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Items: 27

1.

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways.

Young PA, Senkal CE, Suchanek AL, Grevengoed TJ, Lin DD, Zhao L, Crunk AE, Klett EL, Füllekrug J, Obeid LM, Coleman RA.

J Biol Chem. 2018 Oct 26;293(43):16724-16740. doi: 10.1074/jbc.RA118.004049. Epub 2018 Sep 6.

PMID:
30190326
2.

Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.

Schwartz NU, Linzer RW, Truman JP, Gurevich M, Hannun YA, Senkal CE, Obeid LM.

FASEB J. 2018 Mar;32(3):1716-1728. doi: 10.1096/fj.201701067R. Epub 2018 Jan 3.

3.

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.

Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B.

Sci Signal. 2017 Oct 24;10(502). pii: eaam7464. doi: 10.1126/scisignal.aam7464.

4.

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.

Williams B, Correnti J, Oranu A, Lin A, Scott V, Annoh M, Beck J, Furth E, Mitchell V, Senkal CE, Obeid L, Carr RM.

FASEB J. 2018 Jan;32(1):130-142. doi: 10.1096/fj.201601142R. Epub 2017 Sep 1.

5.

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.

Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558. doi: 10.1073/pnas.1705134114. Epub 2017 Jun 26.

6.

Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.

Senkal CE, Salama MF, Snider AJ, Allopenna JJ, Rana NA, Koller A, Hannun YA, Obeid LM.

Cell Metab. 2017 Mar 7;25(3):686-697. doi: 10.1016/j.cmet.2017.02.010.

7.

Sphingolipids in mitochondria.

Hernández-Corbacho MJ, Salama MF, Canals D, Senkal CE, Obeid LM.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):56-68. doi: 10.1016/j.bbalip.2016.09.019. Epub 2016 Sep 30. Review.

8.

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.

Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM.

J Biol Chem. 2015 Oct 16;290(42):25356-73. doi: 10.1074/jbc.M115.658658. Epub 2015 Aug 28.

9.

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.

El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA.

FASEB J. 2014 Jan;28(1):495-505. doi: 10.1096/fj.13-230557. Epub 2013 Oct 11.

10.

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B.

EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25.

11.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.

Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B.

Nat Chem Biol. 2012 Oct;8(10):831-8. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

12.

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.

Meyers-Needham M, Ponnusamy S, Gencer S, Jiang W, Thomas RJ, Senkal CE, Ogretmen B.

EMBO Mol Med. 2012 Feb;4(2):78-92. doi: 10.1002/emmm.201100189. Epub 2011 Dec 19.

13.

Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.

Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B.

J Biol Chem. 2011 Dec 9;286(49):42446-58. doi: 10.1074/jbc.M111.287383. Epub 2011 Oct 19.

14.

Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response.

Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B.

Clin Cancer Res. 2011 Sep 15;17(18):6097-105. doi: 10.1158/1078-0432.CCR-11-0930. Epub 2011 Jul 26.

15.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B.

Blood. 2011 Jun 2;117(22):5941-52. doi: 10.1182/blood-2010-08-300772. Epub 2011 Apr 28.

16.

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B.

Future Oncol. 2010 Oct;6(10):1603-24. doi: 10.2217/fon.10.116. Review.

17.

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.

Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, Ogretmen B, Cabot MC, Shah GV, Sylvester PW, Jazwinski SM, Liu YY.

PLoS One. 2009 Sep 9;4(9):e6938. doi: 10.1371/journal.pone.0006938.

18.

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.

Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B.

FASEB J. 2010 Jan;24(1):296-308. doi: 10.1096/fj.09-135087. Epub 2009 Sep 1.

19.

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.

Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B.

FASEB J. 2009 Mar;23(3):751-63. doi: 10.1096/fj.08-120550. Epub 2008 Nov 21.

20.

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.

Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B.

Cancer Lett. 2007 Oct 18;256(1):101-11. Epub 2007 Jul 9.

21.

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.

Wooten-Blanks LG, Song P, Senkal CE, Ogretmen B.

FASEB J. 2007 Oct;21(12):3386-97. Epub 2007 Jun 4.

PMID:
17548428
22.

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.

Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B.

Mol Cancer Ther. 2007 Feb;6(2):712-22.

23.

Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells.

Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B.

J Biol Chem. 2007 Apr 13;282(15):10922-34. Epub 2007 Feb 15.

24.

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA.

J Biol Chem. 2006 Dec 1;281(48):36793-802. Epub 2006 Oct 9.

25.

Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.

Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B.

J Pharmacol Exp Ther. 2006 Jun;317(3):1188-99. Epub 2006 Mar 1.

PMID:
16510697
26.

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B.

Biochem J. 2006 Jan 15;393(Pt 2):513-21.

27.

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.

Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B.

J Biol Chem. 2004 Oct 22;279(43):44311-9. Epub 2004 Aug 17.

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