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Ganglioside GM3 Up-Regulate Chondrogenic Differentiation by Transform Growth Factor Receptors.

Ryu JS, Seo SY, Jeong EJ, Kim JY, Koh YG, Kim YI, Choo YK.

Int J Mol Sci. 2020 Mar 13;21(6). pii: E1967. doi: 10.3390/ijms21061967.


Functional switching of NPR1 between chloroplast and nucleus for adaptive response to salt stress.

Seo SY, Wi SJ, Park KY.

Sci Rep. 2020 Mar 9;10(1):4339. doi: 10.1038/s41598-020-61379-3.


Design and Synthesis of New Porphyrin Analogues as Potent Photosensitizers for Photodynamic Therapy: Spectroscopic Approach.

Mahajan PG, Dige NC, Vanjare BD, Kim CH, Seo SY, Lee KH.

J Fluoresc. 2020 Mar;30(2):397-406. doi: 10.1007/s10895-020-02513-2. Epub 2020 Feb 22.


SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling.

Kim MJ, Je IG, Song J, Fei X, Lee S, Yang H, Kang W, Jang YH, Seo SY, Kim SH.

Front Immunol. 2020 Jan 28;11:50. doi: 10.3389/fimmu.2020.00050. eCollection 2020.


Chronic Hyperglycemia before Spinal Cord Injury Increases Inflammatory Reaction and Astrogliosis after Injury: Human and Rat Studies.

Park KS, Kim JB, Keung M, Seo YJ, Seo SY, Mun SA, Lee YS, Cho DC, Hwang JH, Han I, Kim CH, Kim KT.

J Neurotrauma. 2020 Apr 1. doi: 10.1089/neu.2019.6724. [Epub ahead of print]


Nearly room temperature ferromagnetism in a magnetic metal-rich van der Waals metal.

Seo J, Kim DY, An ES, Kim K, Kim GY, Hwang SY, Kim DW, Jang BG, Kim H, Eom G, Seo SY, Stania R, Muntwiler M, Lee J, Watanabe K, Taniguchi T, Jo YJ, Lee J, Min BI, Jo MH, Yeom HW, Choi SY, Shim JH, Kim JS.

Sci Adv. 2020 Jan 17;6(3):eaay8912. doi: 10.1126/sciadv.aay8912. eCollection 2020 Jan.


Isocadiolides A-H: Polybrominated Aromatics from a Synoicum sp. Ascidian.

Bae J, Cho E, Park JS, Won TH, Seo SY, Oh DC, Oh KB, Shin J.

J Nat Prod. 2020 Feb 28;83(2):429-437. doi: 10.1021/acs.jnatprod.9b00968. Epub 2020 Jan 22.


Endoscopic Management of Malignant Colonic Obstruction.

Seo SY, Kim SW.

Clin Endosc. 2020 Jan;53(1):9-17. doi: 10.5946/ce.2019.051. Epub 2020 Jan 7.


Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.

Raza H, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Hassan M, Abbas Q, Hong H, Shah SAA, Shahid M, Seo SY.

Bioorg Chem. 2020 Jan;94:103445. doi: 10.1016/j.bioorg.2019.103445. Epub 2019 Nov 22.


Increasing Polyamine Contents Enhances the Stress Tolerance via Reinforcement of Antioxidative Properties.

Seo SY, Kim YJ, Park KY.

Front Plant Sci. 2019 Oct 31;10:1331. doi: 10.3389/fpls.2019.01331. eCollection 2019.


Biological safety of Electroacupuncture with STS316 needles.

Choi KH, Yeon SH, Cho SJ, Kwon OS, Lee S, Seo SY, Kang SY, Ryu Y.

BMC Complement Altern Med. 2019 Oct 28;19(1):285. doi: 10.1186/s12906-019-2674-6.


Cell Factory Design and Culture Process Optimization for Dehydroshikimate Biosynthesis in Escherichia coli.

Choi SS, Seo SY, Park SO, Lee HN, Song JS, Kim JY, Park JH, Kim S, Lee SJ, Chun GT, Kim ES.

Front Bioeng Biotechnol. 2019 Oct 9;7:241. doi: 10.3389/fbioe.2019.00241. eCollection 2019.


Synthesis and exploration of a novel chlorobenzylated 2-aminothiazole-phenyltriazole hybrid as migratory inhibitor of B16F10 in melanoma cells.

Athar Abbasi M, Yu SM, Aziz-Ur-Rehman, Siddiqui SZ, Kim SJ, Raza H, Hassan M, Rehman Sadiq Butt A, Shah SAA, Seo SY.

Toxicol Rep. 2019 Aug 26;6:897-903. doi: 10.1016/j.toxrep.2019.08.016. eCollection 2019.


Electroluminescence from h-BN by using Al2O3/h-BN multiple heterostructure.

Lee SH, Jeong H, Kim DY, Seo SY, Han C, Okello OFN, Lo JI, Peng YC, Oh CH, Lee GW, Shim JI, Cheng BM, Song K, Choi SY, Jo MH, Kim JK.

Opt Express. 2019 Jul 8;27(14):19692-19701. doi: 10.1364/OE.27.019692.


A mechanical acupuncture instrument mitigates the endoplasmic reticulum stress and oxidative stress of ovariectomized rats.

Seo SY, Kang SY, Kwon OS, Bang SK, Kim SP, Choi KH, Moon JY, Ryu Y.

Integr Med Res. 2019 Sep;8(3):187-194. doi: 10.1016/j.imr.2019.07.001. Epub 2019 Jul 11.


Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches.

Hassan M, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Shahzadi S, Raza H, Hussain G, Shah SAA, Ashraf M, Shahid M, Seo SY, Malik A.

Bioorg Chem. 2019 Oct;91:103138. doi: 10.1016/j.bioorg.2019.103138. Epub 2019 Jul 22.


Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies.

Dige NC, Mahajan PG, Raza H, Hassan M, Vanjare BD, Hong H, Hwan Lee K, Latip J, Seo SY.

Bioorg Chem. 2019 Nov;92:103201. doi: 10.1016/j.bioorg.2019.103201. Epub 2019 Aug 13.


Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells.

Zhu SM, Park YR, Seo SY, Kim IH, Lee ST, Kim SW.

Intest Res. 2019 Oct;17(4):527-536. doi: 10.5217/ir.2019.00031. Epub 2019 Aug 23.


Synthesis and biological evaluation of 1,2,4-triazolidine-3-thiones as potent acetylcholinesterase inhibitors: in vitro and in silico analysis through kinetics, chemoinformatics and computational approaches.

Mahajan PG, Dige NC, Vanjare BD, Raza H, Hassan M, Seo SY, Kim CH, Lee KH.

Mol Divers. 2019 Aug 8. doi: 10.1007/s11030-019-09983-y. [Epub ahead of print]


Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Heo M, Lee B, Sishtla K, Fei X, Lee S, Park S, Yuan Y, Lee S, Kwon S, Lee J, Kim S, Corson TW, Seo SY.

J Org Chem. 2019 Aug 16;84(16):9995-10011. doi: 10.1021/acs.joc.9b01134. Epub 2019 Aug 5.


Densely substituted piperidines as a new class of elastase inhibitors: Synthesis and molecular modeling studies.

Hamdani SS, Khan BA, Saeed A, Larik FA, Hameed S, Channar PA, Ahmad K, Mughal EU, Abbas Q, Amin NU, Ghumro SA, Maitlo H, Hassan M, Raza H, Seo SY.

Arch Pharm (Weinheim). 2019 Aug;352(8):e1900061. doi: 10.1002/ardp.201900061. Epub 2019 Jul 24.


Synthesis of Either C2- or C4'-Alkylated Derivatives of Honokiol and Their Biological Evaluation for Anti-inflammatory Activity.

Lee SH, Fei X, Lee C, Do HTT, Rhee I, Seo SY.

Chem Pharm Bull (Tokyo). 2019 Sep 1;67(9):966-976. doi: 10.1248/cpb.c19-00207. Epub 2019 Jun 28.


Feasibility of Adopting the "Step-up Approach" in Managing Necrotizing Pancreatitis-induced Pancreatic-colonic Fistula.

Yim SK, Kim SH, Seo SY, Yang HC, Lee SO.

Korean J Gastroenterol. 2019 Jun 25;73(6):365-369. doi: 10.4166/kjg.2019.73.6.365.


Synthesis, molecular docking and kinetic studies of novel quinolinyl based acyl thioureas as mushroom tyrosinase inhibitors and free radical scavengers.

Mustafa MN, Saeed A, Channar PA, Larik FA, Zain-Ul Abideen M, Shabir G, Abbas Q, Hassan M, Raza H, Seo SY.

Bioorg Chem. 2019 Sep;90:103063. doi: 10.1016/j.bioorg.2019.103063. Epub 2019 Jun 12.


Assessment of Electrocardiogram Rhythms by GoogLeNet Deep Neural Network Architecture.

Kim JH, Seo SY, Song CG, Kim KS.

J Healthc Eng. 2019 Apr 28;2019:2826901. doi: 10.1155/2019/2826901. eCollection 2019.


Small molecule target identification using photo-affinity chromatography.

Seo SY, Corson TW.

Methods Enzymol. 2019;622:347-374. doi: 10.1016/bs.mie.2019.02.028. Epub 2019 Mar 15.


Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics.

Shahzad D, Saeed A, Larik FA, Channar PA, Abbas Q, Alajmi MF, Arshad MI, Erben MF, Hassan M, Raza H, Seo SY, El-Seedi HR.

Molecules. 2019 Apr 17;24(8). pii: E1511. doi: 10.3390/molecules24081511.


Metal-Based Scaffolds of Schiff Bases Derived from Naproxen: Synthesis, Antibacterial Activities, and Molecular Docking Studies.

Shaheen MA, Feng S, Anthony M, Tahir MN, Hassan M, Seo SY, Ahmad S, Iqbal M, Saleem M, Lu C.

Molecules. 2019 Mar 29;24(7). pii: E1237. doi: 10.3390/molecules24071237.


Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A.

Im EJ, Lee CH, Moon PG, Rangaswamy GG, Lee B, Lee JM, Lee JC, Jee JG, Bae JS, Kwon TK, Kang KW, Jeong MS, Lee JE, Jung HS, Ro HJ, Jun S, Kang W, Seo SY, Cho YE, Song BJ, Baek MC.

Nat Commun. 2019 Mar 27;10(1):1387. doi: 10.1038/s41467-019-09387-4.


Experimental Study on Shear Capacity of Reinforced Concrete Beams with Corroded Longitudinal Reinforcement.

Han SJ, Joo HE, Choi SH, Heo I, Kim KS, Seo SY.

Materials (Basel). 2019 Mar 12;12(5). pii: E837. doi: 10.3390/ma12050837.


Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation.

Ujan R, Saeed A, Channar PA, Larik FA, Abbas Q, Alajmi MF, El-Seedi HR, Rind MA, Hassan M, Raza H, Seo SY.

Molecules. 2019 Feb 28;24(5). pii: E860. doi: 10.3390/molecules24050860.


Synthesis of sulfonamide, amide and amine hybrid pharmacophore, an entry of new class of carbonic anhydrase II inhibitors and evaluation of chemo-informatics and binding analysis.

Ahmed A, Channar PA, Saeed A, Kalesse M, Kazi MA, Larik FA, Abbas Q, Hassan M, Raza H, Seo SY.

Bioorg Chem. 2019 May;86:624-630. doi: 10.1016/j.bioorg.2019.01.060. Epub 2019 Feb 10.


Down-regulation of miR-9 promotes epithelial mesenchymal transition via regulating anoctamin-1 (ANO1) in CRC cells.

Park YR, Lee ST, Kim SL, Zhu SM, Lee MR, Kim SH, Kim IH, Lee SO, Seo SY, Kim SW.

Cancer Genet. 2019 Feb;231-232:22-31. doi: 10.1016/j.cancergen.2018.12.004. Epub 2018 Dec 27.


Epitaxial van der Waals Contacts between Transition-Metal Dichalcogenide Monolayer Polymorphs.

Lee CS, Oh SJ, Heo H, Seo SY, Kim J, Kim YH, Kim D, Ngome Okello OF, Shin H, Sung JH, Choi SY, Kim JS, Kim JK, Jo MH.

Nano Lett. 2019 Mar 13;19(3):1814-1820. doi: 10.1021/acs.nanolett.8b04869. Epub 2019 Feb 26.


Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies.

Larik FA, Faisal M, Saeed A, Channar PA, Korabecny J, Jabeen F, Mahar IA, Kazi MA, Abbas Q, Murtaza G, Khan GS, Hassan M, Seo SY.

Bioorg Chem. 2019 May;86:473-481. doi: 10.1016/j.bioorg.2019.02.011. Epub 2019 Feb 8.


Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies.

Butt ARS, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Raza H, Hassan M, Shah SAA, Shahid M, Seo SY.

Bioorg Chem. 2019 May;86:459-472. doi: 10.1016/j.bioorg.2019.01.036. Epub 2019 Jan 26.


Mouse Pharmacokinetics and in Vitro Metabolism of (±)-Cremastranone.

Kim EY, Lee B, Seo SY, Lee K.

Biol Pharm Bull. 2019;42(2):187-193. doi: 10.1248/bpb.b18-00554.


Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and computational contemplations.

Butt ARS, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Hassan M, Raza H, Shah SAA, Seo SY.

Bioorg Chem. 2019 May;86:197-209. doi: 10.1016/j.bioorg.2019.01.040. Epub 2019 Jan 28. Review.


Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses.

Hanif M, Kanwal F, Rafiq M, Hassan M, Mustaqeem M, Seo SY, Zhang Y, Lu C, Chen T, Saleem M.

Molecules. 2019 Jan 16;24(2). pii: E312. doi: 10.3390/molecules24020312.


Bi-heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches.

Abbasi MA, Nazir M, Ur-Rehman A, Siddiqui SZ, Hassan M, Raza H, Shah SAA, Shahid M, Seo SY.

Arch Pharm (Weinheim). 2019 Mar;352(3):e1800278. doi: 10.1002/ardp.201800278. Epub 2019 Jan 9.


One-pot four-component synthesis of thiazolidin-2-imines using CuI/ZnII dual catalysis: A new class of acetylcholinesterase inhibitors.

Shehzadi SA, Khan I, Saeed A, Larik FA, Channar PA, Hassan M, Raza H, Abbas Q, Seo SY.

Bioorg Chem. 2019 Mar;84:518-528. doi: 10.1016/j.bioorg.2018.12.002. Epub 2018 Dec 5.


Corynebacterium Cell Factory Design and Culture Process Optimization for Muconic Acid Biosynthesis.

Lee HN, Shin WS, Seo SY, Choi SS, Song JS, Kim JY, Park JH, Lee D, Kim SY, Lee SJ, Chun GT, Kim ES.

Sci Rep. 2018 Dec 21;8(1):18041. doi: 10.1038/s41598-018-36320-4.


The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches.

Hassan M, Raza H, Abbasi MA, Moustafa AA, Seo SY.

Biomed Pharmacother. 2019 Jan;109:2513-2526. doi: 10.1016/j.biopha.2018.11.115. Epub 2018 Dec 3.


Enantioselective synthesis and absolute configuration determination of hydroxywilfordic acid in sesquiterpene pyridine alkaloids.

Yuan Y, Jung JW, Seo SY.

Org Biomol Chem. 2018 Dec 19;17(1):44-48. doi: 10.1039/c8ob02364f.


1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation.

Mahar J, Saeed A, Belfield KD, Ali Larik F, Ali Channar P, Ali Kazi M, Abbas Q, Hassan M, Raza H, Seo SY.

Bioorg Chem. 2019 Mar;84:170-176. doi: 10.1016/j.bioorg.2018.11.031. Epub 2018 Nov 24.


Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol.

Yuan Y, Subedi L, Lim D, Jung JK, Kim SY, Seo SY.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):329-333. doi: 10.1016/j.bmcl.2018.11.014. Epub 2018 Nov 9.


Computational investigation of mechanistic insights of Aβ42 interactions against extracellular domain of nAChRα7 in Alzheimer's disease.

Hassan M, Shahzadi S, Raza H, Abbasi MA, Alashwal H, Zaki N, Moustafa AA, Seo SY.

Int J Neurosci. 2019 Jul;129(7):666-680. doi: 10.1080/00207454.2018.1543670. Epub 2019 Jan 9.


Treatment Outcome and Renal Safety of 3-Year Tenofovir Disoproxil Fumarate Therapy in Chronic Hepatitis B Patients with Preserved Glomerular Filtration Rate.

Min IS, Lee CH, Shin IS, Lee NE, Son HS, Kim SB, Seo SY, Kim SH, Kim SW, Lee SO, Lee ST, Kim IH.

Gut Liver. 2019 Jan 15;13(1):93-103. doi: 10.5009/gnl18183.


Synthesis of novel N-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses.

Athar Abbasi M, Raza H, Aziz-Ur-Rehman, Zahra Siddiqui S, Adnan Ali Shah S, Hassan M, Seo SY.

Bioorg Chem. 2019 Mar;83:63-75. doi: 10.1016/j.bioorg.2018.10.018. Epub 2018 Oct 12.


Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy.

An H, Lee S, Lee JM, Jo DH, Kim J, Jeong YS, Heo MJ, Cho CS, Choi H, Seo JH, Hwang S, Lim J, Kim T, Jun HO, Sim J, Lim C, Hur J, Ahn J, Kim HS, Seo SY, Na Y, Kim SH, Lee J, Lee J, Chung SJ, Kim YM, Kim KW, Kim SG, Kim JH, Suh YG.

J Med Chem. 2018 Oct 25;61(20):9266-9286. doi: 10.1021/acs.jmedchem.8b00971. Epub 2018 Oct 9.


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