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Items: 47


Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.


TLT-1: please release me, let me go.

Senis YA.

Blood. 2018 Dec 6;132(23):2427-2429. doi: 10.1182/blood-2018-10-879676. No abstract available.


The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.

Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA.

Blood. 2019 Jan 24;133(4):331-343. doi: 10.1182/blood-2018-09-877787. Epub 2018 Nov 14.


Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis.

Al Ghaithi R, Mori J, Nagy Z, Maclachlan A, Hardy L, Philippou H, Hethershaw E, Morgan NV, Senis YA, Harrison P.

Platelets. 2018 Oct 26:1-8. doi: 10.1080/09537104.2018.1535704. [Epub ahead of print]


Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation.

Boraschi-Diaz I, Mort JS, Brömme D, Senis YA, Mazharian A, Komarova SV.

Bone. 2018 Dec;117:23-30. doi: 10.1016/j.bone.2018.09.006. Epub 2018 Sep 12.


TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.

Smith CW, Raslan Z, Parfitt L, Khan AO, Patel P, Senis YA, Mazharian A.

Blood Adv. 2018 Aug 28;2(16):2072-2078. doi: 10.1182/bloodadvances.2018017756. No abstract available.


Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.

Harrison MJ, Chimen M, Hussain M, Iqbal AJ, Senis YA, Nash GB, Watson SP, Rainger GE.

J Cell Mol Med. 2018 Sep;22(9):4317-4327. doi: 10.1111/jcmm.13721. Epub 2018 Jul 4.


Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA.

Blood. 2018 Sep 27;132(13):1399-1412. doi: 10.1182/blood-2017-08-802769. Epub 2018 Jun 13.


Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith CW, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Eble JA, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA.

Blood. 2018 Sep 27;132(13):1413-1425. doi: 10.1182/blood-2017-10-802975. Epub 2018 Jun 11.


Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?

Senis YA, Barr AJ.

Molecules. 2018 Mar 2;23(3). pii: E569. doi: 10.3390/molecules23030569. Review.


Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA.

Blood. 2018 Mar 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4.


ITIM receptors: more than just inhibitors of platelet activation.

Coxon CH, Geer MJ, Senis YA.

Blood. 2017 Jun 29;129(26):3407-3418. doi: 10.1182/blood-2016-12-720185. Epub 2017 May 2. Review.


Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.

Smith CW, Thomas SG, Raslan Z, Patel P, Byrne M, Lordkipanidzé M, Bem D, Meyaard L, Senis YA, Watson SP, Mazharian A.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):823-835. doi: 10.1161/ATVBAHA.117.309253. Epub 2017 Mar 23.


Ups and downs of the ADP phosphoproteome.

Nagy Z, Senis YA.

Blood. 2017 Jan 12;129(2):135-136. doi: 10.1182/blood-2016-11-751917. No abstract available.


Cross talk between serine/threonine and tyrosine kinases regulates ADP-induced thromboxane generation in platelets.

Bhavanasi D, Badolia R, Manne BK, Janapati S, Dangelmaier CT, Mazharian A, Jin J, Kim S, Zhang X, Chen X, Senis YA, Kunapuli SP.

Thromb Haemost. 2015 Aug 31;114(3):558-68. doi: 10.1160/TH14-09-0775. Epub 2015 May 7.


Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.

Tautz L, Senis YA, Oury C, Rahmouni S.

Bioorg Med Chem. 2015 Jun 15;23(12):2786-97. doi: 10.1016/j.bmc.2015.03.075. Epub 2015 Apr 4. Review.


Proplatelets slip slidin' away.

Mazharian A, Senis YA.

Blood. 2015 Jan 29;125(5):747-8. doi: 10.1182/blood-2014-12-614131.


Src family kinases: at the forefront of platelet activation.

Senis YA, Mazharian A, Mori J.

Blood. 2014 Sep 25;124(13):2013-24. doi: 10.1182/blood-2014-01-453134. Epub 2014 Aug 12. Review.


Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.

Senis YA.

J Thromb Haemost. 2013 Oct;11(10):1800-13. doi: 10.1111/jth.12359. Review.


Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Mazharian A, Mori J, Wang YJ, Heising S, Neel BG, Watson SP, Senis YA.

Blood. 2013 May 16;121(20):4205-20. doi: 10.1182/blood-2012-08-449272. Epub 2013 Mar 18.


Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.

Mazharian A, Wang YJ, Mori J, Bem D, Finney B, Heising S, Gissen P, White JG, Berndt MC, Gardiner EE, Nieswandt B, Douglas MR, Campbell RD, Watson SP, Senis YA.

Sci Signal. 2012 Oct 30;5(248):ra78. doi: 10.1126/scisignal.2002936.


Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.

Mori J, Wang YJ, Ellison S, Heising S, Neel BG, Tremblay ML, Watson SP, Senis YA.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2956-65. doi: 10.1161/ATVBAHA.112.300447. Epub 2012 Oct 11.


Distinct and overlapping functional roles of Src family kinases in mouse platelets.

Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP.

J Thromb Haemost. 2012 Aug;10(8):1631-45. doi: 10.1111/j.1538-7836.2012.04814.x.


Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG.

Cell. 2011 Sep 2;146(5):826-40. doi: 10.1016/j.cell.2011.07.020.


Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling.

Séverin S, Pollitt AY, Navarro-Nuñez L, Nash CA, Mourão-Sá D, Eble JA, Senis YA, Watson SP.

J Biol Chem. 2011 Feb 11;286(6):4107-16. doi: 10.1074/jbc.M110.167502. Epub 2010 Nov 22.


Src family kinases are essential for primary aggregation by G(i) -coupled receptors.

Nash CA, Séverin S, Dawood BB, Makris M, Mumford A, Wilde J, Senis YA, Watson SP.

J Thromb Haemost. 2010 Oct;8(10):2273-82. doi: 10.1111/j.1538-7836.2010.03992.x.


CD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases.

Ellison S, Mori J, Barr AJ, Senis YA.

J Thromb Haemost. 2010 Jul;8(7):1575-83. doi: 10.1111/j.1538-7836.2010.03865.x. Epub 2010 Mar 23.


Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.

Senis YA, Antrobus R, Severin S, Parguiña AF, Rosa I, Zitzmann N, Watson SP, García A.

J Thromb Haemost. 2009 Oct;7(10):1718-26. doi: 10.1111/j.1538-7836.2009.03565.x. Epub 2009 Aug 11.


The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.

Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP.

Blood. 2009 May 14;113(20):4942-54. doi: 10.1182/blood-2008-08-174318. Epub 2009 Feb 25.


G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

Mori J, Pearce AC, Spalton JC, Grygielska B, Eble JA, Tomlinson MG, Senis YA, Watson SP.

J Biol Chem. 2008 Dec 19;283(51):35419-27. doi: 10.1074/jbc.M806895200. Epub 2008 Oct 27.


Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains.

Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG.

Biochem J. 2009 Jan 1;417(1):391-400. doi: 10.1042/BJ20081126.


Minimal regulation of platelet activity by PECAM-1.

Dhanjal TS, Ross EA, Auger JM, McCarty OJ, Hughes CE, Senis YA, Buckley CD, Watson SP.

Platelets. 2007 Feb;18(1):56-67. Erratum in: Platelets. 2007 Mar;18(2):174. Buckley, Chris D [added]. Platelets. 2007 Sep;18(6):472.


A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.

Senis YA, Tomlinson MG, García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP.

Mol Cell Proteomics. 2007 Mar;6(3):548-64. Epub 2006 Dec 23.


Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara.

Senis YA, Kim PY, Fuller GL, García A, Prabhakar S, Wilkinson MC, Brittan H, Zitzmann N, Wait R, Warrell DA, Watson SP, Kamiguti AS, Theakston RD, Nesheim ME, Laing GD.

Biochim Biophys Acta. 2006 May;1764(5):863-71. Epub 2006 Apr 7.


Characterization of a novel protein from Proatheris superciliaris venom: proatherocytin, a 34-kDa platelet receptor PAR1 agonist.

Laing GD, Compton SJ, Ramachandran R, Fuller GL, Wilkinson MC, Wagstaff SC, Watson SP, Kamiguti AS, Theakston RD, Senis YA.

Toxicon. 2005 Oct;46(5):490-9.


Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.

Senis YA, Atkinson BT, Pearce AC, Wonerow P, Auger JM, Okkenhaug K, Pearce W, Vigorito E, Vanhaesebroeck B, Turner M, Watson SP.

Platelets. 2005 May-Jun;16(3-4):191-202.


Adhesion of human and mouse platelets to collagen under shear: a unifying model.

Auger JM, Kuijpers MJ, Senis YA, Watson SP, Heemskerk JW.

FASEB J. 2005 May;19(7):825-7. Epub 2005 Mar 9.


Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

Pearce AC, Senis YA, Billadeau DD, Turner M, Watson SP, Vigorito E.

J Biol Chem. 2004 Dec 24;279(52):53955-62. Epub 2004 Sep 27.


GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase.

Marshall SJ, Senis YA, Auger JM, Feil R, Hofmann F, Salmon G, Peterson JT, Burslem F, Watson SP.

Blood. 2004 Apr 1;103(7):2601-9. Epub 2003 Dec 18.


Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis.

Senis YA, Craig AW, Greer PA.

Exp Hematol. 2003 Aug;31(8):673-81.


Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation.

Senis YA, Sangrar W, Zirngibl RA, Craig AW, Lee DH, Greer PA.

J Thromb Haemost. 2003 May;1(5):1062-70.


GPVI levels in platelets: relationship to platelet function at high shear.

Best D, Senis YA, Jarvis GE, Eagleton HJ, Roberts DJ, Saito T, Jung SM, Moroi M, Harrison P, Green FR, Watson SP.

Blood. 2003 Oct 15;102(8):2811-8. Epub 2003 Jun 26.


Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin.

McCafferty DM, Craig AW, Senis YA, Greer PA.

J Immunol. 2002 May 15;168(10):4930-5.


Changes in the pattern of distribution of von Willebrand factor in rat aortic endothelial cells following thrombin generation in vivo.

Senis YA, Richardson M, Tinlin S, Maurice DH, Giles AR.

Br J Haematol. 1996 Apr;93(1):195-203.


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