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Items: 1 to 50 of 111

1.

Open-Label Single-Dose Study to Assess the Effect of Mild and Moderate Hepatic Impairment on the Pharmacokinetics of Mirogabalin.

Duchin K, Senaldi G, Warren V, Marbury T, Lasseter K, Zahir H.

Clin Drug Investig. 2018 Nov;38(11):1001-1009. doi: 10.1007/s40261-018-0692-7.

PMID:
30171457
2.

Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a.

Burvenich IJG, Parakh S, Lee FT, Guo N, Liu Z, Gan HK, Rigopoulos A, O'Keefe GJ, Gong SJ, Goh YW, Tochon-Danguy H, Scott FE, Kotsuma M, Hirotani K, Senaldi G, Scott AM.

Theranostics. 2018 Jul 30;8(15):4199-4209. doi: 10.7150/thno.25575. eCollection 2018.

3.

First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors.

Moore KN, Bendell JC, LoRusso PM, Olszanski AJ, Zwick-Wallasch E, Jansen M, Vandell AG, Senaldi G.

Invest New Drugs. 2019 Feb;37(1):147-158. doi: 10.1007/s10637-018-0646-1. Epub 2018 Jul 28.

PMID:
30056611
4.

A Phase I, Single-Ascending-Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DS-2969b, a Novel GyrB Inhibitor.

Dennie J, Vandell AG, Inoue S, Gajee R, Pav J, Zhang G, Zamora C, Masuda N, Uchiyama M, Yamada M, Senaldi G.

J Clin Pharmacol. 2018 Dec;58(12):1557-1565. doi: 10.1002/jcph.1151. Epub 2018 May 10.

PMID:
29746725
5.

Phase 1 Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Oral Doses of DS-2969b, a Novel GyrB Inhibitor, in Healthy Subjects.

Vandell AG, Inoue S, Dennie J, Nagasawa Y, Gajee R, Pav J, Zhang G, Zamora C, Masuda N, Senaldi G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02537-17. doi: 10.1128/AAC.02537-17. Print 2018 May.

6.

A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of DS-3801b, a Motilin Receptor Agonist, in Healthy Subjects.

Dennie J, Atiee G, Warren V, Tao B, Morimoto K, Senaldi G.

J Clin Pharmacol. 2017 Sep;57(9):1221-1230. doi: 10.1002/jcph.919. Epub 2017 May 2.

PMID:
28464321
7.

First-in-human study of the antibody DR5 agonist DS-8273a in patients with advanced solid tumors.

Forero A, Bendell JC, Kumar P, Janisch L, Rosen M, Wang Q, Copigneaux C, Desai M, Senaldi G, Maitland ML.

Invest New Drugs. 2017 Jun;35(3):298-306. doi: 10.1007/s10637-016-0420-1. Epub 2017 Jan 3.

PMID:
28050790
8.

In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy.

Burvenich IJ, Lee FT, Guo N, Gan HK, Rigopoulos A, Parslow AC, O'Keefe GJ, Gong SJ, Tochon-Danguy H, Rudd SE, Donnelly PS, Kotsuma M, Ohtsuka T, Senaldi G, Scott AM.

Theranostics. 2016 Sep 25;6(12):2225-2234. eCollection 2016.

9.

Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.

Burvenich IJ, Parakh S, Gan HK, Lee FT, Guo N, Rigopoulos A, Lee ST, Gong S, O'Keefe GJ, Tochon-Danguy H, Kotsuma M, Hasegawa J, Senaldi G, Scott AM.

J Nucl Med. 2016 Jun;57(6):974-80. doi: 10.2967/jnumed.115.169839. Epub 2016 Mar 3.

10.

Neonatal death in mice lacking cardiotrophin-like cytokine is associated with multifocal neuronal hypoplasia.

Zou X, Bolon B, Pretorius JK, Kurahara C, McCabe J, Christiansen KA, Sun N, Duryea D, Foreman O, Senaldi G, Itano AA, Siu G.

Vet Pathol. 2009 May;46(3):514-9. doi: 10.1354/vp.08-VP-0239-B-BC. Epub 2008 Dec 19.

PMID:
19098279
11.

Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys.

Chen G, Luke PP, Yang H, Visser L, Sun H, Garcia B, Qian H, Xiang Y, Huang X, Liu W, Senaldi G, Schneider A, Poppema S, Wang H, Jevnikar AM, Zhong R.

Am J Transplant. 2007 Jan;7(1):27-37.

12.

Granulocyte colony-stimulating factor decreases tumor necrosis factor production in whole blood: role of interleukin-10 and prostaglandin E(2).

Agnello D, Mascagni P, Bertini R, Villa P, Senaldi G, Ghezzi P.

Eur Cytokine Netw. 2004 Oct-Dec;15(4):323-6.

13.

CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin.

Byrne FR, Morony S, Warmington K, Geng Z, Brown HL, Flores SA, Fiorino M, Yin SL, Hill D, Porkess V, Duryea D, Pretorius JK, Adamu S, Manoukian R, Danilenko DM, Sarosi I, Lacey DL, Kostenuik PJ, Senaldi G.

Gut. 2005 Jan;54(1):78-86. Erratum in: Gut. 2005 Feb;54(2):316. Manuokian, R [corrected to Manoukian, R].

14.

Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.

Siegmund B, Sennello JA, Lehr HA, Senaldi G, Dinarello CA, Fantuzzi G.

Eur J Immunol. 2004 Sep;34(9):2356-64.

15.

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?

Auernhammer CJ, Kopp FB, Vlotides G, Dorn F, Isele NB, Spöttl G, Cengic N, Weber MM, Senaldi G, Engelhardt D.

Neuroimmunomodulation. 2004;11(4):224-32.

PMID:
15249728
16.

TNFalpha in experimental diseases of the CNS.

Furlan R, Villa P, Senaldi G, Martino G.

Methods Mol Med. 2004;98:171-90.

PMID:
15064439
18.

Regulatory effects of osteoprotegerin on cellular and humoral immune responses.

Stolina M, Guo J, Faggioni R, Brown H, Senaldi G.

Clin Immunol. 2003 Dec;109(3):347-54.

PMID:
14697750
19.

Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.

Burger R, Bakker F, Guenther A, Baum W, Schmidt-Arras D, Hideshima T, Tai YT, Shringarpure R, Catley L, Senaldi G, Gramatzki M, Anderson KC.

Br J Haematol. 2003 Dec;123(5):869-78.

PMID:
14632778
21.

Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.

Banda NK, Vondracek A, Kraus D, Dinarello CA, Kim SH, Bendele A, Senaldi G, Arend WP.

J Immunol. 2003 Feb 15;170(4):2100-5.

22.

Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.

Kim MR, Manoukian R, Yeh R, Silbiger SM, Danilenko DM, Scully S, Sun J, DeRose ML, Stolina M, Chang D, Van GY, Clarkin K, Nguyen HQ, Yu YB, Jing S, Senaldi G, Elliott G, Medlock ES.

Blood. 2002 Oct 1;100(7):2330-40.

PMID:
12239140
23.

Regulatory effects of novel neurotrophin-1/b cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function.

Senaldi G, Stolina M, Guo J, Faggioni R, McCabe S, Kaufman SA, Van G, Xu W, Fletcher FA, Boone T, Chang MS, Sarmiento U, Cattley RC.

J Immunol. 2002 Jun 1;168(11):5690-8.

24.

rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.

Byrne FR, Farrell CL, Aranda R, Rex KL, Scully S, Brown HL, Flores SA, Gu LH, Danilenko DM, Lacey DL, Ziegler TR, Senaldi G.

Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G690-701.

25.

Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1.

Wieland CW, Siegmund B, Senaldi G, Vasil ML, Dinarello CA, Fantuzzi G.

Infect Immun. 2002 Mar;70(3):1352-8.

26.

Role of IL-18 in acute lung inflammation.

Jordan JA, Guo RF, Yun EC, Sarma V, Warner RL, Crouch LD, Senaldi G, Ulich TR, Ward PA.

J Immunol. 2001 Dec 15;167(12):7060-8.

27.

A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer.

Yan XQ, Sarmiento U, Sun Y, Huang G, Guo J, Juan T, Van G, Qi MY, Scully S, Senaldi G, Fletcher FA.

Blood. 2001 Dec 15;98(13):3793-9.

PMID:
11739188
28.

IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice.

Faggioni R, Cattley RC, Guo J, Flores S, Brown H, Qi M, Yin S, Hill D, Scully S, Chen C, Brankow D, Lewis J, Baikalov C, Yamane H, Meng T, Martin F, Hu S, Boone T, Senaldi G.

J Immunol. 2001 Nov 15;167(10):5913-20.

29.

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection.

Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, Mu S, Xia M, Wakeham AC, Nishina H, Potter J, Saris CJ, Mak TW.

Immunity. 2001 Oct;15(4):569-78.

30.

Stimulatory effects of B7-related protein-1 on cellular and humoral immune responses in mice.

Guo J, Stolina M, Bready JV, Yin S, Horan T, Yoshinaga SK, Senaldi G.

J Immunol. 2001 May 1;166(9):5578-84.

31.

APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.

Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ, Sarosi I, Hsu H, Senaldi G, Theill LE.

Nat Immunol. 2000 Sep;1(3):252-6.

PMID:
10973284
32.

Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity.

Fantuzzi G, Reed D, Qi M, Scully S, Dinarello CA, Senaldi G.

Eur J Immunol. 2001 Feb;31(2):369-75.

33.

TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.

Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H.

J Exp Med. 2000 Jul 3;192(1):137-43.

34.

Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice.

Piguet PF, Da Laperrousaz C, Vesin C, Tacchini-Cottier F, Senaldi G, Grau GE.

Infect Immun. 2000 Jul;68(7):3822-9.

35.

PEG-rHuMGDF promotes multilineage hematopoietic recovery in myelosuppressed mice.

Ulich TR, del Castillo J, Senaldi G, Hartley C, Molineux G.

Exp Hematol. 1999 Dec;27(12):1776-81.

PMID:
10641595
36.

T-cell co-stimulation through B7RP-1 and ICOS.

Yoshinaga SK, Whoriskey JS, Khare SD, Sarmiento U, Guo J, Horan T, Shih G, Zhang M, Coccia MA, Kohno T, Tafuri-Bladt A, Brankow D, Campbell P, Chang D, Chiu L, Dai T, Duncan G, Elliott GS, Hui A, McCabe SM, Scully S, Shahinian A, Shaklee CL, Van G, Mak TW, Senaldi G.

Nature. 1999 Dec 16;402(6763):827-32.

PMID:
10617205
37.

Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1.

Senaldi G, Shaklee CL, Guo J, Martin L, Boone T, Mak TW, Ulich TR.

J Immunol. 1999 Dec 15;163(12):6820-6.

38.

Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.

Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11458-63.

39.
40.

Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, de la Pompa JL, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW.

J Immunol. 1999 Mar 1;162(5):3022-30.

41.

The prolonged hematologic effects of a single injection of PEG-rHuMGDF in normal and thrombocytopenic mice.

Ulich TR, del Castillo J, Senaldi G, Cheung E, Roskos L, Young J, Molineux G, Guo J, Schoemperlen J, Munyakazi L, Murphy-Filkins R, Tarpley JE, Toombs CF, Kaufman S, Yin S, Nelson AG, Nichol JL, Sheridan WP.

Exp Hematol. 1999 Jan;27(1):117-30.

PMID:
9923450
42.

Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family.

Agnello D, Meazza C, Rowan CG, Villa P, Ghezzi P, Senaldi G.

Am J Physiol. 1998 Sep;275(3):R913-9. doi: 10.1152/ajpregu.1998.275.3.R913.

PMID:
9728091
43.

Granulocyte colony-stimulating factor and antibiotics in the prophylaxis of a murine model of polymicrobial peritonitis and sepsis.

Villa P, Shaklee CL, Meazza C, Agnello D, Ghezzi P, Senaldi G.

J Infect Dis. 1998 Aug;178(2):471-7.

PMID:
9697729
44.

Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro.

Senaldi G, Shaklee CL, Simon B, Rowan CG, Lacey DL, Hartung T.

Hepatology. 1998 Jun;27(6):1584-91.

PMID:
9620331
46.

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ.

Cell. 1998 Apr 17;93(2):165-76.

47.

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW.

Genes Dev. 1998 Mar 15;12(6):806-19.

48.

Carbohydrate moiety of Plasmodium falciparum glycoproteins: the nature of the carbohydrate-peptide linkage in the MSP-2 glycoprotein.

Khan AH, Qazi AM, Hoessli DC, Torred-Duarte AP, Senaldi G, Qazi MH, Walker-Nasir E, Nasir-ud-Din.

Biochem Mol Biol Int. 1997 Oct;43(3):655-68.

PMID:
9352084
49.

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.

Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, Wakeham A, Shahinian A, Catzavelos C, Rak J, Furlonger C, Zakarian A, Simard JJ, Ohashi PS, Paige CJ, Gutierrez-Ramos JC, Mak TW.

Blood. 1997 Sep 15;90(6):2217-33.

PMID:
9310473
50.

Platelets play a role in the pathogenesis of the irritant reaction in mice.

Senaldi G, Piguet PF.

J Invest Dermatol. 1997 Mar;108(3):248-52.

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