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CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy.

Burger MC, Zhang C, Harter PN, Romanski A, Strassheimer F, Senft C, Tonn T, Steinbach JP, Wels WS.

Front Immunol. 2019 Nov 14;10:2683. doi: 10.3389/fimmu.2019.02683. eCollection 2019. Review.


Regorafenib CSF Penetration, Efficacy, and MRI Patterns in Recurrent Malignant Glioma Patients.

Zeiner PS, Kinzig M, Divé I, Maurer GD, Filipski K, Harter PN, Senft C, Bähr O, Hattingen E, Steinbach JP, Sörgel F, Voss M, Steidl E, Ronellenfitsch MW.

J Clin Med. 2019 Nov 21;8(12). pii: E2031. doi: 10.3390/jcm8122031.


Does aneurysm side influence the infarction side and patients´ outcome after subarachnoid hemorrhage?

Brawanski N, Kashefiolasl S, Won SY, Tritt S, Berkefeld J, Senft C, Seifert V, Konczalla J.

PLoS One. 2019 Nov 7;14(11):e0224013. doi: 10.1371/journal.pone.0224013. eCollection 2019.


Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF.

Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Günther S, Devraj K, Plate KH, Reiss Y.

Cancer Immunol Res. 2019 Dec;7(12):1910-1927. doi: 10.1158/2326-6066.CIR-18-0865. Epub 2019 Oct 9.


Surgery for Diffuse WHO Grade II Gliomas: Volumetric Analysis of a Multicenter Retrospective Cohort From the German Study Group for Intraoperative Magnetic Resonance Imaging.

Scherer M, Ahmeti H, Roder C, Gessler F, Jungk C, Pala A, Mayer B, Senft C, Tatagiba M, Synowitz M, Wirtz CR, Unterberg AW, Coburger J.

Neurosurgery. 2020 Jan 1;86(1):E64-E74. doi: 10.1093/neuros/nyz397.


Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project.

Pala A, Nadji-Ohl M, Faust K, Rückriegel S, Roder C, von der Brelie C, Forster MT, Löbel F, Schommer S, Löhr M, Grübel N, Rothenbacher D, König R, Engelke J, Schmitz B, Wirtz CR, Senft C, Rohde V, Tatagiba M, Ernestus RI, Vajkoczy P, Ganslandt O, Nagel G, Coburger J.

J Neurol Surg A Cent Eur Neurosurg. 2020 Jan;81(1):48-57. doi: 10.1055/s-0039-1693650. Epub 2019 Sep 24.


To treat or not to treat? A retrospective multicenter assessment of survival in patients with IDH-mutant low-grade glioma based on adjuvant treatment.

Paľa A, Coburger J, Scherer M, Ahmeti H, Roder C, Gessler F, Jungk C, Scheuerle A, Senft C, Tatagiba M, Synowitz M, Wirtz CR, Schmitz B, Unterberg AW.

J Neurosurg. 2019 Jul 19:1-8. doi: 10.3171/2019.4.JNS183395. [Epub ahead of print]


Management of hydrocephalus after resection of posterior fossa lesions in pediatric and adult patients-predictors for development of hydrocephalus.

Won SY, Dubinski D, Behmanesh B, Bernstock JD, Seifert V, Konczalla J, Tritt S, Senft C, Gessler F.

Neurosurg Rev. 2019 Jul 9. doi: 10.1007/s10143-019-01139-8. [Epub ahead of print]


Controversial roles for dexamethasone in glioblastoma - Opportunities for novel vascular targeting therapies.

Dubinski D, Hattingen E, Senft C, Seifert V, Peters KG, Reiss Y, Devraj K, Plate KH.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1460-1468. doi: 10.1177/0271678X19859847. Epub 2019 Jun 25.


Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas.

Rapp C, Dettling S, Liu F, Ull AT, Warta R, Jungk C, Roesch S, Mock A, Sahm F, Schmidt M, Jungwirth G, Zweckberger K, Lamszus K, Gousias K, Kessler AF, Grabe N, Loehr M, Ketter R, Urbschat S, Senft C, Westphal M, Abdollahi A, Debus J, von Deimling A, Unterberg A, Simon M, Herold-Mende CC.

Clin Cancer Res. 2019 Sep 1;25(17):5260-5270. doi: 10.1158/1078-0432.CCR-19-0389. Epub 2019 Jun 21.


Low-Frequency Oscillations Code Speech during Verbal Working Memory.

Gehrig J, Michalareas G, Forster MT, Lei J, Hok P, Laufs H, Senft C, Seifert V, Schoffelen JM, Hanslmayr S, Kell CA.

J Neurosci. 2019 Aug 14;39(33):6498-6512. doi: 10.1523/JNEUROSCI.0018-19.2019. Epub 2019 Jun 13.


Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas.

Filipski K, Braun Y, Zinke J, Roller B, Baumgarten P, Wagner M, Senft C, Zeiner PS, Ronellenfitsch MW, Steinbach JP, Plate KH, Gasparoni G, Mittelbronn M, Capper D, Harter PN.

Acta Neuropathol. 2019 Aug;138(2):331-334. doi: 10.1007/s00401-019-02025-9. Epub 2019 May 7. No abstract available.


Identification of KIF11 As a Novel Target in Meningioma.

Jungwirth G, Yu T, Moustafa M, Rapp C, Warta R, Jungk C, Sahm F, Dettling S, Zweckberger K, Lamszus K, Senft C, Loehr M, Keßler AF, Ketter R, Westphal M, Debus J, von Deimling A, Simon M, Unterberg A, Abdollahi A, Herold-Mende C.

Cancers (Basel). 2019 Apr 15;11(4). pii: E545. doi: 10.3390/cancers11040545.


Influence of pregnancy on glioma patients.

Forster MT, Baumgarten P, Gessler F, Maurer G, Senft C, Hattingen E, Seifert V, Harter PN, Franz K.

Acta Neurochir (Wien). 2019 Mar;161(3):535-543. doi: 10.1007/s00701-019-03823-6. Epub 2019 Jan 29.


A novel grading system for the prediction of the need for cerebrospinal fluid drainage following posterior fossa tumor surgery.

Won SY, Gessler F, Dubinski D, Eibach M, Behmanesh B, Herrmann E, Seifert V, Konczalla J, Tritt S, Senft C.

J Neurosurg. 2019 Jan 4:1-10. doi: 10.3171/2018.8.JNS181005. [Epub ahead of print]


Comparison of carotid and basilar bifurcation aneurysms versus non-T-angled bifurcations: the geometry is associated with the outcome.

Brawanski N, Bruder M, Won SY, Tritt S, Berkefeld J, Senft C, Seifert V, Konczalla J.

Neurosurg Rev. 2019 Dec;42(4):853-858. doi: 10.1007/s10143-018-01056-2. Epub 2018 Dec 12.


The clinical relevance of ABO blood type in 100 patients with acute subdural hematoma.

Dubinski D, Won SY, Behmanesh B, Brawanski N, Geisen C, Seifert V, Senft C, Konczalla J.

PLoS One. 2018 Oct 4;13(10):e0204331. doi: 10.1371/journal.pone.0204331. eCollection 2018.


Impact of resection on overall survival of recurrent Glioblastoma in elderly patients.

Hager J, Herrmann E, Kammerer S, Dinc N, Won SY, Senft C, Seifert V, Marquardt G, Quick-Weller J.

Clin Neurol Neurosurg. 2018 Nov;174:21-25. doi: 10.1016/j.clineuro.2018.08.033. Epub 2018 Sep 1.


Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.

Ronellenfitsch MW, Zeiner PS, Mittelbronn M, Urban H, Pietsch T, Reuter D, Senft C, Steinbach JP, Westphal M, Harter PN.

Acta Neuropathol Commun. 2018 Aug 21;6(1):81. doi: 10.1186/s40478-018-0583-4.


Ventriculoperitoneal Shunts Equipped with On-Off Valves for Intraventricular Therapies in Patients with Communicating Hydrocephalus due to Leptomeningeal Metastases.

Burger MC, Wagner M, Franz K, Harter PN, Bähr O, Steinbach JP, Senft C.

J Clin Med. 2018 Aug 14;7(8). pii: E216. doi: 10.3390/jcm7080216.


Vasospasm of the basilar artery following spontaneous SAH-clinical observations and implications for vascular research.

Dinc N, Quick-Weller J, Tritt S, Konczalla J, Mersmann J, Bruder M, Herrmann E, Seifert V, Senft C.

Neurosurg Rev. 2019 Dec;42(4):983-989. doi: 10.1007/s10143-018-1015-4. Epub 2018 Aug 7.


Pre- and early postoperative GFAP serum levels in glioma and brain metastases.

Baumgarten P, Quick-Weller J, Gessler F, Wagner M, Tichy J, Forster MT, Foerch C, Seifert V, Mittelbronn M, Senft C.

J Neurooncol. 2018 Sep;139(3):541-546. doi: 10.1007/s11060-018-2898-1. Epub 2018 May 24.


Tractography Verified by Intraoperative Magnetic Resonance Imaging and Subcortical Stimulation During Tumor Resection Near the Corticospinal Tract.

Münnich T, Klein J, Hattingen E, Noack A, Herrmann E, Seifert V, Senft C, Forster MT.

Oper Neurosurg (Hagerstown). 2019 Feb 1;16(2):197-210. doi: 10.1093/ons/opy062.


Surgery for Glioblastoma in Light of Molecular Markers: Impact of Resection and MGMT Promoter Methylation in Newly Diagnosed IDH-1 Wild-Type Glioblastomas.

Gessler F, Bernstock JD, Braczynski A, Lescher S, Baumgarten P, Harter PN, Mittelbronn M, Wu T, Seifert V, Senft C.

Neurosurgery. 2019 Jan 1;84(1):190-197. doi: 10.1093/neuros/nyy049.


Influence of ABO blood type on the outcome after non-aneurysmal subarachnoid hemorrhage.

Dubinski D, Won SY, Behmanesh B, Kashefiolasl S, Geisen C, Seifert V, Senft C, Konczalla J.

Acta Neurochir (Wien). 2018 Apr;160(4):761-766. doi: 10.1007/s00701-018-3489-9. Epub 2018 Feb 17.


Incidence, Risk Factors, and Outcome of Acute Kidney Injury in Neurocritical Care.

Büttner S, Stadler A, Mayer C, Patyna S, Betz C, Senft C, Geiger H, Jung O, Finkelmeier F.

J Intensive Care Med. 2020 Apr;35(4):338-346. doi: 10.1177/0885066617748596. Epub 2018 Jan 29.


Dexamethasone-induced leukocytosis is associated with poor survival in newly diagnosed glioblastoma.

Dubinski D, Won SY, Gessler F, Quick-Weller J, Behmanesh B, Bernatz S, Forster MT, Franz K, Plate KH, Seifert V, Harter PN, Senft C.

J Neurooncol. 2018 May;137(3):503-510. doi: 10.1007/s11060-018-2761-4. Epub 2018 Jan 18.


Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease.

Burger MC, Ronellenfitsch MW, Lorenz NI, Wagner M, Voss M, Capper D, Tzaridis T, Herrlinger U, Steinbach JP, Stoffels G, Langen KJ, Brandts C, Senft C, Harter PN, Bähr O.

Oncol Rep. 2017 Dec;38(6):3291-3296. doi: 10.3892/or.2017.6013. Epub 2017 Oct 2.


Takotsubo Cardiomyopathy Triggered by Venous Air Embolism During Craniotomy in the Sitting Position.

Raimann F, Senft C, Honold J, Zacharowski K, Seifert V, Mersmann J.

World Neurosurg. 2017 Nov;107:1045.e1-1045.e4. doi: 10.1016/j.wneu.2017.07.124. Epub 2017 Jul 29.


Serum concentrations of glial fibrillary acidic protein (GFAP) do not indicate tumor recurrence in patients with glioblastoma.

Vietheer JM, Rieger J, Wagner M, Senft C, Tichy J, Foerch C.

J Neurooncol. 2017 Oct;135(1):193-199. doi: 10.1007/s11060-017-2565-y. Epub 2017 Jul 17.


Cerebral Vasospasm-Dependent and Cerebral Vasospasm-Independent Cerebral Infarctions Predict Outcome After Nonaneurysmal Subarachnoid Hemorrhage: A Single-Center Series with 250 Patients.

Konczalla J, Kashefiolasl S, Brawanski N, Bruder M, Gessler F, Senft C, Berkefeld J, Seifert V, Tritt S.

World Neurosurg. 2017 Oct;106:861-869.e4. doi: 10.1016/j.wneu.2017.07.017. Epub 2017 Jul 12.


Subarachnoid Hemorrhage in Advanced Age: Comparison of Patients Aged 70-79 Years and 80 Years and Older.

Brawanski N, Kunze F, Bruder M, Tritt S, Senft C, Berkefeld J, Seifert V, Konczalla J.

World Neurosurg. 2017 Oct;106:139-144. doi: 10.1016/j.wneu.2017.06.056. Epub 2017 Jun 17.


Assessment of molecular markers demonstrates concordance between samples acquired via stereotactic biopsy and open craniotomy in both anaplastic astrocytomas and glioblastomas.

Gessler F, Baumgarten P, Bernstock JD, Harter P, Lescher S, Senft C, Seifert V, Marquardt G, Weise L.

J Neurooncol. 2017 Jun;133(2):399-407. doi: 10.1007/s11060-017-2448-2. Epub 2017 May 15.


Treatment of refractory and super-refractory status epilepticus with brivaracetam: A cohort study from two German university hospitals.

Strzelczyk A, Steinig I, Willems LM, Reif PS, Senft C, Voss M, Gaida B, von Podewils F, Rosenow F.

Epilepsy Behav. 2017 May;70(Pt A):177-181. doi: 10.1016/j.yebeh.2017.03.028. Epub 2017 Apr 17.


Risk factors governing the development of cerebral vein and dural sinus thrombosis after craniotomy in patients with intracranial tumors.

Gessler F, Bruder M, Duetzmann S, Tritt S, Bernstock JD, Seifert V, Senft C.

J Neurosurg. 2018 Feb;128(2):373-379. doi: 10.3171/2016.11.JNS161871. Epub 2017 Apr 7.


MRI-detection rate and incidence of lumbar bleeding sources in 190 patients with non-aneurysmal SAH.

Kashefiolasl S, Brawanski N, Platz J, Bruder M, Senft C, Marquardt G, Seifert V, Tritt S, Konczalla J.

PLoS One. 2017 Apr 3;12(4):e0174734. doi: 10.1371/journal.pone.0174734. eCollection 2017.


Secondary Glioblastoma: Molecular and Clinical Factors That Affect Outcome After Malignant Progression of a Lower Grade Tumor.

Gessler F, Zappi J, Konczalla J, Bernstock JD, Forster MT, Wagner M, Mittelbronn M, Seifert V, Senft C.

World Neurosurg. 2017 Jun;102:49-55. doi: 10.1016/j.wneu.2017.02.104. Epub 2017 Mar 2.


Outcome, Prognostic Factors, and Follow-Up Results After Subarachnoid Hemorrhage from Pericallosal Artery Aneurysms.

Dinc N, Lescher S, Quick-Weller J, Berkefeld J, Platz J, Senft C, Seifert V, Konczalla J.

World Neurosurg. 2017 Mar;99:566-571. doi: 10.1016/j.wneu.2016.12.079. Epub 2016 Dec 27.


Outcome and prognostic factors after delayed second subarachnoid haemorrhage.

Brawanski N, Platz J, Bruder M, Senft C, Berkefeld J, Seifert V, Konczalla J.

Acta Neurochir (Wien). 2017 Feb;159(2):307-315. doi: 10.1007/s00701-016-3045-4. Epub 2016 Dec 10.


Cerebral foreign body granuloma in brain triggering generalized seizures without obvious craniocerebral injury: A case report and review of the literature.

Brawanski N, Baumgarten P, Konczalla J, Seifert V, Senft C.

Surg Neurol Int. 2016 Nov 11;7(Suppl 29):S775-S778. eCollection 2016.


A Single-Center Prospective Observational Study of Ultrasonography for 6 Months after Surgical Decompression of the Median Nerve at the Carpal Tunnel.

Tas S, Staub F, Dombert T, Marquardt G, Senft C, Seifert V, Duetzmann S.

J Neurol Surg A Cent Eur Neurosurg. 2017 Jul;78(4):329-336. doi: 10.1055/s-0036-1593437. Epub 2016 Nov 30.


The Role of ABO Blood Group in Cerebral Vasospasm, Associated Intracranial Hemorrhage, and Delayed Cerebral Ischemia in 470 Patients with Subarachnoid Hemorrhage.

Dubinski D, Won SY, Konczalla J, Mersmann J, Geisen C, Herrmann E, Seifert V, Senft C.

World Neurosurg. 2017 Jan;97:532-537. doi: 10.1016/j.wneu.2016.10.065. Epub 2016 Oct 21.


Costs and cost-driving factors for acute treatment of adults with status epilepticus: A multicenter cohort study from Germany.

Kortland LM, Alfter A, Bähr O, Carl B, Dodel R, Freiman TM, Hubert K, Jahnke K, Knake S, von Podewils F, Reese JP, Runge U, Senft C, Steinmetz H, Rosenow F, Strzelczyk A.

Epilepsia. 2016 Dec;57(12):2056-2066. doi: 10.1111/epi.13584. Epub 2016 Oct 18.


Decision-making in a patient with cardiac arrest due to venous thromboembolism within 24 h after glioblastoma resection.

Dubinski D, Won SY, Bruder M, Forster MT, Seifert V, Senft C, Berkefeld J, Mersmann J.

Acta Neurochir (Wien). 2016 Dec;158(12):2259-2263. Epub 2016 Oct 14.


Resection of central nervous system lymphoma (CNSL): a paradigm shift?

Brawanski N, Atta J, Weise LM, Konczalla J, Quick-Weller J, Forster MT, Marquardt G, Seifert V, Senft C.

J Neurosurg Sci. 2016 Sep 28. [Epub ahead of print]


Brain invasion in otherwise benign meningiomas does not predict tumor recurrence.

Baumgarten P, Gessler F, Schittenhelm J, Skardelly M, Tews DS, Senft C, Dunst M, Imoehl L, Plate KH, Wagner M, Steinbach JP, Seifert V, Mittelbronn M, Harter PN.

Acta Neuropathol. 2016 Sep;132(3):479-81. doi: 10.1007/s00401-016-1598-1. Epub 2016 Jul 27. No abstract available.


Intratumoral Concentrations and Effects of Orally Administered Micellar Curcuminoids in Glioblastoma Patients.

Dützmann S, Schiborr C, Kocher A, Pilatus U, Hattingen E, Weissenberger J, Geßler F, Quick-Weller J, Franz K, Seifert V, Frank J, Senft C.

Nutr Cancer. 2016 Aug-Sep;68(6):943-8. doi: 10.1080/01635581.2016.1187281. Epub 2016 Jun 24.


Aneurysm Location as a Prognostic Outcome Factor After Subarachnoid Hemorrhage From Internal Carotid Artery Aneurysms and Potential Impact for Further Experimental Subarachnoid Hemorrhage Models.

Konczalla J, Brawanski N, Platz J, Senft C, Kashefiolasl S, Seifert V.

World Neurosurg. 2016 Aug;92:273-278. doi: 10.1016/j.wneu.2016.04.086. Epub 2016 May 2.


Non-aneurysmal non-perimesencephalic subarachnoid hemorrhage: effect of rehabilitation at short-term and in a prospective study of long-term follow-up.

Konczalla J, Schmitz J, Kashefiolasl S, Senft C, Platz J, Seifert V.

Top Stroke Rehabil. 2016 Aug;23(4):261-8. doi: 10.1080/10749357.2016.1149982. Epub 2016 Mar 15.


Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.

Schmidt M, Mock A, Jungk C, Sahm F, Ull AT, Warta R, Lamszus K, Gousias K, Ketter R, Roesch S, Rapp C, Schefzyk S, Urbschat S, Lahrmann B, Kessler AF, Löhr M, Senft C, Grabe N, Reuss D, Beckhove P, Westphal M, von Deimling A, Unterberg A, Simon M, Herold-Mende C.

Oncotarget. 2016 Mar 22;7(12):14551-68. doi: 10.18632/oncotarget.7396.

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