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Items: 1 to 50 of 73

1.

Rab GTPases as Physiological Substrates of LRRK2 Kinase.

Seol W, Nam D, Son I.

Exp Neurobiol. 2019 Apr;28(2):134-145. doi: 10.5607/en.2019.28.2.134. Epub 2019 Apr 30. Review.

2.

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses.

Ho DH, Lee H, Son I, Seol W.

Anim Cells Syst (Seoul). 2019 Mar 1;23(2):106-111. doi: 10.1080/19768354.2019.1585948. eCollection 2019 Apr.

3.

Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein.

Ho DH, Seol W, Son I.

Cell Cycle. 2019 Feb;18(4):467-475. doi: 10.1080/15384101.2019.1577666. Epub 2019 Feb 6.

PMID:
30712480
4.

Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.

Jang J, Oh H, Nam D, Seol W, Seo MK, Park SW, Kim HG, Seo H, Son I, Ho DH.

Anim Cells Syst (Seoul). 2018 Sep 12;22(5):273-280. doi: 10.1080/19768354.2018.1518262. eCollection 2018.

5.

Characterization of Parkinson's disease-related pathogenic TMEM230 mutants.

Nam D, Kim H, Choi DJ, Bae YH, Lee BD, Son I, Seol W.

Anim Cells Syst (Seoul). 2018 Mar 22;22(2):140-147. doi: 10.1080/19768354.2018.1453545. eCollection 2018.

6.

LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase.

Ho DH, Kim H, Nam D, Sim H, Kim J, Kim HG, Son I, Seol W.

Cell Biochem Funct. 2018 Dec;36(8):431-442. doi: 10.1002/cbf.3364. Epub 2018 Nov 8.

PMID:
30411383
7.

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation.

Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W.

Exp Neurobiol. 2018 Jun;27(3):171-180. doi: 10.5607/en.2018.27.3.171. Epub 2018 Jun 30.

8.

Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson's Disease.

Jang J, Jeong S, Lee SI, Seol W, Seo H, Son I, Ho DH.

Parkinsons Dis. 2018 May 14;2018:1241757. doi: 10.1155/2018/1241757. eCollection 2018.

9.

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression.

Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W.

Mol Brain. 2017 Oct 6;10(1):48. doi: 10.1186/s13041-017-0327-6. No abstract available.

10.

LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.

Yoon JH, Mo JS, Kim MY, Ann EJ, Ahn JS, Jo EH, Lee HJ, Lee YC, Seol W, Yarmoluk SM, Gasser T, Kahle PJ, Liu GH, Belmonte JCI, Park HS.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2356-2368. doi: 10.1016/j.bbamcr.2017.09.001. Epub 2017 Sep 6.

11.

Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.

Han KA, Yoo L, Sung JY, Chung SA, Um JW, Kim H, Seol W, Chung KC.

Front Cell Neurosci. 2017 May 11;11:125. doi: 10.3389/fncel.2017.00125. eCollection 2017.

12.

Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity.

Ho DH, Seol W, Eun JH, Son IH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1088-1094. doi: 10.1016/j.bbrc.2016.11.163. Epub 2016 Dec 1.

PMID:
27914807
13.

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.

Han KA, Shin WH, Jung S, Seol W, Seo H, Ko C, Chung KC.

Hum Mol Genet. 2017 Jan 1;26(1):1-18. doi: 10.1093/hmg/ddw363.

PMID:
27798112
14.

LRRK2 interferes with aggresome formation for autophagic clearance.

Bang Y, Kim KS, Seol W, Choi HJ.

Mol Cell Neurosci. 2016 Sep;75:71-80. doi: 10.1016/j.mcn.2016.06.007. Epub 2016 Jun 28.

PMID:
27364102
15.

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.

Ho DH, Jang J, Joe EH, Son I, Seo H, Seol W.

Biomed Res Int. 2016;2016:7917128. doi: 10.1155/2016/7917128. Epub 2016 May 25.

16.

p11 mediates the BDNF-protective effects in dendritic outgrowth and spine formation in B27-deprived primary hippocampal cells.

Park SW, Nhu le H, Cho HY, Seo MK, Lee CH, Ly NN, Choi CM, Lee BJ, Kim GM, Seol W, Lee JG, Kim YH.

J Affect Disord. 2016 May 15;196:1-10. doi: 10.1016/j.jad.2016.02.010. Epub 2016 Feb 9.

PMID:
26896741
17.

Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.

Mani M, Lee UH, Yoon NA, Kim HJ, Ko MS, Seol W, Joe Y, Chung HT, Lee BJ, Moon CH, Cho WJ, Park JW.

Mol Biol Cell. 2016 Jan 15;27(2):334-48. doi: 10.1091/mbc.E15-08-0558. Epub 2015 Nov 18.

18.

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.

Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W.

Mol Brain. 2015 Sep 18;8:54. doi: 10.1186/s13041-015-0145-7. Erratum in: Mol Brain. 2017 Oct 6;10(1):48.

19.

Hypoxia-inducible factor-1α upregulates tyrosine hydroxylase and dopamine transporter by nuclear receptor ERRγ in SH-SY5Y cells.

Lim J, Kim HI, Bang Y, Seol W, Choi HS, Choi HJ.

Neuroreport. 2015 Apr 15;26(6):380-6. doi: 10.1097/WNR.0000000000000356.

PMID:
25807177
20.

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.

Yun HJ, Kim H, Ga I, Oh H, Ho DH, Kim J, Seo H, Son I, Seol W.

J Biochem. 2015 Jun;157(6):485-95. doi: 10.1093/jb/mvv005. Epub 2015 Jan 19.

PMID:
25605758
21.

Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.

Ho DH, Yi S, Seo H, Son I, Seol W.

Biomed Res Int. 2014;2014:704678. doi: 10.1155/2014/704678. Epub 2014 Nov 13.

22.

Clinicopathological characteristics of colon cancer diagnosed at primary health care institutions.

Park SH, Song CW, Kim YB, Kim YS, Chun HR, Lee JH, Seol WJ, Yoon HS, Lee MK, Lee JH, Bhang CS, Park JH, Park JY, Do BH, Park YD, Yoon SJ, Park CW, Yoon SM, Choi JH, Shin KC, Ko DH, Kim YJ, Seol DC.

Intest Res. 2014 Apr;12(2):131-8. doi: 10.5217/ir.2014.12.2.131. Epub 2014 Apr 29.

23.

Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons.

Park SW, Lee JG, Seo MK, Cho HY, Lee CH, Lee JH, Lee BJ, Baek JH, Seol W, Kim YH.

Bipolar Disord. 2015 May;17(3):278-90. doi: 10.1111/bdi.12262. Epub 2014 Oct 13.

PMID:
25307211
24.

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.

Park SW, Lee JG, Seo MK, Lee CH, Cho HY, Lee BJ, Seol W, Kim YH.

Int J Neuropsychopharmacol. 2014 Nov;17(11):1831-46. doi: 10.1017/S1461145714000534. Epub 2014 Jun 5.

PMID:
24901414
25.

Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures.

Seo MK, Lee CH, Cho HY, Lee JG, Lee BJ, Kim JE, Seol W, Kim YH, Park SW.

Neuropharmacology. 2014 Apr;79:222-33. doi: 10.1016/j.neuropharm.2013.11.019. Epub 2013 Dec 1.

PMID:
24296153
26.
27.

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W.

Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.

28.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ.

Lab Invest. 2013 Jun;93(6):663-76. doi: 10.1038/labinvest.2013.60. Epub 2013 Apr 22.

29.

Effects of antipsychotic drugs on the expression of synaptic proteins and dendritic outgrowth in hippocampal neuronal cultures.

Park SW, Lee CH, Cho HY, Seo MK, Lee JG, Lee BJ, Seol W, Kee BS, Kim YH.

Synapse. 2013 May;67(5):224-34. doi: 10.1002/syn.21634. Epub 2013 Feb 14.

PMID:
23335099
30.

[Clinicopathologic characteristics of superficial gastric cancer diagnosed at primary health care institutions in 2011].

Park SH, Song CW, Kim YB, Kim YS, Chun HR, Lee JH, Seol WJ, Yoon HS, Lee MK, Lee JH, Bhang CS, Park JH, Park YH, Do BH, Park YD, Yoon SJ, Park CW, Kim JP, Choi JH, Shin KC, Park SM.

Korean J Gastroenterol. 2012 Nov;60(5):285-91. Korean.

31.

Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia.

Kim B, Yang MS, Choi D, Kim JH, Kim HS, Seol W, Choi S, Jou I, Kim EY, Joe EH.

PLoS One. 2012;7(4):e34693. doi: 10.1371/journal.pone.0034693. Epub 2012 Apr 9.

32.

Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells.

Park SW, Seo MK, Cho HY, Lee JG, Lee BJ, Seol W, Kim YH.

Neuropharmacology. 2011 Sep;61(4):761-9. doi: 10.1016/j.neuropharm.2011.05.022. Epub 2011 Jun 2.

PMID:
21663752
33.

Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease.

Chung JY, Lee SJ, Lee SH, Jung YS, Ha NC, Seol W, Park BJ.

Neurosignals. 2011;19(2):86-96. doi: 10.1159/000325028. Epub 2011 Apr 8.

34.

Identification of chemicals to inhibit the kinase activity of leucine-rich repeat kinase 2 (LRRK2), a Parkinson's disease-associated protein.

Yun H, Heo HY, Kim HH, DooKim N, Seol W.

Bioorg Med Chem Lett. 2011 May 15;21(10):2953-7. doi: 10.1016/j.bmcl.2011.03.061. Epub 2011 Mar 21.

PMID:
21474311
35.

Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses.

Kim JH, Min KJ, Seol W, Jou I, Joe EH.

J Neurochem. 2010 Dec;115(5):1161-71. doi: 10.1111/j.1471-4159.2010.07004.x. Epub 2010 Oct 12.

36.

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5.

Heo HY, Kim KS, Seol W.

Exp Neurobiol. 2010 Sep;19(2):97-105. doi: 10.5607/en.2010.19.2.97. Epub 2010 Sep 30.

38.

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.

Heo HY, Park JM, Kim CH, Han BS, Kim KS, Seol W.

Exp Cell Res. 2010 Feb 15;316(4):649-56. doi: 10.1016/j.yexcr.2009.09.014. Epub 2009 Sep 19.

PMID:
19769964
39.
40.

Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3.

Yun HJ, Kwon J, Seol W.

Biol Chem. 2008 Oct;389(10):1313-8. doi: 10.1515/BC.2008.149.

PMID:
18713018
41.

Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra.

Han BS, Iacovitti L, Katano T, Hattori N, Seol W, Kim KS.

Neurosci Lett. 2008 Sep 19;442(3):190-4. doi: 10.1016/j.neulet.2008.06.086. Epub 2008 Jul 10.

42.

LRRK2 regulates synaptic vesicle endocytosis.

Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W.

Exp Cell Res. 2008 Jun 10;314(10):2055-65. doi: 10.1016/j.yexcr.2008.02.015. Epub 2008 Mar 5.

PMID:
18445495
43.

Regulation of tyrosine hydroxylase gene expression by retinoic acid receptor.

Jeong H, Kim MS, Kim SW, Kim KS, Seol W.

J Neurochem. 2006 Jul;98(2):386-94.

44.

Artificial transcription factors increase production of recombinant antibodies in Chinese hamster ovary cells.

Kwon RJ, Kim SK, Lee SI, Hwang SJ, Lee GM, Kim JS, Seol W.

Biotechnol Lett. 2006 Jan;28(1):9-15.

PMID:
16369868
45.

Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor.

Jeong H, Kim MS, Kwon J, Kim KS, Seol W.

Neurosci Lett. 2006 Mar 20;396(1):57-61. Epub 2005 Dec 13.

PMID:
16356647
46.

Identification and use of zinc finger transcription factors that increase production of recombinant proteins in yeast and mammalian cells.

Park KS, Seol W, Yang HY, Lee SI, Kim SK, Kwon RJ, Kim EJ, Roh YH, Seong BL, Kim JS.

Biotechnol Prog. 2005 May-Jun;21(3):664-70.

PMID:
15932240
47.

Artificial zinc finger fusions targeting Sp1-binding sites and the trans-activator-responsive element potently repress transcription and replication of HIV-1.

Kim YS, Kim JM, Jung DL, Kang JE, Lee S, Kim JS, Seol W, Shin HC, Kwon HS, Van Lint C, Hernandez N, Hur MW.

J Biol Chem. 2005 Jun 3;280(22):21545-52. Epub 2005 Mar 2.

48.
49.

Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.

Park KS, Lee DK, Lee H, Lee Y, Jang YS, Kim YH, Yang HY, Lee SI, Seol W, Kim JS.

Nat Biotechnol. 2003 Oct;21(10):1208-14. Epub 2003 Sep 7. Erratum in: Nat Biotechnol. 2004 Apr;22(4):459. Lee, Sung-Il [corrected to Lee, Seong-il].

PMID:
12960965
50.

Human zinc fingers as building blocks in the construction of artificial transcription factors.

Bae KH, Kwon YD, Shin HC, Hwang MS, Ryu EH, Park KS, Yang HY, Lee DK, Lee Y, Park J, Kwon HS, Kim HW, Yeh BI, Lee HW, Sohn SH, Yoon J, Seol W, Kim JS.

Nat Biotechnol. 2003 Mar;21(3):275-80. Epub 2003 Feb 18.

PMID:
12592413

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