Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 219


Lnc(ing) interferon production and action.

Sen GC, Williams BRG.

Cell Res. 2019 Sep;29(9):690-691. doi: 10.1038/s41422-019-0207-y. No abstract available.


Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection.

Kimura T, Flynn CT, Alirezaei M, Sen GC, Whitton JL.

PLoS Pathog. 2019 Apr 8;15(4):e1007674. doi: 10.1371/journal.ppat.1007674. eCollection 2019 Apr.


TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation.

Cai G, Zhu L, Chen X, Sun K, Liu C, Sen GC, Stark GR, Qin J, Li X.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11531-11536. doi: 10.1073/pnas.1809599115. Epub 2018 Oct 23.


Constitutively Bound EGFR-Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal.

Veleeparambil M, Poddar D, Abdulkhalek S, Kessler PM, Yamashita M, Chattopadhyay S, Sen GC.

J Immunol. 2018 Apr 15;200(8):2809-2818. doi: 10.4049/jimmunol.1700691. Epub 2018 Mar 12.


Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.

EMBO J. 2018 Apr 13;37(8). pii: e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1.


A new mechanism of interferon's antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7.

Subramanian G, Kuzmanovic T, Zhang Y, Peter CB, Veleeparambil M, Chakravarti R, Sen GC, Chattopadhyay S.

PLoS Pathog. 2018 Jan 30;14(1):e1006877. doi: 10.1371/journal.ppat.1006877. eCollection 2018 Jan.


Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.

Davis BM, Fensterl V, Lawrence TM, Hudacek AW, Sen GC, Schnell MJ.

J Virol. 2017 Aug 10;91(17). pii: e00889-17. doi: 10.1128/JVI.00889-17. Print 2017 Sep 1.


STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection.

Wang X, Majumdar T, Kessler P, Ozhegov E, Zhang Y, Chattopadhyay S, Barik S, Sen GC.

Cell Host Microbe. 2017 Jun 14;21(6):788. doi: 10.1016/j.chom.2017.05.007. No abstract available.


RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway.

Chattopadhyay S, Sen GC.

Protein Cell. 2017 Mar;8(3):165-168. doi: 10.1007/s13238-016-0334-x. Epub 2016 Nov 4. Review.


STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection.

Wang X, Majumdar T, Kessler P, Ozhegov E, Zhang Y, Chattopadhyay S, Barik S, Sen GC.

Cell Host Microbe. 2016 Sep 14;20(3):329-341. doi: 10.1016/j.chom.2016.08.002. Erratum in: Cell Host Microbe. 2017 Jun 14;21(6):788.


Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis.

Chattopadhyay S, Kuzmanovic T, Zhang Y, Wetzel JL, Sen GC.

Immunity. 2016 May 17;44(5):1151-61. doi: 10.1016/j.immuni.2016.04.009. Epub 2016 May 10.


Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.

White CL, Kessler PM, Dickerman BK, Ozato K, Sen GC.

J Biol Chem. 2016 Jun 24;291(26):13535-45. doi: 10.1074/jbc.M115.705467. Epub 2016 May 2.


No Love Lost Between Viruses and Interferons.

Fensterl V, Chattopadhyay S, Sen GC.

Annu Rev Virol. 2015 Nov;2(1):549-72. doi: 10.1146/annurev-virology-100114-055249. Epub 2015 Sep 25. Review.


The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.

Dickerman BK, White CL, Kessler PM, Sadler AJ, Williams BR, Sen GC.

FEBS J. 2015 Dec;282(24):4766-81. doi: 10.1111/febs.13533. Epub 2015 Oct 26.


Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus.

Tseng YY, Liao GR, Sen GC, Lin FY, Hsu WL.

J Virol. 2015 Nov;89(22):11619-29. doi: 10.1128/JVI.01739-15. Epub 2015 Sep 9.


EGFR kinase activity is required for TLR4 signaling and the septic shock response.

Chattopadhyay S, Veleeparambil M, Poddar D, Abdulkhalek S, Bandyopadhyay SK, Fensterl V, Sen GC.

EMBO Rep. 2015 Nov;16(11):1535-47. doi: 10.15252/embr.201540337. Epub 2015 Sep 4.


Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.

Majumdar T, Chattopadhyay S, Ozhegov E, Dhar J, Goswami R, Sen GC, Barik S.

PLoS Pathog. 2015 Mar 26;11(3):e1004779. doi: 10.1371/journal.ppat.1004779. eCollection 2015 Mar.


Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.

Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza RF, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA.

Nat Commun. 2014 Dec 15;5:5811. doi: 10.1038/ncomms6811.


Interferon-induced Ifit proteins: their role in viral pathogenesis.

Fensterl V, Sen GC.

J Virol. 2015 Mar;89(5):2462-8. doi: 10.1128/JVI.02744-14. Epub 2014 Nov 26. Review.


Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon.

Wetzel JL, Fensterl V, Sen GC.

J Virol. 2014 Dec;88(23):13593-601. doi: 10.1128/JVI.02201-14. Epub 2014 Sep 17.


Tyrosine phosphorylation in Toll-like receptor signaling.

Chattopadhyay S, Sen GC.

Cytokine Growth Factor Rev. 2014 Oct;25(5):533-41. doi: 10.1016/j.cytogfr.2014.06.002. Epub 2014 Jun 21. Review.


Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.

Fensterl V, Wetzel JL, Sen GC.

J Virol. 2014 Sep;88(18):10303-11. doi: 10.1128/JVI.01341-14. Epub 2014 Jul 2.


dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects.

Chattopadhyay S, Sen GC.

J Interferon Cytokine Res. 2014 Jun;34(6):427-36. doi: 10.1089/jir.2014.0034. Review.


Biological functions of double-stranded RNA and its binding proteins.

Sen GC.

J Interferon Cytokine Res. 2014 Jun;34(6):413-4. doi: 10.1089/jir.2014.0062. No abstract available.


Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation.

Chattopadhyay S, Sen GC.

Mol Cell. 2014 Apr 24;54(2):210-1. doi: 10.1016/j.molcel.2014.04.008.


Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

Chattopadhyay S, Kessler SP, Colucci JA, Yamashita M, Senanayake Pd, Sen GC.

PLoS One. 2014 Jan 27;9(1):e87484. doi: 10.1371/journal.pone.0087484. eCollection 2014.


Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.

Butchi NB, Hinton DR, Stohlman SA, Kapil P, Fensterl V, Sen GC, Bergmann CC.

J Virol. 2014 Jan;88(2):1051-64. doi: 10.1128/JVI.02272-13. Epub 2013 Nov 6.


The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.

Ogolla PS, Portillo JA, White CL, Patel K, Lamb B, Sen GC, Subauste CS.

PLoS Pathog. 2013;9(8):e1003557. doi: 10.1371/journal.ppat.1003557. Epub 2013 Aug 22.


Viral degradasome hijacks mitochondria to suppress innate immunity.

Goswami R, Majumdar T, Dhar J, Chattopadhyay S, Bandyopadhyay SK, Verbovetskaya V, Sen GC, Barik S.

Cell Res. 2013 Aug;23(8):1025-42. doi: 10.1038/cr.2013.98. Epub 2013 Jul 23.


A role for Ifit2 in restricting West Nile virus infection in the brain.

Cho H, Shrestha B, Sen GC, Diamond MS.

J Virol. 2013 Aug;87(15):8363-71. doi: 10.1128/JVI.01097-13. Epub 2013 Jun 5.


Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.

Chattopadhyay S, Fensterl V, Zhang Y, Veleeparambil M, Wetzel JL, Sen GC.

MBio. 2013 Mar 26;4(2). pii: e00636-12. doi: 10.1128/mBio.00636-12.


Antiviral innate immunity disturbs podocyte cell function.

Yamashita M, Millward CA, Inoshita H, Saikia P, Chattopadhyay S, Sen GC, Emancipator SN.

J Innate Immun. 2013;5(3):231-41. doi: 10.1159/000345255. Epub 2012 Dec 22.


The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2.

Dickerman BK, McDonald JA, Sen GC.

Version 2. F1000Res. 2013 Oct 18 [revised 2014 Jan 1];2:220. doi: 10.12688/f1000research.2-220.v2. eCollection 2013.


p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.

Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98. doi: 10.1073/pnas.1216922110. Epub 2012 Dec 10.


Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus.

Chattopadhyay S, Fensterl V, Zhang Y, Veleeparambil M, Yamashita M, Sen GC.

J Virol. 2013 Jan;87(1):16-24. doi: 10.1128/JVI.01853-12. Epub 2012 Oct 17.


Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs.

Sen GC, Fensterl V.

Cell Res. 2012 Oct;22(10):1407-9. doi: 10.1038/cr.2012.130. Epub 2012 Sep 11.


Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.

Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel JL, Sen GC.

Sci Signal. 2012 Jul 17;5(233):ra50. doi: 10.1126/scisignal.2002581.


Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.

Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC.

PLoS Pathog. 2012;8(5):e1002712. doi: 10.1371/journal.ppat.1002712. Epub 2012 May 17.


2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M Jr, Virgin HW, Klein RS, Sen GC, Diamond MS.

PLoS Pathog. 2012;8(5):e1002698. doi: 10.1371/journal.ppat.1002698. Epub 2012 May 10.


A TRIF-independent branch of TLR3 signaling.

Yamashita M, Chattopadhyay S, Fensterl V, Zhang Y, Sen GC.

J Immunol. 2012 Mar 15;188(6):2825-33. doi: 10.4049/jimmunol.1103220. Epub 2012 Feb 8.


Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.

Dickerman BK, White CL, Chevalier C, Nalesso V, Charles C, Fouchécourt S, Guillou F, Viriot L, Sen GC, Hérault Y.

PLoS One. 2011;6(12):e28537. doi: 10.1371/journal.pone.0028537. Epub 2011 Dec 14.


Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.

Sears N, Sen GC, Stark GR, Chattopadhyay S.

J Biol Chem. 2011 Sep 23;286(38):33037-44. doi: 10.1074/jbc.M111.257022. Epub 2011 Aug 4.


Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.

Jha BK, Polyakova I, Kessler P, Dong B, Dickerman B, Sen GC, Silverman RH.

J Biol Chem. 2011 Jul 29;286(30):26319-26. doi: 10.1074/jbc.M111.253443. Epub 2011 Jun 2.


IRF-3 and Bax: a deadly affair.

Chattopadhyay S, Sen GC.

Cell Cycle. 2010 Jul 1;9(13):2479-80. doi: 10.4161/cc.9.13.12237. No abstract available.


Phosphatidylinositol 3-kinase signaling delays sendai virus-induced apoptosis by preventing XIAP degradation.

White CL, Chattopadhyay S, Sen GC.

J Virol. 2011 May;85(10):5224-7. doi: 10.1128/JVI.00053-11. Epub 2011 Mar 2.


The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication.

Chattopadhyay S, Yamashita M, Zhang Y, Sen GC.

J Virol. 2011 Apr;85(8):3708-16. doi: 10.1128/JVI.02133-10. Epub 2011 Feb 9.


The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.

Wan Y, Kim TW, Yu M, Zhou H, Yamashita M, Kang Z, Yin W, Wang JA, Thomas J, Sen GC, Stark GR, Li X.

J Immunol. 2011 Mar 1;186(5):3006-14. doi: 10.4049/jimmunol.1003217. Epub 2011 Jan 26.


2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.

Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, Buller RM, Gale M Jr, Shi PY, Diamond MS.

Nature. 2010 Nov 18;468(7322):452-6. doi: 10.1038/nature09489.


The ISG56/IFIT1 gene family.

Fensterl V, Sen GC.

J Interferon Cytokine Res. 2011 Jan;31(1):71-8. doi: 10.1089/jir.2010.0101. Epub 2010 Oct 15. Review.


The inhibitory action of P56 on select functions of E1 mediates interferon's effect on human papillomavirus DNA replication.

Saikia P, Fensterl V, Sen GC.

J Virol. 2010 Dec;84(24):13036-9. doi: 10.1128/JVI.01194-10. Epub 2010 Oct 6.

Supplemental Content

Support Center