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Items: 12

1.

Characterization of the in vitro inhibitory potential of the oligonucleotide imetelstat on human cytochrome P450 enzymes with predictions of in vivo drug-drug interactions.

Kazmi F, Sensenhauser C, Greway T.

Drug Metab Dispos. 2018 Nov 2. pii: dmd.118.084103. doi: 10.1124/dmd.118.084103. [Epub ahead of print]

PMID:
30389730
2.

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J.

Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20.

3.

In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.

Monbaliu J, Gonzalez M, Bernard A, Jiao J, Sensenhauser C, Snoeys J, Stieltjes H, Wynant I, Smit JW, Chien C.

Drug Metab Dispos. 2016 Oct;44(10):1682-91. doi: 10.1124/dmd.116.070672. Epub 2016 Aug 8.

4.

A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4.

Templeton I, Ravenstijn P, Sensenhauser C, Snoeys J.

Biopharm Drug Dispos. 2016 Jan;37(1):15-27. doi: 10.1002/bdd.1992.

PMID:
26356245
5.

Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model.

Xia L, Hong X, Sakban RB, Qu Y, Singh NH, McMillian M, Dallas S, Silva J, Sensenhauser C, Zhao S, Lim HK, Yu H.

J Appl Toxicol. 2016 Feb;36(2):320-9. doi: 10.1002/jat.3189. Epub 2015 Jul 21.

PMID:
26201057
6.

Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes.

Dallas S, Chattopadhyay S, Sensenhauser C, Batheja A, Singer M, Silva J.

Drug Metab Dispos. 2013 Apr;41(4):689-93. doi: 10.1124/dmd.112.048884. Epub 2013 Jan 24.

7.

De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes.

Dallas S, Sensenhauser C, Batheja A, Singer M, Markowska M, Zakszewski C, Mamidi RN, McMillia M, Han C, Zhou H, Silva J.

Curr Drug Metab. 2012 Sep 1;13(7):923-9.

PMID:
22475265
8.

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC.

Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28.

PMID:
21667953
9.

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC.

Rapid Commun Mass Spectrom. 2008 Apr;22(8):1295-311. doi: 10.1002/rcm.3504.

PMID:
18383206
10.

Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60,000 in external calibration mode using an LTQ/Orbitrap.

Lim HK, Chen J, Sensenhauser C, Cook K, Subrahmanyam V.

Rapid Commun Mass Spectrom. 2007;21(12):1821-32.

PMID:
17497624
11.

Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.

Roymans D, Annaert P, Van Houdt J, Weygers A, Noukens J, Sensenhauser C, Silva J, Van Looveren C, Hendrickx J, Mannens G, Meuldermans W.

Drug Metab Dispos. 2005 Jul;33(7):1004-16. Epub 2005 Mar 31.

12.

The influence of fluoranthene on the metabolism and DNA binding of benzo[a]pyrene in vivo in mouse skin.

Rice JE, Defloria MC, Sensenhauser C, Lavoie EJ.

Chem Biol Interact. 1988;68(1-2):127-36.

PMID:
3203403

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