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Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.

Michalson KT, Macintyre AN, Sempowski GD, Bourland JD, Howard TD, Hawkins GA, Dugan GO, Cline JM, Register TC.

Radiat Res. 2019 Jun 4. doi: 10.1667/RR15310.1. [Epub ahead of print]


Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.

Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG.

Cell Host Microbe. 2019 Jun 12;25(6):827-835.e6. doi: 10.1016/j.chom.2019.04.003. Epub 2019 May 16.


Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.

Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G.

Cell. 2019 May 16;177(5):1124-1135.e16. doi: 10.1016/j.cell.2019.03.048.


Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation.

Caudell DL, Michalson KT, Andrews RN, Snow WW, Bourland JD, DeBo RJ, Cline JM, Sempowski GD, Register TC.

Radiat Res. 2019 Jul;192(1):40-52. doi: 10.1667/RR15100.1. Epub 2019 May 6.


Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.

Choi HW, Chan C, Shterev ID, Lynch HE, Robinette TJ, Johnson-Weaver BT, Shi J, Sempowski GD, Kim SY, Dickson JK, Gooden DM, Abraham SN, Staats HF.

SLAS Discov. 2019 Jul;24(6):628-640. doi: 10.1177/2472555219834699. Epub 2019 Mar 27.


Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.

Poston TB, Lee DE, Darville T, Zhong W, Dong L, O'Connell CM, Wiesenfeld HC, Hillier SL, Sempowski GD, Zheng X.

J Infect Dis. 2019 Jun 19;220(2):330-339. doi: 10.1093/infdis/jiz087.


Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.

Hale LP, Rajam G, Carlone GM, Jiang C, Owzar K, Dugan G, Caudell D, Chao N, Cline JM, Register TC, Sempowski GD.

PLoS One. 2019 Feb 13;14(2):e0210663. doi: 10.1371/journal.pone.0210663. eCollection 2019.


Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice.

Johnson-Weaver BT, Sempowski GD, Staats HF.

Allergy. 2019 Feb 12. doi: 10.1111/all.13738. [Epub ahead of print] No abstract available.


Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.

Collier MA, Junkins RD, Gallovic MD, Johnson BM, Johnson MM, Macintyre AN, Sempowski GD, Bachelder EM, Ting JP, Ainslie KM.

Mol Pharm. 2018 Nov 5;15(11):4933-4946. doi: 10.1021/acs.molpharmaceut.8b00579. Epub 2018 Oct 15.


Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.

Hayashi T, Lynch HE, Geyer S, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Misumi M, Shterev I, Nikolich-Žugich J, Murasko D, Hale LP, Sempowski GD, Nakachi K.

Vaccine. 2018 Oct 29;36(45):6650-6659. doi: 10.1016/j.vaccine.2018.09.054. Epub 2018 Sep 28.


Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.

Jin C, Shelburne CP, Li G, Potts EN, Riebe KJ, Sempowski GD, Foster WM, Abraham SN.

J Clin Invest. 2018 Oct 1;128(10):4742-4743. doi: 10.1172/JCI123039. Epub 2018 Oct 1. No abstract available.


Bayesian Multi-Plate High-Throughput Screening of Compounds.

Shterev ID, Dunson DB, Chan C, Sempowski GD.

Sci Rep. 2018 Jun 22;8(1):9551. doi: 10.1038/s41598-018-27531-w.


Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation.

Zhu W, Tomberg J, Knilans KJ, Anderson JE, McKinnon KP, Sempowski GD, Nicholas RA, Duncan JA.

J Biol Chem. 2018 Jul 13;293(28):11218-11229. doi: 10.1074/jbc.RA117.001209. Epub 2018 May 11.


Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC.

Immunity. 2018 Jan 16;48(1):174-184.e9. doi: 10.1016/j.immuni.2017.12.009.


Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan.

Kajimura J, Lynch HE, Geyer S, French B, Yamaoka M, Shterev ID, Sempowski GD, Kyoizumi S, Yoshida K, Misumi M, Ohishi W, Hayashi T, Nakachi K, Kusunoki Y.

Radiat Res. 2018 Jan;189(1):84-94. doi: 10.1667/RR4854.


The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome.

Kurkjian CJ, Guo H, Montgomery ND, Cheng N, Yuan H, Merrill JR, Sempowski GD, Brickey WJ, Ting JP.

Sci Rep. 2017 Dec 11;7(1):17355. doi: 10.1038/s41598-017-17729-9.


Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan.

Kajimura J, Lynch HE, Geyer S, French B, Yamaoka M, Shterev ID, Sempowski GD, Kyoizumi S, Yoshida K, Misumi M, Ohishi W, Hayashi T, Nakachi K, Kusunoki Y.

Radiat Res. 2017 Nov 30. doi: 10.1667/RR14854.1. [Epub ahead of print]


A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination.

Junkins RD, Gallovic MD, Johnson BM, Collier MA, Watkins-Schulz R, Cheng N, David CN, McGee CE, Sempowski GD, Shterev I, McKinnon K, Bachelder EM, Ainslie KM, Ting JP.

J Control Release. 2018 Jan 28;270:1-13. doi: 10.1016/j.jconrel.2017.11.030. Epub 2017 Nov 21.


Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.

Xiao S, Shterev ID, Zhang W, Young L, Shieh JH, Moore M, van den Brink M, Sempowski GD, Manley NR.

J Immunol. 2017 Oct 15;199(8):2701-2712. doi: 10.4049/jimmunol.1600934. Epub 2017 Sep 20.


Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.

Jin C, Shelburne CP, Li G, Potts EN, Riebe KJ, Sempowski GD, Foster WM, Abraham SN.

J Clin Invest. 2017 Oct 2;127(10):3913. doi: 10.1172/JCI97321. Epub 2017 Sep 18. No abstract available.


Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites.

Thome JJ, Grinshpun B, Kumar BV, Kubota M, Ohmura Y, Lerner H, Sempowski GD, Shen Y, Farber DL.

Sci Immunol. 2016 Dec;1(6). pii: eaah6506. doi: 10.1126/sciimmunol.aah6506. Epub 2016 Dec 2.


Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.

Ito R, Hale LP, Geyer SM, Li J, Sornborger A, Kajimura J, Kusunoki Y, Yoshida K, van den Brink MRM, Kyoizumi S, Manley NR, Nakachi K, Sempowski GD.

Radiat Res. 2017 May;187(5):589-598. doi: 10.1667/RR4554.1. Epub 2017 Mar 20.


Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.

Pardi N, Hogan MJ, Pelc RS, Muramatsu H, Andersen H, DeMaso CR, Dowd KA, Sutherland LL, Scearce RM, Parks R, Wagner W, Granados A, Greenhouse J, Walker M, Willis E, Yu JS, McGee CE, Sempowski GD, Mui BL, Tam YK, Huang YJ, Vanlandingham D, Holmes VM, Balachandran H, Sahu S, Lifton M, Higgs S, Hensley SE, Madden TD, Hope MJ, Karikó K, Santra S, Graham BS, Lewis MG, Pierson TC, Haynes BF, Weissman D.

Nature. 2017 Mar 9;543(7644):248-251. doi: 10.1038/nature21428. Epub 2017 Feb 2.


Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.

Feinstein L, Ferrando-Martínez S, Leal M, Zhou X, Sempowski GD, Wildman DE, Uddin M, Aiello AE.

Biodemography Soc Biol. 2016;62(2):208-21. doi: 10.1080/19485565.2016.1172199.


Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge.

Jones DI, McGee CE, Sample CJ, Sempowski GD, Pickup DJ, Staats HF.

Clin Vaccine Immunol. 2016 Jul 5;23(7):648-51. doi: 10.1128/CVI.00216-16. Print 2016 Jul.


NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.

Cell Host Microbe. 2016 Apr 13;19(4):515-528. doi: 10.1016/j.chom.2016.03.001.


Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.

Samo M, Choudhary NR, Riebe KJ, Shterev I, Staats HF, Sempowski GD, Leduc I.

Vaccine. 2016 Feb 24;34(9):1193-200. doi: 10.1016/j.vaccine.2016.01.024. Epub 2016 Jan 24.


Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.

Powell DA, Roberts LM, Ledvina HE, Sempowski GD, Curtiss R 3rd, Frelinger JA.

Cell Immunol. 2016 Jan;299:42-9. doi: 10.1016/j.cellimm.2015.10.002. Epub 2015 Oct 22.


Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

Callaway JB, Smith SA, Widman DG, McKinnon KP, Scholle F, Sempowski GD, Dittmer DP, Crowe JE Jr, de Silva AM, Ting JP.

PLoS One. 2015 Aug 24;10(8):e0136708. doi: 10.1371/journal.pone.0136708. eCollection 2015.


In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.

Bowles RD, Karikari IO, VanDerwerken DN, Sinclair MS, Bell RD, Riebe KJ, Huebner JL, Kraus VB, Sempowski GD, Setton LA.

Eur J Pain. 2016 Mar;20(3):365-76. doi: 10.1002/ejp.732. Epub 2015 May 29.


Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.

Roberts LM, Ledvina HE, Tuladhar S, Rana D, Steele SP, Sempowski GD, Frelinger JA.

Immun Inflamm Dis. 2015 Jun;3(2):71-81. doi: 10.1002/iid3.51. Epub 2015 Mar 23.


Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.

Fusco WG, Choudhary NR, Stewart SM, Alam SM, Sempowski GD, Elkins C, Leduc I.

Monoclon Antib Immunodiagn Immunother. 2015 Apr;34(2):73-82. doi: 10.1089/mab.2014.0054.


Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.

Int J Radiat Biol. 2015 Jun;91(6):510-8. doi: 10.3109/09553002.2015.1028597. Epub 2015 Apr 22.


Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.

Robbins GR, Roberts RA, Guo H, Reuter K, Shen T, Sempowski GD, McKinnon KP, Su L, DeSimone JM, Ting JP.

Nanomedicine. 2015 Apr;11(3):589-99. doi: 10.1016/j.nano.2014.11.010. Epub 2015 Jan 14.


Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.

Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J.

Aging Cell. 2015 Feb;14(1):130-8. doi: 10.1111/acel.12280. Epub 2014 Nov 26.


Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor.

Szabolcs P, Buckley RH, Davis RD, Moffet J, Voynow J, Antony J, Chen X, Sempowski GD, Zaas DW.

J Allergy Clin Immunol. 2015 Feb;135(2):567-70. doi: 10.1016/j.jaci.2014.07.058. Epub 2014 Sep 26. No abstract available.


TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.

Roberts LM, Ledvina HE, Sempowski GD, Frelinger JA.

Front Immunol. 2014 Sep 5;5:426. doi: 10.3389/fimmu.2014.00426. eCollection 2014.


Histone deacetylation critically determines T cell subset radiosensitivity.

Pugh JL, Sukhina AS, Seed TM, Manley NR, Sempowski GD, van den Brink MR, Smithey MJ, Nikolich-Žugich J.

J Immunol. 2014 Aug 1;193(3):1451-8. doi: 10.4049/jimmunol.1400434. Epub 2014 Jul 2.


Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.

Yan Q, Sharma-Kuinkel BK, Deshmukh H, Tsalik EL, Cyr DD, Lucas J, Woods CW, Scott WK, Sempowski GD, Thaden JT, Rude TH, Ahn SH, Fowler VG Jr.

PLoS Pathog. 2014 Jun 5;10(6):e1004149. doi: 10.1371/journal.ppat.1004149. eCollection 2014 Jun. Erratum in: PLoS Pathog. 2014 Jun;10(6):e1004259. Thaden, Joshua [corrected to Thaden, Joshua T].


The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid.

Fusco WG, Choudhary NR, Routh PA, Ventevogel MS, Smith VA, Koch GG, Almond GW, Orndorff PE, Sempowski GD, Leduc I.

Vaccine. 2014 Jun 24;32(30):3752-8. doi: 10.1016/j.vaccine.2014.05.031. Epub 2014 May 18.


IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.

Roberts LM, Davies JS, Sempowski GD, Frelinger JA.

Vaccine. 2014 Jun 17;32(29):3595-603. doi: 10.1016/j.vaccine.2014.05.013. Epub 2014 May 14.


Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays.

Lynch HE, Sanchez AM, D'Souza MP, Rountree W, Denny TN, Kalos M, Sempowski GD.

J Immunol Methods. 2014 Jul;409:62-71. doi: 10.1016/j.jim.2014.04.011. Epub 2014 May 4. Review.


Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection.

Packiam M, Yedery RD, Begum AA, Carlson RW, Ganguly J, Sempowski GD, Ventevogel MS, Shafer WM, Jerse AE.

Infect Immun. 2014 Jun;82(6):2170-9. doi: 10.1128/IAI.01504-14. Epub 2014 Mar 31.


Identification of early interactions between Francisella and the host.

Roberts LM, Tuladhar S, Steele SP, Riebe KJ, Chen CJ, Cumming RI, Seay S, Frothingham R, Sempowski GD, Kawula TH, Frelinger JA.

Infect Immun. 2014 Jun;82(6):2504-10. doi: 10.1128/IAI.01654-13. Epub 2014 Mar 31.


Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.

Holmer SM, Evans KS, Asfaw YG, Saini D, Schell WA, Ledford JG, Frothingham R, Wright JR, Sempowski GD, Perfect JR.

Infect Immun. 2014 Feb;82(2):683-93. doi: 10.1128/IAI.00855-13. Epub 2013 Nov 25.


Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.

Lynch HE, Stewart SM, Kepler TB, Sempowski GD, Alam SM.

J Immunol Methods. 2014 Feb;404:1-12. doi: 10.1016/j.jim.2013.11.026. Epub 2013 Dec 4.


Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.

Zhou X, Gao X, Broglie PM, Kebaier C, Anderson JE, Thom N, Apicella MA, Sempowski GD, Duncan JA.

Infect Immun. 2014 Jan;82(1):184-92. doi: 10.1128/IAI.00890-13. Epub 2013 Oct 14.


Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.

Cain DW, O'Koren EG, Kan MJ, Womble M, Sempowski GD, Hopper K, Gunn MD, Kelsoe G.

J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.


Thymic rejuvenation and aging.

Ventevogel MS, Sempowski GD.

Curr Opin Immunol. 2013 Aug;25(4):516-22. doi: 10.1016/j.coi.2013.06.002. Epub 2013 Jul 4. Review.


Association of age-dependent liver injury and fibrosis with immune cell populations.

Collins BH, Holzknecht ZE, Lynn KA, Sempowski GD, Smith CC, Liu S, Parker W, Rockey DC.

Liver Int. 2013 Sep;33(8):1175-86. doi: 10.1111/liv.12202. Epub 2013 May 26.

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