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Laminin γ2 knockout mice rescued with the human protein exhibit enamel maturation defects.

Wazen RM, Viegas-Costa LC, Fouillen A, Moffatt P, Adair-Kirk TL, Senior RM, Nanci A.

Matrix Biol. 2016 May-Jul;52-54:207-218. doi: 10.1016/j.matbio.2016.03.002. Epub 2016 Mar 5.


Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol.

Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF; GRADS Sarcoidosis Study Group.

Ann Am Thorac Soc. 2015 Oct;12(10):1561-71. doi: 10.1513/AnnalsATS.201503-172OT.


Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol.

Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methé BA, Kaminski N, Sandhaus RA; GRADS Alpha-1 Study Group.

Ann Am Thorac Soc. 2015 Oct;12(10):1551-60. doi: 10.1513/AnnalsATS.201503-143OC.


The Red journal at 25. A perspective from the founding editors.

Senior RM, Brody JS, Williams MC.

Am J Respir Cell Mol Biol. 2014 May;50(5):840-1. doi: 10.1165/rcmb.2014-0105ED. No abstract available.


Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels.

Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1006-15. doi: 10.1152/ajplung.00015.2014. Epub 2014 Apr 4.


The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report.

Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM.

Am J Respir Crit Care Med. 2013 Jun 15;187(12):1382-7. doi: 10.1164/rccm.201303-0488WS.


Accurate measurement of small airways on low-dose thoracic CT scans in smokers.

Lutey BA, Conradi SH, Atkinson JJ, Zheng J, Schechtman KB, Senior RM, Gierada DS.

Chest. 2013 May;143(5):1321-1329. doi: 10.1378/chest.12-0034.


The fibrotic matrix in control: does the extracellular matrix drive progression of idiopathic pulmonary fibrosis?

Tschumperlin DJ, Jones JC, Senior RM.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):814-6. doi: 10.1164/rccm.201208-1561ED. No abstract available.


Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.

Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM.

PLoS One. 2012;7(9):e45546. doi: 10.1371/journal.pone.0045546. Epub 2012 Sep 18.


Pulmonary research in 2013 and beyond: a National Heart, Lung, and Blood Institute perspective.

Kiley JP, Senior RM.

Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L729-32. doi: 10.1152/ajplung.00305.2012. Epub 2012 Sep 7. No abstract available.


Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.

Kim ST, Adair-Kirk TL, Senior RM, Miner JH.

PLoS One. 2012;7(7):e41348. doi: 10.1371/journal.pone.0041348. Epub 2012 Jul 20.


Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.

Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro SD, An L, Giudice GJ, Diaz LA, Senior RM, Liu Z.

Matrix Biol. 2012 Jan;31(1):38-44. doi: 10.1016/j.matbio.2011.09.003. Epub 2011 Sep 25.


In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometry.

Quirk JD, Lutey BA, Gierada DS, Woods JC, Senior RM, Lefrak SS, Sukstanskii AL, Conradi MS, Yablonskiy DA.

Radiology. 2011 Sep;260(3):866-74. doi: 10.1148/radiol.11102226. Epub 2011 Jul 6.


The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema.

Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):876-84. doi: 10.1164/rccm.201005-0718OC. Epub 2010 Nov 5.


Measuring small airways in transverse CT images correction for partial volume averaging and airway tilt.

Conradi SH, Lutey BA, Atkinson JJ, Wang W, Senior RM, Gierada DS.

Acad Radiol. 2010 Dec;17(12):1525-34. doi: 10.1016/j.acra.2010.08.005. Epub 2010 Oct 14.


Maintenance of glomerular filtration barrier integrity requires laminin alpha5.

Goldberg S, Adair-Kirk TL, Senior RM, Miner JH.

J Am Soc Nephrol. 2010 Apr;21(4):579-86. doi: 10.1681/ASN.2009091004. Epub 2010 Feb 11.


Smoking and nicotine exposure delay development of collagen-induced arthritis in mice.

Lindblad SS, Mydel P, Jonsson IM, Senior RM, Tarkowski A, Bokarewa M.

Arthritis Res Ther. 2009;11(3):R88. doi: 10.1186/ar2728. Epub 2009 Jun 11.


Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis.

Kyriakides TR, Wulsin D, Skokos EA, Fleckman P, Pirrone A, Shipley JM, Senior RM, Bornstein P.

Matrix Biol. 2009 Mar;28(2):65-73. doi: 10.1016/j.matbio.2009.01.001. Epub 2009 Jan 20.


Characterization of mouse alveolar epithelial cell monolayers.

Demaio L, Tseng W, Balverde Z, Alvarez JR, Kim KJ, Kelley DG, Senior RM, Crandall ED, Borok Z.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1051-8. doi: 10.1152/ajplung.00021.2009. Epub 2009 Mar 27.


Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9.

MacLauchlan S, Skokos EA, Meznarich N, Zhu DH, Raoof S, Shipley JM, Senior RM, Bornstein P, Kyriakides TR.

J Leukoc Biol. 2009 Apr;85(4):617-26. doi: 10.1189/jlb.1008588. Epub 2009 Jan 13.


Smoke particulates stress lung cells.

Adair-Kirk TL, Atkinson JJ, Senior RM.

Nat Med. 2008 Oct;14(10):1024-5. doi: 10.1038/nm1008-1024. No abstract available.


Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells.

Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):400-11. doi: 10.1165/rcmb.2007-0295OC. Epub 2008 Apr 25.


Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.

Cheung C, Marchant D, Walker EK, Luo Z, Zhang J, Yanagawa B, Rahmani M, Cox J, Overall C, Senior RM, Luo H, McManus BM.

Circulation. 2008 Mar 25;117(12):1574-82. doi: 10.1161/CIRCULATIONAHA.107.733238. Epub 2008 Mar 10.


Fragments of extracellular matrix as mediators of inflammation.

Adair-Kirk TL, Senior RM.

Int J Biochem Cell Biol. 2008;40(6-7):1101-10. doi: 10.1016/j.biocel.2007.12.005. Epub 2007 Dec 24. Review.


Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure.

Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M.

Respir Res. 2008 Jan 21;9:7. doi: 10.1186/1465-9921-9-7.


Clara cell adhesion and migration to extracellular matrix.

Atkinson JJ, Adair-Kirk TL, Kelley DG, Demello D, Senior RM.

Respir Res. 2008 Jan 7;9:1. doi: 10.1186/1465-9921-9-1.


Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.

Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM.

J Biol Chem. 2008 Apr 11;283(15):9513-22. doi: 10.1074/jbc.M706239200. Epub 2008 Jan 4.


Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine.

Elizur A, Adair-Kirk TL, Kelley DG, Griffin GL, Demello DE, Senior RM.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):8-15. Epub 2007 Aug 2.


Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury.

Atkinson JJ, Toennies HM, Holmbeck K, Senior RM.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L600-10. Epub 2007 Jun 8.


Clara cells impact the pulmonary innate immune response to LPS.

Elizur A, Adair-Kirk TL, Kelley DG, Griffin GL, deMello DE, Senior RM.

Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L383-92. Epub 2007 May 25.


Extracellular matrix metalloproteinase inducer in interstitial pneumonias.

Odajima N, Betsuyaku T, Nasuhara Y, Itoh T, Fukuda Y, Senior RM, Nishimura M.

Hum Pathol. 2006 Aug;37(8):1058-65. Epub 2006 Jun 2.


Laminin isoforms and lung development: all isoforms are not equal.

Nguyen NM, Senior RM.

Dev Biol. 2006 Jun 15;294(2):271-9. Epub 2006 Apr 3. Review.


Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.

Zhang L, Ikegami M, Korfhagen TR, McCormack FX, Yoshida M, Senior RM, Shipley JM, Shapiro SD, Whitsett JA.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L181-90. Epub 2006 Feb 24.


Elastin fragments drive disease progression in a murine model of emphysema.

Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD.

J Clin Invest. 2006 Mar;116(3):753-9. Epub 2006 Feb 9.


Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung.

Nguyen NM, Kelley DG, Schlueter JA, Meyer MJ, Senior RM, Miner JH.

Dev Biol. 2005 Jun 1;282(1):111-25.


Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury.

Lian X, Qin Y, Hossain SA, Yang L, White A, Xu H, Shipley JM, Li T, Senior RM, Du H, Yan C.

J Immunol. 2005 Jun 1;174(11):7250-6.


Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.

Liu Z, Li N, Diaz LA, Shipley M, Senior RM, Werb Z.

J Clin Invest. 2005 Apr;115(4):879-87.


Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency.

Fernández FG, Campbell LG, Liu W, Shipley JM, Itohara S, Patterson GA, Senior RM, Mohanakumar T, Jaramillo A.

Am J Transplant. 2005 Apr;5(4 Pt 1):671-83.


Membrane-type 1 matrix metalloproteinase is required for normal alveolar development.

Atkinson JJ, Holmbeck K, Yamada S, Birkedal-Hansen H, Parks WC, Senior RM.

Dev Dyn. 2005 Apr;232(4):1079-90.


Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection.

Campbell LG, Ramachandran S, Liu W, Shipley JM, Itohara S, Rogers JG, Moazami N, Senior RM, Jaramillo A.

Am J Transplant. 2005 Mar;5(3):517-28.


A chemotactic peptide from laminin alpha 5 functions as a regulator of inflammatory immune responses via TNF alpha-mediated signaling.

Adair-Kirk TL, Atkinson JJ, Kelley DG, Arch RH, Miner JH, Senior RM.

J Immunol. 2005 Feb 1;174(3):1621-9.


Characterization of hematopoietic progenitor mobilization in protease-deficient mice.

Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC.

Blood. 2004 Jul 1;104(1):65-72. Epub 2004 Mar 9.


Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation.

McMillan SJ, Kearley J, Campbell JD, Zhu XW, Larbi KY, Shipley JM, Senior RM, Nourshargh S, Lloyd CM.

J Immunol. 2004 Feb 15;172(4):2586-94.


Gelatinase B(MMP-9) an apoptotic factor in diabetic transgenic mice.

Camp TM, Tyagi SC, Senior RM, Hayden MR, Tyagi SC.

Diabetologia. 2003 Oct;46(10):1438-45. Epub 2003 Aug 20.


A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis.

Adair-Kirk TL, Atkinson JJ, Broekelmann TJ, Doi M, Tryggvason K, Miner JH, Mecham RP, Senior RM.

J Immunol. 2003 Jul 1;171(1):398-406.


Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid.

Betsuyaku T, Tanino M, Nagai K, Nasuhara Y, Nishimura M, Senior RM.

Am J Respir Crit Care Med. 2003 Jul 15;168(2):222-7. Epub 2003 Apr 24.


Increased basigin in bleomycin-induced lung injury.

Betsuyaku T, Kadomatsu K, Griffin GL, Muramatsu T, Senior RM.

Am J Respir Cell Mol Biol. 2003 May;28(5):600-6.


Clinical research in chronic obstructive pulmonary disease: needs and opportunities.

Croxton TL, Weinmann GG, Senior RM, Wise RA, Crapo JD, Buist AS.

Am J Respir Crit Care Med. 2003 Apr 15;167(8):1142-9.


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