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Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study.

Vozella V, Basit A, Piras F, Realini N, Armirotti A, Bossù P, Assogna F, Sensi SL, Spalletta G, Piomelli D.

Aging (Albany NY). 2019 Jan 8;11(1):73-88. doi: 10.18632/aging.101719.


Functional signature of conversion of patients with mild cognitive impairment.

Delli Pizzi S, Punzi M, Sensi SL; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Feb;74:21-37. doi: 10.1016/j.neurobiolaging.2018.10.004. Epub 2018 Oct 12.


Copper and Zinc Dysregulation in Alzheimer's Disease.

Sensi SL, Granzotto A, Siotto M, Squitti R.

Trends Pharmacol Sci. 2018 Dec;39(12):1049-1063. doi: 10.1016/ Epub 2018 Oct 20. Review.


Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging.

Brem AK, Sensi SL.

Trends Neurosci. 2018 Dec;41(12):885-897. doi: 10.1016/j.tins.2018.09.009. Epub 2018 Oct 18. Review.


Alzheimer's Disease, time to turn the tide.

Sensi SL.

Aging (Albany NY). 2018 Oct 13;10(10):2537-2538. doi: 10.18632/aging.101581. No abstract available.


The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.

Frazzini V, Granzotto A, Bomba M, Massetti N, Castelli V, d'Aurora M, Punzi M, Iorio M, Mosca A, Delli Pizzi S, Gatta V, Cimini A, Sensi SL.

Sci Rep. 2018 Jun 27;8(1):9768. doi: 10.1038/s41598-018-28083-9.


Influence of APOE and RNF219 on Behavioral and Cognitive Features of Female Patients Affected by Mild Cognitive Impairment or Alzheimer's Disease.

Mosca A, Sperduti S, Pop V, Ciavardelli D, Granzotto A, Punzi M, Stuppia L, Gatta V, Assogna F, Banaj N, Piras F, Piras F, Caltagirone C, Spalletta G, Sensi SL.

Front Aging Neurosci. 2018 Apr 13;10:92. doi: 10.3389/fnagi.2018.00092. eCollection 2018.


Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice.

Bomba M, Granzotto A, Castelli V, Massetti N, Silvestri E, Canzoniero LMT, Cimini A, Sensi SL.

Neurobiol Aging. 2018 Apr;64:33-43. doi: 10.1016/j.neurobiolaging.2017.12.009. Epub 2017 Dec 19.


Modafinil-Induced Changes in Functional Connectivity in the Cortex and Cerebellum of Healthy Elderly Subjects.

Punzi M, Gili T, Petrosini L, Caltagirone C, Spalletta G, Sensi SL.

Front Aging Neurosci. 2017 Mar 30;9:85. doi: 10.3389/fnagi.2017.00085. eCollection 2017.


Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.

Ciavardelli D, Piras F, Consalvo A, Rossi C, Zucchelli M, Di Ilio C, Frazzini V, Caltagirone C, Spalletta G, Sensi SL.

Neurobiol Aging. 2016 Jul;43:1-12. doi: 10.1016/j.neurobiolaging.2016.03.005. Epub 2016 Mar 15.


Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model.

Frazzini V, Guarnieri S, Bomba M, Navarra R, Morabito C, Mariggiò MA, Sensi SL.

Cell Death Dis. 2016 Feb 18;7:e2100. doi: 10.1038/cddis.2016.18.


Left hippocampus-amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals.

Manna A, Piras F, Caltagirone C, Bossù P, Sensi SL, Spalletta G.

Brain Behav. 2015 Jul;5(7):e00334. doi: 10.1002/brb3.334. Epub 2015 May 26.


Intracellular zinc is a critical intermediate in the excitotoxic cascade.

Granzotto A, Sensi SL.

Neurobiol Dis. 2015 Sep;81:25-37. doi: 10.1016/j.nbd.2015.04.010. Epub 2015 May 1.


Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.

Isopi E, Granzotto A, Corona C, Bomba M, Ciavardelli D, Curcio M, Canzoniero LM, Navarra R, Lattanzio R, Piantelli M, Sensi SL.

Neurobiol Dis. 2015 Sep;81:214-24. doi: 10.1016/j.nbd.2014.11.013. Epub 2014 Nov 28.


Modafinil alters intrinsic functional connectivity of the right posterior insula: a pharmacological resting state fMRI study.

Cera N, Tartaro A, Sensi SL.

PLoS One. 2014 Sep 19;9(9):e107145. doi: 10.1371/journal.pone.0107145. eCollection 2014.


Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals.

Pieramico V, Esposito R, Cesinaro S, Frazzini V, Sensi SL.

Front Syst Neurosci. 2014 Sep 2;8:153. doi: 10.3389/fnsys.2014.00153. eCollection 2014. Review.


Age-Dependent Modifications of AMPA Receptor Subunit Expression Levels and Related Cognitive Effects in 3xTg-AD Mice.

Cantanelli P, Sperduti S, Ciavardelli D, Stuppia L, Gatta V, Sensi SL.

Front Aging Neurosci. 2014 Aug 5;6:200. doi: 10.3389/fnagi.2014.00200. eCollection 2014.


Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.

Gatta V, D'Aurora M, Granzotto A, Stuppia L, Sensi SL.

Cell Death Dis. 2014 Feb 13;5:e1054. doi: 10.1038/cddis.2014.11.


Characterization of resting state activity in MCI individuals.

Esposito R, Mosca A, Pieramico V, Cieri F, Cera N, Sensi SL.

PeerJ. 2013 Aug 20;1:e135. doi: 10.7717/peerj.135. eCollection 2013.


Acute effects of modafinil on brain resting state networks in young healthy subjects.

Esposito R, Cilli F, Pieramico V, Ferretti A, Macchia A, Tommasi M, Saggino A, Ciavardelli D, Manna A, Navarra R, Cieri F, Stuppia L, Tartaro A, Sensi SL.

PLoS One. 2013 Jul 25;8(7):e69224. doi: 10.1371/journal.pone.0069224. Print 2013.


nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge.

Canzoniero LM, Granzotto A, Turetsky DM, Choi DW, Dugan LL, Sensi SL.

Front Physiol. 2013 May 16;4:112. doi: 10.3389/fphys.2013.00112. eCollection 2013.


Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.

Bomba M, Ciavardelli D, Silvestri E, Canzoniero LM, Lattanzio R, Chiappini P, Piantelli M, Di Ilio C, Consoli A, Sensi SL.

Cell Death Dis. 2013 May 2;4:e612. doi: 10.1038/cddis.2013.139.


Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice.

Masciopinto F, Di Pietro N, Corona C, Bomba M, Pipino C, Curcio M, Di Castelnuovo A, Ciavardelli D, Silvestri E, Canzoniero LM, Sekler I, Pandolfi A, Sensi SL.

Cell Death Dis. 2012 Dec 20;3:e448. doi: 10.1038/cddis.2012.189.


Characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xTg-AD mice by alternated cool and normal plasma ICP-MS.

Ciavardelli D, Consalvo A, Caldaralo V, Di Vacri ML, Nisi S, Corona C, Frazzini V, Sacchetta P, Urbani A, Di Ilio C, Sensi SL.

Metallomics. 2012 Dec;4(12):1321-32. doi: 10.1039/c2mt20162c. Epub 2012 Nov 14.


The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

Nita II, Hershfinkel M, Fishman D, Ozeri E, Rutter GA, Sensi SL, Khananshvili D, Lewis EC, Sekler I.

PLoS One. 2012;7(10):e46649. doi: 10.1371/journal.pone.0046649. Epub 2012 Oct 8.


Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.

Pieramico V, Esposito R, Sensi F, Cilli F, Mantini D, Mattei PA, Frazzini V, Ciavardelli D, Gatta V, Ferretti A, Romani GL, Sensi SL.

PLoS One. 2012;7(8):e43901. doi: 10.1371/journal.pone.0043901. Epub 2012 Aug 28.


The neurophysiology and pathology of brain zinc.

Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M.

J Neurosci. 2011 Nov 9;31(45):16076-85. doi: 10.1523/JNEUROSCI.3454-11.2011. Review.


New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.

Corona C, Pensalfini A, Frazzini V, Sensi SL.

Cell Death Dis. 2011 Jun 23;2:e176. doi: 10.1038/cddis.2011.57. Review.


Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL.

PLoS One. 2011 Mar 15;6(3):e17971. doi: 10.1371/journal.pone.0017971.


Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction.

Corona C, Masciopinto F, Silvestri E, Viscovo AD, Lattanzio R, Sorda RL, Ciavardelli D, Goglia F, Piantelli M, Canzoniero LM, Sensi SL.

Cell Death Dis. 2010 Oct 28;1:e91. doi: 10.1038/cddis.2010.73.


Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease.

Ciavardelli D, Silvestri E, Del Viscovo A, Bomba M, De Gregorio D, Moreno M, Di Ilio C, Goglia F, Canzoniero LM, Sensi SL.

Cell Death Dis. 2010 Oct 28;1:e90. doi: 10.1038/cddis.2010.68.


Microarray analysis on human neuroblastoma cells exposed to aluminum, β(1-42)-amyloid or the β(1-42)-amyloid aluminum complex.

Gatta V, Drago D, Fincati K, Valenti MT, Dalle Carbonare L, Sensi SL, Zatta P.

PLoS One. 2011 Jan 27;6(1):e15965. doi: 10.1371/journal.pone.0015965.


Zinc pre-treatment enhances NMDAR-mediated excitotoxicity in cultured cortical neurons from SOD1(G93A) mouse, a model of amyotrophic lateral sclerosis.

Nutini M, Frazzini V, Marini C, Spalloni A, Sensi SL, Longone P.

Neuropharmacology. 2011 Jun;60(7-8):1200-8. doi: 10.1016/j.neuropharm.2010.11.001. Epub 2010 Nov 5.


The thiol-modifying agent N-ethylmaleimide elevates the cytosolic concentration of free Zn(2+) but not of Ca(2+) in murine cortical neurons.

Gibon J, Tu P, Frazzini V, Sensi SL, Bouron A.

Cell Calcium. 2010 Jul;48(1):37-43. doi: 10.1016/j.ceca.2010.06.004. Epub 2010 Jul 25.


Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo.

Cordeiro MF, Guo L, Coxon KM, Duggan J, Nizari S, Normando EM, Sensi SL, Sillito AM, Fitzke FW, Salt TE, Moss SE.

Cell Death Dis. 2010;1:e3. doi: 10.1038/cddis.2009.3.


NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte C, Fishman D, Shoshan-Barmatz V, Herrmann S, Khananshvili D, Sekler I.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41. doi: 10.1073/pnas.0908099107. Epub 2009 Dec 15.


Decreased numeric density of succinic dehydrogenase-positive mitochondria in CA1 pyramidal neurons of 3xTg-AD mice.

Fattoretti P, Balietti M, Casoli T, Giorgetti B, Di Stefano G, Bertoni-Freddari C, Lattanzio F, Sensi SL.

Rejuvenation Res. 2010 Apr-Jun;13(2-3):144-7. doi: 10.1089/rej.2009.0937.


Zinc in the physiology and pathology of the CNS.

Sensi SL, Paoletti P, Bush AI, Sekler I.

Nat Rev Neurosci. 2009 Nov;10(11):780-91. doi: 10.1038/nrn2734. Epub 2009 Oct 14. Review.


Alzheimer's disease, metal ions and metal homeostatic therapy.

Zatta P, Drago D, Bolognin S, Sensi SL.

Trends Pharmacol Sci. 2009 Jul;30(7):346-55. doi: 10.1016/ Epub 2009 Jun 17. Review.


Ratiometric-pericam-mt, a novel tool to evaluate intramitochondrial zinc.

Caporale T, Ciavardelli D, Di Ilio C, Lanuti P, Drago D, Sensi SL.

Exp Neurol. 2009 Aug;218(2):228-34. doi: 10.1016/j.expneurol.2009.04.003. Epub 2009 Apr 15.


Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease.

Drago D, Cavaliere A, Mascetra N, Ciavardelli D, di Ilio C, Zatta P, Sensi SL.

Rejuvenation Res. 2008 Oct;11(5):861-71. doi: 10.1089/rej.2008.0761.


Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease.

Bertoni-Freddari C, Sensi SL, Giorgetti B, Balietti M, Di Stefano G, Canzoniero LM, Casoli T, Fattoretti P.

Rejuvenation Res. 2008 Apr;11(2):309-13. doi: 10.1089/rej.2008.0660.


Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease.

Sensi SL, Rapposelli IG, Frazzini V, Mascetra N.

Exp Gerontol. 2008 May;43(5):488-92. Epub 2007 Nov 12.


Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis.

Esposito E, Capasso M, di Tomasso N, Corona C, Pellegrini F, Uncini A, Vitaglione P, Fogliano V, Piantelli M, Sensi SL.

Brain Res. 2007 Sep 7;1168:90-6. Epub 2007 Jul 31.


Mechanism and regulation of cellular zinc transport.

Sekler I, Sensi SL, Hershfinkel M, Silverman WF.

Mol Med. 2007 Jul-Aug;13(7-8):337-43. Review.


Mild acidosis enhances AMPA receptor-mediated intracellular zinc mobilization in cortical neurons.

Frazzini V, Rapposelli IG, Corona C, Rockabrand E, Canzoniero LM, Sensi SL.

Mol Med. 2007 Jul-Aug;13(7-8):356-61.


Heavy metal ions in normal physiology, toxic stress, and cytoprotection.

Lynes MA, Kang YJ, Sensi SL, Perdrizet GA, Hightower LE.

Ann N Y Acad Sci. 2007 Oct;1113:159-72. Epub 2007 May 4. Review.


The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

Rockabrand E, Slepko N, Pantalone A, Nukala VN, Kazantsev A, Marsh JL, Sullivan PG, Steffan JS, Sensi SL, Thompson LM.

Hum Mol Genet. 2007 Jan 1;16(1):61-77. Epub 2006 Nov 29.


Oxidative stress and brain aging: is zinc the link?

Frazzini V, Rockabrand E, Mocchegiani E, Sensi SL.

Biogerontology. 2006 Oct-Dec;7(5-6):307-14. Review.


Acidosis enhances toxicity induced by kainate and zinc exposure in aged cultured astrocytes.

Sensi SL, Rockabrand E, Canzoniero LM.

Biogerontology. 2006 Oct-Dec;7(5-6):367-74.


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