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Items: 39

1.

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.

Lukas J, Pospech J, Oppermann C, Hund C, Iwanov K, Pantoom S, Petters J, Frech M, Seemann S, Thiel FG, Modenbach JM, Bolsmann R, de Freitas Chama L, Kraatz F, El-Hage F, Gronbach M, Klein A, Müller R, Salloch S, Weiss FU, Simon P, Wagh P, Klemenz A, Krüger E, Mayerle J, Delcea M, Kragl U, Beller M, Rolfs A, Lerch MM, Sendler M.

Adv Med Sci. 2019 Apr 9;64(2):315-323. doi: 10.1016/j.advms.2019.03.004. [Epub ahead of print] Review.

PMID:
30978662
2.

Genetics, Cell Biology, and Pathophysiology of Pancreatitis.

Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M.

Gastroenterology. 2019 May;156(7):1951-1968.e1. doi: 10.1053/j.gastro.2018.11.081. Epub 2019 Jan 18. Review.

PMID:
30660731
3.

Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.

John DS, Aschenbach J, Krüger B, Sendler M, Weiss FU, Mayerle J, Lerch MM, Aghdassi AA.

J Biol Chem. 2019 Jan 11;294(2):697-707. doi: 10.1074/jbc.RA118.004376. Epub 2018 Nov 19.

PMID:
30455353
4.

Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity.

Frost F, Kacprowski T, Rühlemann M, Bülow R, Kühn JP, Franke A, Heinsen FA, Pietzner M, Nauck M, Völker U, Völzke H, Aghdassi AA, Sendler M, Mayerle J, Weiss FU, Homuth G, Lerch MM.

Gastroenterology. 2019 Mar;156(4):1010-1015. doi: 10.1053/j.gastro.2018.10.047. Epub 2018 Nov 2.

PMID:
30391469
5.

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma.

Mahajan UM, Langhoff E, Goni E, Costello E, Greenhalf W, Halloran C, Ormanns S, Kruger S, Boeck S, Ribback S, Beyer G, Dombroswki F, Weiss FU, Neoptolemos JP, Werner J, D'Haese JG, Bazhin A, Peterhansl J, Pichlmeier S, Büchler MW, Kleeff J, Ganeh P, Sendler M, Palmer DH, Kohlmann T, Rad R, Regel I, Lerch MM, Mayerle J.

Gastroenterology. 2018 Nov;155(5):1625-1639.e2. doi: 10.1053/j.gastro.2018.08.009. Epub 2018 Aug 6.

PMID:
30092175
6.

The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl- Channel.

Venglovecz V, Pallagi P, Kemény LV, Balázs A, Balla Z, Becskeházi E, Gál E, Tóth E, Zvara Á, Puskás LG, Borka K, Sendler M, Lerch MM, Mayerle J, Kühn JP, Rakonczay Z Jr, Hegyi P.

Front Physiol. 2018 Jul 12;9:854. doi: 10.3389/fphys.2018.00854. eCollection 2018.

7.

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis.

Balázs A, Balla Z, Kui B, Maléth J, Rakonczay Z Jr, Duerr J, Zhou-Suckow Z, Schatterny J, Sendler M, Mayerle J, Kühn JP, Tiszlavicz L, Mall MA, Hegyi P.

Front Physiol. 2018 May 29;9:632. doi: 10.3389/fphys.2018.00632. eCollection 2018.

8.

Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.

Aghdassi AA, John DS, Sendler M, Weiss FU, Reinheckel T, Mayerle J, Lerch MM.

J Biol Chem. 2018 Jan 19;293(3):1018-1029. doi: 10.1074/jbc.M117.814772. Epub 2017 Dec 11.

9.

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

Sendler M, Weiss FU, Golchert J, Homuth G, van den Brandt C, Mahajan UM, Partecke LI, Döring P, Gukovsky I, Gukovskaya AS, Wagh PR, Lerch MM, Mayerle J.

Gastroenterology. 2018 Feb;154(3):704-718.e10. doi: 10.1053/j.gastro.2017.10.018. Epub 2018 Jan 10.

10.

Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.

Maertin S, Elperin JM, Lotshaw E, Sendler M, Speakman SD, Takakura K, Reicher BM, Mareninova OA, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G524-G536. doi: 10.1152/ajpgi.00138.2017. Epub 2017 Jul 13.

11.

Necrosis, Apoptosis, Necroptosis, Pyroptosis: It Matters How Acinar Cells Die During Pancreatitis.

Sendler M, Mayerle J, Lerch MM.

Cell Mol Gastroenterol Hepatol. 2016 May 31;2(4):407-408. doi: 10.1016/j.jcmgh.2016.05.007. eCollection 2016 Jul. No abstract available.

12.

Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFα in a murine pancreatic cancer model.

Partecke LI, Käding A, Trung DN, Diedrich S, Sendler M, Weiss F, Kühn JP, Mayerle J, Beyer K, von Bernstorff W, Heidecke CD, Keßler W.

Oncotarget. 2017 Apr 4;8(14):22501-22512. doi: 10.18632/oncotarget.15019.

13.

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B Jr, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A.

Gut. 2017 Mar;66(3):473-486. doi: 10.1136/gutjnl-2016-312423. Epub 2016 Sep 15.

14.

Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.

Malla SR, Kärrman Mårdh C, Günther A, Mahajan UM, Sendler M, D'Haese J, Weiss FU, Lerch MM, Hansen MB, Mayerle J.

Pancreatology. 2016 Sep-Oct;16(5):761-9. doi: 10.1016/j.pan.2016.07.005. Epub 2016 Jul 14.

PMID:
27450968
15.

Development of Pancreatic Cancer: Targets for Early Detection and Treatment.

Lerch MM, Mayerle J, Mahajan U, Sendler M, Weiss FU, Aghdassi A, Moskwa P, Simon P.

Dig Dis. 2016;34(5):525-31. doi: 10.1159/000445233. Epub 2016 Jun 22.

PMID:
27332960
16.

Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.

Sendler M, Maertin S, John D, Persike M, Weiss FU, Krüger B, Wartmann T, Wagh P, Halangk W, Schaschke N, Mayerle J, Lerch MM.

J Biol Chem. 2016 Jul 8;291(28):14717-31. doi: 10.1074/jbc.M116.718999. Epub 2016 May 12.

17.

Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer.

Mahajan UM, Teller S, Sendler M, Palankar R, van den Brandt C, Schwaiger T, Kühn JP, Ribback S, Glöckl G, Evert M, Weitschies W, Hosten N, Dombrowski F, Delcea M, Weiss FU, Lerch MM, Mayerle J.

Gut. 2016 Nov;65(11):1838-1849. doi: 10.1136/gutjnl-2016-311393. Epub 2016 May 12.

18.

Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade.

Partecke LI, Speerforck S, Käding A, Seubert F, Kühn S, Lorenz E, Schwandke S, Sendler M, Keßler W, Trung DN, Oswald S, Weiss FU, Mayerle J, Henkel C, Menges P, Beyer K, Lerch MM, Heidecke CD, von Bernstorff W.

Pancreatology. 2016 May-Jun;16(3):423-33. doi: 10.1016/j.pan.2016.03.005. Epub 2016 Mar 23.

PMID:
27083074
19.

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.

Mareninova OA, Sendler M, Malla SR, Yakubov I, French SW, Tokhtaeva E, Vagin O, Oorschot V, Lüllmann-Rauch R, Blanz J, Dawson D, Klumperman J, Lerch MM, Mayerle J, Gukovsky I, Gukovskaya AS.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):678-694.

20.

TRAIL Promotes Tumor Growth in a Syngeneic Murine Orthotopic Pancreatic Cancer Model and Affects the Host Immune Response.

Beyer K, Normann L, Sendler M, Käding A, Heidecke CD, Partecke LI, von Bernstorff W.

Pancreas. 2016 Mar;45(3):401-8. doi: 10.1097/MPA.0000000000000469.

PMID:
26390425
21.

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis.

Sendler M, Beyer G, Mahajan UM, Kauschke V, Maertin S, Schurmann C, Homuth G, Völker U, Völzke H, Halangk W, Wartmann T, Weiss FU, Hegyi P, Lerch MM, Mayerle J.

Gastroenterology. 2015 Sep;149(3):765-76.e10. doi: 10.1053/j.gastro.2015.05.012. Epub 2015 May 19.

22.

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.

Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S, Molven A.

Nat Genet. 2015 May;47(5):518-522. doi: 10.1038/ng.3249. Epub 2015 Mar 16.

23.

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P.

Gastroenterology. 2015 Feb;148(2):427-39.e16. doi: 10.1053/j.gastro.2014.11.002. Epub 2014 Nov 7.

24.

Surgical trauma leads to a shorter survival in a murine orthotopic pancreatic cancer model.

Menges P, Klöcker C, Diedrich S, Sendler M, Maier S, Weiss FU, Heidecke CD, von Bernstorff W, Partecke LI.

Eur Surg Res. 2015;54(1-2):87-94. doi: 10.1159/000368226. Epub 2014 Nov 11.

PMID:
25402012
25.

Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.

Cendrowski J, Lobo VJ, Sendler M, Salas A, Kühn JP, Molero X, Fukunaga R, Mayerle J, Lerch MM, Real FX.

Gut. 2015 Jun;64(6):937-47. doi: 10.1136/gutjnl-2013-306068. Epub 2014 Jul 18.

PMID:
25037190
26.

Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis.

Schick V, Scheiber JA, Mooren FC, Turi S, Ceyhan GO, Schnekenburger J, Sendler M, Schwaiger T, Omercevic A, Brandt Cv, Fluhr G, Domschke W, Krüger B, Mayerle J, Lerch MM.

Gut. 2014 Sep;63(9):1469-80. doi: 10.1136/gutjnl-2012-304274. Epub 2013 Nov 25.

PMID:
24277728
27.

Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: a quid pro quo in pancreatic cancer.

Partecke LI, Günther C, Hagemann S, Jacobi C, Merkel M, Sendler M, van Rooijen N, Käding A, Nguyen Trung D, Lorenz E, Diedrich S, Weiss FU, Heidecke CD, von Bernstorff W.

Pancreatology. 2013 Sep-Oct;13(5):508-16. doi: 10.1016/j.pan.2013.06.010. Epub 2013 Jul 6.

PMID:
24075516
28.

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice.

Sendler M, Dummer A, Weiss FU, Krüger B, Wartmann T, Scharffetter-Kochanek K, van Rooijen N, Malla SR, Aghdassi A, Halangk W, Lerch MM, Mayerle J.

Gut. 2013 Mar;62(3):430-9. doi: 10.1136/gutjnl-2011-300771. Epub 2012 Apr 5.

PMID:
22490516
29.

Differential roles of inflammatory cells in pancreatitis.

Mayerle J, Dummer A, Sendler M, Malla SR, van den Brandt C, Teller S, Aghdassi A, Nitsche C, Lerch MM.

J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:47-51. doi: 10.1111/j.1440-1746.2011.07011.x. Review.

PMID:
22320916
30.

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer.

Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, Friess H, Büchler M, Evert M, Lerch MM, Weiss FU.

Gut. 2012 Mar;61(3):439-48. doi: 10.1136/gutjnl-2011-300060. Epub 2011 Dec 5.

PMID:
22147512
31.

Animal models for investigating chronic pancreatitis.

Aghdassi AA, Mayerle J, Christochowitz S, Weiss FU, Sendler M, Lerch MM.

Fibrogenesis Tissue Repair. 2011 Dec 1;4(1):26. doi: 10.1186/1755-1536-4-26.

32.

A syngeneic orthotopic murine model of pancreatic adenocarcinoma in the C57/BL6 mouse using the Panc02 and 6606PDA cell lines.

Partecke LI, Sendler M, Kaeding A, Weiss FU, Mayerle J, Dummer A, Nguyen TD, Albers N, Speerforck S, Lerch MM, Heidecke CD, von Bernstorff W, Stier A.

Eur Surg Res. 2011;47(2):98-107. doi: 10.1159/000329413. Epub 2011 Jun 30.

PMID:
21720167
33.

Breaking down haem attenuates acute pancreatitis: a new treatment option?

Mayerle J, Sendler M, Lerch MM.

Gut. 2011 May;60(5):569-70. doi: 10.1136/gut.2010.230136. Epub 2011 Feb 11. No abstract available.

PMID:
21317171
34.

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model.

Partecke IL, Kaeding A, Sendler M, Albers N, Kühn JP, Speerforck S, Roese S, Seubert F, Diedrich S, Kuehn S, Weiss UF, Mayerle J, Lerch MM, Hadlich S, Hosten N, Heidecke CD, Puls R, von Bernstorff W.

BMC Cancer. 2011 Jan 28;11:40. doi: 10.1186/1471-2407-11-40.

36.

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.

Nambaru PK, Hübner T, Köck K, Mews S, Grube M, Payen L, Guitton J, Sendler M, Jedlitschky G, Rimmbach C, Rosskopf D, Kowalczyk DW, Kroemer HK, Weiss FU, Mayerle J, Lerch MM, Ritter CA.

Drug Metab Dispos. 2011 Jan;39(1):132-9. doi: 10.1124/dmd.110.033613. Epub 2010 Oct 7.

PMID:
20930123
37.

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM.

Gastroenterology. 2010 Feb;138(2):726-37. doi: 10.1053/j.gastro.2009.10.048. Epub 2009 Nov 10.

39.

Cloning of the pig renal organic anion transporter 1 (pOAT1).

Hagos Y, Bahn A, Asif AR, Krick W, Sendler M, Burckhardt G.

Biochimie. 2002 Dec;84(12):1221-4.

PMID:
12628298

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