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Items: 47

1.

BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics.

Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, Cuellar Camacho JL, Haag R, Ruppert C, Sengle G, Cavalcanti-Adam EA, Blank KG, Knaus P.

PLoS Biol. 2019 Dec 11;17(12):e3000557. doi: 10.1371/journal.pbio.3000557. eCollection 2019 Dec.

2.

Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D.

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Elisabeth Heumüller S, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R.

Nat Protoc. 2019 Dec;14(12):3395-3425. doi: 10.1038/s41596-019-0225-8. Epub 2019 Nov 8.

PMID:
31705125
3.

C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes.

Heumüller SE, Talantikite M, Napoli M, Armengaud J, Mörgelin M, Hartmann U, Sengle G, Paulsson M, Moali C, Wagener R.

J Biol Chem. 2019 Sep 13;294(37):13769-13780. doi: 10.1074/jbc.RA119.008641. Epub 2019 Jul 25.

PMID:
31346034
4.

Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) - potential in the prevention and treatment of septic arthritis.

Elezagic D, Mörgelin M, Hermes G, Hamprecht A, Sengle G, Lau D, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR.

Osteoarthritis Cartilage. 2019 Oct;27(10):1564-1573. doi: 10.1016/j.joca.2019.06.007. Epub 2019 Jul 4.

PMID:
31279936
5.

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR.

Eur Respir J. 2019 Mar 7;53(3). pii: 1800840. doi: 10.1183/13993003.00840-2018. Print 2019 Mar.

PMID:
30578393
6.

Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER.

Lockhart-Cairns MP, Lim KTW, Zuk A, Godwin ARF, Cain SA, Sengle G, Baldock C.

Matrix Biol. 2019 Apr;77:73-86. doi: 10.1016/j.matbio.2018.08.006. Epub 2018 Aug 18.

7.

ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome.

Mularczyk EJ, Singh M, Godwin ARF, Galli F, Humphreys N, Adamson AD, Mironov A, Cain SA, Sengle G, Boot-Handford RP, Cossu G, Kielty CM, Baldock C.

Hum Mol Genet. 2018 Nov 1;27(21):3675-3687. doi: 10.1093/hmg/ddy276.

8.

Identification of antibodies against extracellular matrix proteins in human osteoarthritis.

Ruthard J, Hermes G, Hartmann U, Sengle G, Pongratz G, Ostendorf B, Schneider M, Höllriegl S, Zaucke F, Wagener R, Streichert T, Klatt AR.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1273-1277. doi: 10.1016/j.bbrc.2018.07.036. Epub 2018 Jul 9.

PMID:
30001809
9.

Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program.

Do NN, Willenborg S, Eckes B, Jüngst C, Sengle G, Zaucke F, Eming SA.

J Immunol. 2018 Jul 15;201(2):663-674. doi: 10.4049/jimmunol.1701791. Epub 2018 Jun 13.

10.

Fibrillin microfibrils and proteases, key integrators of fibrotic pathways.

Zigrino P, Sengle G.

Adv Drug Deliv Rev. 2019 Jun;146:3-16. doi: 10.1016/j.addr.2018.04.019. Epub 2018 Apr 27. Review.

PMID:
29709492
11.

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts.

Schulz JN, Plomann M, Sengle G, Gullberg D, Krieg T, Eckes B.

Matrix Biol. 2018 Aug;68-69:522-532. doi: 10.1016/j.matbio.2018.01.025. Epub 2018 Feb 12. Review.

PMID:
29408278
12.

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B.

Autophagy. 2018;14(3):465-486. doi: 10.1080/15548627.2017.1422850. Epub 2018 Mar 11.

13.

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S.

Nat Commun. 2017 Oct 31;8(1):1218. doi: 10.1038/s41467-017-01120-3.

14.

Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.

Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G.

Sci Rep. 2017 Jul 17;7(1):5526. doi: 10.1038/s41598-017-05835-7.

15.

Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models.

Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G.

Acta Biomater. 2017 Apr 1;52:41-48. doi: 10.1016/j.actbio.2016.12.019. Epub 2016 Dec 9.

PMID:
27956365
16.

EMILIN3, an extracellular matrix molecule with restricted distribution in skin.

Corallo D, Schiavinato A, Bizzotto D, Milanetto M, Guljelmovic M, Keene DR, Sengle G, Braghetta P, Bonaldo P.

Exp Dermatol. 2017 May;26(5):435-438. doi: 10.1111/exd.13254. Epub 2017 Mar 2.

PMID:
27892605
17.

Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration.

Gkogkolou P, Hildebrandt K, Broekaert S, Metze D, Sengle G, Böhm M.

Br J Dermatol. 2017 Mar;176(3):832-835. doi: 10.1111/bjd.15196. Epub 2017 Jan 19. No abstract available. Erratum in: Br J Dermatol. 2018 Jan;178(1):307.

PMID:
27873303
18.

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway.

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C.

Matrix Biol. 2016 Sep;55:49-62. doi: 10.1016/j.matbio.2016.01.019. Epub 2016 Jan 29.

19.

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.

Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A.

Dis Model Mech. 2016 Nov 1;9(11):1367-1374. Epub 2016 Sep 1.

20.

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1.

Wohl AP, Troilo H, Collins RF, Baldock C, Sengle G.

J Biol Chem. 2016 Jun 10;291(24):12732-46. doi: 10.1074/jbc.M115.704734. Epub 2016 Apr 8.

21.

Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix.

Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G.

J Invest Dermatol. 2016 Jun;136(6):1150-1160. doi: 10.1016/j.jid.2016.02.021. Epub 2016 Mar 2.

22.

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL.

J Biol Chem. 2016 Jan 15;291(3):1103-14. doi: 10.1074/jbc.M115.681775. Epub 2015 Nov 24.

23.

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.

Troilo H, Barrett AL, Wohl AP, Jowitt TA, Collins RF, Bayley CP, Zuk AV, Sengle G, Baldock C.

Biochem Soc Trans. 2015 Oct;43(5):795-800. doi: 10.1042/BST20150071. Review.

24.

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice.

Sengle G, Carlberg V, Tufa SF, Charbonneau NL, Smaldone S, Carlson EJ, Ramirez F, Keene DR, Sakai LY.

PLoS Genet. 2015 Jun 26;11(6):e1005340. doi: 10.1371/journal.pgen.1005340. eCollection 2015 Jun.

25.

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

Sengle G, Sakai LY.

Matrix Biol. 2015 Sep;47:3-12. doi: 10.1016/j.matbio.2015.05.002. Epub 2015 May 7. Review.

26.

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.

Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A.

Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20.

27.

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding.

Troilo H, Zuk AV, Tunnicliffe RB, Wohl AP, Berry R, Collins RF, Jowitt TA, Sengle G, Baldock C.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13063-8. doi: 10.1073/pnas.1404166111. Epub 2014 Aug 25.

28.

Molecular and cellular basis of scleroderma.

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T.

J Mol Med (Berl). 2014 Sep;92(9):913-24. doi: 10.1007/s00109-014-1190-x. Epub 2014 Jul 18. Review.

PMID:
25030650
29.

AMACO is a component of the basement membrane-associated Fraser complex.

Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R.

J Invest Dermatol. 2014 May;134(5):1313-1322. doi: 10.1038/jid.2013.492. Epub 2013 Nov 14.

30.

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug.

Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K.

Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.

31.

A correlative method for imaging identical regions of samples by micro-CT, light microscopy, and electron microscopy: imaging adipose tissue in a model system.

Sengle G, Tufa SF, Sakai LY, Zulliger MA, Keene DR.

J Histochem Cytochem. 2013 Apr;61(4):263-71. doi: 10.1369/0022155412473757. Epub 2012 Dec 20.

32.

Microenvironmental regulation by fibrillin-1.

Sengle G, Tsutsui K, Keene DR, Tufa SF, Carlson EJ, Charbonneau NL, Ono RN, Sasaki T, Wirtz MK, Samples JR, Fessler LI, Fessler JH, Sekiguchi K, Hayflick SJ, Sakai LY.

PLoS Genet. 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5.

33.

Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability.

Sengle G, Ono RN, Sasaki T, Sakai LY.

J Biol Chem. 2011 Feb 18;286(7):5087-99. doi: 10.1074/jbc.M110.188615. Epub 2010 Dec 6.

34.

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

Nistala H, Lee-Arteaga S, Smaldone S, Siciliano G, Carta L, Ono RN, Sengle G, Arteaga-Solis E, Levasseur R, Ducy P, Sakai LY, Karsenty G, Ramirez F.

J Cell Biol. 2010 Sep 20;190(6):1107-21. doi: 10.1083/jcb.201003089.

35.

In vivo studies of mutant fibrillin-1 microfibrils.

Charbonneau NL, Carlson EJ, Tufa S, Sengle G, Manalo EC, Carlberg VM, Ramirez F, Keene DR, Sakai LY.

J Biol Chem. 2010 Aug 6;285(32):24943-55. doi: 10.1074/jbc.M110.130021. Epub 2010 Jun 7.

36.

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.

Tsutsui K, Manabe R, Yamada T, Nakano I, Oguri Y, Keene DR, Sengle G, Sakai LY, Sekiguchi K.

J Biol Chem. 2010 Feb 12;285(7):4870-82. doi: 10.1074/jbc.M109.076919. Epub 2009 Nov 23.

37.

Proteolytic processing causes extensive heterogeneity of tissue matrilin forms.

Ehlen HW, Sengle G, Klatt AR, Talke A, Müller S, Paulsson M, Wagener R.

J Biol Chem. 2009 Aug 7;284(32):21545-56. doi: 10.1074/jbc.M109.016568. Epub 2009 Jun 16.

38.

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bächinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY.

J Biol Chem. 2009 Jun 19;284(25):16872-81. doi: 10.1074/jbc.M809348200. Epub 2009 Apr 6.

39.

A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.

Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.

J Mol Biol. 2008 Sep 12;381(4):1025-39. doi: 10.1016/j.jmb.2008.06.074. Epub 2008 Jul 2.

40.

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bächinger HP, Sakai LY.

J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

41.

Effects of fibrillin-1 degradation on microfibril ultrastructure.

Kuo CL, Isogai Z, Keene DR, Hazeki N, Ono RN, Sengle G, Bächinger HP, Sakai LY.

J Biol Chem. 2007 Feb 9;282(6):4007-20. Epub 2006 Dec 7.

42.

Matrilins mediate weak cell attachment without promoting focal adhesion formation.

Mann HH, Sengle G, Gebauer JM, Eble JA, Paulsson M, Wagener R.

Matrix Biol. 2007 Apr;26(3):167-74. Epub 2006 Nov 3.

PMID:
17156989
43.

The matrilins--adaptor proteins in the extracellular matrix.

Wagener R, Ehlen HW, Ko YP, Kobbe B, Mann HH, Sengle G, Paulsson M.

FEBS Lett. 2005 Jun 13;579(15):3323-9. Epub 2005 Mar 22. Review.

44.

Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney.

Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R.

J Biol Chem. 2003 Dec 12;278(50):50240-9. Epub 2003 Sep 23.

45.

A ribozyme with michaelase activity: synthesis of the substrate precursors.

Eisenführ A, Arora PS, Sengle G, Takaoka LR, Nowick JS, Famulok M.

Bioorg Med Chem. 2003 Jan 17;11(2):235-49.

PMID:
12470718
46.

Novel RNA catalysts for the Michael reaction.

Sengle G, Eisenführ A, Arora PS, Nowick JS, Famulok M.

Chem Biol. 2001 May;8(5):459-73.

47.

Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends.

Sengle G, Jenne A, Arora PS, Seelig B, Nowick JS, Jäschke A, Famulok M.

Bioorg Med Chem. 2000 Jun;8(6):1317-29.

PMID:
10896110

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