan A, Sepúlveda P.

Ann Transplant. 2017 May 9;22:285-295.


Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.

Olvedy M, Tisserand JC, Luciani F, Boeckx B, Wouters J, Lopez S, Rambow F, Aibar S, Thienpont B, Barra J, Köhler C, Radaelli E, Tartare-Deckert S, Aerts S, Dubreuil P, van den Oord JJ, Lambrechts D, De Sepulveda P, Marine JC.

J Clin Invest. 2017 Jun 1;127(6):2310-2325. doi: 10.1172/JCI91291. Epub 2017 May 2.


Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes.

Gonzalez-King H, García NA, Ontoria-Oviedo I, Ciria M, Montero JA, Sepúlveda P.

Stem Cells. 2017 Jul;35(7):1747-1759. doi: 10.1002/stem.2618. Epub 2017 Apr 24.


Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability.

Harvey E, Zhang H, Sepúlveda P, Garcia SP, Sweeney D, Choudry FA, Castellano D, Thomas GN, Kattach H, Petersen R, Blake DJ, Taggart DP, Frontini M, Watt SM, Martin-Rendon E.

Stem Cells Transl Med. 2017 May;6(5):1399-1411. doi: 10.1002/sctm.16-0229. Epub 2017 Feb 16.


Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis.

Castellano D, Sanchis A, Blanes M, Pérez Del Caz MD, Ruiz-Saurí A, Piquer-Gil M, Pelacho B, Marco B, Garcia N, Ontoria-Oviedo I, Cambra V, Prosper F, Sepúlveda P.

J Tissue Eng Regen Med. 2018 Feb;12(2):e983-e994. doi: 10.1002/term.2420. Epub 2017 Jun 4.


Pesticide residues in leafy vegetables and human health risk assessment in North Central agricultural areas of Chile.

Elgueta S, Moyano S, Sepúlveda P, Quiroz C, Correa A.

Food Addit Contam Part B Surveill. 2017 Jun;10(2):105-112. doi: 10.1080/19393210.2017.1280540. Epub 2017 Jan 29.


IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells.

Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C.

PLoS One. 2017 Jan 11;12(1):e0169362. doi: 10.1371/journal.pone.0169362. eCollection 2017.


Peripapillary choroidal thickness by enhanced depth imaging optical coherence tomography: the impact of metabolic syndrome.

Loureiro M, Braga AC, Meira D, Sepúlveda P, Agrelos L, Torres P.

Eur J Ophthalmol. 2017 Jun 26;27(4):428-432. doi: 10.5301/ejo.5000911. Epub 2016 Nov 21.


Factors associated with thrombotic complications in pediatric patients with vascular malformations.

Sepúlveda P, Zavala A, Zúñiga P.

J Pediatr Surg. 2017 Mar;52(3):400-404. doi: 10.1016/j.jpedsurg.2016.10.048. Epub 2016 Nov 6.


Bilateral Chorioretinitis as Syphilis Presentation: Multimodal Characterization and Therapy Response.

Loureiro MM, Sepúlveda PA.

J Clin Diagn Res. 2016 Sep;10(9):ND01-ND02. Epub 2016 Sep 1.


Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension.

Gabrielli L, Ocaranza MP, Sitges M, Kanacri A, Saavedra R, Sepulveda P, Sepulveda L, Rossel V, Zagolin M, Verdejo HE, Baraona F, Zalaquett R, Chiong M, Lavandero S, Castro PF.

Echocardiography. 2017 Jan;34(1):53-60. doi: 10.1111/echo.13401. Epub 2016 Oct 14.


[Survival of patients with pulmonary arterial hypertension after the advent of specific pulmonary vasodilator therapies].

Herrera S, Gabrielli L, Paredes A, Saavedra R, Ocaranza MP, Sepúlveda P, Donoso H, López L, Verdejo H, Baraona F, Castro P.

Rev Med Chil. 2016 Jul;144(7):829-36. doi: 10.4067/S0034-98872016000700002. Spanish.


Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT.

Da Silva Figueiredo Celestino Gomes P, Chauvot De Beauchêne I, Panel N, Lopez S, De Sepulveda P, Geraldo Pascutti P, Solary E, Tchertanov L.

PLoS One. 2016 Jul 28;11(7):e0160165. doi: 10.1371/journal.pone.0160165. eCollection 2016.


Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P.

Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976.


An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.

Lopez S, Voisset E, Tisserand JC, Mosca C, Prebet T, Santamaria D, Dubreuil P, De Sepulveda P.

Oncotarget. 2016 Aug 9;7(32):51163-51173. doi: 10.18632/oncotarget.9965.


[Gender differences in health-related quality of life of Chilean adolescent students].

González A E, Martínez N V, Molina G T, George L M, SepúLveda P R, Molina C R, Hidalgo-Rasmussen C.

Rev Med Chil. 2016 Mar;144(3):298-306. doi: 10.4067/S0034-98872016000300004. Spanish.


How feedback, motor imagery, and reward influence brain self-regulation using real-time fMRI.

Sepulveda P, Sitaram R, Rana M, Montalba C, Tejos C, Ruiz S.

Hum Brain Mapp. 2016 Sep;37(9):3153-71. doi: 10.1002/hbm.23228. Epub 2016 Jun 6.


Continuous infusion or bolus injection of loop diuretics for congestive heart failure?

Zepeda P, Rain C, Sepúlveda P.

Medwave. 2016 Apr 22;16 Suppl 2:e6426. doi: 10.5867/medwave.2016.6426. Review. English, Spanish.


[Characteristics, management, and outcomes of illicit drug consumers with acute myocardial infarction].

Bartolucci J, Nazzal N C, Verdugo FJ, Prieto JC, Sepúlveda P, Corbalán R.

Rev Med Chil. 2016 Jan;144(1):39-46. doi: 10.4067/S0034-98872016000100006. Spanish.


Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

Sepulveda PV, Lamon S, Hagg A, Thomson RE, Winbanks CE, Qian H, Bruce CR, Russell AP, Gregorevic P.

Sci Rep. 2015 Dec 11;5:17535. doi: 10.1038/srep17535.


Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes.

Garcia NA, Moncayo-Arlandi J, Sepulveda P, Diez-Juan A.

Cardiovasc Res. 2016 Mar 1;109(3):397-408. doi: 10.1093/cvr/cvv260. Epub 2015 Nov 25.


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